acetylcysteine has been researched along with Alzheimer Disease in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (10.53) | 18.2507 |
| 2000's | 13 (22.81) | 29.6817 |
| 2010's | 30 (52.63) | 24.3611 |
| 2020's | 8 (14.04) | 2.80 |
| Authors | Studies |
|---|---|
| de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M | 1 |
| Bastida, A; Chioua, M; Colmena, I; de los Ríos, C; Del Barrio, L; Gandía, L; González-Lafuente, L; López, MG; Marco-Contelles, J; Martín-de-Saavedra, MD; Romero, A; Samadi, A; Valderas, C; Villarroya, M | 1 |
| Chen, SH; Chen, SY; Chen, Y; Gu, LQ; Huang, ZS; Li, YP; Ou, TM; Tan, JH | 1 |
| Finkin-Groner, E; Ginsburg, I; Lerman, L; Nudelman, A; Shalom, H; Weill, T; Weinstock, M; Yanovsky, I; Zaikin, A; Zeeli, S | 1 |
| Andrisano, V; Bartolini, M; Belluti, F; Bisi, A; Bottegoni, G; Cavalli, A; De Simone, A; Djemil, A; Gobbi, S; Montanari, S; Rampa, A; Tarozzi, A | 1 |
| Bartolini, M; Bolognesi, ML; Guidotti, L; Hrabinova, M; Jeřábek, J; Korábečný, J; Kuča, K; Monti, B; Peña-Altamira, LE; Petralla, S; Roberti, M; Sepsova, V; Soukup, O; Uliassi, E | 1 |
| Boice, A; He, L; Jiang, Y; Liu, K; Yan, X; Zhang, S | 1 |
| Ge, SL; Huang, J; Li, SL; Ma, L; Wang, R; Wu, Y; Yang, GX | 1 |
| Huang, J; Huang, Y; Li, J; Ma, L; Su, L; Tang, Y; Wang, R; Wu, YH; Yang, GX; Zhang, L; Zheng, LL; Zhou, LC | 1 |
| Gan, H; Ma, L; Sang, D; Su, L; Wang, R; Wu, Y; Yang, G; Zhang, L; Zhou, J | 1 |
| Huang, W; Huang, Y; Ma, L; Wang, R; Yang, G | 1 |
| Ashida, A; Ikenaka, A; Kazuki, Y; Li, L; Nakahata, T; Nishinaka-Arai, Y; Niwa, A; Russell, DW; Saito, MK; Tamai, H; Toshikawa, H | 1 |
| Hamid Reza Momeni, -; Matin Ramezani, -; Niloufar Darbandi, -; Samira Moghadasi, - | 1 |
| Alkandari, AF; Madhyastha, S; Rao, MS | 1 |
| Lian, M; Wang, Y; Wu, S; Zhou, J | 1 |
| Barot, T; Kulkarni, P; Rawtani, D | 1 |
| Asl, SS; Komaki, A; Sarihi, A; Shahidi, S; Zargooshnia, S | 1 |
| Blaszczyk, AT; Chintapenta, M; Kwon, HI; Spence, J | 1 |
| Chen, SP; Fuh, JL; Hsu, WC; Liu, TY; Tsou, HH; Wang, HT | 1 |
| Guo, H; Mei, L; Pan, JX; Shun, C; Tang, F; Wang, B; Xia, WF; Xiong, F; Xiong, L; Xiong, WC; Zeng, P; Zhao, K | 1 |
| Biasi, F; Gamba, P; Gargiulo, S; Giaccone, G; Guglielmotto, M; Iuliano, L; Leonarduzzi, G; Mauro, A; Monteleone, D; Poli, G; Tamagno, E; Testa, G; Zerbinati, C | 1 |
| Dias, IH; Fell, S; Griffiths, HR; Lip, GY; Mistry, J; Polidori, MC; Reis, A; Spickett, CM | 1 |
| Chang, NS; Chen, BH; Cheng, NW; Chu, CY; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH | 1 |
| Higashi, K; Igarashi, K; Kashiwagi, K; Kuni, K; Mizoi, M; Nakamura, M; Saiki, R; Toida, T; Uemura, K; Waragai, M; Yoshida, M | 1 |
| Bernardi, J; Brandão, R; Costa, L; Costa, M; Fiuza, T; Pereira, ME | 1 |
| Barrentine, LW; Curole, MV; Hara, J; Shankle, WR | 1 |
| Aboulkassim, T; Fernandes, P; Hamel, E; Lecrux, C; Nicolakakis, N; Ongali, B; Rosa-Neto, P; Tong, XK | 1 |
| Araki, W; Oda, A; Tamaoka, A | 1 |
| Hudson, PR; McCaddon, A | 1 |
| Cummings, JL | 1 |
| Chang, SS; Ko, SY; Lin, YP; Lin, YS | 1 |
| Ahn, JY; Bennett, JP; Onyango, IG; Swerdlow, RH; Tuttle, JB | 1 |
| Aluise, CD; Butterfield, DA; Huang, Q; Joshi, G; Markesbery, WR; St Clair, DK; Sultana, R | 1 |
| Green, KN; Hendrix, C; LaFerla, FM; Parachikova, A | 1 |
| Baker, AS; Butterfield, DA; Cai, J; Huang, Q; Joshi, G; Markesbery, WR; Pierce, W; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Butterfield, DA; Pocernich, CB | 1 |
| Chen, SH; Gean, PW; Hsiao, YH; Kuo, JR | 1 |
| Abuladze, N; Bragin, A; Cascio, D; Damoiseaux, R; Faull, K; Pushkin, A; Schibler, MJ; Tsirulnikov, K | 1 |
| Johnson, WM; Mieyal, JJ; Wilson-Delfosse, AL | 1 |
| Amarnath, V; Montine, KS; Montine, TJ; Olsen, SJ; Picklo, MJ; Sidell, KR | 1 |
| Gasic-Milenkovic, J; Loske, C; Münch, G | 1 |
| Balaspiri, L; Bogdanovic, N; Karelson, E; Land, T; Langel, U; Mahlapuu, R; Saar, K; Soomets, U; Viht, K; Zilmer, M | 1 |
| Andreoni, S; Appollonio, I; Begni, B; Beretta, S; Brighina, L; Ferrarese, C; Fumagalli, L; Isella, V; Malaplate-Armand, C; Oster, T; Sirtori, E | 1 |
| Graves, M; Ortiz, D; Rogers, E; Shea, TB; Tchantchou, F | 1 |
| Ahl, M; Bush, A; Huang, X; Rogers, JT; Tucker, S; Westaway, D | 1 |
| Hazell, AS; Kennedy, G; Norenberg, MD; Normandin, L; Yi, JH | 1 |
| Ahl, M; Bandyopadhyay, S; Bush, AI; Cho, HH; Cuny, GD; Goldstein, LE; Huang, X; Rogers, JT; Tucker, S; Westaway, D | 1 |
| Fujii, N; Hamamoto, T; Kagawa, Y; Kinouchi, T; Nishio, H; Nishiuchi, Y; Takada, K; Tsunemi, M | 1 |
| Cumming, RC; Dargusch, R; Fischer, WH; Schubert, D | 1 |
| Harris, PL; Moreira, PI; Oliveira, CR; Perry, G; Santos, MS; Smith, MA; Zhu, X | 1 |
| Haass, C; Ihara, Y; Omura, S; Saido, TC; Yamazaki, T | 1 |
| Checler, F; Lopez-Perez, E; Marambaud, P; Wilk, S | 1 |
| Ancolio, K; Checler, F; Lopez-Perez, E; Marambaud, P | 1 |
| Alkon, DL; Favit, A; Grimaldi, M; Nelson, TJ | 1 |
| Honda, T; Mercken, M; Murayama, M; Murayama, O; Nihonmatsu, N; Omori, A; Saido, TC; Sato, K; Takahashi, H; Takashima, A; Tsubuki, S; Yasutake, K | 1 |
| Benussi, L; Bianchetti, A; Binetti, G; Curti, D; Gasparini, L; Govoni, S; Moraschi, S; Racchi, M; Trabucchi, M | 1 |
| Adair, JC; Knoefel, JE; Morgan, N | 1 |
5 review(s) available for acetylcysteine and Alzheimer Disease
| Article | Year |
|---|---|
A Brief Review of Three Common Supplements Used in Alzheimer's Disease.
Topics: Acetylcysteine; Aequorin; Alzheimer Disease; Apoproteins; Dietary Supplements; Fatty Acids, Omega-3; Humans; Recombinant Proteins | 2017 |
L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
Topics: Acetylcysteine; Alzheimer Disease; Cognition Disorders; Free Radical Scavengers; Homocysteine; Humans; Oxidative Stress; Plaque, Amyloid; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex | 2010 |
Elevation of glutathione as a therapeutic strategy in Alzheimer disease.
Topics: Acetylcysteine; Alzheimer Disease; Antioxidants; Dipeptides; DNA; Glutathione; Humans; Oxidation-Reduction | 2012 |
Dysregulation of glutathione homeostasis in neurodegenerative diseases.
Topics: Acetylcysteine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Brain; Friedreich Ataxia; Glutathione; Homeostasis; Humans; Huntington Disease; Neurodegenerative Diseases; Parkinson Disease | 2012 |
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Fibroblasts; Humans; Immunohistochemistry; Mitochondria; Oxidative Stress; Thioctic Acid | 2007 |
1 trial(s) available for acetylcysteine and Alzheimer Disease
| Article | Year |
|---|---|
Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease.
Topics: Acetylcysteine; Alzheimer Disease; Double-Blind Method; Female; Free Radical Scavengers; Humans; Male; Treatment Outcome | 2001 |
51 other study(ies) available for acetylcysteine and Alzheimer Disease
| Article | Year |
|---|---|
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship | 2010 |
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Topics: Acetylcholinesterase; Alzheimer Disease; Cell Line, Tumor; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Neuroprotective Agents; Nitriles; Tacrine; Vascular Diseases | 2011 |
Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Chelating Agents; Curcumin; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Peptide Fragments; Reactive Oxygen Species; Stereoisomerism; Structure-Activity Relationship | 2011 |
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; Carbamates; Chickens; Cholinesterase Inhibitors; Humans; Indoles; Neurons | 2012 |
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Antioxidants; Benzophenones; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2014 |
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Ligands; Liver; Molecular Targeted Therapy; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats; Resveratrol; Stilbenes; Tacrine | 2017 |
Design and characterization of bivalent compounds as potential neuroprotectants for Alzheimer's disease: Impact of the spacer on biological activity.
Topics: Alzheimer Disease; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Neuroprotective Agents; Piperazine; Piperazines; Structure-Activity Relationship | 2018 |
Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antioxidants; Drug Design; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Piperazines; Protein Aggregates; Rats; RAW 264.7 Cells; Spirostans | 2018 |
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Carbamates; Cell Line, Tumor; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Galactose; Humans; Inflammation; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Protein Aggregates; Structure-Activity Relationship | 2020 |
Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coumarins; Drug Design; Humans; Molecular Docking Simulation; Neuroprotective Agents; Peptide Fragments; Structure-Activity Relationship | 2020 |
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents.
Topics: Alzheimer Disease; Animals; Cell Line; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Inflammation; Lipopolysaccharides; Molecular Conformation; Neuroprotective Agents; Nitric Oxide; Rats; Structure-Activity Relationship; Triazoles | 2021 |
N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Down Syndrome; Down-Regulation; Humans; Induced Pluripotent Stem Cells; Nerve Tissue Proteins; Neurons; Oxidative Stress | 2021 |
Comparing the acute and chronic effects of metformin and antioxidant protective effects of N-acetyl cysteine on memory retrieval and oxidative stress in rats with Alzheimer's disease.
Topics: Acetylcysteine; Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Maze Learning; Metformin; Oxidative Stress; Rats; Streptozocin | 2023 |
N-Acetylcysteine Amide against Aβ-Induced Alzheimer's-like Pathology in Rats.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Gliosis; Glutathione; Male; Neuroprotective Agents; Rats; Rats, Wistar; Synaptophysin | 2023 |
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidant Response Elements; Apoptosis; Brain; Caspase 3; DEAD-box RNA Helicases; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Hippocampus; Humans; Male; Membrane Potential, Mitochondrial; Mice, Transgenic; Neurons; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Peptide Fragments; Presenilin-1; Reactive Oxygen Species; Ribonuclease III; Spatial Learning | 2020 |
Design, development and in-vitro/in-vivo evaluation of intranasally delivered Rivastigmine and N-Acetyl Cysteine loaded bifunctional niosomes for applications in combinative treatment of Alzheimer's disease.
Topics: Acetylcysteine; Administration, Intranasal; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Delayed-Action Preparations; Drug Combinations; Drug Evaluation, Preclinical; Drug Liberation; Free Radical Scavengers; Humans; Liposomes; Male; Models, Animal; Nasal Mucosa; Particle Size; Rats; Rivastigmine; Sheep | 2021 |
Influence of N-acetyl cysteine on beta-amyloid-induced Alzheimer's disease in a rat model: A behavioral and electrophysiological study.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory; Neurons; Rats; Rats, Wistar | 2017 |
Alterations in Acrolein Metabolism Contribute to Alzheimer's Disease.
Topics: Acetylcysteine; Acrolein; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Case-Control Studies; Creatinine; Disease Progression; Early Diagnosis; Female; Humans; Male; Middle Aged | 2018 |
APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Apoptosis; Bone and Bones; Bone Resorption; Brain; Cells, Cultured; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Osteoblasts; Osteogenesis; Oxidative Stress; Reactive Oxygen Species | 2018 |
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Disease Progression; Humans; Hydroxycholesterols; Neurons; Oxidative Stress; Up-Regulation | 2014 |
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line, Tumor; Cell Survival; Cholesterol, LDL; Desipramine; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Humans; Hydroxycholesterols; Lipid Metabolism; Lipoproteins, LDL; Membrane Microdomains; Oxidation-Reduction; Sphingomyelin Phosphodiesterase | 2014 |
Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases.
Topics: Acetylcysteine; Aging; Alzheimer Disease; Animals; Animals, Genetically Modified; Cathepsin B; Cell Movement; Embryo, Nonmammalian; Folic Acid; Folic Acid Deficiency; gamma-Glutamyl Hydrolase; Green Fluorescent Proteins; Hot Temperature; Microtubule-Associated Proteins; Neural Crest; Neural Tube Defects; Oxidative Stress; Time Factors; Zebrafish; Zebrafish Proteins | 2014 |
Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
Topics: Acetylcysteine; Acrolein; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged | 2015 |
N-acetylcysteine protects memory decline induced by streptozotocin in mice.
Topics: Acetylcholinesterase; Acetylcysteine; Alzheimer Disease; Animals; Butyrylcholinesterase; Cerebral Cortex; Energy Metabolism; Hippocampus; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Streptozocin | 2016 |
CerefolinNAC Therapy of Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer's Disease and Cerebrovascular Disease.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Cerebral Cortex; Cerebrovascular Disorders; Dietary Supplements; Female; Humans; Hyperhomocysteinemia; Male; Middle Aged; Tetrahydrofolates; Vitamin B 12; Vitamin B Complex; White Matter | 2016 |
Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist.
Topics: Acetylcholine; Acetylcysteine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Behavior, Animal; Cerebrovascular Disorders; Disease Models, Animal; Gene Expression Regulation; Humans; Hypoglycemic Agents; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Nitric Oxide Synthase; Peptide Fragments; Pioglitazone; PPAR gamma; Superoxide Dismutase; Thiazolidinediones | 2008 |
Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antioxidants; Brain; Cell Line, Tumor; Ethacrynic Acid; Glutathione; Heme Oxygenase-1; Humans; Membrane Microdomains; Mutation; Neurons; Oxidative Stress; Presenilin-1; RNA, Messenger; Up-Regulation | 2010 |
Commentary on: L-methylfolate, methylcobolamine, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
Topics: Acetylcysteine; Alzheimer Disease; Cognition Disorders; Free Radical Scavengers; Humans; Tetrahydrofolates; Vitamin B 12 | 2010 |
Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Survival; Glycation End Products, Advanced; Humans; Peptide Fragments; Reactive Oxygen Species | 2010 |
Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer's disease cybrids.
Topics: Acetylcysteine; Aged; Alzheimer Disease; Amyloid beta-Peptides; Cell Survival; Cells, Cultured; DNA, Mitochondrial; Female; Glutathione; Humans; Hybrid Cells; Male; Mitochondria; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurons; NF-kappa B; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptor, trkA; Receptors, Nerve Growth Factor; Signal Transduction; Tyrosine | 2010 |
Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment.
Topics: Acetylcysteine; Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Gene Knock-In Techniques; Humans; Male; Mice; Mice, Transgenic; Mutation; Oxidative Stress; Presenilin-1; Time Factors | 2010 |
Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
Topics: Acetylcysteine; Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Benzodioxoles; Brain; Catechin; Cerebral Cortex; Cognition; Curcumin; Dietary Supplements; Folic Acid; Hippocampus; Humans; Immunoblotting; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Piperidines; Polyunsaturated Alkamides; Thioctic Acid; Vitamin B Complex; Vitamins | 2010 |
Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognitive Dysfunction; Free Radical Scavengers; Gene Expression Regulation; Gene Knock-In Techniques; Humans; Mice; Mutation; Presenilin-1; Proteome; Proteomics | 2011 |
Amelioration of social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antioxidants; Biophysics; Biotinylation; Calpain; Cell Line, Transformed; Cognition Disorders; Conditioning, Psychological; Cyclin-Dependent Kinase 5; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Fear; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Patch-Clamp Techniques; Peptide Fragments; Presenilin-1; Protein Kinase C-delta; Receptors, Metabotropic Glutamate; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Social Isolation; Time Factors; Transfection | 2012 |
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
Topics: Acetylation; Acetylcysteine; Acrolein; Aldehydes; Alzheimer Disease; Amidohydrolases; Aminooxyacetic Acid; Animals; Cerebral Cortex; Enzyme Inhibitors; Male; Neurons; Parkinson Disease; Rats; Rats, Wistar | 2012 |
Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum.
Topics: Acetylcysteine; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Fatty Acids, Unsaturated; Glutathione Transferase; Humans; Immunohistochemistry; Lipid Peroxidation; Male; Neurons; Oxidative Stress; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptosomes | 2003 |
Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y.
Topics: Acetylcysteine; Alzheimer Disease; Brain; Cells, Cultured; Estradiol; Free Radicals; Glycation End Products, Advanced; Humans; Lipid Peroxidation; Neurons; Oxidative Stress; Signal Transduction; Thioctic Acid | 2003 |
Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain.
Topics: Acetylcysteine; Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Binding Sites; Case-Control Studies; Cell Membrane; Deferoxamine; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Frontal Lobe; Glutathione; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Hydrogen Peroxide; Iron Chelating Agents; Oxidants; Peptide Fragments; Sulfur Isotopes | 2003 |
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency.
Topics: Acetylcysteine; Alzheimer Disease; Animals; Animals, Genetically Modified; Apolipoproteins E; Brain; Folic Acid; Mice; Oxidative Stress; Vitamin E Deficiency | 2005 |
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.
Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Drug Approval; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Pilot Projects | 2005 |
Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment.
Topics: Acetylcysteine; Alzheimer Disease; Analysis of Variance; Animals; Antioxidants; Astrocytes; Cerebral Cortex; Chelating Agents; Disease Models, Animal; Drug Interactions; Edetic Acid; Male; Manganese; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.
Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Drug Evaluation, Preclinical; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Peptide Fragments; Pilot Projects; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Messenger | 2006 |
Isolation and characterization of mammalian D-aspartyl endopeptidase.
Topics: Acetylcysteine; Aging; Alzheimer Disease; Animals; Aspartic Acid Endopeptidases; Caenorhabditis elegans; D-Aspartic Acid; Escherichia coli; Glutamate Dehydrogenase; Mice; Mitochondrial Membranes; Mitochondrial Proteins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Saccharomyces cerevisiae; Succinate Dehydrogenase | 2007 |
Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Catalytic Domain; Cerebellar Cortex; Female; Free Radical Scavengers; Gene Expression; Hippocampus; Humans; Isoenzymes; Male; Middle Aged; Neurons; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Peroxiredoxins; Rats; Sulfhydryl Compounds | 2007 |
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Calcimycin; Calcium-Binding Proteins; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Embryo, Mammalian; Humans; Kidney; Peptide Fragments; Transfection | 1997 |
Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Humans; Multienzyme Complexes; Oligopeptides; PC12 Cells; Phorbol 12,13-Dibutyrate; Proteasome Endopeptidase Complex; Protein Kinase C; Rats; Time Factors | 1997 |
Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Kidney; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Peptide Fragments; Presenilin-1; Proteasome Endopeptidase Complex; Ubiquitins | 1998 |
Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Brain; Cells, Cultured; Cycloheximide; Fibroblasts; Humans; Isoenzymes; Peptide Fragments; Protein Kinase C; Protein Kinase C-alpha; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1998 |
Dual roles of proteasome in the metabolism of presenilin 1.
Topics: Acetylcysteine; Alzheimer Disease; Amino Acid Sequence; Brain Chemistry; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycoproteins; Humans; Isocoumarins; Kidney; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Mutation; Neuroblastoma; Peptide Fragments; Precipitin Tests; Presenilin-1; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sulfones; Trypsin Inhibitors; Tumor Cells, Cultured | 1999 |
Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Antioxidants; Cells, Cultured; Energy Metabolism; Fibroblasts; Glucose; Glutathione; Humans; Hypoglycemia; Lipid Peroxidation; Reference Values; Skin; Sodium Azide | 1999 |