Compounds > acetylcysteine

acetylcysteine and Anoxemia

acetylcysteine has been researched along with Anoxemia in 93 studies

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-19904 (4.30)18.7374
1990's9 (9.68)18.2507
2000's37 (39.78)29.6817
2010's37 (39.78)24.3611
2020's6 (6.45)2.80

Authors

AuthorsStudies
Ge, X; He, C; Huang, C; Liu, S; Yang, C; Yang, S; Zhang, X1
Chen, L; Huang, J; Lin, QC; Lin, T; Wang, B; Xie, H; Yang, Y1
Chhabra, A; Jain, N; Kumar, B; Kumar, G; Meena, RN; Mishra, S; Prasad, DN; Sethy, NK; Sharma, M; Tulsawani, R1
Araujo Júnior, E; Cintra, ÁU; Martins, JL; Montero, EFS; Moron, AF; Silvares, SG; Simões, MJ1
Alamdari, AH; Alamdari, DH; Amini, S; Banpour, H; Damsaz, M; Keramati, MR; Koliakos, G; Moghaddam, AB; Yarahmadi, A; Zarmehri, AM1
Celorrio, M; Davies, M; Friess, SH; Rhodes, J; Vadivelu, S1
Manskikh, VN; Pavlenko, TA; Pevzner, IB; Plotnikov, EY; Silachev, DN; Sukhikh, GT; Zorov, DB; Zorova, LD1
Chi, GF; Ding, Y; Feng, CS; Ge, PF; Luo, YN; Piao, MH; Wang, HF; Wang, ZQ1
Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F1
Li, Y; Liu, T; Liu, Y; Shi, X; Wang, H; Wang, Y; Xia, T1
Czyzyk-Krzeska, M; Gozal, D; Kawedia, JD; Menon, AG; Sartor, MA; Yang, F1
He, J; He, R; Hu, C; Pan, P; Peng, S; Su, X1
Andrade, CF; da Rosa, DP; e Silva, MB; Fiori, CZ; Forgiarini, LF; Marroni, NP; Martinez, D1
Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP1
Chen, M; Dasgupta, C; Hu, XQ; Xiao, D; Yang, S; Zhang, L1
Deng, Y; Guo, X; Liu, H; Pan, Y; Wang, Y; Wang, Z; Yuan, X; Zhu, D1
Chi, SG; Chung, YG; Kang, SH; Park, DH; Park, KJ; Yu, MO1
Geiser, T; Hefti, U; Huber, AR; Leichtle, A; Merz, TM; Pichler Hefti, J; Stutz, M1
Caffrey, JL; Downey, HF; Estrada, JA; Gonzalez, L; Mallet, RT; Sun, J; Williams, AG1
Chen, S; Eubank, WL; Jouett, NP; Moralez, G; Raven, PB; Smith, ML; Tian, J; White, DW; Zimmerman, MC1
Ahmed, MS; Alfaro-Cervello, C; Baumbusch, LO; Benterud, T; Bjørås, M; Florholmen, G; Manueldas, S; Norgren, S; Pankratov, L; Sandvik, L; Saugstad, OD; Solberg, R; Ystgaard, MB1
Hu, C; Huang, L; Liu, B; Pan, P; Su, X; Zhang, Y1
Kulagin, KN; Levchenkova, OS; Novikov, VE; Parfenov, EA1
Gavrilova, SA; Goriacheva, AV; Kalenchuk, VU; Koshelev, VB; Malyshev, IIu; Manukhina, EB1
Choi, JW; Kim, AY; Kim, JB; Kim, M; Lee, YS; Masuzaki, H; Park, KS; Son, HJ; Yasue, S1
Bigam, DL; Chan, E; Cheung, PY; Johnson, ST; Obaid, L1
Averbukh, Z; Berman, S; Efrati, S; Ilgiyeav, I; Siman-Tov, Y; Weissgarten, J1
Bigam, DL; Cheung, PY; Emara, M; Jewell, LD; Johnson, ST; Korbutt, G; Obaid, L; Slack, G; Van Aerde, J2
Kurashima, Y; Ogura, T; Sakagami, H; Sugiyama, K; Tajima, M1
Cheung, PY; Lee, TF; Schulz, R; Tymafichuk, CN1
Bradford, A; Jones, JF; O'Halloran, KD; Skelly, JR1
Abdelsaid, MA; Al-Shabrawey, M; El-Remessy, AB; Matragoon, S; Pillai, BA; Prakash, R1
Liu, JN; Lu, G; Qiu, Y; Yang, D; Yin, GY; Zhang, JX; Zhang, XL1
Cock, ML; Duncan, JR; Hale, N; Harding, R; Probyn, ME; Rees, SM; Shields, A; Tolcos, M1
Kekec, Z; Ozturk, F; Sever, H; Seydaoglul, G1
Ahn, YS; Jung, SE; Kim, YK; Ko, JH; Lee, JH; Lim, MH; Youn, DY1
Cao, KJ; Chen, HW; Chen, ML; Ju, WZ; Wang, J; Yang, B; Zhang, FX1
Kuo, TB; Lai, CJ; Li, WS; Lin, YN; Lin, YS; Yang, CC; Yuan, ZF1
Adams, DH; Afford, SC; Bhogal, RH; Curbishley, SM; Weston, CJ1
Brown-Steinke, K; deRonde, K; Palmer, LA; Yemen, S1
Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ1
He, RX; Hu, CP; Luo, YQ; Su, XL; Xiang, YH1
Balková, P; Hlaváčková, M; Kolář, F; Milerová, M; Neckář, J; Novák, F; Nováková, O1
Arrais-Silva, WW; Colhone, MC; Degrossoli, A; Gadelha, FR; Giorgio, S; Joazeiro, PP1
Baek, JH; Chae, HS; Han, DH; Hwang, HR; Kim, YH; Kwon, A; Lim, WH; Park, HJ; Yi, WJ1
Ball, MK; Dokic, D; Jairaman, A; Mungai, PT; Prakriya, M; Schumacker, PT; Waypa, GB1
Adachi, T; Aida, K; Hara, H; Kamiya, T; Nishihara, H1
Dixon, B; Patterson, AJ; Xiao, D; Xiong, F; Zhang, L1
Evans, LC; Liu, H; Pinkas, GA; Thompson, LP1
Akimoto, M; Hisanaga, T; Honma, Y; Shimojo, Y; Tajima, Y; Takenaga, K; Tanaka, T1
Goldfarb, M; Heyman, SN; Karmeli, F; Rosen, S; Shina, A1
SEGAL, S1
Nikinmaa, M; Pursiheimo, S; Soitamo, AJ1
Bonanou, S; Chachami, G; Hatziefthimiou, A; Molyvdas, PA; Paraskeva, E; Simos, G1
Brimioulle, S; Kerbaul, F; Melot, C; Naeije, R; Pierre, S; Rondelet, B; Van der Linden, P1
Nieminen, AL; Qanungo, S; Wang, M1
Kimoto-Kinoshita, S; Nishida, S; Tomura, TT1
Cheng, CH; Waye, MM; Woo, AY1
Hampl, V; Herget, J; Hnilicková, O; Lachmanová, V; Povýsilová, V1
Hamasu, T; Inanami, O; Kashiwakura, I; Kuwabara, M; Takahashi, E; Tsujitani, M; Yokoyama, K1
Banerjee, PK; Ilavazhagan, G; Jayalakshmi, K; Sairam, M; Sharma, SK; Singh, SB1
Chang, H; Fang, WJ; Liou, JY; Shyu, KG; Wang, BW1
Brüne, B; Callapina, M; Köhl, R; Schmid, T; Zhou, J1
Kumar, GK; Peng, YJ; Prabhakar, NR; Rai, V; Ramakrishnan, DP; Sharma, SD; Souvannakitti, D1
Ameri, K; Culmsee, C; Davis, RJ; Denko, N; Hai, T; Hammond, EM; Harris, AL; Katschinski, DM; Raida, M; Wagner, E; Wenger, RH1
Cho, YS; Choi, SO; Kim, HL; Park, JW1
Billiar, TR; Levy, RM; McCloskey, CA; Mollen, KP; Prince, JM; Tanaka, H; Zuckerbraun, BS1
Ilavazhagan, G; Jayalakshmi, K; Kalpana, B; Muthuraju, S; Sairam, M; Singh, SB1
Chhabra, P; Doctor, A; Forbes, MS; Gaston, B; Karlinsey, MZ; Laubach, VE; Macdonald, T; Palmer, LA; Sheram, ML1
Cheung, PY; Jantzie, LL; Lee, TF; Todd, KG1
Cagiano, R; Cazzato, A; Colantuono, G; D'Agostino, D; Di Venosa, N; Federici, A; Fiore, T; Rastaldo, R; Tiravanti, EA1
Downey, HF; Jung, ME; Mallet, RT; Simpkins, JW; Wilson, AM1
Shibata, S; Tominaga, K; Watanabe, S1
Ausserer, WA; Bourrat-Floeck, B; Green, CJ; Laderoute, KR; Sutherland, RM1
Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH1
Ashino, Y; Fujimura, S; Hoshikawa, Y; Noda, M; Ono, S; Sakuma, T; Tabata, T; Tanita, T; Ueda, S1
Fellay, M; Kehtari, R1
Agustí, AG; Bergada, J; Ibañez, J; Jorda, R; Maimó, A; Marse, P; Raurich, JM; Togores, B1
Borger, DR; Essig, DA1
Clanton, TL; Merola, AJ; Mohanraj, P; Wright, VP1
Cabot, MC; Maurer, BJ; Metelitsa, LS; Reynolds, CP; Seeger, RC1
Bärtsch, P; Heberlein, W; Mairbäurl, H; Wodopia, R1
Lei, S; Ogiso, Y; Omura, S; Tomida, A; Tsuruo, T1
Lai, CC; Ryter, SW; Si, M; Su, CY1
de Abreu, R; Dekhuijzen, PN; Heunks, LM; Machiels, HA; van der Heijden, HF; Zhu, XP1
Agapito, MT; González, C; Obeso, A; Sanz-Alfayate, G1
Alexander, S; Bärtsch, P; Dröge, W; Hildebrandt, W1
Choi, Y; Chung, WJ; Kim, HH; Kim, MS; Kim, SW; Kwack, K; Lee, SE; Lee, ZH; Park, H1
Freudenthaler, SM; Gleiter, CH; Pilz, J; Schreeb, KH; Wiese, A1
Archer, SL; Chesler, E; Kulik, TJ; Weir, EK1
Brooks, RC; Rao, S; Sproule, BJ; Wilson, DB1
Ramirez, J1

Reviews

1 review(s) available for acetylcysteine and Anoxemia

ArticleYear
[Focus: fulminant and subfulminant hepatic insufficiency].
    Revue medicale de la Suisse romande, 1996, Volume: 116, Issue:6

    Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Critical Care; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Hypoxia; Liver Failure, Acute; Liver Transplantation; Prognosis

1996

Trials

4 trial(s) available for acetylcysteine and Anoxemia

ArticleYear
Increased endothelial microparticles and oxidative stress at extreme altitude.
    European journal of applied physiology, 2016, Volume: 116, Issue:4

    Topics: Acetylcysteine; Adult; Altitude; Antioxidants; Apoptosis; Biomarkers; Cell-Derived Microparticles; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hypoxia; Male; Middle Aged; Oxidative Stress; Prostaglandins; Vitamins

2016
Effects of N-acetylcysteine on tissue oxygenation in patients with multiple organ failure and evidence of tissue hypoxia.
    The European respiratory journal, 1997, Volume: 10, Issue:9

    Topics: Acetylcysteine; Adult; Aged; Cross-Over Studies; Hemodynamics; Humans; Hydrogen-Ion Concentration; Hypoxia; Infusions, Intravenous; Middle Aged; Multiple Organ Failure; Oxygen; Oxygen Consumption; Prospective Studies

1997
Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivity.
    Blood, 2002, Mar-01, Volume: 99, Issue:5

    Topics: Acetylcysteine; Adult; Erythropoietin; Humans; Hypoxia; Male; Oxidation-Reduction; Oxygen; Pulmonary Ventilation; Respiration; Sulfhydryl Compounds; Time Factors

2002
Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans.
    Acta physiologica Scandinavica, 2002, Volume: 174, Issue:3

    Topics: Acetylcysteine; Adult; Antioxidants; Area Under Curve; Erythropoietin; Free Radical Scavengers; Humans; Hypoxia; Male; Malondialdehyde; Thioctic Acid

2002

Other Studies

88 other study(ies) available for acetylcysteine and Anoxemia

ArticleYear
N-Acetylcysteine protects against cobalt chloride-induced endothelial dysfunction by enhancing glucose-6-phosphate dehydrogenase activity.
    FEBS open bio, 2022, Volume: 12, Issue:8

    Topics: Acetylcysteine; Cobalt; Glucosephosphate Dehydrogenase; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Vascular Diseases

2022
The role of ferroptosis and endoplasmic reticulum stress in intermittent hypoxia-induced myocardial injury.
    Sleep & breathing = Schlaf & Atmung, 2023, Volume: 27, Issue:3

    Topics: Acetylcysteine; Animals; Endoplasmic Reticulum Stress; Ferroptosis; Humans; Hypoxia; Mice; Sleep Apnea, Obstructive

2023
Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 07-01, Volume: 1866, Issue:7

    Topics: Acetylcysteine; Adaptation, Physiological; Adult; Altitude Sickness; Animals; Brain; Cerebrovascular Circulation; Cystathionine beta-Synthase; Cysteine; Disease Models, Animal; Energy Metabolism; Humans; Hydrogen Sulfide; Hypoxia; Male; Oxygen Consumption; Prodrugs; Rats; Young Adult

2020
Histological analysis of the intestinal wall of newborn rats submitted to hypoxia and reoxygenation to evaluate the protective effect of N-Acetylcysteine.
    Acta cirurgica brasileira, 2020, Volume: 35, Issue:4

    Topics: Acetylcysteine; Animals; Disease Models, Animal; Enterocolitis, Necrotizing; Female; Hypoxia; Ileum; Male; Pregnancy; Protective Agents; Rats, Wistar; Reference Values; Reproducibility of Results; Time Factors; Treatment Outcome

2020
Application of methylene blue -vitamin C -N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial.
    European journal of pharmacology, 2020, Oct-15, Volume: 885

    Topics: Acetylcysteine; Ascorbic Acid; Clinical Trials, Phase I as Topic; Compassionate Use Trials; Coronavirus Infections; COVID-19; Critical Illness; Female; Humans; Hypoxia; Male; Methylene Blue; Middle Aged; Pandemics; Pneumonia, Viral

2020
N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury.
    Experimental neurology, 2021, Volume: 335

    Topics: Acetylcysteine; Animals; Axons; Behavior, Animal; Brain Injuries, Traumatic; Fear; Glutathione; Hippocampus; Hypoxia; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Psychomotor Performance; Social Behavior

2021
The role of oxidative stress in acute renal injury of newborn rats exposed to hypoxia and endotoxin.
    The FEBS journal, 2017, Volume: 284, Issue:18

    Topics: Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Animals; Animals, Newborn; Antioxidants; Biomarkers; Blood Urea Nitrogen; Cell Adhesion Molecules; Disease Models, Animal; Gene Expression; Humans; Hypoxia; Infant; Lipocalin-2; Lipocalins; Lipopolysaccharides; Oxidative Stress; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Rats; Reactive Oxygen Species

2017
Endoplasmic reticulum stress regulates oxygen-glucose deprivation-induced parthanatos in human SH-SY5Y cells via improvement of intracellular ROS.
    CNS neuroscience & therapeutics, 2018, Volume: 24, Issue:1

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Free Radical Scavengers; Glucose; Glutathione; Humans; Hypoxia; L-Lactate Dehydrogenase; Lipid Peroxidation; Membrane Potential, Mitochondrial; Neuroblastoma; Phenylbutyrates; Reactive Oxygen Species; RNA, Small Interfering; Time Factors; Transfection

2018
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-6; Ischemia; Lactic Acid; Male; Muscle, Skeletal; Nitrates; Nitrites; Oxidative Stress; Oxygen; Oxygen Consumption; Peroxidase; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vascular Endothelial Growth Factor A

2018
Pathogenesis of Abnormal Hepatic Lipid Metabolism Induced by Chronic Intermittent Hypoxia in Rats and the Therapeutic Effect of N-Acetylcysteine.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Jul-03, Volume: 24

    Topics: Acetylcysteine; Animals; Body Weight; Cytokines; Hypoxia; Inflammation; Lipid Metabolism; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction

2018
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathways.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Acetylcysteine; Animals; Aquaporin 5; Cell Hypoxia; Cell Line; Cobalt; Epithelial Cells; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Mice; Oxygen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Respiratory Mucosa; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Water

2013
[Endarterium injury and the related pathway in chronic intermittent hypoxia rats].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013, Volume: 38, Issue:7

    Topics: Acetylcysteine; Animals; Aorta, Thoracic; C-Reactive Protein; Endothelium, Vascular; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lipoproteins, LDL; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serum Amyloid P-Component

2013
Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015, Volume: 64, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspases; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Liver; Male; Melatonin; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Sleep Apnea Syndromes; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2015
Melatonin prevents hyperglycemia in a model of sleep apnea.
    Archives of endocrinology and metabolism, 2015, Volume: 59, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Disease Models, Animal; Free Radical Scavengers; Hyperglycemia; Hypoxia; Melatonin; Mice, Inbred BALB C; Sleep Apnea, Obstructive; Time Factors; Triglycerides

2015
Hypoxia Represses ER-α Expression and Inhibits Estrogen-Induced Regulation of Ca2+-Activated K+ Channel Activity and Myogenic Tone in Ovine Uterine Arteries: Causal Role of DNA Methylation.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 66, Issue:1

    Topics: Acetylcysteine; Animals; Azacitidine; Decitabine; DNA Methylation; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation; Hypoxia; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Pregnancy; Pregnancy Complications; Progesterone; Promoter Regions, Genetic; Reactive Oxygen Species; Sheep; Uterine Artery; Vascular Resistance

2015
N-acetylcysteine Ameliorates the Erectile Dysfunction Caused by Chronic Intermittent Hypoxia in Rats: Partly Involvement of Endoplasmic Reticulum Stress.
    Urology, 2015, Volume: 86, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Endoplasmic Reticulum Stress; Erectile Dysfunction; Free Radical Scavengers; Hypoxia; Immunohistochemistry; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

2015
Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma.
    Journal of neuro-oncology, 2015, Volume: 125, Issue:1

    Topics: Acetylcysteine; Brain Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia; NADPH Oxidase 4; NADPH Oxidases; Neovascularization, Pathologic; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A

2015
δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium.
    Basic research in cardiology, 2016, Volume: 111, Issue:2

    Topics: Acetylcysteine; Animals; Arrhythmias, Cardiac; Dogs; Female; Hematocrit; Hypoxia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardium; Naltrexone; Reactive Oxygen Species; Receptors, Opioid, delta

2016
N-Acetylcysteine reduces hyperacute intermittent hypoxia-induced sympathoexcitation in human subjects.
    Experimental physiology, 2016, Volume: 101, Issue:3

    Topics: Acetylcysteine; Adult; Blood Pressure; Female; Humans; Hypoxia; Male; Muscles; Reactive Oxygen Species; Respiration; Sleep Apnea, Obstructive; Superoxides; Sympathetic Nervous System

2016
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia.
    Neonatology, 2017, Volume: 111, Issue:1

    Topics: Acetylcysteine; Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Brain; Female; Hypoxia; Interleukin-1beta; Male; Neuroprotective Agents; NF-kappa B; Oxygen; Swine; Time Factors; Tumor Necrosis Factor-alpha

2017
[Effect of chronic intermittent hypoxia on the expression of CXC chemokine ligand-10 in rat liver and the interventional effect of N-acetylcysteine].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2016, Volume: 41, Issue:8

    Topics: Acetylcysteine; Animals; Chemokine CXCL10; Fatty Liver; Hypoxia; Inflammation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley

2016
Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia.
    Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Carotid Arteries; Cerebrum; Combined Modality Therapy; Coumarins; Female; Hypoxia; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Ligation; Male; Neuroprotective Agents; Nicotinic Acids; Rats; Rats, Wistar; Umbelliferones

2016
[Organ specificity in nitric oxide storage in the blood vessel walls during adaptation to hypoxia].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2008, Volume: 94, Issue:2

    Topics: Acetylcysteine; Adaptation, Physiological; Animals; Basilar Artery; Coronary Vessels; Hypoxia; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Organ Specificity; Rats; Rats, Wistar; Serotonin; Vasoconstriction

2008
Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:9

    Topics: 3T3-L1 Cells; Acetylcysteine; Adipose Tissue; Animals; Antioxidants; Base Sequence; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Humans; Hypoxia; Kidney; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oxidative Stress; PPAR gamma; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Tumor Necrosis Factor-alpha

2008
N-acetylcysteine administration improves platelet aggregation in hypoxia-reoxygenation injury.
    Proceedings of the Western Pharmacology Society, 2007, Volume: 50

    Topics: Acetylcysteine; Animals; Hypoxia; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oxygen; Platelet Aggregation; Platelet Count; Swine

2007
Differential effects of N-acetylcysteine, theophylline or bicarbonate on contrast-induced rat renal vasoconstriction.
    American journal of nephrology, 2009, Volume: 29, Issue:3

    Topics: Acetylcysteine; Animals; Contrast Media; Dinoprostone; Free Radical Scavengers; Hypoxia; Iothalamic Acid; Isoprostanes; Kidney; Microcirculation; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Sodium Bicarbonate; Theophylline; Vasoconstriction; Vasodilator Agents

2009
Effects of N-acetylcysteine on intestinal reoxygenation injury in hypoxic newborn piglets resuscitated with 100% oxygen.
    Neonatology, 2009, Volume: 96, Issue:3

    Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; Enterocolitis; Hypoxia; Ileum; Oxygen; Oxygen Inhalation Therapy; Reperfusion Injury; Splanchnic Circulation; Swine

2009
The redox state of glutathione regulates the hypoxic induction of HIF-1.
    European journal of pharmacology, 2009, Mar-15, Volume: 606, Issue:1-3

    Topics: Acetylcysteine; Animals; Azoles; Cell Line, Tumor; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Glutathione Reductase; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Isoindoles; Organoselenium Compounds; Oxidation-Reduction; RNA, Messenger; Transcriptional Activation; Vascular Endothelial Growth Factor A

2009
Post-resuscitation NOS inhibition does not improve hemodynamic recovery of hypoxic newborn pigs.
    Intensive care medicine, 2009, Volume: 35, Issue:9

    Topics: Acetylcysteine; Alberta; Animals; Antioxidants; Blood Gas Analysis; Hemodynamics; Hypoxia; Nitric Oxide; Random Allocation; Resuscitation; Stroke Volume; Swine

2009
Superoxide scavengers improve rat pharyngeal dilator muscle performance.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:6

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Animals; Cyclic N-Oxides; Electric Stimulation; Free Radical Scavengers; Hyperoxia; Hypoxia; In Vitro Techniques; Isometric Contraction; Male; Muscle Strength; Pharyngeal Muscles; Rats; Rats, Wistar; Sleep Apnea, Obstructive; Spin Labels; Superoxides; Time Factors

2010
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Catechin; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glutathione; Hyperoxia; Hypoxia; Ischemia; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Protective Agents; Retinal Neovascularization; Retinal Vessels; Tyrosine

2010
The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia.
    Chinese medical journal, 2010, Jan-05, Volume: 123, Issue:1

    Topics: Acetylcysteine; Animals; Free Radical Scavengers; Heart; Hypoxia; Malondialdehyde; Mice; Mice, Inbred ICR; Myocardium; Oxidative Stress; Random Allocation; Superoxide Dismutase

2010
The anti-inflammatory agent N-acetyl cysteine exacerbates endotoxin-induced hypoxemia and hypotension and induces polycythemia in the ovine fetus.
    Neonatology, 2010, Volume: 98, Issue:2

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Disease Models, Animal; Drug Synergism; Fetus; Gestational Age; Hemodynamics; Hypotension; Hypoxia; Lipopolysaccharides; Oximetry; Oxygen; Polycythemia; Sheep

2010
The effect of antioxidants (N-acetylcysteine and melatonin) on hypoxia due to carbonmonoxide poisoning.
    Bratislavske lekarske listy, 2010, Volume: 111, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Carbon Monoxide Poisoning; Female; Hypoxia; Lung; Melatonin; Rats; Rats, Wistar

2010
Down-modulation of Bis sensitizes cell death in C6 glioma cells induced by oxygen-glucose deprivation.
    Brain research, 2010, Aug-19, Volume: 1349

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Catalase; Cell Death; Cell Line, Tumor; Down-Regulation; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; Glioma; Glucose; Hypoxia; L-Lactate Dehydrogenase; NF-kappa B; Rats; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Superoxide Dismutase

2010
[The anti-apoptotic effects of N-acetylcysteine in neonatal rat cardiomyocytes underwent hypoxia-reoxygenation injury].
    Zhonghua xin xue guan bing za zhi, 2010, Volume: 38, Issue:5

    Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Cell Death; Cell Hypoxia; Cells, Cultured; Hypoxia; Myocytes, Cardiac; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2010
Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats.
    Respiratory physiology & neurobiology, 2011, Jan-31, Volume: 175, Issue:1

    Topics: Acetylcysteine; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Free Radical Scavengers; Hypoxia; Lipid Peroxidation; Lung; Male; Medulla Oblongata; Metalloporphyrins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reflex; Spectrum Analysis; Wakefulness

2011
Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2010, Volume: 16, Issue:11

    Topics: Acetylcysteine; Annexin A5; Antioxidants; Apoptosis; Female; Flow Cytometry; Hepatocytes; Humans; Hypoxia; Inflammation; Kupffer Cells; Liver; Liver Diseases; Male; Mitochondria; Models, Biological; NADPH Oxidases; Reactive Oxygen Species; Reperfusion Injury; Young Adult

2010
Gender differences in S-nitrosoglutathione reductase activity in the lung.
    PloS one, 2010, Nov-16, Volume: 5, Issue:11

    Topics: Acetylcysteine; Aldehyde Oxidoreductases; Animals; Bronchodilator Agents; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Estrogens; Female; Free Radical Scavengers; Hypoxia; Lung; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Orchiectomy; S-Nitrosoglutathione; Sex Factors

2010
Effects of post-resuscitation treatment with N-acetylcysteine on cardiac recovery in hypoxic newborn piglets.
    PloS one, 2010, Dec-21, Volume: 5, Issue:12

    Topics: Acetylcysteine; Animals; Animals, Newborn; Caspase 3; Heart; Hemodynamics; Hydrogen Peroxide; Hypoxia; Lactates; Lipids; Myocardium; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Reactive Oxygen Species; Stroke Volume; Swine; Troponin I

2010
[A study of the related pathways of oxidative stress in chronic intermittent hypoxia rats and the effect of N-acetylcysteine].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2010, Volume: 33, Issue:12

    Topics: Acetylcysteine; Animals; Antioxidants; Blood Pressure; Hypertension; Hypoxia; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sleep Apnea, Obstructive

2010
N-acetylcysteine treatment prevents the up-regulation of MnSOD in chronically hypoxic rat hearts.
    Physiological research, 2011, Volume: 60, Issue:3

    Topics: Acetylcysteine; Animals; Free Radical Scavengers; Hypoxia; Male; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Up-Regulation

2011
The influence of low oxygen on macrophage response to Leishmania infection.
    Scandinavian journal of immunology, 2011, Volume: 74, Issue:2

    Topics: Acetylcysteine; Animals; Azoles; Basic Helix-Loop-Helix Transcription Factors; Female; Free Radical Scavengers; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-10; Interleukin-12; Isoindoles; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Organoselenium Compounds; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2011
The effect of antioxidants on the production of pro-inflammatory cytokines and orthodontic tooth movement.
    Molecules and cells, 2011, Volume: 32, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Fibroblasts; Humans; Hypoxia; Inflammation; Inflammation Mediators; Interleukin-1beta; Male; Molar; Periodontal Ligament; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Stress, Mechanical; Tooth Mobility; Tumor Necrosis Factor-alpha; Up-Regulation

2011
Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.
    Molecular and cellular biology, 2011, Volume: 31, Issue:17

    Topics: Acetylcysteine; Adenosine Monophosphate; AMP-Activated Protein Kinases; Animals; Blotting, Western; Calcium; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Endoplasmic Reticulum; Enzyme Activation; Fluorescence Resonance Energy Transfer; Humans; Hypoxia; Lung; Membrane Proteins; Mice; Mice, Knockout; Neoplasm Proteins; ORAI1 Protein; Rats; Reactive Oxygen Species; RNA Interference; Stromal Interaction Molecule 1; Thapsigargin

2011
Effect of hypoxia mimetic cobalt chloride on the expression of extracellular-superoxide dismutase in retinal pericytes.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:8

    Topics: Acetylcysteine; Animals; Apoptosis; Butyric Acid; Caspase 3; Cobalt; Diabetic Retinopathy; DNA Fragmentation; Down-Regulation; Free Radical Scavengers; Hypoxia; Pericytes; Rats; Reactive Oxygen Species; Retina; Superoxide Dismutase

2011
Hypoxia-derived oxidative stress mediates epigenetic repression of PKCε gene in foetal rat hearts.
    Cardiovascular research, 2012, Feb-01, Volume: 93, Issue:2

    Topics: Acetylcysteine; Animals; Cyclic N-Oxides; DNA Methylation; Epigenesis, Genetic; Female; Fetal Heart; Gene Expression Regulation, Developmental; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Myocardial Reperfusion Injury; NADPH Oxidases; Oxidative Stress; Pregnancy; Promoter Regions, Genetic; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels

2012
Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts.
    Pediatric research, 2012, Volume: 71, Issue:1

    Topics: Acetylcysteine; Animals; Body Weight; Collagen; Female; Fetal Heart; Guinea Pigs; Hypoxia; Lipid Peroxidation; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Organ Size; Peroxynitrous Acid; Pregnancy; Tyrosine

2012
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.
    Clinical & experimental metastasis, 2013, Volume: 30, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; Transcription Factors; Tumor Cells, Cultured; Twist-Related Protein 1

2013
N-acetylcysteine ameliorates renal microcirculation: studies in rats.
    Kidney international, 2003, Volume: 63, Issue:2

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Dinoprostone; Enzyme Inhibitors; Hypoxia; Kidney Cortex; Kidney Diseases; Kidney Medulla; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation

2003
INHALATION THERAPY.
    Canadian Medical Association journal, 1965, Jan-09, Volume: 92

    Topics: Acetylcysteine; Anti-Bacterial Agents; Bronchial Spasm; Cysteine; Drug Therapy; Epinephrine; Equipment and Supplies; Humans; Hypoxia; Isoproterenol; Mucus; Oxygen Inhalation Therapy; Phenylephrine; Propylene Glycols; Respiratory Therapy; Respiratory Tract Diseases

1965
Redox state regulates HIF-1alpha and its DNA binding and phosphorylation in salmonid cells.
    Journal of cell science, 2004, Jul-01, Volume: 117, Issue:Pt 15

    Topics: Acetylcysteine; Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cell Line; Cysteine; Dimerization; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Oncorhynchus mykiss; Oxidation-Reduction; Oxidative Stress; Oxygen; Phosphorylation; Proline; Propyl Gallate; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; RNA; Time Factors; Transcription Factors; Transcriptional Activation

2004
Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.
    American journal of respiratory cell and molecular biology, 2004, Volume: 31, Issue:5

    Topics: Acetylcysteine; Androstadienes; Animals; Blotting, Western; Cell Nucleus; Chromones; Cobalt; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microscopy, Fluorescence; Models, Biological; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Plasmids; Potassium Chloride; Rabbits; Reactive Oxygen Species; Time Factors; Trachea; Transcription Factors; Transcription, Genetic; Transfection; Wortmannin

2004
Prevention of hemodilution-induced inhibition of hypoxic pulmonary vasoconstriction by N-acetylcysteine in dogs.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Acetylcysteine; Animals; Blood Gas Analysis; Blood Pressure; Blood Viscosity; Cardiac Output; Dogs; Hemodilution; Hypoxia; Lung Compliance; Pulmonary Circulation; Vascular Resistance; Vasoconstriction

2004
N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts.
    The Journal of biological chemistry, 2004, Nov-26, Volume: 279, Issue:48

    Topics: Acetylcysteine; Animals; Apoptosis; Cell Survival; Cytochromes c; Fibroblasts; Glutathione; Hypoxia; I-kappa B Proteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Proteins; Reactive Oxygen Species; X-Linked Inhibitor of Apoptosis Protein

2004
Diethyldithiocarbamate can induce two different type of death: apoptosis and necrosis mediating the differential MAP kinase activation and redox regulation in HL60 cells.
    Molecular and cellular biochemistry, 2004, Volume: 265, Issue:1-2

    Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Survival; Chelating Agents; Ditiocarb; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; HL-60 Cells; Humans; Hypoxia; Intracellular Membranes; Ions; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potentials; Metals; Mitochondria; Necrosis; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase; Time Factors

2004
Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.
    Cardiovascular research, 2005, Jan-01, Volume: 65, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium; Catalase; Cells, Cultured; Dicumarol; Enzyme Inhibitors; Flavanones; Flavonoids; Hypoxia; L-Lactate Dehydrogenase; Myocytes, Cardiac; Rats

2005
N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia.
    Life sciences, 2005, May-27, Volume: 77, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Male; Rats; Rats, Wistar

2005
Post-irradiation hypoxic incubation of X-irradiated MOLT-4 cells reduces apoptotic cell death by changing the intracellular redox state and modulating SAPK/JNK pathways.
    Apoptosis : an international journal on programmed cell death, 2005, Volume: 10, Issue:3

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Enzyme Activation; fas Receptor; Glutathione; Humans; Hypoxia; Imidazoles; Leukemia; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Radiation-Sensitizing Agents

2005
Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture.
    Brain research, 2005, Jun-07, Volume: 1046, Issue:1-2

    Topics: Acetylcysteine; Animals; Antioxidants; Cell Death; Cells, Cultured; DNA Fragmentation; Free Radicals; Hippocampus; Hypoxia; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species

2005
Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart.
    Journal of biomedical science, 2005, Volume: 12, Issue:2

    Topics: Acetylcysteine; Animals; Antihypertensive Agents; Aorta; Arteries; Blotting, Western; Body Weight; Carbazoles; Carvedilol; Down-Regulation; Doxazosin; Echocardiography; Hemodynamics; Hypertrophy; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Myocardium; Nerve Growth Factor; Organ Size; Pressure; Propanolamines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Transcription Factors; Valine; Valsartan; Vascular Endothelial Growth Factor A; Vasodilator Agents

2005
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species.
    Free radical biology & medicine, 2005, Oct-01, Volume: 39, Issue:7

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Carcinoma, Hepatocellular; Cell Line; Humans; Hydroxylation; Hypoxia; Naphthoquinones; Nitric Oxide; Nitric Oxide Donors; Procollagen-Proline Dioxygenase; Reactive Oxygen Species; Triazenes; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein

2005
Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.
    The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1

    Topics: Acetylcysteine; Adrenal Medulla; Animals; Antioxidants; Blood Pressure; Catecholamines; Epinephrine; Hypoxia; Male; Nicotine; Nicotinic Agonists; Norepinephrine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors

2006
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
    Oncogene, 2007, Jan-11, Volume: 26, Issue:2

    Topics: Acetylcysteine; Activating Transcription Factor 3; Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cells, Cultured; Cyanides; Deferoxamine; Enzyme Activation; Free Radical Scavengers; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Mixed Function Oxygenases; Neurons; Oxygen; Proto-Oncogene Proteins c-jun; Siderophores; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Von Hippel-Lindau Tumor Suppressor Protein

2007
ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.
    Biochemical and biophysical research communications, 2007, Apr-27, Volume: 356, Issue:1

    Topics: Acetylcysteine; Animals; Antimicrobial Cationic Peptides; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha; Cell Hypoxia; Cell Line, Tumor; Dithiothreitol; Down-Regulation; Free Radical Scavengers; Gene Expression; Hepcidins; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1; Mice; Mice, Inbred BALB C; Oxidants; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; STAT3 Transcription Factor; Transcription, Genetic

2007
Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes.
    Shock (Augusta, Ga.), 2007, Volume: 28, Issue:3

    Topics: Acetylcysteine; Animals; Enzyme Activation; Fluoresceins; Hepatocytes; Hypoxia; Isotonic Solutions; JNK Mitogen-Activated Protein Kinases; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Onium Compounds; rac1 GTP-Binding Protein; Reactive Oxygen Species; Shock, Hemorrhagic; Specific Pathogen-Free Organisms

2007
N-acetylcysteine improves the hemodynamics and oxidative stress in hypoxic newborn pigs reoxygenated with 100% oxygen.
    Shock (Augusta, Ga.), 2007, Volume: 28, Issue:4

    Topics: Acetylcysteine; Animals; Animals, Newborn; Blood Flow Velocity; Blood Pressure; Female; Glutathione; Hypoxia; Kidney; Lipid Peroxides; Male; Myocardium; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Stroke Volume; Swine; Time Factors

2007
N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia.
    Physiology & behavior, 2007, Nov-23, Volume: 92, Issue:4

    Topics: Acetylcysteine; Altitude Sickness; Analysis of Variance; Animals; Atmospheric Pressure; Dietary Supplements; Free Radicals; Hippocampus; Hypoxia; Male; Maze Learning; Memory, Short-Term; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Space Perception

2007
S-nitrosothiols signal hypoxia-mimetic vascular pathology.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:9

    Topics: Acetylcysteine; Animals; Erythrocytes; Glutathione; Hypertension; Hypoxia; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Nitro Compounds; Nitroso Compounds; Oxygen; Pulmonary Artery; S-Nitrosothiols; Signal Transduction

2007
Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain.
    Intensive care medicine, 2008, Volume: 34, Issue:1

    Topics: Acetylcysteine; Animals; Brain; Free Radical Scavengers; Hydrogen Peroxide; Hypoxia; Oxidative Stress; Prospective Studies; Resuscitation; Swine

2008
Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:1

    Topics: Acetylcysteine; Animals; Blood Pressure; Coronary Circulation; Decanoic Acids; Disease Models, Animal; Free Radical Scavengers; Glyburide; Heart Rate; Hydroxy Acids; Hypoxia; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Reactive Oxygen Species; Respiration, Artificial; Time Factors; Ventricular Function, Left; Ventricular Pressure

2008
Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Animal; Brain Chemistry; Central Nervous System Depressants; Dextrins; Diet; Ethanol; Hypoxia; Ischemic Preconditioning; Male; Mitochondria; Mitochondrial Membranes; Mitochondrial Swelling; Oxidants; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Superoxides

2008
Glutathione protects against hypoxic/hypoglycemic decreases in 2-deoxyglucose uptake and presynaptic spikes in hippocampal slices.
    European journal of pharmacology, 1995, Jan-24, Volume: 273, Issue:1-2

    Topics: Acetylcysteine; Action Potentials; Animals; Deoxyglucose; Electrophysiology; Free Radical Scavengers; Glutathione; Hippocampus; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Nerve Fibers; Rats; Rats, Wistar; Receptors, Presynaptic

1995
Regulation of c-jun expression during hypoxic and low-glucose stress.
    Molecular and cellular biology, 1994, Volume: 14, Issue:8

    Topics: Acetylcysteine; Base Sequence; Gene Expression Regulation; Genes, fos; Genes, jun; Glucose; Humans; Hypoxia; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Kinase C; Proto-Oncogene Mas; RNA, Messenger; Transcription, Genetic

1994
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
    Journal of cellular physiology, 1993, Volume: 156, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured

1993
[Contribution of oxidative stress to pulmonary hypertension induced by chronic hypoxia].
    Nihon Kyobu Shikkan Gakkai zasshi, 1995, Volume: 33, Issue:11

    Topics: Acetylcysteine; Animals; Chronic Disease; Free Radical Scavengers; Hypertension, Pulmonary; Hypoxia; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley

1995
Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with N-acetyl-L-cysteine.
    The American journal of physiology, 1998, Volume: 274, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Gene Expression Regulation; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Hypoxia; Isoenzymes; Myocardium; Oxygenases; Rats; Reactive Oxygen Species; RNA, Messenger

1998
Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:6

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Animals; Antioxidants; Dimethyl Sulfoxide; Electric Stimulation; Free Radical Scavengers; Hypoxia; In Vitro Techniques; Male; Muscle Contraction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Respiratory Muscles; Superoxide Dismutase

1998
Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines.
    Journal of the National Cancer Institute, 1999, Jul-07, Volume: 91, Issue:13

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Ceramides; DNA Fragmentation; DNA, Neoplasm; Drug Interactions; Fenretinide; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Necrosis; Reactive Oxygen Species; Retinoblastoma; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Possible role of ROS as mediators of hypoxia-induced ion transport inhibition of alveolar epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:4

    Topics: Acetylcysteine; Biological Transport; Epithelial Cells; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hyperoxia; Hypoxia; Ions; Oxidants; Pulmonary Alveoli; Reactive Oxygen Species; Rubidium; Sodium; Tumor Cells, Cultured

2000
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
    Cancer research, 2000, May-01, Volume: 60, Issue:9

    Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Northern; Cell Cycle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Glucose; Humans; Hypoxia; Immunoblotting; Isoenzymes; Methotrexate; Mice; Mice, Nude; Multienzyme Complexes; Neoplasm Transplantation; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Time Factors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vincristine

2000
Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6

    Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Aorta, Thoracic; Carbon Monoxide; Cattle; Cell Hypoxia; Cells, Cultured; Deferoxamine; Endothelium, Vascular; Enzyme Activation; Ferric Compounds; Free Radical Scavengers; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Iron Chelating Agents; Male; Oxidative Stress; Phenanthrolines; Photosensitizing Agents; Quaternary Ammonium Compounds

2000
Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:6

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Adenosine Triphosphate; Allopurinol; Animals; Diaphragm; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Hypoxia; In Vitro Techniques; Indicators and Reagents; Isotonic Contraction; Male; Muscle Fatigue; Rats; Rats, Wistar; Xanthine Oxidase

2001
Reduced to oxidized glutathione ratios and oxygen sensing in calf and rabbit carotid body chemoreceptor cells.
    The Journal of physiology, 2001, Nov-15, Volume: 537, Issue:Pt 1

    Topics: Acetylcysteine; Animals; Carotid Body; Catecholamines; Cattle; Chemoreceptor Cells; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hypoxia; Ionomycin; Ionophores; Oxygen; Potassium; Rabbits

2001
Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells.
    Cytokine, 2002, Jan-07, Volume: 17, Issue:1

    Topics: Acetylcysteine; Blotting, Western; Calcitriol; Cell Line; Cobalt; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Free Radical Scavengers; Gene Expression; Glucocorticoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Lymphokines; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 183, Issue:1

    Topics: Acetylcysteine; Animals; Aorta; Atropine; Blood Pressure; Dinoprost; Dogs; Hypoxia; Lung; Meclofenamic Acid; Methylene Blue; Prostaglandins F; Pulmonary Artery; Substance P; Vascular Resistance; Vasoconstriction

1986
Acute effects of nebulization of N-acetylcysteine on pulmonary mechanics and gas exchange.
    The American review of respiratory disease, 1970, Volume: 102, Issue:1

    Topics: Acetylcysteine; Aerosols; Blood Gas Analysis; Bronchial Spasm; Female; Humans; Hypercapnia; Hypoxia; Lung Compliance; Lung Diseases; Male; Respiration; Spirometry; Ventilation-Perfusion Ratio

1970
Alveolar proteinosis: importance of pulmonary lavage.
    The American review of respiratory disease, 1971, Volume: 103, Issue:5

    Topics: Acetylcysteine; Adult; Aerosols; Heparin; Humans; Hypoxia; Isoniazid; L-Lactate Dehydrogenase; Male; Middle Aged; Oxygen; Prednisone; Pulmonary Alveolar Proteinosis; Radiography; Therapeutic Irrigation; Trypsin

1971