Compounds > acetylcysteine

acetylcysteine and Cognitive Decline

acetylcysteine has been researched along with Cognitive Decline in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (63.16)24.3611
2020's7 (36.84)2.80

Authors

AuthorsStudies
Sekhar, RV1
Citraro, R; Constanti, A; De Caro, C; De Sarro, G; Guarnieri, L; Leo, A; Nicoletti, F; Russo, E; Tallarico, M; Zito, MC1
Yan, Y1
Chakraborty, S; Raju, TR; Shankaranarayana Rao, BS; Srikumar, BN; Tripathi, SJ1
Abd El-Rady, NM; Ahmed, AM; El Shehaby, DM; El-Mahdy, RI; Hosny, A1
Jing, GC; Liu, D; Liu, YQ; Zhang, MR1
Asanuma, M; Kitamura, Y; Miyazaki, I; Sendo, T; Sumiyoshi, Y; Ushio, S; Wada, Y1
Amaral, JD; Bernardi, J; Brandão, R; Costa, L; da Costa, M; Fiuza, T; Pereira, ME; Ribeiro, MF; Rodrigues, CMP1
Abramov, AY; Antoine, DJ; Aronica, E; Balosso, S; Del Giudice, E; Liang, LP; Pascente, R; Pastore, A; Patel, M; Pauletti, A; Ravizza, T; Rizzi, M; Salamone, A; Shekh-Ahmad, T; Terrone, G; van Vliet, EA; Vezzani, A; Villa, BR; Walker, MC1
Dai, Z; Shi, H; Wang, L; Wu, P; Zhao, S1
Abdurasulova, IN; Ekimova, IV; Gazizova, AR; Klimenko, VM; Matsulevich, AV; Pastukhov, YF1
Alameda, L; Baumann, PS; Buclin, T; Cleusix, M; Conus, P; Cousins, A; Cuenod, M; Do, KQ; Eap, CB; Ferrari, C; Fournier, M; Gholam-Rezaee, M; Golay, P; Gruetter, R; Jenni, R; Keshavan, MS; Seidman, LJ; Wojcik, J; Woo, TW; Xin, L1
Castle, DJ; Dean, OM; Francis, PS; Galletly, C; Harris, AWF; Hughes, ME; Neill, E; Phillipou, A; Rossell, SL; Sarris, J; Siskind, D; Smith, ZM; Yolland, COB1
Chen, LL; Crawford, J; Fatemi, A; Fulton, WB; Guajardo, A; Hackam, DJ; Hou, Z; Jia, H; Kannan, RM; Kannan, S; Lu, P; Martin, LY; Mori, S; Niño, DF; Pletnikov, M; Prindle, T; Sodhi, CP; Wang, S; Yamaguchi, Y; Zhang, F; Zhou, Q1
Abramov, AY; Aronica, E; Balosso, S; Del Giudice, E; Liang, LP; Pascente, R; Pastore, A; Patel, M; Pauletti, A; Ravizza, T; Rizzi, M; Salamone, A; Shekh-Ahmad, T; Terrone, G; van Vliet, EA; Vezzani, A; Villa, BR; Walker, MC1
Apaijai, N; Arinno, A; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Keawtep, P; Pratchayasakul, W; Prus, D; Saiyasit, N1
Higashi, K; Igarashi, K; Kashiwagi, K; Kuni, K; Mizoi, M; Nakamura, M; Saiki, R; Toida, T; Uemura, K; Waragai, M; Yoshida, M1
Berk, M; Bush, AI; Dean, OM; Dodd, S; Malhi, GS; On, ZX; Rapado-Castro, M; Skvarc, DR1
Baker, AS; Butterfield, DA; Cai, J; Huang, Q; Joshi, G; Markesbery, WR; Pierce, W; Robinson, RA; St Clair, DK; Sultana, R1

Reviews

2 review(s) available for acetylcysteine and Cognitive Decline

ArticleYear
GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.
    The Journal of nutrition, 2021, 12-03, Volume: 151, Issue:12

    Topics: Acetylcysteine; Aged; Animals; Body Composition; Cognitive Dysfunction; Dietary Supplements; Glutathione; Healthy Aging; Humans; Inflammation; Mice; Mitochondria; Muscle Strength; Oxidative Stress; Randomized Controlled Trials as Topic

2021
Improvement of cognitive function in schizophrenia with
    Nutritional neuroscience, 2020, Volume: 23, Issue:2

    Topics: Acetylcysteine; Cognition; Cognitive Dysfunction; Glutathione; Humans; Neuroprotective Agents; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2020

Trials

2 trial(s) available for acetylcysteine and Cognitive Decline

ArticleYear
N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis.
    Schizophrenia bulletin, 2018, 02-15, Volume: 44, Issue:2

    Topics: Acetylcysteine; Adolescent; Adult; Antioxidants; Biomarkers; Cognitive Dysfunction; Double-Blind Method; Female; Glutathione; Glutathione Peroxidase; Humans; Magnetic Resonance Spectroscopy; Male; Outcome Assessment, Health Care; Oxidation-Reduction; Prefrontal Cortex; Psychotic Disorders; Schizophrenia; Young Adult

2018
Cognitive effects of adjunctive N-acetyl cysteine in psychosis.
    Psychological medicine, 2017, Volume: 47, Issue:5

    Topics: Acetylcysteine; Adult; Attention; Bipolar Disorder; Cognitive Dysfunction; Executive Function; Female; Free Radical Scavengers; Humans; Male; Memory, Short-Term; Middle Aged; Psychotic Disorders; Schizophrenia; Treatment Outcome

2017

Other Studies

15 other study(ies) available for acetylcysteine and Cognitive Decline

ArticleYear
N-acetylcysteine aggravates seizures while improving depressive-like and cognitive impairment comorbidities in the WAG/Rij rat model of absence epilepsy.
    Molecular neurobiology, 2022, Volume: 59, Issue:5

    Topics: Acetylcysteine; Animals; Cognitive Dysfunction; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Humans; Rats; Seizures

2022
[Effect of N-acetylcysteine on Cognitive Function and Nuclear Factor Erythroid 2 Related Factor 2/Heme Oxygenase-1 Pathway in Mouse Models of Postoperative Cognitive Dysfunction].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2019, Aug-30, Volume: 41, Issue:4

    Topics: Acetylcysteine; Animals; Cognition; Cognitive Dysfunction; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Postoperative Complications; Random Allocation

2019
N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes.
    Neurochemistry international, 2020, Volume: 132

    Topics: Acetylcysteine; Animals; Cognitive Dysfunction; Depression; Hippocampus; Male; Organ Size; Random Allocation; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors

2020
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine.
    Reproductive toxicology (Elmsford, N.Y.), 2020, Volume: 96

    Topics: Acetylcysteine; Analgesics; Animals; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Erectile Dysfunction; Female; Hippocampus; Ketamine; Luteinizing Hormone; Male; Prefrontal Cortex; Rats; Sperm Count; Sperm Motility; Testis; Testosterone

2020
Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.
    Chinese journal of natural medicines, 2020, Volume: 18, Issue:9

    Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Transcription Factor CHOP

2020
N-Acetylcysteine Attenuates the Anxiety-Like Behavior and Spatial Cognition Impairment Induced by Doxorubicin and Cyclophosphamide Combination Treatment in Rats.
    Pharmacology, 2021, Volume: 106, Issue:5-6

    Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antioxidants; Anxiety; Behavior, Animal; Body Weight; Cognitive Dysfunction; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Glutathione; Glutathione Disulfide; Hippocampus; Interleukin-6; Male; Oxidative Stress; Rats, Wistar; Spatial Navigation; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2021
N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin.
    Chemico-biological interactions, 2017, Jun-25, Volume: 272

    Topics: Acetylcholinesterase; Acetylcysteine; Animals; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Maze Learning; Mice; Motor Activity; Neuronal Plasticity; Neuroprotective Agents; Oxidative Stress; Physostigmine; Receptor, trkB; Streptozocin; Superoxide Dismutase

2017
Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.
    Brain : a journal of neurology, 2017, Jul-01, Volume: 140, Issue:7

    Topics: Acetylcysteine; Animals; Astrocytes; Biomarkers; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; HMG-Box Domains; HMGB1 Protein; Isothiocyanates; Male; Nerve Degeneration; Neurons; Oxidative Stress; Rats; Sulfoxides

2017
Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
    Bioscience reports, 2017, Dec-22, Volume: 37, Issue:6

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Ferritins; Glutathione; Malondialdehyde; Memory Disorders; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Oxidative Stress; Superoxide Dismutase

2017
Impairment of non-associative learning in a rat experimental model of preclinical stage of Parkinson's disease.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2017, Volume: 476, Issue:1

    Topics: Acetylcysteine; Animals; Axons; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dopaminergic Neurons; Humans; Learning; Mesencephalon; Parkinson Disease, Secondary; Prefrontal Cortex; Rats

2017
Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.
    Science translational medicine, 2018, 12-12, Volume: 10, Issue:471

    Topics: Acetylcysteine; Administration, Oral; Animals; Animals, Newborn; Antioxidants; Brain; Cognitive Dysfunction; Dendrimers; Enterocolitis, Necrotizing; HMGB1 Protein; Humans; Intestinal Mucosa; Mice, Inbred C57BL; Microglia; Myelin Sheath; Toll-Like Receptor 4

2018
Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.
    Brain : a journal of neurology, 2019, 07-01, Volume: 142, Issue:7

    Topics: Acetylcysteine; Animals; Astrocytes; Biomarkers; Case-Control Studies; Cell Count; Cognitive Dysfunction; Disease Models, Animal; Electric Stimulation; Epilepsy; Glutathione; Hippocampus; HMGB1 Protein; Humans; Isothiocyanates; Male; Neurons; Oxidative Stress; Rats; Status Epilepticus; Sulfoxides

2019
N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats.
    Aging, 2019, 06-03, Volume: 11, Issue:11

    Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Brain; Castration; Cognition; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy, Combination; Dysbiosis; Hippocampus; Inflammation; Inulin; Male; Malondialdehyde; Microglia; Motor Activity; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Testosterone

2019
Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-20, Volume: 441

    Topics: Acetylcysteine; Acrolein; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged

2015
Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive
    Proteomics, 2011, Volume: 11, Issue:21

    Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognitive Dysfunction; Free Radical Scavengers; Gene Expression Regulation; Gene Knock-In Techniques; Humans; Mice; Mutation; Presenilin-1; Proteome; Proteomics

2011