acetylcysteine and Bipolar Disorder

acetylcysteine has been researched along with Bipolar Disorder in 40 studies

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (5.00)29.6817
2010's25 (62.50)24.3611
2020's13 (32.50)2.80

Authors

AuthorsStudies
Brown, A; Glue, P1
Back, SE; Berk, M; Bradlow, RCJ; Kalivas, PW; Kanaan, RA1
Biederman, J; Ceranoglu, TA; Cook, E; DiSalvo, M; Faraone, SV; Farrell, A; Joshi, G; Uchida, M; Vaudreuil, C; Wozniak, J1
Berk, M; Brietzke, E; Gabriel, FC; Jacka, FN; Lafer, B; Oliveira, M1
Ashton, MM; Berk, M; Cotton, SM; Dash, SR; Dean, OM; Dodd, S; Faye-Chauhan, K; Hebert, JR; Hopwood, M; Jacka, FN; Kim, Y; Malhi, GS; Marx, W; Mohebbi, M; Ng, CH; Sarris, J; Shivappa, N; Turner, A1
Berk, M; Bortolasci, CC; Cotton, SM; Dean, OM; Dodd, S; Dowling, N; Gray, L; Malhi, GS; Mohebbi, M; Ng, CH; Sarris, J; Turner, A; Voigt, C; Walder, K1
Iwata, N; Kishi, T; Miyake, N; Okuya, M; Sakuma, K1
DelBello, MP; Li, W; Nery, FG; Welge, JA1
Bozikas, PV; Haidich, AB; Papazisis, G; Pittas, S; Theodoridis, X1
Filip, M; Frankowska, M; Smaga, I1
Adler, CM; Blom, TJ; Cecil, KM; DelBello, MP; Nery, FG; Patino, LR; Tallman, MJ1
Andrade, C1
Ashton, M; Berk, M; Bortolasci, CC; Dean, OM; Gray, L; Jacka, F; Kowalski, GM; Liu, ZS; Marx, W; Mohebbi, M; Turner, A; Walder, K; Walker, AJ1
Gambhir, HS; Pruthi, S; Shah, S1
Colpo, GD; Dantzer, R; Leboyer, M; Teixeira, AL; Trivedi, MH1
Berk, M; Cai, DB; Ng, CH; Ning, YP; Qiu, Y; Ungvari, GS; Xiang, YT; Yang, XH; Zhang, QE; Zheng, W1
Berk, M; Bortolasci, C; Bush, AI; Cotton, SM; Dean, OM; Dodd, S; Gama, C; Gray, L; Hasebe, K; Kapczinski, F; Kidnapillai, S; Magalhães, PV; Malhi, GS; Mohebbi, M; Panizzutti, B; Walder, K1
Bauer, IE; Colpo, GD; Durkin, K; Green, C; Selvaraj, S; Soares, JC; Teixeira, AL; Zunta-Soares, GB1
Berk, M; Cotton, SM; Dean, OM; Dodd, S; Dowling, N; Malhi, GS; McAulay, C; Ng, CH; Owen, L; Samuni, Y; Sarris, J; Smith, D; Tanious, M; Turner, A; Waterdrinker, A1
Berk, M; Dean, OM; Ellegaard, PK; Licht, RW; Mohebbi, M; Nielsen, CT; Nielsen, RE; Poulsen, HE1
Kalivas, P; Post, RM1
Anderson-Hunt, M; Berk, M; Bush, AI; Copolov, DL; Dean, OM; Jeavons, S; Kohlmann, K; Magalhães, PV; Malhi, GS; Schapkaitz, I3
Ayorech, Z; Baumeister, D; Giaroli, G; Tracy, DK1
Hwang, ES; Kaufman, KR1
Amboni, RT; Arent, CO; Bianchini, G; Dal-Pont, GC; Lopes-Borges, J; Quevedo, J; Resende, WR; Steckert, AV; Valvassori, SS1
Racz, R; Sohoni, P; Sweet, BV1
Berk, M; Dean, OM; Rapado-Castro, M; Turner, A; Venugopal, K; Waterdrinker, A1
Dowling, NA; Lorains, FK; Merkouris, SS1
Berk, M; Bush, AI; Dean, OM; Dodd, S; Malhi, GS; On, ZX; Rapado-Castro, M; Skvarc, DR1
Anderson-Hunt, M; Berk, M; Bush, AI; Copolov, DL; Dean, O; Jeavons, S; Lu, K; Schapkaitz, I1
Berk, M; Bush, AI; Copolov, DL; Dean, OM; Mavros, C; van den Buuse, M1
Allwang, C; Berk, M; Bush, AI; Cobb, H; Cotton, SM; Dean, O; Dodd, S; Fernandes, BS; Gama, CS; Hewitt, K; Jeavons, S; Kapczinski, F; Kohlmann, K; Malhi, GS; Schapkaitz, I1
Hoenders, R; Lake, J; Sarris, J1
Fries, GR; Kapczinski, F1
Anderson-Hunt, M; Berk, M; Bush, AI; Copolov, DL; Dean, OM; Jeavons, S; Kohlmann, K; Magalhães, PV; Malhi, GS; Schapkaitz, I; Weisinger, D1
Allwang, C; Berk, M; Bush, AI; Cobb, H; Cotton, SM; Dean, OM; Dodd, S; Fernandes, B; Gama, CS; Hewitt, K; Jeavons, S; Kapczinski, F; Kohlmann, K; Malhi, GS; Moss, K; Schapkaitz, I1
Anderson-Hunt, M; Berk, M; Bush, AI; Copolov, DL; Dean, OM; Jeavons, S; Kohlmann, K; Schapkaitz, I1
Boeck, CR; Dal-Pizzol, F; Kapczinski, F; Oliveira, VB; Petronilho, FC; Quevedo, J; Réus, GZ; Steckert, AV; Valvassori, SS1

Reviews

13 review(s) available for acetylcysteine and Bipolar Disorder

ArticleYear
The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders.
    CNS drugs, 2022, Volume: 36, Issue:5

    Topics: Acetylcysteine; Anxiety Disorders; Bipolar Disorder; Humans; Obsessive-Compulsive Disorder; Schizophrenia

2022
Nutrition and bipolar disorder: a systematic review.
    Nutritional neuroscience, 2023, Volume: 26, Issue:7

    Topics: Acetylcysteine; Bipolar Disorder; Diet; Fatty Acids, Omega-3; Humans; Micronutrients; Vitamins

2023
N-acetylcysteine as an adjunctive treatment for bipolar depression and major depressive disorder: a systematic review and meta-analysis of double-blind, randomized placebo-controlled trials.
    Psychopharmacology, 2020, Volume: 237, Issue:11

    Topics: Acetylcysteine; Adult; Bipolar Disorder; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome

2020
N-acetylcysteine as an adjunctive treatment for bipolar depression: A systematic review and meta-analysis of randomized controlled trials.
    Bipolar disorders, 2021, Volume: 23, Issue:7

    Topics: Acetylcysteine; Bipolar Disorder; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Treatment Outcome

2021
The effect of N-acetylcysteine on bipolar depression: a systematic review and meta-analysis of randomized controlled trials.
    Psychopharmacology, 2021, Volume: 238, Issue:7

    Topics: Acetylcysteine; Bipolar Disorder; Combined Modality Therapy; Humans; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome

2021
N-acetylcysteine as a new prominent approach for treating psychiatric disorders.
    British journal of pharmacology, 2021, Volume: 178, Issue:13

    Topics: Acetylcysteine; Animals; Anxiety; Anxiety Disorders; Bipolar Disorder; Humans; Obsessive-Compulsive Disorder

2021
Immune-based strategies for mood disorders: facts and challenges.
    Expert review of neurotherapeutics, 2018, Volume: 18, Issue:2

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Bipolar Disorder; Cytokines; Depressive Disorder, Major; Exercise Therapy; Fatty Acids, Unsaturated; Humans; Inflammation; Mesenchymal Stem Cell Transplantation; Mood Disorders; Neuroimmunomodulation; Probiotics

2018
N-acetylcysteine for major mental disorders: a systematic review and meta-analysis of randomized controlled trials.
    Acta psychiatrica Scandinavica, 2018, Volume: 137, Issue:5

    Topics: Acetylcysteine; Antioxidants; Bipolar Disorder; Depressive Disorder, Major; Humans; Randomized Controlled Trials as Topic; Schizophrenia

2018
Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation.
    The British journal of psychiatry : the journal of mental science, 2013, Volume: 202, Issue:3

    Topics: Acetylcysteine; Age of Onset; Animals; Basal Ganglia; Behavior, Addictive; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Comorbidity; Diagnosis, Dual (Psychiatry); Disease Models, Animal; Disease Progression; Dopamine Uptake Inhibitors; Epigenomics; Free Radical Scavengers; Humans; Recurrence; Stress, Psychological

2013
Taking the fuel out of the fire: evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders.
    Journal of affective disorders, 2015, Mar-15, Volume: 174

    Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Fatty Acids, Omega-3; Humans

2015
Oral acetylcysteine for neuropsychiatric disorders.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Jun-01, Volume: 72, Issue:11

    Topics: Acetylcysteine; Administration, Oral; Autistic Disorder; Bipolar Disorder; Complementary Therapies; Dietary Supplements; Humans; Mental Disorders; Obsessive-Compulsive Disorder; Schizophrenia; Trichotillomania

2015
Interventions for comorbid problem gambling and psychiatric disorders: Advancing a developing field of research.
    Addictive behaviors, 2016, Volume: 58

    Topics: Acetylcysteine; Antimanic Agents; Antipsychotic Agents; Anxiety Disorders; Behavior Therapy; Bipolar Disorder; Citalopram; Cognitive Behavioral Therapy; Comorbidity; Free Radical Scavengers; Gambling; Humans; Lithium Compounds; Mental Disorders; Motivational Interviewing; Naltrexone; Narcotic Antagonists; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Tobacco Use Disorder

2016
Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations.
    Journal of alternative and complementary medicine (New York, N.Y.), 2011, Volume: 17, Issue:10

    Topics: Acetylcysteine; Acupuncture Therapy; Amino Acids, Branched-Chain; Bipolar Disorder; Complementary Therapies; Dietary Supplements; Drug Therapy, Combination; Fatty Acids, Omega-3; Humans; Integrative Medicine; Magnesium; Micronutrients; Psychotropic Drugs; Tryptophan

2011

Trials

18 trial(s) available for acetylcysteine and Bipolar Disorder

ArticleYear
Findings from a pilot open-label trial of N-acetylcysteine for the treatment of pediatric mania and hypomania.
    BMC psychiatry, 2022, 05-03, Volume: 22, Issue:1

    Topics: Acetylcysteine; Adolescent; Antimanic Agents; Bipolar Disorder; Child; Child, Preschool; Humans; Mania; Pilot Projects

2022
Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive
    The Australian and New Zealand journal of psychiatry, 2020, Volume: 54, Issue:2

    Topics: Acetylcysteine; Adult; Aged; Bipolar Disorder; Body Mass Index; Diet; Dietary Supplements; Female; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult

2020
Interleukin-6 and total antioxidant capacity levels following
    Acta neuropsychiatrica, 2020, Volume: 32, Issue:6

    Topics: Acetylcysteine; Antioxidants; Bipolar Disorder; Case-Control Studies; Depressive Disorder; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Energy Metabolism; Female; Free Radical Scavengers; Humans; Inflammation; Interleukin-6; Male; Mitochondria; Oxidative Stress; Placebos; Treatment Outcome

2020
N-acetylcysteine for depression and glutamate changes in the left prefrontal cortex in adolescents and young adults at risk for bipolar disorder: A pilot study.
    Early intervention in psychiatry, 2022, Volume: 16, Issue:2

    Topics: Acetylcysteine; Adolescent; Bipolar Disorder; Depression; Glutamic Acid; Humans; Pilot Projects; Prefrontal Cortex; Young Adult

2022
Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial.
    Journal of psychiatric research, 2021, Volume: 142

    Topics: Acetylcysteine; Bipolar Disorder; Depression; Double-Blind Method; Drug Therapy, Combination; Humans; Treatment Outcome

2021
Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.
    Acta neuropsychiatrica, 2018, Volume: 30, Issue:6

    Topics: Acetylcysteine; Adult; Aged; Bipolar Disorder; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Encephalitis; Female; Humans; Interleukins; Male; Middle Aged; Neurogenesis; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult

2018
A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression.
    The Journal of clinical psychiatry, 2018, 12-04, Volume: 80, Issue:1

    Topics: Acetylcysteine; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bayes Theorem; Bipolar Disorder; Chemotherapy, Adjuvant; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Oxidative Stress; Treatment Outcome

2018
A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo.
    BMC medicine, 2019, 01-25, Volume: 17, Issue:1

    Topics: Acetylcysteine; Adult; Bipolar Disorder; Combined Modality Therapy; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Mitochondria; Treatment Outcome

2019
The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: A randomized placebo-controlled study.
    Journal of affective disorders, 2019, 02-15, Volume: 245

    Topics: Acetylcysteine; Adult; Antidepressive Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Young Adult

2019
A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania.
    The Australian and New Zealand journal of psychiatry, 2013, Volume: 47, Issue:6

    Topics: Acetylcysteine; Adult; Antioxidants; Bipolar Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales

2013
Cognitive effects of adjunctive N-acetyl cysteine in psychosis.
    Psychological medicine, 2017, Volume: 47, Issue:5

    Topics: Acetylcysteine; Adult; Attention; Bipolar Disorder; Cognitive Dysfunction; Executive Function; Female; Free Radical Scavengers; Humans; Male; Memory, Short-Term; Middle Aged; Psychotic Disorders; Schizophrenia; Treatment Outcome

2017
N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial.
    Biological psychiatry, 2008, Sep-15, Volume: 64, Issue:6

    Topics: Acetylcysteine; Adult; Antidepressive Agents; Bipolar Disorder; Depression; Double-Blind Method; Female; Humans; Male; Middle Aged; Surveys and Questionnaires

2008
N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial.
    Journal of affective disorders, 2011, Volume: 129, Issue:1-3

    Topics: Acetylcysteine; Adult; Bipolar Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome

2011
The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: an open label trial.
    Journal of affective disorders, 2011, Volume: 135, Issue:1-3

    Topics: Acetylcysteine; Adult; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Depression; Depressive Disorder; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Mood Disorders; Quality of Life; Severity of Illness Index; Treatment Outcome

2011
N-acetylcysteine for major depressive episodes in bipolar disorder.
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2011, Volume: 33, Issue:4

    Topics: Acetylcysteine; Adult; Antidepressive Agents; Bipolar Disorder; Chemotherapy, Adjuvant; Depressive Disorder; Female; Humans; Male; Psychiatric Status Rating Scales; Treatment Outcome

2011
Systemic illness moderates the impact of N-acetyl cysteine in bipolar disorder.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Apr-27, Volume: 37, Issue:1

    Topics: Acetylcysteine; Adult; Bipolar Disorder; Cardiovascular Diseases; Double-Blind Method; Endocrine System Diseases; Female; Free Radical Scavengers; Humans; Inflammation; Male; Middle Aged; Oxidative Stress

2012
Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial.
    BMC medicine, 2012, Aug-14, Volume: 10

    Topics: Acetylcysteine; Adult; Antidepressive Agents; Bipolar Disorder; Female; Humans; Maintenance Chemotherapy; Male; Middle Aged; New Zealand; Placebos; Quality of Life; Secondary Prevention; Time Factors; Treatment Outcome

2012
Effects of N-acetyl cysteine on cognitive function in bipolar disorder.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:6

    Topics: Acetylcysteine; Adult; Analysis of Variance; Bipolar Disorder; Cognition; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Trail Making Test; Treatment Outcome; Verbal Behavior

2012

Other Studies

9 other study(ies) available for acetylcysteine and Bipolar Disorder

ArticleYear
Possible mechanisms for treatment heterogeneity in clinical trials of adjunctive N-acetylcysteine for bipolar depression.
    Bipolar disorders, 2022, Volume: 24, Issue:2

    Topics: Acetylcysteine; Bipolar Disorder; Clinical Trials as Topic; Double-Blind Method; Humans; Quality of Life; Treatment Outcome

2022
N-Acetylcysteine Augmentation for Patients With Major Depressive Disorder and Bipolar Depression.
    The Journal of clinical psychiatry, 2021, 02-18, Volume: 82, Issue:1

    Topics: Acetylcysteine; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Major; Drug Synergism; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Outcome Assessment, Health Care; Tranquilizing Agents

2021
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion.
    QJM : monthly journal of the Association of Physicians, 2017, Sep-01, Volume: 110, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Bipolar Disorder; Brain Diseases; Detergents; Female; Ferrocyanides; Free Radical Scavengers; Humans; Indoles; Methemoglobinemia; Methylene Blue; Respiration, Artificial; Respiratory Insufficiency; Suicide, Attempted; Treatment Outcome; Young Adult

2017
Culture, impaired access to mental health care, and bipolar disorder: case analysis.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2015, Volume: 27, Issue:1

    Topics: Acetylcysteine; Adult; Asian; Bipolar Disorder; Culture; Drug Overdose; Female; Free Radical Scavengers; Health Services Accessibility; Humans; Mental Health Services; Suicide, Attempted; Young Adult

2015
The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania.
    Journal of psychiatric research, 2015, Volume: 65

    Topics: Acetylcysteine; Aldehydes; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Deferoxamine; Disease Models, Animal; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sleep Deprivation; Tyrosine

2015
Effects of N-Acetyl cysteine on suicidal ideation in bipolar depression.
    The Journal of clinical psychiatry, 2015, Volume: 76, Issue:5

    Topics: Acetylcysteine; Bipolar Disorder; Free Radical Scavengers; Humans; Randomized Controlled Trials as Topic; Suicidal Ideation

2015
N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder.
    Neuroscience letters, 2011, Jul-25, Volume: 499, Issue:3

    Topics: Acetylcysteine; Animals; Bipolar Disorder; Brain; Corpus Striatum; Cyclohexanones; Dextroamphetamine; Disease Models, Animal; Frontal Lobe; Glutathione; Male; Rats; Rats, Sprague-Dawley; Schizophrenia

2011
N-acetylcysteine as a mitochondrial enhancer: a new class of psychoactive drugs?
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2011, Volume: 33, Issue:4

    Topics: Acetylcysteine; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Female; Humans; Male

2011
Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, May-15, Volume: 32, Issue:4

    Topics: Acetylcysteine; Animals; Bipolar Disorder; Central Nervous System Stimulants; Deferoxamine; Dextroamphetamine; Free Radical Scavengers; Hyperkinesis; Male; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar

2008