acetylcysteine has been researched along with Diabetes Mellitus, Adult-Onset in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 16 (34.04) | 29.6817 |
| 2010's | 20 (42.55) | 24.3611 |
| 2020's | 6 (12.77) | 2.80 |
| Authors | Studies |
|---|---|
| Cowan, PJ; Cui, Y; Fichman, Y; Hao, H; He, X; Hill, MA; Liu, Z; Mittler, R; Wang, M; Xu, H; Yang, C; Zhang, G; Zhou, S; Zhu, Q | 1 |
| Argaev-Frenkel, L; Rosenzweig, T | 1 |
| Baratashvili, N; Gvaramia, L; Kandelaki, M; Samsonia, M | 1 |
| Finsen, SH; Hansen, MR; Hansen, PBL; Mortensen, SP | 1 |
| Baum, SJ; Chakravarthy, MV; Chera, H; Gunn, NT; Harrison, SA; Kohli, A; Koziel, MJ; Patil, R; Younes, ZH; Zhao, J | 1 |
| Dias, SC; Dludla, PV; Johnson, R; Louw, J; Nkambule, BB; Obonye, N | 1 |
| Chatterjee Bhowmick, D; Jeremic, A | 1 |
| Dalugama, C; Gawarammana, IB | 1 |
| Lee, S; Liu, Q; Wang, P | 1 |
| Wang, H | 1 |
| Bochi, GV; Cargnin, LP; de Carvalho, JA; Gomes, P; Moresco, RN; Torbitz, VD | 1 |
| Baotic, I; Bienengraeber, M; Bosnjak, ZJ; Kersten, JR; Lazar, J; Muravyeva, M; Sedlic, F; Warltier, DC | 1 |
| Chen, YY; Guo, R; Jin, KK; Shen, YL; Wang, LX; Wang, Y; Ying, L | 1 |
| Alicic, RZ; Tuttle, KR | 1 |
| Gamage, AM; Gan, YH; Lee, KO | 1 |
| Annabi, A; Dhouib, IB; El Fazaa, S; Gharbi, N; Lasram, MM | 1 |
| Chen, H; Fan, HQ; He, W; Wang, ZX; Xu, KF; Xu, XY | 1 |
| Chung, CH; Kang, JS; Kim, HM; Kim, HS; Kim, YM; Kwon, MH; Lee, ES; Lee, EY; Yadav, D | 1 |
| Attanasio, R; Feroe, AG; Scinicariello, F | 1 |
| Borchert, A; Bumke-Vogt, C; Guzmán-Pérez, V; Mewis, I; Pfeiffer, AF; Schreiner, M | 1 |
| Cen, LJ; Chen, L; Li, CC; Li, X; Meng, FH; Wen, YH; Yang, CT; Zhang, H | 1 |
| Bandow, K; Kakimoto, K; Machigashira, M; Matsuguchi, T; Matsuyama, T; Ohnishi, T | 1 |
| Ha, H; Kim, YO; Lee, HB; Noh, H; Oh, EY; Seo, JY; Yu, MR | 1 |
| Biasi, F; Brocato, L; Dinatale, S; Martina, V; Mascia, C; Masha, A | 1 |
| Barrett, F; Gibson, KR; MacRury, SM; Megson, IL; Sharma, S; Winterburn, TJ | 1 |
| Bhalla, K; Choi, JH; Dewi, R; Girnun, GD; Hwang, BJ; Mclenithan, J; Ou, L; Pozharski, E; Stock, J; Twaddel, W | 1 |
| Aghamohammadzadeh, N; Heydarnejad, M; Khalaj, MR; Mobasseri, M; Noshad, H; Rasi Hashemi, S; Tabrizi, A; Tayebi Khosroshahi, H | 1 |
| Ieiri, I; Iwase, M; Kitazono, T; Matsuyama, N; Ohdo, S; Sonoki, K; Takata, Y | 1 |
| Barr, C; Barrett, F; Dransfield, I; Mackenzie, I; MacRury, SM; Megson, IL; Rushworth, GF; Treweeke, AT; Winterburn, TJ | 1 |
| Calzada, C; Coulon, L; Lagarde, M; Moulin, P; Véricel, E | 1 |
| Irie, K; Maru, Y; Muraki, T; Ohba, K; Uchida, Y; Yoshioka, T | 1 |
| Li, L; Renier, G; Sawamura, T | 1 |
| Abate, G; Bordonaro, F; Calvagno, S; Cilio, D; Ignaccolo, L; Leotta, C; Mauceri, B; Neri, S; Pulvirenti, D; Signorelli, SS; Torrisi, B | 1 |
| Barrett, BJ; Parfrey, PS | 1 |
| Coderre, L; Pelletier, A | 1 |
| Cengiz, M; Cobanoglu, A; Kanigur, G; Ozaydin, A; Ozkilic, AC | 1 |
| Jóźwiak, Z; Kania, K; Zych, A | 1 |
| Harmon, JS; Robertson, R; Zhang, T; Zhou, H | 1 |
| Allister, EM; Bikopoulos, G; Fantus, IG; Giacca, A; Lewis, GF; Naassan, A; Oprescu, AI; Park, E; Rozakis-Adcock, M; Tang, C; Uchino, H; Wheeler, MB | 1 |
| Adachi, Y; Sakurai, H; Yoshikawa, Y | 1 |
| Berchio, A; Bergamini, S; Brocato, L; Della Casa, L; Gigliardi, VR; Iannone, A; Manzato, E; Martina, V; Masha, A; Massarenti, P; Settanni, F | 1 |
| Collins, P; Gilligan, S; Johnson, A; Owens, D; Stinson, J; Tomkin, GH | 1 |
| Fujitani, Y; Kajimoto, Y; Kamada, T; Kaneto, H; Kawamori, R; Kishimoto, M; Matsuoka, T; Umayahara, Y; Watada, H; Yamasaki, Y | 1 |
| Armiento, A; Bravi, MC; Cassone-Faldetta, M; De Luca, O; De Mattia, G; Ferri, C; Laurenti, O; Proietti, A | 1 |
| Gleason, CE; Harmon, JS; Robertson, RP; Tanaka, Y; Tran, PO | 1 |
| Fujitani, Y; Hanafusa, T; Hori, M; Kajimoto, Y; Kaneto, H; Matsuoka, T; Matsuzawa, Y; Miyagawa, J; Umayahara, Y; Yamasaki, Y | 1 |
| Malorni, W; Masella, R; Paganelli, R; Rivabene, R; Santulli, M; Straface, E | 1 |
4 review(s) available for acetylcysteine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications.
Topics: Acetylcysteine; Antioxidants; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Humans; Protective Agents | 2018 |
Novel therapies for diabetic kidney disease.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antioxidants; Bosentan; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endothelins; Enzyme Inhibitors; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Indoles; Janus Kinases; Maleimides; Polyamines; Protein Kinase C; Pyridones; Pyridoxamine; Sevelamer; Sulfonamides | 2014 |
A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Diabetes Mellitus, Type 2; Humans; Insulin Resistance | 2015 |
Clinical practice. Preventing nephropathy induced by contrast medium.
Topics: Acetylcysteine; Aged; Contrast Media; Coronary Angiography; Diabetes Mellitus, Type 2; Fluid Therapy; Humans; Hypertension; Kidney Diseases; Male; Practice Guidelines as Topic; Risk Factors | 2006 |
8 trial(s) available for acetylcysteine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Aldosterone Induces Vasoconstriction in Individuals with Type 2 Diabetes: Effect of Acute Antioxidant Administration.
Topics: Acetylcysteine; Adult; Aldosterone; Antioxidants; Case-Control Studies; Denmark; Diabetes Mellitus, Type 2; Female; Femoral Artery; Hemodynamics; Humans; Leg; Male; Middle Aged; Regional Blood Flow; Vasoconstriction | 2021 |
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease.
Topics: Acetylcysteine; Administration, Oral; Arginine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Female; Glutamine; Humans; Isoleucine; Leucine; Liver; Magnetic Resonance Imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Single-Blind Method; Treatment Outcome; Valine | 2021 |
Angiotensin receptor blocker and N-acetyl cysteine for reduction of proteinuria in patients with type 2 diabetes mellitus.
Topics: Acetylcysteine; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Losartan; Male; Middle Aged; Proteinuria; Statistics, Nonparametric | 2012 |
Telmisartan and N-acetylcysteine suppress group V secretory phospholipase A2 expression in TNFα-stimulated human endothelial cells and reduce associated atherogenicity.
Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Atherosclerosis; Benzimidazoles; Benzoates; Chemokine CCL2; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Group V Phospholipases A2; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Lipoproteins, LDL; Lysophosphatidylcholines; Male; Middle Aged; RNA, Messenger; Telmisartan; Tumor Necrosis Factor-alpha | 2012 |
N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.
Topics: Acetylcysteine; Administration, Oral; Aged; Blood Platelets; Cardiovascular Diseases; Cell Communication; Cell-Derived Microparticles; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Free Radical Scavengers; Glutathione; Humans; Hypoglycemic Agents; Male; Middle Aged; Monocytes; Placebos | 2012 |
Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls.
Topics: Acetylcysteine; Adult; Antioxidants; Ascorbic Acid; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glucose Intolerance; Humans; Male; Oxidants; Oxidative Stress; Postprandial Period; Single-Blind Method; Vitamin E | 2005 |
Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes.
Topics: Acetylcysteine; Administration, Oral; Aged; Arginine; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Endothelium, Vascular; Humans; Hypertension; Hypoglycemic Agents; Male; Middle Aged; Placebos; Systole | 2008 |
Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin-dependent diabetes.
Topics: Acetylcysteine; Administration, Oral; Adult; Blood Glucose; Blood Pressure; Cholesterol; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Female; Free Radical Scavengers; Glutathione Disulfide; Humans; Insulin; Male; Middle Aged; Oxidative Stress; Reference Values; Triglycerides; Vascular Cell Adhesion Molecule-1 | 1998 |
35 other study(ies) available for acetylcysteine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Combination of Antioxidant Enzyme Overexpression and N-Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes.
Topics: Acetylcysteine; Animals; Antioxidants; Bone Marrow; Bone Marrow Cells; Chronic Limb-Threatening Ischemia; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutathione Peroxidase; Ischemia; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Reactive Oxygen Species; Superoxide Dismutase | 2021 |
Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin Secretion; Mice; Oxidation-Reduction; Oxidative Stress | 2022 |
NEUROPROTECTIVE AND ANTIOXIDANT POTENTIAL OF MONTELUKAST-ACETYLCYSTEINE COMBINATION THERAPY FOR BRAIN PROTECTION IN PATIENTS WITH COVID-19 INDUCED PNEUMONIA.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; COVID-19; Diabetes Mellitus, Type 2; Humans; Interleukin-6; Microcirculation; Middle Aged; Oxygen; Pneumonia, Viral; Respiratory Distress Syndrome; SARS-CoV-2 | 2023 |
Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Down-Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Insulin-Secreting Cells; Insulinoma; Islet Amyloid Polypeptide; Leupeptins; Mice; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2018 |
Lessons learnt from managing a case of dengue hemorrhagic fever complicated with acute liver failure and acute kidney injury: a case report.
Topics: Acetylcysteine; Acidosis, Lactic; Acute Kidney Injury; Adult; Antioxidants; Diabetes Mellitus, Type 2; Erythrocyte Transfusion; Female; Fluid Therapy; Humans; Liver Failure, Acute; Renal Replacement Therapy; Severe Dengue | 2018 |
Diabetes-associated oxidative damage to DNA base in colon cells.
Topics: Acetylcysteine; Animals; Colon; Colonic Neoplasms; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Damage; DNA Glycosylases; Glucose; Guanine; HCT116 Cells; HT29 Cells; Humans; Mice; Oxidative Stress | 2019 |
N-acetyl-L-cysteine relieves myocardial injury in type 2 diabetic rats via inhibiting oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Humans; Oxidative Stress; Random Allocation; Rats; Rats, Inbred Strains | 2020 |
An alternative pathway through the Fenton reaction for the formation of advanced oxidation protein products, a new class of inflammatory mediators.
Topics: Acetylcysteine; Advanced Oxidation Protein Products; Antioxidants; Case-Control Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fructosediphosphates; Humans; Hydrogen Peroxide; Inflammation Mediators; Iron; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2014 |
Cardioprotection during diabetes: the role of mitochondrial DNA.
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA, Mitochondrial; Free Radical Scavengers; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Reactive Oxygen Species | 2014 |
Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats.
Topics: Acetylcysteine; Animals; Carbon Monoxide; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Induction; Heme Oxygenase-1; Hemin; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin; Vasodilation | 2014 |
Effect of oral N-acetyl cysteine supplementation in type 2 diabetic patients on intracellular glutathione content and innate immune responses to Burkholderia pseudomallei.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Burkholderia pseudomallei; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glutathione; Humans; Immunity, Innate; Interferon-gamma; Interleukin-12; Male; Middle Aged | 2014 |
FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells.
Topics: Acetylcysteine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucose; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; NF-kappa B; Oxo-Acid-Lyases; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Signal Transduction | 2015 |
Oleanolic acid and N-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Oxidative Stress; Rats; Rats, Inbred OLETF; Reactive Oxygen Species | 2016 |
Acrolein metabolites, diabetes and insulin resistance.
Topics: Acetylcysteine; Acrolein; Adult; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Insulin Resistance; Male; Nutrition Surveys | 2016 |
Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Cell Line; Cell Survival; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Gene Expression; Gene Knockdown Techniques; Gluconeogenesis; Glucose-6-Phosphatase; Hep G2 Cells; Humans; Hypoglycemic Agents; Isothiocyanates; NF-E2-Related Factor 2; Phosphoenolpyruvate Carboxykinase (ATP); Plants, Medicinal; Protein Transport; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; RNA, Small Interfering; Sirtuin 1; Thiocyanates; Thioglucosides; Tropaeolum | 2016 |
Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine.
Topics: Acetylcysteine; Aged; Case-Control Studies; Cell Adhesion; Cell Line; Cell Movement; Cell Survival; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Interleukin-6; Interleukin-8; Male; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Protective Agents; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Up-Regulation | 2017 |
Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes.
Topics: Acetylcysteine; Alveolar Bone Loss; Animals; Antioxidants; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Gingiva; Hydrogen Peroxide; Keratinocytes; Male; Mandible; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nitric Oxide Synthase Type III; Oxidative Stress; Reactive Oxygen Species | 2009 |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recombinant Proteins; Repressor Proteins; RNA Interference; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid | 2009 |
N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with Type 2 diabetes mellitus.
Topics: Acetylcysteine; Aged; Aldehydes; Case-Control Studies; Diabetes Mellitus, Type 2; E-Selectin; Endothelium, Vascular; Female; Free Radical Scavengers; Glucose; Glycemic Index; Humans; Insulin; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Postprandial Period; Vascular Cell Adhesion Molecule-1 | 2009 |
Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes.
Topics: Acetylcysteine; Adenosine Diphosphate; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glutathione; Humans; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reactive Oxygen Species; Thrombin; Thrombosis | 2011 |
N-Acetylfarnesylcysteine is a novel class of peroxisome proliferator-activated receptor γ ligand with partial and full agonist activity in vitro and in vivo.
Topics: 3T3-L1 Cells; Acetylcysteine; Animals; Cysteine; Diabetes Mellitus, Type 2; Glucose; Homeostasis; Hypoglycemic Agents; Ligands; Mice; Mice, Knockout; PPAR gamma; Protein Binding; Rosiglitazone; Thiazolidinediones | 2011 |
Activation of p38 mitogen-activated protein kinase/cytosolic phospholipase A2 cascade in hydroperoxide-stressed platelets.
Topics: Acetylcysteine; Arachidonic Acid; Blood Platelets; Cytosol; Diabetes Mellitus, Type 2; Enzyme Activation; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Leukotrienes; Mitogen-Activated Protein Kinases; Oxidative Stress; Oxygen; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phospholipids | 2003 |
Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adipocytes; Aldehydes; Animals; Antioxidants; Buthionine Sulfoximine; Cells, Cultured; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Free Radical Scavengers; Glycation End Products, Advanced; Lipid Peroxidation; Male; NF-kappa B; Oxidative Stress; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred OLETF; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2004 |
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Topics: Acetylcysteine; Adult; Aged; Anti-Infective Agents; Antioxidants; Arteriosclerosis; Cells, Cultured; Curcumin; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Flavonoids; Foam Cells; Gene Expression Regulation; Glucose; Glycation End Products, Advanced; Humans; Hyperglycemia; Macrophages; Male; MAP Kinase Signaling System; Mesylates; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Processing, Post-Translational; Pyrroles; Receptors, LDL; RNA, Messenger; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2004 |
Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes.
Topics: 2,4-Dinitrophenol; 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Protein Kinases; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Free Radical Scavengers; Glucose; Ketone Bodies; Male; Multienzyme Complexes; Myocytes, Cardiac; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Uncoupling Agents | 2007 |
The role of N-acetylcysteine treatment on anti-oxidative status in patients with type II diabetes mellitus.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Type 2; Enzymes; Female; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; Male; Middle Aged | 2006 |
Involvement of reactive oxygen species in aclarubicin-induced death of human trisomic and diabetic fibroblasts.
Topics: Acetylcysteine; Aclarubicin; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Calcium; Cell Line; Diabetes Mellitus, Type 2; Down Syndrome; Fibroblasts; Humans; Membrane Potential, Mitochondrial; Necrosis; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates | 2007 |
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Type 2; Gene Expression; Glucose; Glutathione Peroxidase; Glyceraldehyde; Homeodomain Proteins; Hyperlipidemias; Insulin; Insulin-Secreting Cells; Interleukin-1beta; Maf Transcription Factors, Large; Models, Biological; Oxidative Stress; Reactive Oxygen Species; Trans-Activators; Transfection | 2007 |
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucose; Infusions, Intravenous; Insulin; Insulin Secretion; Obesity; Oleic Acid; Oxidative Stress; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taurine | 2007 |
Antidiabetic zinc(II)-N-acetyl-L-cysteine complex: evaluations of in vitro insulinomimetic and in vivo blood glucose-lowering activities.
Topics: Acetylcysteine; Adipocytes; Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Evaluation, Preclinical; Glucose Tolerance Test; Hemoglobins; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Mice; Mice, Knockout; Oxidative Stress; Rats; Rats, Wistar; Zinc | 2007 |
The effect of reduction of lipoprotein (a) on cellular cholesterol synthesis in non-diabetic and type 2 diabetic subjects.
Topics: Acetylcysteine; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Leukocytes, Mononuclear; Lipoprotein(a); Lipoproteins, LDL; Lymphocytes; Male; Oxidation-Reduction | 1995 |
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
Topics: Acetylcysteine; B-Lymphocytes; Blotting, Northern; Cells, Cultured; Cloning, Molecular; Diabetes Mellitus, Type 2; Gene Expression Regulation; Genes, Reporter; Glucose; Glycation End Products, Advanced; Guanidines; Homeodomain Proteins; Humans; Insulin; Promoter Regions, Genetic; Ribose; RNA, Messenger; Trans-Activators; Transcription, Genetic | 1997 |
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.
Topics: Acetylcysteine; Age Factors; Animals; Cell Line; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glucose; Glucose Tolerance Test; Guanidines; Homeodomain Proteins; Insulin; Islets of Langerhans; Male; Mice; Oxidative Stress; Promoter Regions, Genetic; Rats; Rats, Zucker; RNA, Messenger; Trans-Activators | 1999 |
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Insulin Resistance; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Vitamin E | 1999 |
Structural changes of the erythrocyte as a marker of non-insulin-dependent diabetes: protective effects of N-acetylcysteine.
Topics: Acanthocytes; Acetylcysteine; Aged; Aged, 80 and over; Antioxidants; Cell Size; Cytoskeleton; Diabetes Mellitus, Type 2; Disease Progression; Erythrocyte Membrane; Erythrocytes; Female; Glutathione; Humans; Microscopy, Electron, Scanning; Receptor, Insulin; Spectrin | 2002 |