acetylcysteine has been researched along with Cancer of Pancreas in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.52) | 18.7374 |
| 1990's | 2 (4.35) | 18.2507 |
| 2000's | 11 (23.91) | 29.6817 |
| 2010's | 25 (54.35) | 24.3611 |
| 2020's | 5 (10.87) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, G; Hardy, M; Kalyanaraman, B | 1 |
| Fan, G; Hu, Q; Ji, S; Liu, M; Liu, W; Qin, Y; Sun, Q; Xu, W; Xu, X; Ye, Z; Yu, X; Zhang, Z; Zhuo, Q | 1 |
| Feng, H; Ikenaga, N; Iwamoto, C; Mizumoto, K; Moriyama, T; Nagai, S; Nakamura, M; Nakata, K; Ohuchida, K; Sheng, N; Shindo, K; Shirahane, K | 1 |
| Amin, S; K Pandey, M; Karelia, DN; Kim, S; Lu, J; Plano, D; Sharma, AK | 1 |
| Ardenkjær-Larsen, JH; Blackman, B; Brender, JR; Choyke, PL; Crooks, DR; Kishimoto, S; Krishna, MC; Linehan, WM; Malinowski, RM; Mitchell, JB; Opina, A; Oshima, N; Otowa, Y; Saida, Y; Sail, D; Saito, K; Seki, T; Swenson, RE; Yamamoto, K | 1 |
| Chung, MH; Hahm, KB; Han, YM; Jeong, M; Ko, KH; Kwon, CI; Park, JM | 1 |
| Hattori, N; Hori, M; Kodera, Y; Mizuno, M; Nakamura, K; Sato, Y; Takeda, S; Tanaka, H; Yamada, S | 1 |
| Kasukabe, T; Kumakura, S; Yamaguchi, Y | 1 |
| Hu, Q; Ji, S; Liu, J; Liu, W; Ni, Q; Qin, Y; Sun, Q; Xiang, J; Xu, J; Xu, W; Yu, X; Zhang, B; Zhang, Z | 1 |
| Arpicco, S; Dalla Pozza, E; Dando, I; Fanelli, G; Fattal, E; Forciniti, S; Heeschen, C; Marengo, A; Palmieri, M; Stella, B; Tsapis, N; Yagoubi, N | 1 |
| Chen, B; Fang, D; Li, D; Luo, J; Ni, F; Xiang, Y; Xu, X; Zhou, M; Zhu, X | 1 |
| Juránek, I; Rapta, P; Šoltés, L; Valachová, K; Valent, I | 1 |
| Daneker, GW; Kim, B; McDonald, JF; Mezencev, R; Sulchek, TA; Wang, L; Xu, W | 1 |
| Costanzo, C; D'Alessandro, A; Dalla Pozza, E; Dando, I; Donadelli, M; Palmieri, M; Zolla, L | 1 |
| Hiraga, R; Kamata, T; Kato, M; Miyagawa, S | 1 |
| Cheng, ZX; Ding, L; Guo, LQ; Hou, J; Liu, T; Liu, WX; Qu, YK; Wang, DW; Xia, WB; Xu, J; Zhang, YH; Zhong, ZH | 1 |
| Distler, AM; Hill, EG; Lemasters, JJ; Manevich, Y; Mieyal, JJ; Nieminen, AL; Qanungo, S; Shaner, B; Townsend, DM; Uys, JD | 1 |
| Akyol, A; Besler, HT; Buyuktuncer, Z; Kuyumcu, A; Ozmen, MM | 1 |
| Harada, M; Harashima, N; Huang, W; Moritani, T; Zhang, M | 1 |
| Hiroshima, K; Jiang, Y; Kawamura, K; Kubo, S; Morinaga, T; Okamoto, S; Sekine, I; Shimada, H; Shingyoji, M; Tada, Y; Tagawa, M; Tatsumi, K; Yamauchi, S | 1 |
| Ali, SA; Batra, SK; Chakraborty, S; Das, B; Dash, P; Jain, S; Mohanty, AK; Panda, SK; Senapati, S; Suklabaidya, S; Swaminathan, S | 1 |
| Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X | 1 |
| Higuchi, Y; Honma, Y; Kasukabe, T; Kato, N; Kumakura, S; Okabe-Kado, J | 1 |
| Hong, YH; Wu, JX; Yang, XG | 1 |
| Adachi, M; Wang, W; Zhang, R; Zhou, J; Zhu, D | 1 |
| Bhattacharya, K; Datta, K; Dutta, D; Li, J; Mandal, C; Pal, BC; Samanta, SK; Sarkar, S | 1 |
| Aghazarian, M; Cucchi, S; Galmarini, F; Goldschmidt, P; Golomar, W; Gordon, W; Lasalvia-Galante, E; Lasalvia-Prisco, E; Vázquez, J | 1 |
| Akimoto, M; Hisanaga, T; Honma, Y; Shimojo, Y; Tajima, Y; Takenaga, K; Tanaka, T | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, YB | 1 |
| Akatsuka, Y; Demachi-Okamura, A; Kuzushima, K; Miyoshi, H; Torikai, H; Yoshimori, T | 1 |
| Hu, LH; Li, ZS; Liao, Z; Liu, MH; Wang, L; Ye, B; Zou, WB | 1 |
| Fearon, KC; Maingay, JP; Powell, JJ; Ross, JA; Sangster, K | 1 |
| Allaman-Pillet, N; Billestrup, N; Bonny, C; Karlsen, AE; Mandrup-Poulsen, T; Størling, J | 1 |
| Costanzo, C; Dalla Pozza, E; Donadelli, M; Palmieri, M; Piacentini, P; Scarpa, A; Scupoli, MT | 1 |
| Humphreys, I; Loganathan, S; Srivastava, SK; Zhang, R | 1 |
| Asbury, CR; Aykin-Burns, N; Coleman, MC; Cullen, JJ; Daniels, D; Du, J; Li, L; Smith, BJ; Spitz, DR | 1 |
| Beuneu, C; Goldman, M; Verhasselt, V; Vosters, O | 1 |
| Einhorn, LH; Loehrer, PJ; Williams, SD | 1 |
| Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E | 1 |
| Kowluru, A; Li, G; Metz, SA; Nesher, R; Rabaglia, ME; Seavey, SE; Sorenson, RL; Vadakekalam, J; Weinhaus, AJ | 1 |
| Kobayashi, D; Sasaki, M; Watanabe, N | 2 |
| Aikou, T; Akiyama, S; Baba, M; Kawamura, M; Kusano, C; Makino, M; Noma, H; Okumura, H; Takao, S; Yoh, H | 1 |
| Jamieson, JD; Qiu, X; Valentijn, JA | 1 |
| Einhorn, LH; Loehrer, PJ | 1 |
| Ansari, R; Einhorn, LH; Loehrer, PJ; Williams, SD | 1 |
2 trial(s) available for acetylcysteine and Cancer of Pancreas
| Article | Year |
|---|---|
Improved oxidative status in major abdominal surgery patients after N-acetyl cystein supplementation.
Topics: Abdomen; Acetylcysteine; Aged; Antioxidants; Colonic Neoplasms; Female; Glutathione; Humans; Male; Malondialdehyde; Middle Aged; Nitrates; Oxidative Stress; Pancreatic Neoplasms; Preoperative Care; Reactive Oxygen Species; Rectal Neoplasms; Stomach Neoplasms | 2015 |
Addition of an induction regimen of antiangiogenesis and antitumor immunity to standard chemotherapy improves survival in advanced malignancies.
Topics: Acetylcysteine; Angiogenesis Inhibitors; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma; Carcinoma, Non-Small-Cell Lung; Celecoxib; Cyclophosphamide; Female; Humans; Immunization; Immunotherapy; Induction Chemotherapy; Kaplan-Meier Estimate; Male; Pancreatic Neoplasms; Prostatic Neoplasms; Pyrazoles; Sulfonamides | 2012 |
44 other study(ies) available for acetylcysteine and Cancer of Pancreas
| Article | Year |
|---|---|
Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells.
Topics: Acetylcysteine; Animals; Antioxidants; Humans; Mice; Mitochondria; Pancreatic Neoplasms; Reactive Oxygen Species | 2023 |
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Topics: Acetylcysteine; Animals; Antioxidant Response Elements; Carcinogenesis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Focal Adhesion Kinase 1; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Integrin beta Chains; Male; Mice; Middle Aged; NF-E2-Related Factor 2; Pancreas; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Xenograft Model Antitumor Assays | 2020 |
N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions.
Topics: Acetylcysteine; Animals; Female; Humans; Mice; Pancreatic Neoplasms; Pancreatic Stellate Cells | 2021 |
Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Aspirin; Carcinoma, Pancreatic Ductal; Caspases; Cell Line, Tumor; Cell Proliferation; Cytokines; Deoxycytidine; Enzyme Activation; G1 Phase Cell Cycle Checkpoints; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; NF-kappa B; Pancreatic Neoplasms; Signal Transduction; Transcriptome | 2021 |
Real-Time insight into in vivo redox status utilizing hyperpolarized [1-
Topics: Acetylcysteine; Animals; Apoptosis; Brain; Carbon Isotopes; Cell Proliferation; Glutathione; Humans; Magnetic Resonance Imaging; Mice; Oxidation-Reduction; Pancreatic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Claudin-1; Deoxyguanosine; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Hyaluronan Receptors; Imidazoles; Lung Neoplasms; Matrix Metalloproteinases; Mice; Mice, Nude; NADPH Oxidases; Pancreatic Neoplasms; Pyrroles; rho-Associated Kinases; Signal Transduction; Transcription Factors; Vimentin; Xenograft Model Antitumor Assays; Zonula Occludens-1 Protein | 2017 |
Effect of Plasma-Activated Lactated Ringer's Solution on Pancreatic Cancer Cells In Vitro and In Vivo.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Peritoneal Neoplasms; Reactive Oxygen Species | 2018 |
Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cyclohexylamines; Deferoxamine; Dioxolanes; Diterpenes; Drug Synergism; Fibroblasts; Humans; Iron; Mice; Pancreatic Neoplasms; Phenylenediamines; Quinoxalines; Reactive Oxygen Species; Spiro Compounds; Sulfasalazine | 2018 |
dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Gemcitabine; Glutamate-Cysteine Ligase; Glutathione; Humans; Kelch-Like ECH-Associated Protein 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-E2-Related Factor 2; Pancreatic Neoplasms; Plasmids; Reactive Oxygen Species; Up-Regulation | 2018 |
Pancreatic cancer stem cell proliferation is strongly inhibited by diethyldithiocarbamate-copper complex loaded into hyaluronic acid decorated liposomes.
Topics: Acetylcysteine; Calorimetry, Differential Scanning; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Copper; Cryoelectron Microscopy; Ditiocarb; Drug Screening Assays, Antitumor; Humans; Hyaluronan Receptors; Hyaluronic Acid; Liposomes; Microscopy, Electron, Transmission; Neoplastic Stem Cells; Pancreas; Pancreatic Neoplasms; Phospholipids; Reactive Oxygen Species | 2019 |
High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Glucose; Humans; JNK Mitogen-Activated Protein Kinases; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species | 2018 |
On infusion of high-dose ascorbate in treating cancer: Is it time for N-acetylcysteine pretreatment to enhance susceptibility and to lower side effects?
Topics: Acetylcysteine; Administration, Intravenous; Antioxidants; Ascorbic Acid; Copper; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hyaluronic Acid; Immune System; Kidney; Neoplasms; Pancreatic Neoplasms; Sulfhydryl Compounds | 2019 |
Molecular analysis of the inhibitory effect of N-acetyl-L-cysteine on the proliferation and invasiveness of pancreatic cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; G1 Phase Cell Cycle Checkpoints; Gemcitabine; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Mitomycin; Pancreatic Neoplasms; Reactive Oxygen Species | 2013 |
Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells.
Topics: Acetylcysteine; Adenocarcinoma; Adenosine Monophosphate; Adenosine Triphosphate; Adenylate Kinase; Antineoplastic Agents; Arachidonic Acids; Autophagy; Cannabinoids; Cell Line, Tumor; Cell Nucleus; Citric Acid Cycle; Drug Screening Assays, Antitumor; Energy Metabolism; Enzyme Activation; Glutamine; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Humans; Indoles; Morpholines; Pancreatic Neoplasms; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2013 |
Nox4-derived ROS signaling contributes to TGF-β-induced epithelial-mesenchymal transition in pancreatic cancer cells.
Topics: Acetylcysteine; Antigens, CD; Cadherins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Enzyme Induction; Epithelial-Mesenchymal Transition; Free Radical Scavengers; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1 | 2013 |
Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cell Hypoxia; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Epithelial-Mesenchymal Transition; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; NF-kappa B; Pancreatic Neoplasms; Phenotype; Signal Transduction; Transfection | 2014 |
N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cysteine; Deoxycytidine; Gemcitabine; Glutathione; Humans; Male; Mice; Mice, Nude; NF-kappa B; Oxidative Stress; Pancreatic Neoplasms; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein | 2014 |
The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells.
Topics: Acetylcysteine; Annexin A5; Apoptosis; Caspases; Cell Death; Cell Line, Tumor; Cyclic N-Oxides; Humans; Imidazoles; Indoles; Pancreatic Neoplasms; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Spin Labels; TNF-Related Apoptosis-Inducing Ligand | 2015 |
Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma.
Topics: Acetylcysteine; Adenoviridae; Caspases; Cell Death; Cell Line; Cell Line, Tumor; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cyclooxygenase 2; HEK293 Cells; Humans; Membrane Cofactor Protein; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Reactive Oxygen Species; Transduction, Genetic; Virus Replication | 2015 |
Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disulfiram; Fibrosis; Guinea Pigs; Humans; Pancreas; Pancreatic Neoplasms; Pancreatic Stellate Cells; Pyridones; Rats; Xenograft Model Antitumor Assays | 2016 |
Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Diabetes Complications; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hyperglycemia; Imidazoles; MAP Kinase Signaling System; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Pyridines; Reactive Oxygen Species; Resveratrol; Stilbenes | 2016 |
Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclohexylamines; Diterpenes; Glycosides; Humans; Isothiocyanates; Pancreatic Neoplasms; Phenylenediamines; Quinolines; Reactive Oxygen Species | 2016 |
Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells.
Topics: Acetylcysteine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; G2 Phase Cell Cycle Checkpoints; Glutathione; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Time Factors; Vanadates | 2016 |
A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Growth Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Oxides; Pancreatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays | 2009 |
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
Topics: Acetylcysteine; Adenocarcinoma; Adenosine Triphosphate; Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chaperonins; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Mice; Mice, Nude; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Sulfhydryl Compounds | 2013 |
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; Transcription Factors; Tumor Cells, Cultured; Twist-Related Protein 1 | 2013 |
Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides | 2012 |
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
Topics: Acetylcysteine; Aminopeptidases; Antigens, Neoplasm; Autophagy; Cell Line, Tumor; Epitopes; Fibroblasts; HLA-A24 Antigen; Humans; Leukemia; Molecular Mimicry; Pancreatic Neoplasms; Recombinant Proteins; RNA Interference; T-Lymphocytes, Cytotoxic; Vacuoles | 2012 |
Continuous infusion of N-acetylcysteine by nasobiliary for advanced intraductal papillary mucinous neoplasm of bile ducts (with video).
Topics: Abdominal Pain; Acetylcysteine; Adenocarcinoma, Mucinous; Aged; Antineoplastic Agents; Bile Duct Neoplasms; Bilirubin; Carcinoma, Pancreatic Ductal; Cholangiopancreatography, Endoscopic Retrograde; Expectorants; Female; Humans; Infusions, Intralesional; Pancreatic Neoplasms; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Blotting, Western; Cell Line, Tumor; Cytoplasm; Densitometry; DNA; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Pancreatic Neoplasms; Signal Transduction; Time Factors; Transcription, Genetic | 2003 |
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Insulinoma; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Pancreatic Neoplasms; Proteasome Inhibitors; Rats; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA Primers; Fibroblasts; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoblotting; Mice; Oligonucleotides, Antisense; Pancreatic Neoplasms; Pyrrolidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; Thiocarbamates | 2006 |
Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.
Topics: Acetylcysteine; Animals; Apoptosis; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclin B1; DNA Damage; G2 Phase; Isothiocyanates; Male; Mice; Pancreatic Neoplasms | 2006 |
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxyglucose; Free Radical Scavengers; Glucose; Humans; Mice; Mice, Inbred Strains; NADP; Oxidative Stress; Pancreatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Sulfhydryl Compounds | 2008 |
N-acetylcysteine derivative inhibits CD40-dependent proinflammatory properties of human pancreatic duct cells.
Topics: Acetylcysteine; Adenocarcinoma; CD40 Antigens; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lysine; NF-kappa B; Pancreatic Ducts; Pancreatic Neoplasms; Transcription, Genetic | 2008 |
N-acetylcysteine and ifosfamide in the treatment of unresectable pancreatic adenocarcinoma and refractory testicular cancer.
Topics: Acetylcysteine; Adenocarcinoma; Adult; Aged; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Hematologic Diseases; Hematuria; Humans; Ifosfamide; Male; Middle Aged; Nervous System Diseases; Pancreatic Neoplasms; Testicular Neoplasms | 1983 |
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms | 1996 |
Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion.
Topics: Acetylcysteine; Animals; Blotting, Western; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Cell Line; Cells, Cultured; Enzyme Inhibitors; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Male; Methylation; Pancreatic Neoplasms; Potassium; Protein Methyltransferases; Rats; Rats, Sprague-Dawley | 1996 |
Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic carcinoma cells carrying a mutant p53 gene.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Activation; Gene Expression; Genes, p53; Hot Temperature; Humans; Mutation; Oligopeptides; Pancreatic Neoplasms; Reactive Oxygen Species; RNA, Messenger; Tumor Cells, Cultured | 2001 |
N-acetyl cysteine inhibits cell cycle progression in pancreatic carcinoma cells.
Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Line; Depression, Chemical; Humans; Pancreatic Neoplasms; Tumor Cells, Cultured | 2000 |
Carboxyl-methylation of Rab3D in the rat pancreatic acinar tumor cell line AR42J.
Topics: Acetylcysteine; Animals; Antibody Specificity; Cysteine; Dexamethasone; Diterpenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Isoelectric Focusing; Lovastatin; Methylation; Pancreas; Pancreatic Neoplasms; Protein Isoforms; Protein Methyltransferases; Protein Prenylation; rab3 GTP-Binding Proteins; rab3A GTP-Binding Protein; Rats; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
Augmented adriamycin sensitivity in cells transduced with an antisense tumor necrosis factor gene is mediated by caspase-3 downstream from reactive oxygen species.
Topics: Acetylcysteine; Adenocarcinoma; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Doxorubicin; Drug Resistance, Neoplasm; Genes, p53; Humans; Neoplasm Proteins; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Ifosfamide chemotherapy for pancreatic carcinoma.
Topics: Acetylcysteine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Ifosfamide; Infections; Leukopenia; Male; Middle Aged; Pancreatic Neoplasms; Thrombocytopenia; Urologic Diseases | 1986 |
Ifosfamide: an active drug in the treatment of adenocarcinoma of the pancreas.
Topics: Acetylcysteine; Adenocarcinoma; Adult; Aged; Cyclophosphamide; Female; Humans; Ifosfamide; Male; Middle Aged; Pancreatic Neoplasms | 1985 |