acetylcysteine has been researched along with Alloxan Diabetes in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (8.41) | 18.2507 |
| 2000's | 34 (31.78) | 29.6817 |
| 2010's | 52 (48.60) | 24.3611 |
| 2020's | 12 (11.21) | 2.80 |
| Authors | Studies |
|---|---|
| Cowan, PJ; Cui, Y; Fichman, Y; Hao, H; He, X; Hill, MA; Liu, Z; Mittler, R; Wang, M; Xu, H; Yang, C; Zhang, G; Zhou, S; Zhu, Q | 1 |
| Chen, C; Chen, H; Dou, S; Li, Z; Qu, M; Wan, L; Wang, H; Wang, Q; Xie, L; Xue, J; Zhang, B; Zhang, Y; Zhou, Q | 1 |
| Argaev-Frenkel, L; Rosenzweig, T | 1 |
| Fan, C; Gong, F; Lan, T; Li, Y; Ma, Z; Pan, C; Wang, W; Yu, S; Yuan, M; Zhao, C; Zhao, Z | 1 |
| Cai, Y; Chen, Y; Cheung, CW; Cui, J; Fan, T; Huo, X; Li, Y; Liu, D; Tang, J; Xia, Z; Zhu, D | 1 |
| Jing, GC; Liu, D; Liu, YQ; Zhang, MR | 1 |
| Kawashima, Y; Li, S; Liang, N; Sun, S; Yan, P | 1 |
| Fang, X; Liu, L; Wang, B; Zhou, S; Zhu, M | 1 |
| Gürel, A; Yalçın, A | 1 |
| Alshogran, OY; Alzoubi, KH; El-Elimat, T; Nusair, SD; Obeidat, A; Sweidan, M | 1 |
| He, YL; Li, XM; Nie, F; Xiong, Y; Zhou, XK | 1 |
| Iwasaki, K; Izumi, Y; Kido, D; Matsuura, T; Mikami, R; Mizutani, K; Takeda, K | 1 |
| Barbanera, PO; do Carmo, NOL; Fernandes, AAH; Kaga, AK; Queiroz, PM; Rosa, LRO | 1 |
| Fan, Z; Fang, W; He, Y; Liu, S; Zhou, L | 1 |
| Araujo, SRR; Fernandes, TO; Higa, EMS; Lima, DY; Maciel, FR; Mouro, MG; Nogueira, GB; Oliveira, CS; Punaro, GR; Rodrigues, AM | 1 |
| Ebi, N; Hamada, E; Kinjo, T; Kobayashi, N; Miyagi-Shiohira, C; Nakashima, Y; Noguchi, H; Saitoh, I; Tamaki, Y; Watanabe, M | 1 |
| Chen, X; Fang, M | 1 |
| Lee, S; Liu, Q; Wang, P | 1 |
| Cha, SK; Chung, CH; Kang, JS; Kim, JH; Lee, ES; Lee, EY; Lee, JH; Lee, SJ; Son, SS | 1 |
| Barber, AJ; Dennis, MD; Miller, WP; Toro, AL | 1 |
| Wang, H | 1 |
| Leng, B; Nie, Q; Wang, H; Zhang, L; Zhu, L | 1 |
| Akman, D; Catalucci, D; Turan, B; Yildirim, SS | 1 |
| Irwin, MG; Lei, S; Li, H; Liu, Z; Mao, X; Ng, KF; Qiao, S; Vanhoutte, PM; Wang, J; Wang, T; Wong, GT; Xia, Z; Xu, A | 1 |
| Gan, X; Gao, X; Hei, Z; Irwin, MG; Lei, S; Liu, Y; Wang, T; Xia, Z; Xia, ZY; Xu, J | 1 |
| Gao, X; Irwin, MG; Liao, XL; Liu, Y; Mao, X; Ng, KF; Ou, JS; Vanhoutte, PM; Wang, T; Xia, Z; Xu, Y | 1 |
| Chang, X; Chen, L; Huang, H; Huang, J; Huang, K; Liu, P; Shen, X; Wang, S; Xie, X | 1 |
| Chen, KL; Dong, X; Liu, ZW; Qiu, C; Wei, J; Xue, JH; Zhu, HT | 1 |
| Briot, A; Der, A; Iruela-Arispe, ML; Warren, CM; Ziyad, S | 1 |
| Feng, Q; Gittenberger-de Groot, AC; Lu, X; Ma, NL; Moazzen, H; Urquhart, BL; Velenosi, TJ; Wisse, LJ | 1 |
| Chen, YY; Guo, R; Jin, KK; Shen, YL; Wang, LX; Wang, Y; Ying, L | 1 |
| Okatan, EN; Toy, A; Tuncay, E; Turan, B | 1 |
| Araujo, SR; Bergamaschi, CT; Buri, MV; Curi, MV; Fernandes, MJ; Ferreira, AT; Higa, EM; Maciel, FR; Nogueira, GB; Paredes-Gamero, EJ; Punaro, GR; Rodrigues, AM | 1 |
| Aw, TY; Li, W; Maloney, RE | 1 |
| Duan, YY; Liu, C; Lu, XZ; Ma, J; Shen, MZ; Xing, CY; Yuan, LJ | 1 |
| Abelaira, HM; Bruchchen, L; Carlessi, AS; Ceretta, LB; Dos Santos, MA; Florentino, D; Matias, BI; Petronilho, F; Quevedo, J; Réus, GZ; Titus, SE; Vieira, A; Zugno, AI | 1 |
| Chung, CH; Kang, JS; Kim, HM; Kim, HS; Kim, YM; Kwon, MH; Lee, ES; Lee, EY; Yadav, D | 1 |
| Nazıroğlu, M; Sözbir, E | 1 |
| Irwin, MG; Li, H; Li, Y; Lin, J; Wang, M; Wang, T; Xia, Z | 1 |
| Chen, JZ; Dai, Q; Li, R; Wei, ZH; Wu, H; Xie, J; Xu, B; Zhang, XL | 1 |
| Abelaira, HM; Arent, CO; Bernardini Dos Santos, MA; Bruchchen, L; Carvalho, AF; Dal-Pizzol, F; Ignácio, ZM; Maciel, AL; Matias, BI; Michels, M; Quevedo, J; Réus, GZ; Zugno, AI | 1 |
| Ali, F; Khan, M; Khan, SN; Riazuddin, S | 1 |
| Aw, TY; Stokes, KY; Wang, B | 1 |
| Lei, S; Lian, Q; Liu, H; Su, W; Xia, Z; Xia, ZY; Xu, J; Zhan, L; Zhang, Q; Zhang, Y; Zhu, Q | 1 |
| Catanozi, S; Correa-Giannella, ML; Costa-Pessoa, JM; Da Silva, KS; Fabre, NT; Machado, UF; Monteiro, MB; Oliveira-Souza, M; Passarelli, M; Santos-Bezerra, DP; Thieme, K | 1 |
| Bae, YC; Jung, JS; Kim, DH; Kim, HK; Kim, JT; Kim, YJ; Kim, YK; Kwon, CH | 1 |
| Chopra, K; Kamboj, SS; Sandhir, R | 2 |
| Bukina, SJ; Inchina, VI | 1 |
| Ha, H; Kim, YO; Lee, HB; Noh, H; Oh, EY; Seo, JY; Yu, MR | 1 |
| Hueckstaedt, LK; Li, Q; Ren, J | 1 |
| Cui, JZ; Matsubara, JA; McNeill, JH; Ozerdem, U; Syed, H; Tsai, GY; Xia, Z | 1 |
| Aktunc, E; Barut, F; Buyukates, M; Demircan, N; Kandemir, O; Ozacmak, HS; Ozacmak, VH | 1 |
| Cheng, TJ; Guo, YL; Hsu, CJ; Wu, HP | 1 |
| Baldo, CF; Batalhão, ME; Capellini, VK; Cárnio, EC; Celotto, AC; Evora, PR; Rodrigues, AJ | 1 |
| Kamboj, SS; Sandhir, R | 1 |
| Lautt, WW; Legare, DJ; Macedo, MP; Schafer, J | 1 |
| Lim, Y; Park, NY; Park, SK | 1 |
| Fujita, M; Iwasaka, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K | 1 |
| Araújo, F; Arbo, M; Bairros, A; Brucker, N; Charão, M; Garcia, SC; Leal, M; Moresco, R; Moro, A; Morsch, V; Ribeiro, G; Roehrs, M; Valentini, J | 1 |
| Gao, X; Irwin, MG; Lei, S; Liu, Y; Mao, X; Vanhoutte, PM; Wang, T; Wong, GT; Xia, Z | 1 |
| Ding, YN; Zhang, XL; Zhu, BF; Zhu, Y | 1 |
| Gao, S; Kim, JS; Kim, SH; Park, WH; Shah, A; Yuan, K | 1 |
| Barrière, DA; Busserolles, J; Chanteranne, D; Chapuis, L; Chauvin, MA; Dubray, C; Morio, B; Rieusset, J; Salles, J | 1 |
| Lei, S; Liu, H; Liu, Y; Wang, H; Xia, Z; Yu, H | 1 |
| Cottalasso, D; Domenicotti, C; Furfaro, AL; Marengo, B; Marinari, UM; Nitti, M; Pronzato, MA; Traverso, N | 1 |
| Fujii, J; Ihara, H; Ikeda, Y; Ito, R; Takahashi, M; Tsukamoto, H | 1 |
| Balcı, H; Ozdemir, H; Ozer, H; Toker, H | 1 |
| Cai, L; Dai, J; Jiang, X; Li, W; Wang, G; Zhai, X; Zhao, H; Zhao, Y | 1 |
| Cai, Y; Hou, W; Li, X; Shi, YY; Wang, HY; Wang, YS; Xu, CS; Yao, LB; Ye, Z; Zhang, J | 1 |
| Chen, X; Ding, G; Ma, T; Singhal, PC; Zha, D; Zhu, J | 1 |
| Koppolu, P; Kowluru, RA | 1 |
| Cosso, L; Cottalasso, D; Maineri, EP; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N; Valentini, S | 1 |
| Bryla, J; Drozak, J; Fraczyk, T; Kiersztan, A; Przedlacka, M; Wegrzynowicz, M; Winiarska, K | 1 |
| Bianchi, R; Cuccovillo, I; Doni, M; Fiordaliso, F; Ghezzi, P; Laragione, T; Latini, R; Masson, S; Melucci, S; Salio, M; Santangelo, F; Savino, C; Scanziani, E; Staszewsky, L | 1 |
| Barzilai, N; Berg, AH; Brownlee, M; Combs, TP; Du, X; Fantus, IG; Giacca, A; Hawkins, M; Iyengar, P; Lam, TK; Li, W; Lin, Y; Rajala, MW; Rhodes, CJ; Rollman, B; Scherer, PE | 1 |
| Boor, P; Bozek, P; Cársky, J; Greksák, M; Nakano, M; Sebeková, K; Ulicná, O; Vancová, O | 1 |
| Cottalasso, D; Domenicotti, C; Furfaro, AL; Marinari, UM; Odetti, P; Patriarca, S; Pronzato, MA; Traverso, N | 1 |
| Cheng, X; Leo, JM; Pang, CC; Xia, Z | 1 |
| Guo, Z; McNeill, JH; Nagareddy, PR; Xia, Z; Zhang, W | 1 |
| Cottalasso, D; Furfaro, AL; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N | 1 |
| Bryla, J; Drozak, J; Fraczyk, T; Malinska, D; Winiarska, K | 1 |
| Dnyanmote, AV; Latendresse, JR; Lock, EA; Mehendale, HM; Sawant, SP; Warbritton, AA | 1 |
| MacLeod, KM; McNeill, JH; Nagareddy, PR; Xia, Z | 1 |
| Guo, Z; McNeill, JH; Nagareddy, PR; Xia, Z; Yeung, E; Yuen, V | 1 |
| Guo, Z; Jiang, J; McNeill, JH; Xia, Z | 1 |
| Guo, T; Guo, Z; Jiang, J; Kuo, KH; McNeill, JH; Nagareddy, PR; Wang, F; Xia, Z | 1 |
| Guo, Z; Zhao, Z | 1 |
| Lai, WT; Lee, HC; Sheu, SH; Yen, HW | 1 |
| Ibi, M; Iwata, K; Kakehi, T; Katsuyama, M; Matsuno, K; Nishinaka, T; Yabe-Nishimura, C | 1 |
| Chen, P; Edwards, PA; Guo, AM; Scicli, AG; Trick, G | 1 |
| Abdouh, M; Couture, R; Hasséssian, HM; Talbot, S | 1 |
| Kucharská, J; Matejíková, J; Pancza, D; Ravingerová, T | 1 |
| Chai, FY; Guo, Y; Harding, JJ; Yan, H; Zhang, S | 1 |
| Fukuzawa, M; Muto, G; Muto, Y; Sagara, M; Satoh, J; Takahashi, K; Toyota, T; Zhu, XP | 1 |
| Hida, W; Kikuchi, Y; Sagara, M; Satoh, J; Shindoh, C; Shirato, K; Toyota, T | 1 |
| Fukuzawa, M; Muto, G; Muto, Y; Sagara, M; Satoh, J; Takahashi, K; Toyota, T; Wada, R; Yagihashi, S | 1 |
| Archibald, V; Cameron, NE; Cotter, MA; Keegan, A | 1 |
| Cameron, NE; Cotter, MA; Love, A | 1 |
| Eriksson, UJ; Thunberg, L; Wentzel, P | 1 |
| Pieper, GM; Siebeneich, W | 1 |
| Bray, TM; Chen, G; Ho, E | 1 |
| Bassirat, M; Khalil, Z | 1 |
| Baquer, NZ; Genet, S; Kale, RK | 1 |
| Eriksson, UJ; Gäreskog, MB; Wentzel, CR; Wentzel, P | 1 |
| Kern, TS; Kowluru, RA; Tang, J | 1 |
| Matsuzaki, T; Sakanashi, M | 1 |
107 other study(ies) available for acetylcysteine and Alloxan Diabetes
| Article | Year |
|---|---|
Combination of Antioxidant Enzyme Overexpression and N-Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes.
Topics: Acetylcysteine; Animals; Antioxidants; Bone Marrow; Bone Marrow Cells; Chronic Limb-Threatening Ischemia; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutathione Peroxidase; Ischemia; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Reactive Oxygen Species; Superoxide Dismutase | 2021 |
Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction.
Topics: Acetylcysteine; Animals; Cells, Cultured; Corneal Edema; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Endothelial Cells; Humans; Hyperglycemia; Mice | 2022 |
Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin Secretion; Mice; Oxidation-Reduction; Oxidative Stress | 2022 |
N-acetylcysteine improves diabetic associated erectile dysfunction in streptozotocin-induced diabetic mice by inhibiting oxidative stress.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Humans; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin | 2022 |
CXCR4/CX43 Regulate Diabetic Neuropathic Pain via Intercellular Interactions between Activated Neurons and Dysfunctional Astrocytes during Late Phase of Diabetes in Rats and the Effects of Antioxidant N-Acetyl-L-Cysteine.
Topics: Acetylcysteine; Animals; Antioxidants; Astrocytes; Connexin 43; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperalgesia; Neuralgia; Neurons; Proto-Oncogene Proteins c-fos; Rats; Receptors, Chemokine; Receptors, CXCR4; Spinal Cord | 2022 |
Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Transcription Factor CHOP | 2020 |
Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-β-cyclodextrin for oral insulin delivery.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetylcysteine; Administration, Oral; Animals; Caco-2 Cells; Diabetes Mellitus, Experimental; Drug Carriers; Excipients; Humans; Hypoglycemic Agents; Insulin; Male; Rats; Rats, Wistar | 2021 |
N‑acetylcysteine inhibits atherosclerosis by correcting glutathione‑dependent methylglyoxal elimination and dicarbonyl/oxidative stress in the aorta of diabetic mice.
Topics: Acetylcysteine; Animals; Aorta; Atherosclerosis; Diabetes Complications; Diabetes Mellitus, Experimental; Glutathione; Male; Mice; Mice, Knockout, ApoE; Oxidative Stress; Pyruvaldehyde | 2021 |
Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Kidney; Matrix Metalloproteinase 2; Oxidative Stress; Rats; Rats, Wistar | 2021 |
Evaluation of coenzyme Q10 combined with or without N-acetyl cysteine or atorvastatin for preventing contrast-induced kidney injury in diabetic rats.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Atorvastatin; Contrast Media; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Rats; Rats, Sprague-Dawley; Ubiquinone | 2021 |
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats.
Topics: Acetylcysteine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radical Scavengers; Glycosylation; Heart Diseases; Insulin Resistance; Male; Mitochondria; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Papillary Muscles; Rats, Sprague-Dawley; Signal Transduction; Streptozocin | 2021 |
Impact of diabetes on gingival wound healing via oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Experimental; Gene Expression; Gingiva; Insulin; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Wound Healing | 2017 |
Beneficial effects of N-acetylcysteine on hepatic oxidative stress in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Fatty Acids; Hyperglycemia; Insulin; Liver; Male; Oxidative Stress; Rats, Wistar; Streptozocin; Triglycerides; Urea | 2018 |
Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress.
Topics: Acetylcysteine; Animals; Apoptosis; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Glucose; Male; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; Palmitic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2018 |
N-acetylcysteine protects against diabetic nephropathy through control of oxidative and nitrosative stress by recovery of nitric oxide in rats.
Topics: Acetylcysteine; Animals; Catalase; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutathione; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrosative Stress; Oxidative Stress; Protective Agents; Rats, Wistar; Streptozocin; Thiobarbituric Acid Reactive Substances | 2018 |
Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation.
Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Blood Glucose; Bucladesine; Diabetes Mellitus, Experimental; Female; Gluconates; Glutathione; Hydroxyethyl Starch Derivatives; Insulin; Islets of Langerhans Transplantation; Mice, Nude; Nitroglycerin; Organ Preservation; Organ Preservation Solutions; Pancreas; Raffinose; Reproducibility of Results; Swine; Transplantation, Heterologous; Trehalose | 2018 |
Oxidative stress mediated mitochondrial damage plays roles in pathogenesis of diabetic nephropathy rat.
Topics: Acetylcysteine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Kidney Glomerulus; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Streptozocin | 2018 |
Diabetes-associated oxidative damage to DNA base in colon cells.
Topics: Acetylcysteine; Animals; Colon; Colonic Neoplasms; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; DNA Damage; DNA Glycosylases; Glucose; Guanine; HCT116 Cells; HT29 Cells; Humans; Mice; Oxidative Stress | 2019 |
Angiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease.
Topics: Acetylcysteine; Actin Cytoskeleton; Angiotensin II; Animals; Calcium; Cell Adhesion; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Humans; Losartan; Mice; Mice, Inbred C57BL; Microfilament Proteins; Molecular Motor Proteins; Myosin Heavy Chains; NADPH Oxidase 4; Podocytes; Rats; Rats, Inbred Strains; Reactive Oxygen Species; Receptors, Leptin; RNA Interference; TRPC6 Cation Channel | 2019 |
REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Feedback, Physiological; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Reactive Oxygen Species; Transcription Factors | 2019 |
N-acetyl-L-cysteine relieves myocardial injury in type 2 diabetic rats via inhibiting oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Humans; Oxidative Stress; Random Allocation; Rats; Rats, Inbred Strains | 2020 |
Astragaloside IV protects against hyperglycemia-induced vascular endothelial dysfunction by inhibiting oxidative stress and Calpain-1 activation.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Biomarkers; Calpain; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dipeptides; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Triterpenes; Vasodilation | 2019 |
Relationship between downregulation of miRNAs and increase of oxidative stress in the development of diabetic cardiac dysfunction: junctin as a target protein of miR-1.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Down-Regulation; Gene Expression Regulation; Male; Mice; MicroRNAs; Muscle Proteins; Myocardium; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar | 2013 |
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes.
Topics: Acetylcysteine; Adiponectin; Allopurinol; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Gene Expression Regulation; Humans; Janus Kinases; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitric Oxide; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Signal Transduction; STAT3 Transcription Factor; Up-Regulation | 2013 |
Antioxidant N-acetylcysteine attenuates the reduction of Brg1 protein expression in the myocardium of type 1 diabetic rats.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dinoprost; DNA Helicases; Free Radical Scavengers; Heart; Heme Oxygenase-1; Interleukin-6; Isoprostanes; Myocardium; Nuclear Proteins; Phosphorylation; Rats; STAT3 Transcription Factor; Transcription Factors; Tumor Necrosis Factor-alpha | 2013 |
N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats.
Topics: 2-Methoxyestradiol; Acetylcysteine; Allopurinol; Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dinoprost; Drug Synergism; Echocardiography; Estradiol; Heme Oxygenase (Decyclizing); Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Isoprostanes; Male; Membrane Potential, Mitochondrial; Metalloporphyrins; Myocardial Reperfusion Injury; Protoporphyrins; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase | 2013 |
Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Berberine; Cells, Cultured; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Fibronectins; Free Radical Scavengers; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Male; Mesangial Cells; Nephritis; NF-kappa B; Oxidative Stress; Protein Binding; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta1 | 2013 |
Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.
Topics: Acetylcysteine; Activating Transcription Factor 6; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Free Radical Scavengers; Gene Knockdown Techniques; Glucose; Membrane Proteins; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2013 |
A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes.
Topics: Acetylcysteine; Animals; Blood Vessels; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Glucose; Golgi Apparatus; Human Umbilical Vein Endothelial Cells; Humans; Immunoblotting; Ligands; Mice; Mice, Knockout; Mice, Obese; Mice, Transgenic; Phosphorylation; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes.
Topics: Acetylcysteine; Animals; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; Female; Heart Defects, Congenital; Male; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy in Diabetics | 2014 |
Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats.
Topics: Acetylcysteine; Animals; Carbon Monoxide; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Induction; Heme Oxygenase-1; Hemin; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin; Vasodilation | 2014 |
Enhancement of cellular antioxidant-defence preserves diastolic dysfunction via regulation of both diastolic Zn2+ and Ca2+ and prevention of RyR2-leak in hyperglycemic cardiomyocytes.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Body Weight; Calcium; Diabetes Mellitus, Experimental; Diastole; Heart Ventricles; Hyperglycemia; In Vitro Techniques; Intracellular Space; Male; Myocardium; Myocytes, Cardiac; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Tacrolimus Binding Proteins; Zinc | 2014 |
P2X(7) receptor in the kidneys of diabetic rats submitted to aerobic training or to N-acetylcysteine supplementation [corrected].
Topics: Acetylcysteine; Adenosine Triphosphate; Administration, Oral; Albuminuria; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Exercise Therapy; Gene Expression; Kidney; Lipid Peroxidation; Male; Oxidative Stress; Physical Conditioning, Animal; Purinergic P2X Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2X7; Streptozocin | 2014 |
High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature.
Topics: Acetylcysteine; Animals; Brain; Buthionine Sulfoximine; Cell Line; Diabetes Mellitus, Experimental; Endothelial Cells; Free Radical Scavengers; Glucose; Glutathione; Glycosylation; Humans; Lactoylglutathione Lyase; Male; Microvessels; Occludin; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Wistar; Thiolester Hydrolases | 2015 |
N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition.
Topics: Acetylcysteine; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2015 |
Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behaviour and reduces oxidative stress in brain and pancreas.
Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Animal; Brain; Deferoxamine; Depressive Disorder; Diabetes Mellitus, Experimental; Free Radical Scavengers; Lipid Peroxidation; Male; Oxidative Stress; Pancreas; Rats; Rats, Wistar; Siderophores | 2016 |
Oleanolic acid and N-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Oxidative Stress; Rats; Rats, Inbred OLETF; Reactive Oxygen Species | 2016 |
Diabetes enhances oxidative stress-induced TRPM2 channel activity and its control by N-acetylcysteine in rat dorsal root ganglion and brain.
Topics: Acetylcysteine; Animals; Antioxidants; Brain; Calcium; Diabetes Mellitus, Experimental; Female; Ganglia, Spinal; Glutathione; Hydrogen Peroxide; Lipid Peroxidation; Neurons; Oxidative Stress; Rats, Wistar; TRPM Cation Channels | 2016 |
N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Acetylcysteine; Adiponectin; Animals; Antioxidants; CD36 Antigens; Creatine Kinase, MB Form; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Forkhead Transcription Factors; Male; Methyl Ethers; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nerve Tissue Proteins; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; Sevoflurane; STAT3 Transcription Factor; Time Factors; Troponin I | 2016 |
Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1.
Topics: Acetylcysteine; Animals; Blood Glucose; Body Weight; Bone Marrow Cells; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelial Progenitor Cells; Feedback, Physiological; Glycation End Products, Advanced; Glycyrrhizic Acid; HMGB1 Protein; Male; Mice, Inbred C57BL; Models, Biological; Monocytes; Oxidative Stress; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Up-Regulation | 2016 |
Antioxidant Therapy Alters Brain MAPK-JNK and BDNF Signaling Path-ways in Experimental Diabetes Mellitus.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; Deferoxamine; Diabetes Mellitus, Experimental; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Signal Transduction | 2016 |
N-Acetyl cysteine protects diabetic mouse derived mesenchymal stem cells from hydrogen-peroxide-induced injury: A novel hypothesis for autologous stem cell transplantation.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Diabetes Mellitus, Experimental; Hydrogen Peroxide; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Streptozocin; Transplantation, Autologous | 2016 |
The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress.
Topics: Acetylcysteine; Animals; Antioxidants; Blood-Brain Barrier; Brain; Cerebral Infarction; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose; Glutamate-Cysteine Ligase; Glutathione; Humans; Mice; Oxidative Stress; Pyruvaldehyde; Reperfusion Injury; Stroke | 2016 |
N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Cardiomegaly; Caveolae; Caveolin 3; Cell Hypoxia; Cell Line; Cytoprotection; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Heart Rate; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Streptozocin; Transfection; Ventricular Function, Left | 2016 |
N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glycation End Products, Advanced; Kidney; Macrophages; Male; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Serum Albumin | 2016 |
Alterations in the proangiogenic functions of adipose tissue-derived stromal cells isolated from diabetic rats.
Topics: Acetylcysteine; Adipose Tissue; Animals; Catalase; Cell Proliferation; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glucose; Hindlimb; Humans; Ischemia; Male; Mice; Mice, Nude; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Stromal Cells; Time Factors | 2008 |
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Brain; Brain Diseases; Cognition Disorders; Diabetes Mellitus, Experimental; Hyperglycemia; Lipid Peroxidation; Male; Maze Learning; Neuroprotective Agents; Oxidative Stress; Random Allocation; Rats; Rats, Wistar | 2008 |
Neuroprotective activity of mexidole and 3-hydroxypyridine acetylcysteinate against the background of cerebral ischemia in the complex of experimental diabetes mellitus and exogenous hypercholesterolemia.
Topics: Acetylcysteine; Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Female; Hypercholesterolemia; Male; Neuroprotective Agents; Picolines; Rats; Treatment Outcome | 2008 |
Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Calcium-Transporting ATPases; Cerebral Cortex; Diabetes Mellitus, Experimental; Hyperglycemia; Intracellular Membranes; Lipid Peroxidation; Lipids; Male; Membrane Fluidity; Neuroprotective Agents; Protein Binding; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2009 |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recombinant Proteins; Repressor Proteins; RNA Interference; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid | 2009 |
The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Animals; Antioxidants; Calcium-Binding Proteins; Cardiomyopathies; Diabetes Complications; Diabetes Mellitus, Experimental; High-Temperature Requirement A Serine Peptidase 2; In Vitro Techniques; Male; MAP Kinase Signaling System; Mice; Mitochondrial Proteins; Myocardial Contraction; Myocytes, Cardiac; Protease Inhibitors; Pyrimidinones; Resveratrol; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine Endopeptidases; Stilbenes; Streptozocin; Thiones; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats.
Topics: Acetylcysteine; Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dinoprost; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Immunoenzyme Techniques; Inflammation; Isoprostanes; Macrophages; Male; Microglia; Oxidative Stress; Pericytes; Rats; Rats, Wistar; Retina; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2009 |
N-acetyl cysteine promotes angiogenesis and clearance of free oxygen radicals, thus improving wound healing in an alloxan-induced diabetic mouse model of incisional wound.
Topics: Acetylcysteine; Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radical Scavengers; Glutathione; Hydroxyproline; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; Skin; Vascular Endothelial Growth Factors; Wound Healing; Wounds, Penetrating | 2010 |
N-acetylcysteine attenuates noise-induced permanent hearing loss in diabetic rats.
Topics: Acetylcysteine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Glutathione; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Rats; Rats, Wistar; Streptozocin | 2010 |
Oxidative stress is not associated with vascular dysfunction in a model of alloxan-induced diabetic rats.
Topics: Acetylcysteine; Alloxan; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Free Radical Scavengers; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Time Factors | 2010 |
Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats.
Topics: Acetylcysteine; Animals; Brain Diseases; Cerebral Cortex; Diabetes Complications; Diabetes Mellitus, Experimental; Free Radical Scavengers; Male; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Treatment Outcome | 2011 |
Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats.
Topics: Acetylcysteine; Animals; Bethanechol; Biomimetic Materials; Diabetes Mellitus, Experimental; Fasting; Feeding Behavior; Glutathione; Insulin; Insulin Resistance; Liver; Male; Muscarinic Agonists; Muscle, Skeletal; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Sucrose | 2011 |
Long-term dietary antioxidant cocktail supplementation effectively reduces renal inflammation in diabetic mice.
Topics: Acetylcysteine; Alloxan; Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Lipid Peroxidation; Mice; Nephritis; Oxidative Stress; Thiobarbituric Acid Reactive Substances | 2011 |
Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Biopterins; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
N-acetylcysteine on oxidative damage in diabetic rats.
Topics: Acetylcysteine; Alloxan; Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Injections, Intraperitoneal; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar | 2011 |
PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dinoprost; Drug Evaluation, Preclinical; Enzyme Activation; Free Radical Scavengers; Hypertrophy, Left Ventricular; Indoles; Isoprostanes; Male; Maleimides; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Superoxides; Ultrasonography | 2012 |
Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fluorescent Antibody Technique; Fluorometry; Intercellular Adhesion Molecule-1; Male; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retinal Vessels; Vascular Endothelial Growth Factor A | 2012 |
Suppression of high pacing-induced ANP secretion by antioxidants in isolated rat atria.
Topics: Acetophenones; Acetylcysteine; Animals; Antioxidants; Atrial Function; Atrial Natriuretic Factor; Blood Pressure; Cardiac Pacing, Artificial; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Electric Stimulation; Enzyme Activation; Extracellular Fluid; Heart Atria; Hemodynamics; Hydrogen Peroxide; In Vitro Techniques; Male; Myocardial Contraction; NADPH Oxidase 4; NADPH Oxidases; Pyrogallol; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Thioctic Acid | 2011 |
Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Diabetes Mellitus, Experimental; Disease Models, Animal; Ganglia, Spinal; Glucose Tolerance Test; Glutathione Peroxidase; Hydrogen Peroxide; Hyperalgesia; Hypoxanthine Phosphoribosyltransferase; Male; Microscopy, Electron, Transmission; Mitochondria; Paclitaxel; Pain Measurement; Pain Threshold; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sciatic Nerve; Sensory Receptor Cells; Streptozocin; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels | 2012 |
Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Heart; Kidney; Liver; Lung; Male; NADPH Oxidases; Rats; Rats, Sprague-Dawley | 2012 |
Impaired synthesis contributes to diabetes-induced decrease in liver glutathione.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Glutathione Disulfide; Heme Oxygenase-1; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Taurine | 2012 |
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Topics: Acetylcysteine; Animals; Antibodies; Antibody Specificity; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Liver; Liver Diseases; Male; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Rabbits; Rats; Rats, Inbred LEC; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Vaccination | 2012 |
N-acetylcysteine decreases alveolar bone loss on experimental periodontitis in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Alveolar Bone Loss; Animals; Antioxidants; Diabetes Mellitus, Experimental; Osteoblasts; Periodontitis; Rats; Rats, Wistar; Streptozocin | 2012 |
Effects of Zn deficiency, antioxidants, and low-dose radiation on diabetic oxidative damage and cell death in the testis.
Topics: Acetylcysteine; Animals; Apoptosis; Chelating Agents; Deficiency Diseases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Radiation; Ethylenediamines; Free Radical Scavengers; Infertility, Male; Male; Oxidative Stress; Radiation Dosage; Rats; Testis; X-Ray Therapy; Zinc | 2013 |
Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells.
Topics: Acetylcysteine; Animals; Antioxidants; Choroid; Choroidal Neovascularization; Diabetes Mellitus, Experimental; DNA Damage; Epithelial Cells; Gene Expression; Hyperglycemia; Light Coagulation; Mice; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Retina; Retinal Pigment Epithelium; Severity of Illness Index; Signal Transduction; STAT3 Transcription Factor; Streptozocin; Tyrphostins; Vascular Endothelial Growth Factor A | 2012 |
High glucose induces autophagy in podocytes.
Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blood Glucose; Catalase; Culture Media; Diabetes Mellitus, Experimental; Glucose; Male; Microscopy, Electron; Microtubule-Associated Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Streptozocin; Superoxide Dismutase; Tumor Cells, Cultured | 2013 |
Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antioxidants; Apoptosis; Ascorbic Acid; beta Carotene; Caspase 3; Caspases; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Enzyme Activation; Glucose; In Vitro Techniques; Male; Oxidative Stress; Pericytes; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Retina; Selenium; Thiobarbituric Acid Reactive Substances | 2002 |
Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes.
Topics: Acetylcysteine; Animals; Anticoagulants; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Hydroxyethylrutoside; Kidney; Male; Rats; Rats, Wistar; Skin; Taurine; Time Factors | 2003 |
Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: beneficial action of melatonin and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Creatinine; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Kidney Cortex; Kidney Tubules; Melatonin; Membrane Potentials; Metals, Heavy; Mitochondria; Molybdenum; Rabbits; Tungsten; Urea; Vanadium | 2004 |
Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cardiomegaly; Cell Nucleus; Diabetes Mellitus, Experimental; Glucose; Glutathione; Heart Ventricles; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species | 2004 |
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Topics: 3T3-L1 Cells; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adenoviridae; Adipocytes; Animals; Blotting, Northern; Cell Differentiation; Deoxyguanosine; Diabetes Mellitus, Experimental; Dicarboxylic Acid Transporters; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glucose; Hyperglycemia; Immunoblotting; Inflammation; Insulin; Interleukin-6; Membrane Potentials; Mice; Mitochondria; Oxidative Stress; Oxygen; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Streptozocin; Time Factors; Transcription, Genetic; Up-Regulation | 2005 |
Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Aspalathus; Diabetes Mellitus, Experimental; Hydrogen-Ion Concentration; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar | 2006 |
Supplementation with N-acetylcysteine and taurine failed to restore glutathione content in liver of streptozotocin-induced diabetics rats but protected from oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dioxygenases; Glutathione; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Taurine | 2005 |
The effect of N-acetylcysteine on cardiac contractility to dobutamine in rats with streptozotocin-induced diabetes.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Dinoprost; Dobutamine; Dose-Response Relationship, Drug; Heart Rate; Immunohistochemistry; Male; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2005 |
Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Arteries; Blood Pressure; Diabetes Mellitus, Experimental; Dinoprost; Free Radicals; Heart Rate; Lipid Peroxidation; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Streptozocin; Vasoconstrictor Agents | 2006 |
HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Division; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Hydroxyethylrutoside; Immunohistochemistry; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar; Taurine | 2005 |
Melatonin attenuates diabetes-induced oxidative stress in rabbits.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Hydroxyl Radical; Kidney Cortex; Liver; Male; Melatonin; Oxidative Stress; Rabbits | 2006 |
Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antimitotic Agents; Calcium-Binding Proteins; Calpain; Colchicine; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Kidney Function Tests; Kidney Tubules, Proximal; Longevity; Male; Mice; Regeneration | 2006 |
N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats.
Topics: Acetylcysteine; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; Free Radical Scavengers; Heart Rate; Immunohistochemistry; Insulin; Isoprostanes; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Stress, Physiological; Triglycerides; Tyrosine | 2006 |
Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Diabetes Mellitus, Experimental; Free Radical Scavengers; Heart Diseases; Immunoenzyme Techniques; Male; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2006 |
Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Biomarkers; Blood Glucose; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Diastole; Dinoprost; Down-Regulation; Free Radical Scavengers; Heart Ventricles; Heme Oxygenase (Decyclizing); Insulin; Interleukin-6; Male; Myocardium; NADPH Oxidases; Organ Size; Oxidative Stress; Phosphoproteins; Rats; Rats, Wistar; Superoxide Dismutase | 2007 |
N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Cardiomegaly; Cell Size; Cells, Cultured; Collagen Type I; Collagen Type II; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Dinoprost; Glucose; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Male; Myocardium; Myocytes, Cardiac; Oxidative Stress; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar; Superoxides | 2007 |
Effect of N-acetylcysteine on plasma adiponectin and renal adiponectin receptors in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Adiponectin; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Kidney; Male; Multienzyme Complexes; Oxidative Stress; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Adiponectin; Receptors, Cell Surface; Streptozocin | 2007 |
Effects of acetylcysteine and probucol on contrast medium-induced depression of intrinsic renal glutathione peroxidase activity in diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Contrast Media; Diabetes Mellitus, Experimental; Diatrizoate Meglumine; Free Radical Scavengers; Glutathione Peroxidase; Kidney; Male; Osmolar Concentration; Probucol; Rats; Rats, Wistar; Superoxide Dismutase | 2007 |
The activity of aldose reductase is elevated in diabetic mouse heart.
Topics: Acetylcysteine; Aldehyde Reductase; Animals; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Enzyme Activation; Free Radical Scavengers; Glutathione Disulfide; Male; Mice; Muscle Cells; Myocardium; RNA, Messenger; Streptozocin; Thiobarbituric Acid Reactive Substances | 2007 |
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Topics: Acetophenones; Acetylcysteine; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Imidazoles; Indoles; Leukostasis; Losartan; Male; NADPH Oxidases; Pyridines; Pyrroles; Rats; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Retinal Diseases; Vascular Endothelial Growth Factor A; Vasoconstrictor Agents | 2007 |
Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors.
Topics: Acetylcysteine; Animals; Antioxidants; Benzothiazoles; Blood-Retinal Barrier; Bradykinin; Diabetes Mellitus, Experimental; Diamines; Dose-Response Relationship, Drug; Edema; Evans Blue; Male; Organic Chemicals; Oxidative Stress; Plasma; Quinolines; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
The effect of antioxidant treatment and NOS inhibition on the incidence of ischemia-induced arrhythmias in the diabetic rat heart.
Topics: Acetylcysteine; Adaptation, Physiological; alpha-Tocopherol; Animals; Antioxidants; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Tachycardia, Ventricular; Ubiquinone; Up-Regulation; Ventricular Function, Left | 2008 |
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.
Topics: Acetylcysteine; Animals; Blood Glucose; Body Weight; Catalase; Cataract; Diabetes Mellitus, Experimental; Eye Proteins; Glutathione; Glutathione Reductase; Glycosylation; Injections; Lens, Crystalline; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Solubility; Streptozocin; Sulfhydryl Compounds; Water | 2008 |
Inhibition with N-acetylcysteine of enhanced production of tumor necrosis factor in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Fructosamine; Hexosamines; Rats; Rats, Wistar; Serum Albumin; Time Factors; Triglycerides; Tumor Necrosis Factor-alpha | 1994 |
N-acetylcysteine inhibits loss of diaphragm function in streptozotocin-treated rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diaphragm; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle Relaxation; Rats; Rats, Wistar; Streptozocin; Time Factors | 1996 |
Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine.
Topics: Acetylcysteine; Analysis of Variance; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Free Radical Scavengers; Lipopolysaccharides; Motor Neurons; Neural Conduction; Rats; Rats, Wistar; Reference Values; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Aorta; Butylated Hydroxytoluene; Diabetes Mellitus, Experimental; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Guanidines; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley | 1996 |
Effects of the sulphydryl donor N-acetyl-L-cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Circulation; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Freezing; Male; Nerve Regeneration; Neural Conduction; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1996 |
Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture.
Topics: Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Embryo, Mammalian; Embryonic and Fetal Development; Female; Free Radical Scavengers; In Vitro Techniques; Male; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Teratogens; Time Factors | 1997 |
Oral administration of the antioxidant, N-acetylcysteine, abrogates diabetes-induced endothelial dysfunction.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Free Radical Scavengers; Male; Norepinephrine; Oxidative Stress; Rats; Rats, Sprague-Dawley | 1998 |
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice.
Topics: Acetylcysteine; Administration, Oral; Alloxan; Animals; Blood Glucose; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Pancreas | 1999 |
Endothelin and free radicals modulate microvascular responses in streptozotocin-induced diabetic rats.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Electric Stimulation; Endothelin Receptor Antagonists; Endothelins; Free Radicals; Laser-Doppler Flowmetry; Male; Microcirculation; Nitroprusside; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sciatic Nerve; Skin; Streptozocin; Substance P; Superoxide Dismutase; Vasodilator Agents | 2000 |
Effects of free radicals on cytosolic creatine kinase activities and protection by antioxidant enzymes and sulfhydryl compounds.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Brain; Catalase; Creatine Kinase; Cytosol; Diabetes Mellitus, Experimental; Dithiothreitol; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Free Radicals; Heart; Hydrogen Peroxide; Insulin; Muscle, Skeletal; Myocardium; Rats; Rats, Wistar; Sulfhydryl Compounds; Superoxide Dismutase; Xanthine; Xanthine Oxidase | 2000 |
Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity.
Topics: Abnormalities, Drug-Induced; Acetylcysteine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; Enzyme Inhibitors; Female; Glucose; Indoles; Inositol; Maleimides; Models, Biological; Models, Statistical; Organ Culture Techniques; Oxidative Stress; Phospholipases A; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2001 |
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; beta Carotene; Chromans; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet; Dietary Supplements; Galactosemias; Male; Pericytes; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Selenium; Vitamin E | 2001 |
Comparison of the development of tolerance to nitroglycerin in aortic preparations isolated from non-diabetic and diabetic rats.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; Drug Tolerance; Glycated Hemoglobin; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1992 |