Compounds > acetylcysteine

acetylcysteine and Amyotrophic Lateral Sclerosis

acetylcysteine has been researched along with Amyotrophic Lateral Sclerosis in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19903 (17.65)18.7374
1990's4 (23.53)18.2507
2000's5 (29.41)29.6817
2010's2 (11.76)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Cheng, J; Deng, H; Deng, S; Fan, K; Gong, L; Guo, Y; Kang, M; Li, H; Xu, H; Yang, H; Yang, Z; Yuan, L; Zheng, W1
Glasebach, H; Hans, F; Kahle, PJ1
Alandes, S; Alcácer, J; Banacloche, S; Benlloch, M; Colomer, N; Coronado, JA; Drehmer, E; Estrela, JM; Jihad-Jebbar, A; López-Blanch, R; Marchio, P; Obrador, E; Rivera, P; Salvador, R; Vallés, SL1
Hadano, S; Hirayama, N; Ikeda, JE; Kanno, T; Tanaka, K; Yanagisawa, Y; Yasutake, K; Yoshii, F1
Johnson, WM; Mieyal, JJ; Wilson-Delfosse, AL1
Beretta, S; Carrì, MT; Casciati, A; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G1
Iłzecka, J; Stelmasiak, Z1
Cheema, SS; Lopes, EC; Turner, BJ1
Balakrishnan, S; Carrì, MT; Ebert, S; Goos, M; Jaiswal, MK; Keller, BU; Mitchell, T; Nau, R; Zech, WD1
Bossuyt, PM; de Jong, JM; Louwerse, ES; Meyjes, FE; Weverling, GJ1
Bristol, LA; Brown, RH; Hosler, B; Kuncl, RW; Rothstein, JD1
Bossuyt, PM; de Jong, JM; Louwerse, ES; Timmer, JG; Vyth, A1
de Jong, JM; Guchelaar, HJ; Haasdijk, E; Holstege, JC; Jaarsma, D1
Andreassen, OA; Beal, MF; Bush, AI; Dedeoglu, A; Klivenyi, P1
Küther, G; Lipinski, HG; Struppler, A1
de Jong, JM; den Hartog Jager, WA; Timmer, JG; Vyth, A1
Küther, G; Struppler, A1

Reviews

1 review(s) available for acetylcysteine and Amyotrophic Lateral Sclerosis

ArticleYear
Dysregulation of glutathione homeostasis in neurodegenerative diseases.
    Nutrients, 2012, Oct-09, Volume: 4, Issue:10

    Topics: Acetylcysteine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Brain; Friedreich Ataxia; Glutathione; Homeostasis; Humans; Huntington Disease; Neurodegenerative Diseases; Parkinson Disease

2012

Trials

2 trial(s) available for acetylcysteine and Amyotrophic Lateral Sclerosis

ArticleYear
Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis.
    Archives of neurology, 1995, Volume: 52, Issue:6

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos

1995
Survival in patients with amyotrophic lateral sclerosis, treated with an array of antioxidants.
    Journal of the neurological sciences, 1996, Volume: 139 Suppl

    Topics: Acetylcysteine; Administration, Oral; Amyotrophic Lateral Sclerosis; Antioxidants; Capsules; Chelating Agents; Dithioerythritol; Dithiothreitol; Free Radical Scavengers; Gastric Juice; Humans; Injections, Subcutaneous; Methionine; Succimer; Sulfhydryl Reagents; Survival Analysis

1996

Other Studies

14 other study(ies) available for acetylcysteine and Amyotrophic Lateral Sclerosis

ArticleYear
Analysis of SOD1 variants in Chinese patients with familial amyotrophic lateral sclerosis.
    QJM : monthly journal of the Association of Physicians, 2023, May-27, Volume: 116, Issue:5

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; East Asian People; Humans; Mutation; Neurodegenerative Diseases; Reactive Oxygen Species; Superoxide Dismutase-1

2023
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.
    The Journal of biological chemistry, 2020, 01-17, Volume: 295, Issue:3

    Topics: Acetylcysteine; Adenine; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Frontotemporal Dementia; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; HEK293 Cells; Humans; Indoles; Mutation; Osmotic Pressure; Oxidative Stress; Protein Aggregation, Pathological; Protein Transport; Signal Transduction; Solubility; Sorbitol; Ubiquitination

2020
Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1
    Molecular neurobiology, 2021, Volume: 58, Issue:4

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Cytokines; Female; Male; Metabolome; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Motor Activity; Motor Neurons; Mutation; NAD; Nerve Degeneration; NF-E2-Related Factor 2; Niacinamide; Oxidation-Reduction; Pyridinium Compounds; Reactive Oxygen Species; Sirtuin 1; Sirtuin 3; Spinal Cord; Stilbenes; Superoxide Dismutase-1; Survival Analysis

2021
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
    Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11

    Topics: Acetamides; Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidant Response Elements; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Female; Free Radical Scavengers; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Peroxidation; Male; Metabolic Detoxication, Phase II; Mice; Mice, Transgenic; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Thiazoles

2012
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine.
    Neurobiology of disease, 2003, Volume: 13, Issue:3

    Topics: Acetylcysteine; Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Blotting, Western; Caspase 3; Caspases; Cell Death; DNA Fragmentation; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; L-Lactate Dehydrogenase; Mitochondria; Mutation; Neuroblastoma; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

2003
Creatine kinase activity in amyotrophic lateral sclerosis patients.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24, Issue:4

    Topics: Acetylcysteine; Age Factors; Age of Onset; Amyotrophic Lateral Sclerosis; Analysis of Variance; Creatine Kinase; Extremities; Female; Humans; Male; Middle Aged; Sex Factors; Statistics, Nonparametric

2003
Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.
    Journal of cellular biochemistry, 2004, Apr-01, Volume: 91, Issue:5

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Blotting, Western; Cell Survival; Chelating Agents; Chlorides; Copper; Detergents; Disease Models, Animal; Ditiocarb; Fibroblasts; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Minocycline; Mutation; Oxidative Stress; Paraquat; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Solubility; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Zinc Compounds

2004
Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.
    BMC infectious diseases, 2007, Nov-12, Volume: 7

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antioxidants; Apoptosis; Bacterial Proteins; Calcium; Caspase 3; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Humans; Immunohistochemistry; Lipopeptides; Macrophages; Monocytes; Mutation; Neuroblastoma; Peptides; Streptolysins; Superoxide Dismutase; Toll-Like Receptor 2; Transfection

2007
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-10, Volume: 91, Issue:10

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antioxidants; Apoptosis; Base Sequence; Benzodiazepines; Biological Transport; Choline O-Acetyltransferase; Chromans; Ditiocarb; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Motor Neurons; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Organ Culture Techniques; Piperazines; Rats; Spinal Cord; Superoxide Dismutase

1994
The antioxidant N-acetylcysteine does not delay disease onset and death in a transgenic mouse model of amyotrophic lateral sclerosis.
    Annals of neurology, 1998, Volume: 44, Issue:2

    Topics: Acetylcysteine; Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Disease Progression; Free Radical Scavengers; Half-Life; Mice; Mice, Transgenic; Point Mutation; Vitamin E

1998
N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis.
    Neuroreport, 2000, Aug-03, Volume: 11, Issue:11

    Topics: Acetylcysteine; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Motor Activity; Mutation; Superoxide Dismutase; Survival Rate

2000
Therapeutic trials in ALS--the design of a protocol.
    Advances in experimental medicine and biology, 1987, Volume: 209

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Flunarizine; Humans; Manometry; Muscle Contraction; Muscles; Physical Examination; Research Design; Transducers

1987
Attempted treatment of motor neuron disease with N-acetylcysteine and dithiothreitol.
    Advances in experimental medicine and biology, 1987, Volume: 209

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Dithiothreitol; Drug Evaluation; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Muscular Atrophy; Prednisolone

1987
Therapeutic trial with N-acetylcysteine in amyotrophic lateral sclerosis.
    Advances in experimental medicine and biology, 1987, Volume: 209

    Topics: Acetylcysteine; Adult; Aged; Amyotrophic Lateral Sclerosis; Drug Evaluation; Female; Humans; Male; Middle Aged; Vital Capacity

1987