acetylcysteine has been researched along with Breast Cancer in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.00) | 18.7374 |
| 1990's | 7 (7.00) | 18.2507 |
| 2000's | 34 (34.00) | 29.6817 |
| 2010's | 50 (50.00) | 24.3611 |
| 2020's | 8 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carvalho-Kelly, LF; Cosentino-Gomes, D; Cunha Nascimento, MT; Dick, CF; Lacerda-Abreu, MA; Meyer-Fernandes, JR; Rocco-Machado, N; Rocha-Vieira, TC; Russo-Abrahão, T | 1 |
| Ii, H; Kageyama, S; Kawauchi, A; Nakata, S; Nohara, Y; Taniguchi, K; Yoshiya, T | 1 |
| Auf der Maur, P; Baumann, Z; Bentires-Alj, M; Buczak, K; Correia, AL; Diepenbruck, M; Eichlisberger, T; Fritsch, C; Jensen, MR; Kramer, N; Leroy, C; Okamoto, R; Preca, BT; Rad, R; Ramos, P; Stadler, MB; Trefny, MP; Volkmann, K; Vulin, M; Zilli, F; Zippelius, A | 1 |
| Harahap, Y; Melhan, M; Muhammad, C; Purwanto, DJ; Yanuar, A | 1 |
| Aboelhassan, R; El Wakeel, LM; Khalefa, HG; Shawki, MA | 1 |
| Chen, MC; Hsu, CY; Hsu, LL; Lee, HC; Tseng, LM; Wang, SF | 1 |
| Amzaleg, Y; Hicks, J; Hsu, CJ; Iriondo, O; Kamal, M; Kang, I; Lee, G; Luo, C; Nguyen, JD; Smith, A; Sposto, R; Teng, T; Thomas, A; Yu, M | 1 |
| Hu, H; Huang, Z | 1 |
| Deshidi, R; Jaglan, S; Koul, M; Kumar, A; Shah, BA; Sharma, PR; Sharma, V; Singh, J; Singh, RD; Singh, S | 1 |
| Berger, A; Birbe, R; Cotzia, P; Domingo-Vidal, M; Draganova-Tacheva, R; Lazar, M; Lin, Z; Lisanti, MP; Martinez-Outschoorn, U; Monti, D; Newberg, A; Sotgia, F; Tuluc, M; Whitaker-Menezes, D | 1 |
| Chen, XP; Lu, JJ; Luo, WW; Wang, YT; Zhao, WW | 1 |
| Brooks, MD; Buschhaus, JM; Conley, S; Davis, A; Fath, MA; Gheordunescu, E; Harouaka, R; Jiagge, E; Lozier, A; Luker, GD; Luo, M; McDermott, S; Merajver, SD; Shang, L; Spitz, DR; Triner, D; Wang, Y; Wicha, MS; Zhu, Y | 1 |
| Ahamed, M; Akhtar, MJ; Alhadlaq, HA; Majeed Khan, MA | 1 |
| Chen, X; Feng, Y; Liu, A; Meng, T; Wang, Q; Xu, X | 1 |
| Phelan, S; Taparra, K; Tehan, L | 1 |
| Dong, XZ; Ge, XY; Guo, DH; Liu, P; Wang, K; Zhang, M; Zheng, XL | 1 |
| Conklin, DS; Sun, Y; Wang, X; Wong, J | 1 |
| Amamoto, T; Aramaki, H; Koyachi, K; Matsumoto, K; Nishimura, H; Okamoto, Y; Shindo, M; Takeda, S; Yoshida, K | 1 |
| Hsu, A; Kumar, AP; Sethi, G; Tan, KH; Woo, CC | 1 |
| Cheng, H; Lee, SH; Wu, S | 1 |
| Buttitta, G; Carlisi, D; D'Anneo, A; Di Fiore, R; Emanuele, S; Lauricella, M; Tesoriere, G; Vento, R | 1 |
| Haidari, M; Wakame, K; Zhang, W | 1 |
| Kim, HS; Kim, N; Kim, SM; Ko, SG; Lee, JO; Lee, SK; Moon, JW; Park, SH | 1 |
| Chen, Q; Song, J; Wei, Y; Xing, D | 1 |
| Bandyopadhyay, C; Chandran, B; Dutta, D; Dutta, S; Warshall, C | 1 |
| Alaie, SH; Panjehpour, M | 1 |
| Chan, HL; Chen, YW; Chou, HC; Huang, HJ; Lin, CC; Lin, DY; Lin, ST; Lin, YC; Lyu, KW | 1 |
| Feng, X; Liu, Q; Wang, P; Wang, X; Zhang, Y | 1 |
| Ahamed, M; Akhtar, MJ; Alhadlaq, HA; Alrokayan, SA; Khan, MA | 1 |
| Lu, F; Shen, K; Tan, H; Wang, H; Xie, J; Xu, H; Yu, M; Zhang, H | 1 |
| Chang, HT; Chou, CT; Jan, CR; Kuo, DH; Liang, WZ; Shieh, P | 1 |
| Artero-Castro, A; Castellvi, J; Feliciano, A; Genestar, M; Leal, JA; Lleonart, ME; Peg, V; Perez-Alea, M; Ramón Y Cajal, S | 1 |
| Abbruzzese, C; Di Venere, D; Miccadei, S; Mileo, AM | 1 |
| Almosnid, NM; Altman, E; Chippada-Venkata, UD; Farone, A; Gao, Y; Gong, Y; Hosain, NA; Huang, R; Park, HS; Vick, E; Wen, Q | 1 |
| Calderon-Aparicio, A; Rieber, M; Strasberg-Rieber, M | 1 |
| Chagtoo, M; Chakravarti, B; George, N; Godbole, MM; Khan, S; Lakshmi, S; Singh, A; Tiwari, S | 1 |
| Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E | 1 |
| Chen, T; Wong, YS | 1 |
| Hazra, B; Kumar, A; Kumar, B; Mishra, KP; Pandey, BN | 1 |
| Coveñas, R; Geffard, M; Mangas, A; Pouns, O | 1 |
| Cavalieri, EL; Rogan, EG | 1 |
| Corbet, C; Heldt, JM; Jaouen, G; Jouy, N; Laïos, I; Leclercq, G; Lories, N; Toillon, RA; Vessières, A | 1 |
| Kaufmann, Y; Klimberg, VS; Luo, S; Todorova, VK | 1 |
| Ali, MF; Cavalieri, EL; Rogan, EG; Saeed, M; Zahid, M | 1 |
| Beseler, C; Cavalieri, EL; Rogan, EG; Saeed, M; Zahid, M | 1 |
| Endo, A; Endo, M; Gejima, S; Misumi, S; Shoji, S; Takamune, N | 1 |
| Bahar, M; Khaghani, S; Khorramizadeh, MR; Mirmiranpour, H; Nejad, SG; Paknejad, M; Pasalar, P | 1 |
| Du, J; Gu, L; Hu, Z; Lu, X; Sun, C; Yang, Y; Zheng, D; Zhu, Y | 1 |
| Chen, DR; Chen, GJ; Chen, ST; Lin, C; Lin, PH; Tsai, CH; Wang, TW; Wei, HH; Yang, TC | 1 |
| Bershteĭn, LM; Boiarkina, MP; Kovalenko, IG; Kovalevskiĭ, AIu; Poroshina, TE; Revskoĭ, SIu; Vasil'ev, DA | 1 |
| Bhat, MK; Chaube, B; Pandey, V | 1 |
| Kim, DH; Kim, EH; Kim, NJ; Na, HK; Song, NY; Suh, YG; Surh, YJ | 1 |
| Li, Y; Liu, Q; Wang, P; Wang, X; Zhao, P; Zhu, S | 1 |
| Ghosh, S; Hazra, B; Kumar, A; Kumar, B; Mishra, KP; Pandey, BN | 1 |
| Bershteĭn, LM; Boiarkina, MP; Kisel'nikov, KS; Kovalenko, IG; Poroshina, TE; Vasil'ev, DA; Zaĭtsev, AN | 1 |
| Cho, BJ; Cho, IJ; Hong, SW; Hwang, JJ; Hwang, YI; Jeong, YJ; Jin, DH; Jung, DJ; Kang, JS; Kim, DE; Kim, DJ; Kim, HS; Kim, JE; Kim, TW; Ko, E; Lee, JS; Lee, SH; Lee, WJ; Moon, JH; Noh, DY; Shin, JS | 1 |
| Alexova, P; Benes, P; Knopfova, L; Smarda, J; Spanova, A | 1 |
| Chen, WD; Deng, R; Feng, GK; Li, DD; Li, HJ; Wu, KW; Yang, F; Zhu, XF | 1 |
| Ho, YJ; Hsu, LS; Kao, SH; Lin, JF; Yang, LH; Yeh, CW | 1 |
| Rieber, M; Strasberg-Rieber, M | 1 |
| Balliet, R; Birbe, RC; Bombonati, A; Howell, A; Lamb, R; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Sneddon, S; Sotgia, F; Whitaker-Menezes, D | 1 |
| Kim, IS; Kim, NH; Oh, MK; Park, HJ | 1 |
| Schrey, M; van Hagen, D; Winnett, G | 1 |
| Faivre, E; Horwitz, KB; Lange, CA; Olsen, A; Qiu, M | 1 |
| Buchsbaum, D; Kimberly, R; Makhija, S; Ohtsuka, T; Oliver, P; Zhou, T | 1 |
| Brody, JP; Harris, JW; Lin, F; Thompson, HG; Wold, BJ | 1 |
| Doong, H; Fang, S; Kohn, EC; Kulpa, V; Rizzo, K; Weissman, AM | 1 |
| Alaoui-Jamali, MA; Igdoura, SA; Laird, DW; Qin, H; Shao, Q | 1 |
| Agarwal, A; Claffey, KP; Klueh, U; Muñoz-Nájar, U; Shih, SC | 1 |
| Chang, T; Hayes, EC; Mitra, SW; Peekhaus, NT; Rohrer, SP; Schaeffer, JM; Wilkinson, HA | 1 |
| Levine, L | 1 |
| Cai, YJ; Chen, Y; Ding, J; Huang, M; Lu, HR; Miao, ZH; Zhang, JS; Zhu, H | 1 |
| Alao, JP; Coombes, RC; Lam, EW; Stavropoulou, AV; Vigushin, DM | 1 |
| Ameri, K; Culmsee, C; Davis, RJ; Denko, N; Hai, T; Hammond, EM; Harris, AL; Katschinski, DM; Raida, M; Wagner, E; Wenger, RH | 1 |
| Chen, D; Dou, QP; Fregona, D; Landis-Piwowar, KR; Milacic, V; Ronconi, L | 1 |
| Booy, EP; Eshraghi, M; Ghavami, S; Hashemi, M; Los, M | 1 |
| Bougnoux, P; Chourpa, I; Dubois, P; Goré, J; Mahéo, K; Vibet, S | 1 |
| Carlson, EE; Cravatt, BF | 1 |
| Bottoni, A; Luchin, A; Piccin, D; Tagliati, F; Uberti, EC; Vignali, C; Zatelli, MC | 1 |
| Chen, YC; Lin, CW; Shen, SC; Yang, LY | 1 |
| Campbell, CT; Kha, V; Kleiner, HE; Landry, GM; Prince, M | 1 |
| Han, YS; Kim, DS; Nah, SY; Paik, HD; Park, JH; Shim, HY | 1 |
| Agama, K; Brantley, E; Francis, J; Jimenez, R; McLean, L; Pommier, Y; Soto, U; Sowers, L | 1 |
| Collins, JM; Greene, RF; Jenkins, JF; Myers, CE; Speyer, JL | 1 |
| Chavany, C; Mimnaugh, EG; Neckers, L | 1 |
| Celis, JE; Chen, HY; Davie, JR; Mimnaugh, EG; Neckers, L | 1 |
| Berns, CM; Chen, JC; Corry, PM; Davis, BH; Galoforo, SS; Lee, YJ; Sim, JE; Spitz, DR | 1 |
| Oberley, LW; Oberley, TD; Thongphasuk, J | 1 |
| Banks, L; Mantovani, F | 1 |
| Banerjee, P; Ettenberg, SA; Keane, MM; Lipkowitz, S; Nau, MM; Rubinstein, YR | 1 |
| Ameyar, M; Bouquet, C; Cai, Z; Chouaib, S; Haddada, H; Shatrov, VA; Stancou, R | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Hartman, AR; Kagan, VE; Rudin, CM; Schor, NF; Thompson, CB; Tyurina, YY | 1 |
| Davie, JR; Lucktong, A; Melkoumian, ZK; Moniwa, M; Strobl, JS; Zhou, Q | 1 |
| Chandel, NS; Schumacker, PT; Thompson, CB; Vander Heiden, MG | 1 |
| Kang, MS; Lee, KH; Lee, YJ; Song, SH | 1 |
| Beijnen, JH; Huitema, AD; Rodenhuis, S; van Maanen, MJ | 1 |
| Andrieu-Abadie, N; Carpentier, S; Gouazé, V; Levade, T; Mirault, ME; Salvayre, R | 1 |
| Bruggisser, R; Jundt, G; Schaffner, W; Tullberg-Reinert, H; von Daeniken, K | 1 |
| Arnstein, HR; Cannon, M; Wiseman, H | 1 |
1 review(s) available for acetylcysteine and Breast Cancer
| Article | Year |
|---|---|
Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Breast Neoplasms; DNA Adducts; Estrogens; Female; Humans; Male; Neoplasms; Resveratrol; Stilbenes | 2010 |
2 trial(s) available for acetylcysteine and Breast Cancer
| Article | Year |
|---|---|
Evaluation of the effect of N-acetylcysteine on the prevention and amelioration of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled study.
Topics: Acetylcysteine; Adult; Aged; Antineoplastic Agents, Phytogenic; Biomarkers; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Lipid Peroxidation; Malondialdehyde; Middle Aged; Nerve Growth Factor; Paclitaxel; Peripheral Nervous System Diseases; Prospective Studies; Quality of Life | 2020 |
[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients].
Topics: Acetylcysteine; Aged; Blood Glucose; Body Mass Index; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Endometrial Neoplasms; Estrogens; Female; Free Radical Scavengers; Glucose; Humans; Hypoglycemic Agents; Interleukin-6; Metformin; Middle Aged; Neoplasms; Postmenopause; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
97 other study(ies) available for acetylcysteine and Breast Cancer
| Article | Year |
|---|---|
Hydrogen Peroxide Generation as an Underlying Response to High Extracellular Inorganic Phosphate (Pi) in Breast Cancer Cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Female; Humans; Hydrogen Peroxide; MCF-7 Cells; Membrane Potential, Mitochondrial; NADPH Oxidases; Neoplasm Metastasis; Oxygen Consumption; Phosphates; Protein Kinase C; Reactive Oxygen Species | 2021 |
The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species.
Topics: Acetylcysteine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Female; gamma-Glutamylcyclotransferase; Humans; MCF-7 Cells; Mice; Mitochondria; Reactive Oxygen Species | 2022 |
N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer.
Topics: Acetylcysteine; Animals; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Mice; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases | 2023 |
Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity.
Topics: Acetylcysteine; Acrolein; Adult; Alkylating Agents; Biomarkers; Breast Neoplasms; Chromatography, Liquid; Cyclophosphamide; Female; Hematuria; Humans; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2020 |
ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation.
Topics: Acetylcysteine; Amino Acid Transport System y+; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cell Death; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glucose; Glutamic Acid; Glutathione; Humans; Ketoglutaric Acids; Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering; Sirtuin 3; Sulfasalazine; Up-Regulation | 2020 |
N-Acetyl-L-cysteine Promotes
Topics: Acetylcysteine; Animals; Antioxidants; Breast Neoplasms; Cell Growth Processes; DNA Copy Number Variations; Female; Heat-Shock Proteins; Heterografts; Humans; Mice; Neoplastic Cells, Circulating; Oxidative Stress; Scavenger Receptors, Class A | 2021 |
Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by
Topics: Acetylcysteine; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hydrolases; Immunogenic Cell Death; Mice; Polyethylene Glycols | 2021 |
Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromosomes; Cladosporium; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Microtubules; Naphthols; Reactive Oxygen Species | 2017 |
Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.
Topics: Acetylcysteine; Adult; Apoptosis; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papillary; Caveolin 1; Cell Proliferation; Female; Free Radical Scavengers; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ki-67 Antigen; Mastectomy; Middle Aged; Monocarboxylic Acid Transporters; Muscle Proteins; Neoadjuvant Therapy; Neoplasm Staging; Pilot Projects; Stromal Cells; Treatment Outcome; Tumor Microenvironment | 2017 |
Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells.
Topics: Acetylcysteine; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Female; Fibronectins; Focal Adhesion Kinase 1; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Phosphorylation; Reactive Oxygen Species; Triterpenes | 2018 |
Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.
Topics: Acetylcysteine; AMP-Activated Protein Kinase Kinases; Animals; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Glucose; Glutathione; Glycolysis; Humans; Mice, Inbred NOD; Neoplastic Stem Cells; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Protein Kinases; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Thioredoxins; Xenograft Model Antitumor Assays | 2018 |
Oxidative stress mediated cytotoxicity of tin (IV) oxide (SnO
Topics: Acetylcysteine; Antioxidants; Apoptosis; Breast Neoplasms; Cell Survival; Female; Humans; L-Lactate Dehydrogenase; MCF-7 Cells; Nanoparticles; Oxidants; Oxidative Stress; Tin Compounds | 2018 |
Antitumor effects of seleno-β-lactoglobulin on human breast cancer MCF-7 and MDA-MB-231 cells in vitro.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Free Radical Scavengers; Humans; Lactoglobulins; Organoselenium Compounds; Reactive Oxygen Species; Receptors, Progesterone | 2019 |
Peroxiredoxin overexpression in MCF-7 breast cancer cells and regulation by cell proliferation and oxidative stress.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Breast Neoplasms; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Oxidative Stress; Peroxiredoxins; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2013 |
Sanguinarine inhibits vascular endothelial growth factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells.
Topics: Acetylcysteine; Apoptosis; Benzophenanthridines; Breast Neoplasms; Cell Proliferation; Cell Survival; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; MCF-7 Cells; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2013 |
PPARγ maintains ERBB2-positive breast cancer stem cells.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Anilides; Animals; Benzamides; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Kruppel-Like Factor 4; MCF-7 Cells; Mediator Complex Subunit 1; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Nuclear Receptor Subfamily 1, Group D, Member 1; PPAR gamma; Pyridines; Reactive Oxygen Species; Receptor, ErbB-2 | 2013 |
(-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells.
Topics: Acetylcysteine; Antigens, Neoplasm; Antineoplastic Agents; Breast Neoplasms; Cell Division; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Female; Free Radical Scavengers; Furans; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Intracellular Signaling Peptides and Proteins; Proto-Oncogene Proteins c-fos; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Up-Regulation | 2013 |
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Silencing; Humans; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2013 |
Effects of N-acetyl-L-cysteine on adhesive strength between breast cancer cell and extracellular matrix proteins after ionizing radiation.
Topics: Acetylcysteine; Breast Neoplasms; Catalase; Cell Adhesion; Down-Regulation; Drug Administration Schedule; Extracellular Matrix Proteins; Free Radical Scavengers; Humans; Integrin beta1; Radiation, Ionizing; Reactive Oxygen Species; Tumor Cells, Cultured; Vimentin | 2013 |
Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.
Topics: Acetophenones; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; NADPH Oxidases; NF-kappa B; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Sesquiterpenes; Superoxides; Tyrphostins | 2013 |
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.
Topics: Acetylcysteine; Adherens Junctions; Antigens, CD; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Male; Ovarian Neoplasms; Plant Extracts; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2013 |
Rhus verniciflua extract modulates survival of MCF-7 breast cancer cells through the modulation of AMPK-pathway.
Topics: Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Protein Kinases; Annexin A5; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Survival; Humans; MCF-7 Cells; Phosphorylation; Plant Bark; Plant Extracts; Reactive Oxygen Species; Rhus; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Female; Humans; Imidazoles; Interleukin-1beta; Light; MCF-7 Cells; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Pyridines; Reactive Oxygen Species; Signal Transduction; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2014 |
Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells.
Topics: Acetylcysteine; Autophagy; Breast; Breast Neoplasms; Cell Line, Tumor; Culture Media, Conditioned; DNA; DNA Damage; DNA Repair; Epithelial Cells; Exosomes; Female; Humans; MCF-7 Cells; Phosphorylation; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2014 |
N-acetylcysteine prevents cadmium-induced apoptosis in human breast cancer MDA-MB468 cell line.
Topics: Acetylcysteine; Apoptosis; Breast Neoplasms; Cadmium; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Female; Humans; Oxidative Stress; Protective Agents; Reactive Oxygen Species | 2014 |
Proteomic analysis of rhein-induced cyt: ER stress mediates cell death in breast cancer cells.
Topics: Acetylcysteine; Angiogenesis Inhibitors; Anthraquinones; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Female; Humans; MCF-7 Cells; Oxidation-Reduction; Proteomics; Reactive Oxygen Species; Reproducibility of Results; Rheum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Two-Dimensional Difference Gel Electrophoresis | 2014 |
Energy metabolism targeted drugs synergize with photodynamic therapy to potentiate breast cancer cell death.
Topics: Acetylcysteine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Deoxyglucose; Female; Free Radical Scavengers; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Kinase 4; Mitochondrial Membranes; p38 Mitogen-Activated Protein Kinases; Photochemotherapy; Photosensitizing Agents; Pyruvates; Reactive Oxygen Species | 2014 |
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Topics: Acetylcysteine; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Down-Regulation; Female; G1 Phase Cell Cycle Checkpoints; Gold; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Nanotubes; Particle Size; Platinum; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2016 |
Cambogin Induces Caspase-Independent Apoptosis through the ROS/JNK Pathway and Epigenetic Regulation in Breast Cancer Cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Electrophoresis, Gel, Two-Dimensional; Epigenesis, Genetic; Female; Free Radical Scavengers; HeLa Cells; Hep G2 Cells; Humans; MAP Kinase Signaling System; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Proteomics; Reactive Oxygen Species; Terpenes; Xenograft Model Antitumor Assays | 2015 |
The Mechanism of Ca(2+) Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells.
Topics: Acetylcysteine; Animals; Apoptosis; Boron Compounds; Breast Neoplasms; Calcium; Caspase 3; Caspase 9; Cytosol; Egtazic Acid; Endoplasmic Reticulum; Female; Flavanones; Humans; Indoles; Maleimides; Molecular Structure; Reactive Oxygen Species; Thapsigargin; Type C Phospholipases | 2015 |
Disruption of the ribosomal P complex leads to stress-induced autophagy.
Topics: Acetylcysteine; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Stress; Female; HEK293 Cells; Humans; Mitochondria; Models, Biological; Multiprotein Complexes; Oxidation-Reduction; Phenotype; Protein Biosynthesis; Reactive Oxygen Species; Ribosomal Proteins; RNA, Small Interfering; Unfolded Protein Response; Up-Regulation | 2015 |
Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cynara scolymus; Female; HCT116 Cells; Humans; Polyphenols; Reactive Oxygen Species | 2015 |
The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Averrhoa; Bone Neoplasms; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclohexenes; Cytochromes c; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Lung Neoplasms; MCF-7 Cells; NF-kappa B; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2015 |
Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.
Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chelating Agents; Copper; Disulfiram; Free Radical Scavengers; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Melanoma; Molybdenum; Mutation, Missense; Proto-Oncogene Proteins B-raf; Reactive Oxygen Species; Receptor, ErbB-2; Superoxide Dismutase | 2015 |
Inhibition of Inositol 1, 4, 5-Trisphosphate Receptor Induce Breast Cancer Cell Death Through Deregulated Autophagy and Cellular Bioenergetics.
Topics: Acetylcysteine; Adenine; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Energy Metabolism; Fluorescent Antibody Technique; Humans; Inositol 1,4,5-Trisphosphate Receptors; Macrolides; MCF-7 Cells; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; RNA, Small Interfering | 2017 |
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin | 2008 |
Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspases; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cystine; Cytochromes c; Female; Humans; Membrane Potential, Mitochondrial; Organoselenium Compounds; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2009 |
Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells.
Topics: Acetylcysteine; Allopurinol; Animals; Antimycin A; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cardiolipins; Cell Line, Tumor; Cyclosporine; Cytochromes c; Female; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Vitamin K 3 | 2009 |
Circulating antibodies directed against "polycyclic aromatic hydrocarbon-like" structures in the sera of cancer patients.
Topics: Acetylcysteine; Antibodies, Neoplasm; Antibody Affinity; Antibody Specificity; Breast Neoplasms; Carrier Proteins; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin A; Immunoglobulins; Ligands; Menopause; Ovarian Neoplasms; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; Serum Albumin, Bovine | 2009 |
A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines.
Topics: Acetylcysteine; Antioxidants; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Female; Ferrous Compounds; Humans; Reactive Oxygen Species; Receptors, Estrogen; Tamoxifen | 2010 |
Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake.
Topics: Acetylcysteine; Amino Acid Transport System ASC; Antioxidants; Apoptosis; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Estradiol; Female; Gene Expression; Glutamine; Glutathione; Humans; Minor Histocompatibility Antigens; Oxidative Stress; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen | 2011 |
N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells.
Topics: Acetylcysteine; Animals; Antioxidants; Breast; Breast Neoplasms; Cell Line; DNA Adducts; Estradiol; Estrogens, Catechol; Female; Humans; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice | 2010 |
Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Breast Neoplasms; Carcinoma; Cell Line; Cell Transformation, Neoplastic; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Female; Humans; Mammary Glands, Human; Models, Biological; Resveratrol; Stilbenes | 2011 |
Treatment of breast cancer cells with proteasome inhibitor lactacystin increases the level of sensitivity to cell death induced by human immunodeficiency virus type 1.
Topics: Acetylcysteine; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Female; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Polyubiquitin; Proteasome Inhibitors; Receptors, CXCR4; Staining and Labeling; T-Lymphocytes | 2010 |
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model.
Topics: Acetylcysteine; Biomarkers; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Female; Free Radical Scavengers; Glutamate-Cysteine Ligase; Humans; Hydrogen Peroxide; Matrix Metalloproteinase 2; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Time Factors; Ubiquinone | 2010 |
Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Neoplasm Metastasis; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Signal Transduction | 2010 |
Characterization of estrogen quinone-derived protein adducts and their identification in human serum albumin derived from breast cancer patients and healthy controls.
Topics: Acetylcysteine; Adult; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Gas Chromatography-Mass Spectrometry; Humans; Middle Aged; Serum Albumin; Young Adult | 2011 |
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Female; Fluorouracil; Glucose; Humans; Hyperglycemia; Inhibitory Concentration 50; NF-kappa B; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Verapamil | 2011 |
Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Female; Glutamate-Cysteine Ligase; Glutathione; Humans; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Propionates; Prostaglandin D2; Proto-Oncogene Proteins c-akt; Quinolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Up-Regulation | 2011 |
Apoptosis induced by sonodynamic treatment by protoporphyrin IX on MDA-MB-231 cells.
Topics: Acetylcysteine; Adenosine Diphosphate Ribose; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Enzyme Activation; Female; Humans; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species; Ultrasonic Therapy | 2012 |
Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcium; Calcium Channels; Carcinoma; Cell Line, Tumor; Chelating Agents; Cytosol; Egtazic Acid; Endoplasmic Reticulum; Estrenes; Female; Humans; Mitochondria; Naphthoquinones; Oxidation-Reduction; Phosphodiesterase Inhibitors; Pyrrolidinones; Ruthenium Red; Type C Phospholipases | 2012 |
[The influence of metformin and N-acetylcysteine on mammographic density in postmenopausal women].
Topics: Acetylcysteine; Aged; Apoptosis; Breast; Breast Neoplasms; Cell Proliferation; DNA Repair; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Mammography; Metformin; Middle Aged; Neoplasms, Hormone-Dependent; Postmenopause; Risk Assessment; Risk Factors | 2012 |
SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Autophagy; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Sodium-Coupled Vitamin C Transporters | 2013 |
Redox state alters anti-cancer effects of wedelolactone.
Topics: Acetylcysteine; Antigens, Neoplasm; Antineoplastic Agents; Breast Neoplasms; Catalase; Cell Line, Tumor; Cell Survival; Coumarins; DNA Topoisomerases, Type II; DNA-Binding Proteins; Female; Glutathione; Humans; Immunoblotting; In Vitro Techniques; Molecular Structure; NAD; Oxidation-Reduction | 2012 |
Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Reactive Oxygen Species; Sesquiterpenes | 2012 |
Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities.
Topics: Acetylcysteine; Antioxidants; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Chalcones; Extracellular Signal-Regulated MAP Kinases; Female; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2012 |
Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Hypoxia; Female; Genes, p53; Humans; Hydrogen Peroxide; MCF-7 Cells; Membrane Proteins; Nerve Tissue Proteins; Oxidative Stress; Superoxide Dismutase | 2012 |
BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.
Topics: Acetylcysteine; Antioxidants; Apoptosis; BRCA1 Protein; Breast Neoplasms; Caveolin 1; Cell Line; Coculture Techniques; Cyclic N-Oxides; Female; Glycolysis; Humans; Hydrogen Peroxide; Monocarboxylic Acid Transporters; Muscle Proteins; Mutation; Oxidative Stress; Spin Labels; Tumor Microenvironment; Up-Regulation | 2012 |
Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Auranofin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Gold; Humans; Phosphorylation; STAT3 Transcription Factor; Telomerase | 2013 |
Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy.
Topics: Acetylcysteine; Antioxidants; Aromatase; Aromatase Inhibitors; Breast; Breast Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fibroblasts; Glutathione; Humans; Hydrogen Peroxide; Oxidation-Reduction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Sulfhydryl Reagents; Transcription Factors; Tumor Cells, Cultured | 2003 |
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Breast Neoplasms; Butadienes; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Ligands; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Mutation; Nitriles; Phosphorylation; Promegestone; Proteasome Endopeptidase Complex; Receptors, Progesterone; Serine; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.
Topics: Acetylcysteine; Adenocarcinoma; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carrier Proteins; Caspases; Cisplatin; Cytochrome c Group; DNA Fragmentation; Doxorubicin; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured | 2003 |
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Breast; Breast Neoplasms; Carrier Proteins; Cells, Cultured; Computer Systems; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-ets; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sequestosome-1 Protein; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Benzoquinones; Breast Neoplasms; Carrier Proteins; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Deletion; Gene Expression; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunosorbent Techniques; Lactams, Macrocyclic; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Breast Neoplasms; Brefeldin A; Cell Communication; Cell Membrane; Connexin 43; Cycloheximide; Cysteine Endopeptidases; Gap Junctions; Humans; Immunohistochemistry; Lysosomes; Mammary Neoplasms, Animal; Microscopy, Confocal; Microscopy, Electron; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein Transport; Rats; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2003 |
N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer.
Topics: Acetylcysteine; Angiostatins; Animals; Antioxidants; Apoptosis; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Chickens; Disease Models, Animal; DNA, Complementary; Endothelial Cells; Free Radical Scavengers; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Luminescent Proteins; Lymphatic Metastasis; Mammary Neoplasms, Animal; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Models, Biological; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Vascular Endothelial Growth Factor A | 2004 |
Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.
Topics: Acetylcysteine; Animals; Breast Neoplasms; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fulvestrant; Gene Expression Regulation; Genes, Reporter; Humans; Ligands; Point Mutation; Tamoxifen | 2004 |
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Breast Neoplasms; Cell Line; Cell Line, Tumor; HT29 Cells; Humans; Leupeptins; Liver; Neuroglia; Oligopeptides; Proteasome Inhibitors; Rats | 2004 |
Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; DNA; DNA Damage; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Naphthoquinones; Nuclear Proteins; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Topoisomerase II Inhibitors | 2005 |
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Cytoplasm; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Karyopherins; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA Interference; Transfection; Ubiquitin | 2006 |
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
Topics: Acetylcysteine; Activating Transcription Factor 3; Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cells, Cultured; Cyanides; Deferoxamine; Enzyme Activation; Free Radical Scavengers; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Mixed Function Oxygenases; Neurons; Oxygen; Proto-Oncogene Proteins c-jun; Siderophores; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Von Hippel-Lindau Tumor Suppressor Protein | 2007 |
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Mice; Neoplasm Transplantation; Organogold Compounds; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Thiocarbamates; Transplantation, Heterologous | 2006 |
Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells.
Topics: Acetylcysteine; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Survival; Chelating Agents; Cytochromes c; Ethylenediamines; Humans; Membrane Potentials; Mitochondria; Pentetic Acid; Receptors, Estrogen; Zinc | 2007 |
Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines.
Topics: Acetylcysteine; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cell Survival; Cytosol; Docosahexaenoic Acids; Female; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Microscopy, Confocal; Mitoxantrone; Molecular Structure; Reactive Oxygen Species; Rhodamine 123; Time Factors | 2007 |
Chemoselective probes for metabolite enrichment and profiling.
Topics: Acetylcysteine; Acrylic Resins; Antioxidants; Breast Neoplasms; Chromatography, Liquid; Humans; Polyethylene Glycols; Proteomics; Sulfhydryl Compounds; Tandem Mass Spectrometry; Trypsin; Tumor Cells, Cultured | 2007 |
Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines.
Topics: Acetylcysteine; Arginine-tRNA Ligase; Breast Neoplasms; Cysteine Proteinase Inhibitors; Cytokines; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Neoplasm Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; RNA-Binding Proteins; Transfection; Uterine Cervical Neoplasms | 2007 |
IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Flavanones; Flavonoids; Glycosides; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Molecular Structure; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Quercetin; Reactive Oxygen Species; Signal Transduction; Structure-Activity Relationship; Transfection | 2007 |
Pro-apoptotic effects of 1'-acetoxychavicol acetate in human breast carcinoma cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Ascorbic Acid; Benzyl Alcohols; Breast Neoplasms; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromans; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Terpenes; Time Factors | 2007 |
Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspase Inhibitors; Caspases; Cell Line, Tumor; Female; Flavones; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2007 |
Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA Damage; DNA, Neoplasm; Enzyme Activation; Female; Flavonoids; Free Radical Scavengers; Humans; Reactive Oxygen Species; Receptors, Estrogen; S Phase | 2008 |
Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols.
Topics: Acetylcysteine; Breast Neoplasms; Chromatography, High Pressure Liquid; Doxorubicin; Drug Administration Schedule; Half-Life; Humans; Infusions, Parenteral; Kinetics; Mathematics; Research Design | 1983 |
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
Topics: Acetylcysteine; Benzoquinones; Biopolymers; Breast Neoplasms; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Humans; Lactams, Macrocyclic; Molecular Weight; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Quinones; Receptor, ErbB-2; Rifabutin; Ubiquitins | 1996 |
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
Topics: Acetylcysteine; Breast Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; DNA Replication; Female; Histones; Hot Temperature; Humans; Leupeptins; Multienzyme Complexes; Nucleoproteins; Nucleosomes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitins | 1997 |
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.
Topics: Acetylcysteine; Breast Neoplasms; Carcinoma; Cell Death; Drug Resistance, Multiple; Enzyme Activation; Female; Glucose; Glutamic Acid; Glutamine; Glutathione; Glutathione Disulfide; Humans; Mitogen-Activated Protein Kinase 1; Oxidative Stress; Signal Transduction; Tumor Cells, Cultured | 1998 |
Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Survival; Chlorides; Citrate (si)-Synthase; Cyclic N-Oxides; Cycloheximide; Enzyme Induction; Female; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Manganese Compounds; Manganese Poisoning; RNA, Messenger; Superoxide Dismutase; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Female; Fibrosarcoma; Humans; Leupeptins; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Polymorphism, Genetic; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 1999 |
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Breast Neoplasms; Carrier Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Phosphoproteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tumor Cells, Cultured; Ubiquitin-Protein Ligases; Ubiquitins | 1999 |
Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state.
Topics: Acetylcysteine; Adenoviridae; Breast Neoplasms; Cytopathogenic Effect, Viral; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression; Genetic Vectors; Humans; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2000 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
Cell line dependence of Bcl-2-induced alteration of glutathione handling.
Topics: Acetylcysteine; Animals; Apoptosis; Breast Neoplasms; Female; Glutathione; Humans; PC12 Cells; Prodrugs; Proto-Oncogene Proteins c-bcl-2; Rats; Transfection; Tumor Cells, Cultured | 2000 |
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
Topics: Acetylation; Acetylcysteine; Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chickens; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Female; G1 Phase; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Keratins; Leupeptins; Multienzyme Complexes; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Quinidine; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured | 2000 |
Redox regulation of p53 during hypoxia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Antioxidants; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Death; Cell Division; Cell Hypoxia; Cells, Cultured; Chick Embryo; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Ditiocarb; Fibroblasts; Fluoresceins; Humans; Hydrogen Peroxide; Mice; Mitochondria; Myocardium; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uncoupling Agents | 2000 |
Role of paxillin in metabolic oxidative stress-induced cytoskeletal reorganization: involvement of SAPK signal transduction pathway and PTP-PEST gene expression.
Topics: Acetylcysteine; Antioxidants; Breast Neoplasms; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Doxorubicin; Drug Resistance, Multiple; Female; Gene Expression Regulation, Neoplastic; Glucose; Humans; Mitogen-Activated Protein Kinases; Oxidative Stress; Paxillin; Phosphoproteins; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Signal Transduction; Tumor Cells, Cultured | 2000 |
Urinary excretion of thioTEPA and its metabolites in patients treated with high-dose cyclophosphamide, thioTEPA and carboplatin.
Topics: Acetylcysteine; Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Aziridines; Breast Neoplasms; Carboplatin; Creatinine; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Models, Chemical; Neoplasms, Germ Cell and Embryonal; Thiotepa; Time Factors; Triethylenephosphoramide | 2001 |
Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Buthionine Sulfoximine; Ceramides; Doxorubicin; Drug Interactions; Free Radical Scavengers; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Reactive Oxygen Species; Signal Transduction; Transfection; Tumor Cells, Cultured | 2001 |
Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Breast Neoplasms; Cell Division; Cell Survival; Drug Interactions; Estrogens, Non-Steroidal; Flavonoids; Humans; Isoflavones; Kaempferols; Phytoestrogens; Plant Extracts; Plant Preparations; Plants; Quercetin; Resveratrol; Stilbenes; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2002 |
Protection by glutathione against one component of the bimodal inhibition of growth by tamoxifen in Saccharomyces cerevisiae.
Topics: Acetylcysteine; Ascorbic Acid; Breast Neoplasms; Cell Division; Glutathione; Humans; Saccharomyces cerevisiae; Tamoxifen; Tumor Cells, Cultured | 1990 |