acetylcysteine and Airflow Obstruction, Chronic

acetylcysteine has been researched along with Airflow Obstruction, Chronic in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	38 (36.54)	29.6817
2010's	49 (47.12)	24.3611
2020's	17 (16.35)	2.80

Authors

Authors	Studies
Hu, Z; Liu, X; Lu, X	1
Ilić, A; Kotur-Stevuljević, J; Minić, R; Žujović, D; Žuža, O; Đorđević, B	1
Agic, A; Bogdan, M; Dugajlić, M; Ilić, M; Kolarov, V; Kotur Stevuljević, J; Kutlešić Stević, S; Tot Vereš, K; Tušek, B; Zvezdin, B	1
Du, L; Xiong, Y; Zhang, L	1
Agić, A; Buha, I; Dimic-Janjic, S; Ilić, A; Ilić, B; Milenković, B; Mirić, M; Nagorni-Obradović, L; Popević, S; Simić, M; Škodrić-Trifunović, V; Stjepanović, M	1
Kitura, OY; Korpan, AS; Motorna, NM; Nastroga, TV; Potyazhenko, MM; Sokolyuk, NL	1
Oliva, A; Pallecchi, L; Rossolini, GM; Travaglino, F; Zanatta, P	1
Anzueto, A; Cazzola, M; Celli, BR; Matera, MG; Page, CP; Wedzicha, JA	1
Chen, H; Duan, Y; Fu, Y; Jiang, E; Jiang, Y; Li, W; Luo, C; Luo, T; Xue, G; Zhou, H; Zong, K	1
Bhatnagar, M; Jaiswal, N; Shah, H	1
Deng, Z; Huang, P; Lin, B; Ran, P; Tang, L; Tian, H; Wei, S; Wu, F; Zhao, D; Zheng, J; Zhong, N; Zhou, Y	1
Lin, J; Sun, Y; Xie, M; Zhang, L; Zhou, Q	1
Adir, Y; Avdeev, S; Calverley, PMA; Cordeiro, CR; Jesenak, M; Koblížek, V; Papi, A; Petkova, D; Rogliani, P; Tarraf, H; Tzanakis, N; Ulmeanu, R; Uzaslan, E	1
Calverley, P; Papi, A; Rogliani, P	1
An, L; Li, G; Qu, Y; Wang, J; Ye, W; Zhang, Q; Zhao, X; Zhao, Z; Zheng, D	1
Jiang, C; Lv, Q; Yang, Y; Zou, J	1
Hu, Z; Liu, X; Zhou, H	1
Benedikter, BJ; Grauls, GE; Hellebrand, PHM; Savelkoul, PHM; Stassen, FRM; Volgers, C	1
Calzetta, L; Cazzola, M; Hanania, NA; Matera, MG; Rogliani, P	1
Calzetta, L; Cazzola, M; Facciolo, F; Matera, MG; Rinaldi, B; Rogliani, P	1
Calzetta, L; Cazzola, M; Matera, MG; Rogliani, P	1
Moitra, S	1
Boucher, RC; Delion, MF; Donaldson, SH; Ehre, C; Esther, CR; Fontana, NC; Grubb, BR; Hill, DB; Hothem, LN; Kato, T; Livraghi-Butrico, A; Markovetz, MR; Morrison, CB; Rushton, ZL; Thelin, WR; Villalon, D; Wang, B	1
Bowman, RV; Fong, KM; Jafari, M; Rahman, M; Ristovski, Z; Stevanovic, S; Vaughan, A; Yang, IA	1
Calverley, PMA; Criner, GJ; Fabbri, LM; Papi, A; Zheng, J	1
Calzetta, L; Cazzola, M; Matera, MG; Page, C; Puxeddu, E; Rogliani, P	1
Gross, N	1
Bhosale, S; Brashier, B; Kodgule, R; Madas, S; Salvi, S; Shaikh, M; Sinojia, R; Vaidya, A	1
Adcock, I; Bhavsar, P; Chang, Y; Chung, KF; Clarke, C; Li, F; Seiffert, JM; Wiegman, C; Zhang, J; Zhou, X; Zhu, J	1
Markun, S	1
Claes, R; De Backer, J; De Backer, W; Parizel, PM; Van Holsbeke, C; Vinchurkar, S; Vos, W	1
Cai, W; Lei, S; Shen, Y; Zhang, Z	1
Awab, A; Metcalf, JP; Wu, W	1
Ng, LY; Raiteri, L; Tse, HN; Wong, KY; Yee, KS	1
Lambert, AA; Moon, KK; Parker, AM	1
Cazzola, M; Matera, MG	1
Bai, CX; Chen, P; Gao, Y; Kang, J; Li, X; Ma, LJ; Raiteri, L; Sardina, M; Wan, HY; Wang, BS; Wen, FQ; Yao, WZ; Zheng, JP; Zhong, NS	1
Bothamley, GH; Turner, RD	1
Zheng, JP; Zhong, NS	1
Braido, F; Corsico, A; Di Marco, F; Santus, P; Scichilone, N; Solidoro, P	1
Ng, LY; Raiteri, L; Tse, HN; Tseng, CZS; Wong, KY; Yee, KS	1
Tse, HN; Tseng, CZ	1
Kang, S	1
Ayfer Aytemur, Z; Baysak, A; Köse, T; Ozdemir, O; Sayiner, A	1
Wei, A	1
Bai, J; He, Z; Liu, W; Su, W; Yang, X; Zhong, X	1
Dai, LM; Fang, LZ; Feng, JG; Fu, WP; Liu, H; Liu, L; Shu, JK; Zhang, JQ; Zhao, ZH	1
Akamatsu, K; Hirano, T; Ichikawa, T; Ichinose, M; Kanai, K; Kikuchi, T; Koarai, A; Matsunaga, K; Minakata, Y; Nakanishi, M; Shishikura, Y; Sugiura, H	1
Calzetta, L; Cazzola, M; Chuchalin, AG; Jardim, J; Matera, MG; Page, C; Rogliani, P	1
Calzetta, L; Cazzola, M; Matera, MG	1
Dai, LM; Fang, LZ; Fu, WP; Liu, L; Zhang, JQ	1
Manaf, ZA; Manap, RA; Pirabbasi, E; Rajab, NF; Shahar, S	1
Johnson, K; Kunisaki, KM; McEvoy, CE; Naqvi, S; Nelson, D; Niewoehner, DE; Reilkoff, RA; Tirouvanziam, R; Wendt, C; Wetherbee, EE	1
Blasi, F; Cazzola, M; Matera, MG; Page, C; Pallecchi, L; Rogliani, P; Rossolini, GM	1
Cao, X; Li, S; Wang, Y; Yang, M; Zhang, D; Zhang, F; Zhang, J; Zhang, Y; Zhao, Z	1
Calzetta, L; Cazzola, M; Facciolo, F; Matera, MG; Rogliani, P	1
Canacankatan, N; Hanta, I; Kocabas, A; Kuleci, S	1
Baglole, CJ; Phipps, RP; Sime, PJ	1
Carru, C; Deiana, L; Deledda, A; Fois, AG; Pirina, P; Scanu, B; Sotgia, S; Spada, V; Usai, MF; Zinellu, A	1
Akapo, S; Gupta, J; Martinez, E; McCrea, C; Roach, M; Ye, L	1
de Vries, EG; Homan, S; Postma, DS; Scheper, RJ; Timens, W; Timmer-Bosscha, H; van der Deen, M	1
Akkermans, R; Chavannes, N; Dekhuijzen, R; Muris, J; Schermer, T; van Schayck, O; van Weel, C; Wouters, E	1
Cai, S; Chen, JB; Chen, P; Wu, J; Zhang, C	1
Raz, M; Stav, D	1
Cutz, E; Mateos-Corral, D; Ratjen, F; Solomon, M	1
Legnani, D	1
Adcock, I; Barczyk, A; Barnes, PJ; Borea, PA; Caramori, G; Casolari, P; Chung, KF; Contoli, M; Hansel, T; Leung, E; Maclennan, S; Papi, A; Tosi, A; Triggiani, M; Varani, K; Vincenzi, F	1
Cortijo, J; Gimeno, C; Mata, M; Morcillo, E	1
Gillissen, A	2
Cortijo, J; Juan, G; Milara, J; Peiró, T; Serrano, A	1
Sin, D; van Eeden, SF	1
Chung, KF; Huang, CD; Huang, TT; Kuo, HP; Lee, KY; Lin, HC; Lin, SM; Lo, YL; Wang, CH	1
Sadowska, AM	1
Bai, CX; Chen, P; Gao, Y; Kang, J; Ma, LJ; Wan, HY; Wen, FQ; Xia, QK; Yao, WZ; Zheng, JP; Zhong, NS	1
Armengot, M; Carda, C; Cortijo, J; Martinez, I; Mata, M; Melero, JA; Sarrion, I	1
Chan, MH; Loo, CK; Ng, LY; Raiteri, L; Tse, HN; Wai, KY; Wong, KY; Yee, KS	1
Kerstjens, HA; Postma, DS	1
Gerrits, CM; Herings, RM; Lammers, JW; Leufkens, HG	1
Ernst, P; Suissa, S	1
Galetke, W; Randerath, W	1
Bellet, H; Couillard, A; Cristol, JP; Hayot, M; Koechlin, C; Prefaut, C; Simar, D	1
Dekhuijzen, PN	2
Cai, BQ; Gu, L; Guo, ZJ; Xu, L; Xu, XX; Zhang, H; Zhu, YJ	1
Cai, BQ; Xu, L; Zhu, YJ	1
Aceto, A; De Benedetto, F; Donner, CF; Dragani, B; Formisano, S; Pela, R; Sanguinetti, CM; Spacone, A	1
Blinova, EV; Ignatova, GL; Stepanishcheva, LA	1
García Río, F	1
de Backer, WA; Demkow, U; Górecka, D; van Overveld, FJ; Zielinski, J	1
Altomare, E; Elisiana Carpagnano, G; Foschino Barbaro, MP; Resta, O; Rollo, T; Serviddio, G; Tamborra, R; Vendemiale, G	1
Ardia, A; De Backer, W; Decramer, M; Dekhuijzen, PN; Del Donno, M; Lankhorst, I; Olivieri, D; Pellegrino, R; Troosters, T; van Herwaarden, C; van Schayck, CP	1
De Backer, WA; Manuel-Y-Keenoy, B; Sadowska, AM	1
Chen, SX; Li, YQ; Ma, D; Ni, W; Xu, YJ; Yang, Z; Zhang, ZX	1
Bitter-Suermann, S; Kanniess, F; Magnussen, H; Watz, H	1
Kasielski, M; Luczynski, R; Nowak, D; Rysz, J; Sarniak, A; Stolarek, RA; Wlodarczyk, A	1
Bowler, RP; Crapo, JD; Sutherland, ER	1
Kanniess, F; Magnussen, H; Watz, H	1
Darquennes, K; De Backer, WA; Sadowska, AM; Verbraecken, J	1
Dekhuijzen, PN; van Beurden, WJ	1
Braszko, JJ; Chyczewska, E; Hołownia, A; Mróz, RM; Noparlik, J	1
Ardia, A; Decramer, M; Dekhuijzen, PN; Lankhorst, I; Olivieri, D; Rutten-van Mölken, M; Troosters, T; van Herwaarden, C; van Schayck, CP	1
González-Mangado, N; Morera Prat, J	1
Stey, C	1

Reviews

27 review(s) available for acetylcysteine and Airflow Obstruction, Chronic

Article	Year
Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections. European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:9 Topics: Acetylcysteine; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Expectorants; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Pulmonary Disease, Chronic Obstructive	2023
Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD. Respiratory research, 2023, Jul-31, Volume: 24, Issue:1 Topics: Acetylcysteine; Adrenal Cortex Hormones; Antioxidants; Expectorants; Humans; Inflammation; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Sulfhydryl Compounds	2023
Safety of N-Acetylcysteine at High Doses in Chronic Respiratory Diseases: A Review. Drug safety, 2021, Volume: 44, Issue:3 Topics: Acetylcysteine; Humans; Pulmonary Disease, Chronic Obstructive	2021
Systematic review and meta-analysis of the efficacy of N-acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Annals of palliative medicine, 2021, Volume: 10, Issue:6 Topics: Acetylcysteine; Europe; Forced Expiratory Volume; Humans; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests	2021
Impact of Mucolytic Agents on COPD Exacerbations: A Pair-wise and Network Meta-analysis. COPD, 2017, Volume: 14, Issue:5 Topics: Acetylcysteine; Ambroxol; Carbocysteine; Disease Progression; Expectorants; Humans; Network Meta-Analysis; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Thioglycolates; Thiophenes	2017
Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease. Expert review of respiratory medicine, 2018, Volume: 12, Issue:8 Topics: Acetylcysteine; Antioxidants; Bronchi; Expectorants; Glutathione; Humans; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species	2018
Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respiratory research, 2019, May-27, Volume: 20, Issue:1 Topics: Acetylcysteine; Antioxidants; Carbocysteine; Expectorants; Humans; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Thioglycolates; Thiophenes; Treatment Outcome	2019
Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis. COPD, 2014, Volume: 11, Issue:3 Topics: Acetylcysteine; Antioxidants; Disease Progression; Forced Expiratory Volume; Humans; Pulmonary Disease, Chronic Obstructive	2014
Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. COPD, 2014, Volume: 11, Issue:6 Topics: Acetylcysteine; Antioxidants; Bronchitis, Chronic; Disease Progression; Expectorants; Forced Expiratory Volume; Hospitalization; Humans; Macrophages; Neutrophils; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Respiratory Physiological Phenomena	2014
Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease. International journal of chronic obstructive pulmonary disease, 2014, Volume: 9 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Disease Progression; Dose-Response Relationship, Drug; Humans; Lung; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quality of Life; Severity of Illness Index; Treatment Outcome	2014
Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis. European respiratory review : an official journal of the European Respiratory Society, 2015, Volume: 24, Issue:137 Topics: Acetylcysteine; Bronchitis, Chronic; Bronchodilator Agents; Disease Progression; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Treatment Outcome	2015
Oxidation pathway and exacerbations in COPD: the role of NAC. Expert review of respiratory medicine, 2016, Volume: 10, Issue:1 Topics: Acetylcysteine; Anti-Inflammatory Agents; Antioxidants; Expectorants; Glutathione; Humans; Lung; Oxidative Stress; Patient Selection; Pulmonary Disease, Chronic Obstructive	2016
The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections. Respiratory medicine, 2016, Volume: 117 Topics: Acetylcysteine; Administration, Inhalation; Biofilms; Bronchiectasis; Bronchitis; Bronchitis, Chronic; Cystic Fibrosis; Expectorants; Humans; Injections, Intramuscular; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections	2016
[Acute bacterial exacerbation of chronic obstructive pulmonary disease and biofilm]. Le infezioni in medicina, 2009, Volume: 17 Suppl 2 Topics: Acetylcysteine; Anti-Infective Agents; Antioxidants; Biofilms; Bronchi; Bronchitis; Cystic Fibrosis; Humans; Lung; Pneumocystis carinii; Pneumonia, Bacterial; Pneumonia, Pneumocystis; Pneumonia, Viral; Practice Guidelines as Topic; Pulmonary Disease, Chronic Obstructive	2009
N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease. Therapeutic advances in respiratory disease, 2012, Volume: 6, Issue:3 Topics: Acetylcysteine; Expectorants; Gene Expression Regulation; Humans; Inflammation; Mucins; Mucus; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Signal Transduction	2012
[Medical maintenance treatment of chronic obstructive pulmonary disease (COPD)]. Nederlands tijdschrift voor geneeskunde, 2002, Aug-31, Volume: 146, Issue:35 Topics: Acetylcysteine; Administration, Inhalation; Anti-Bacterial Agents; Bronchodilator Agents; Cholinergic Antagonists; Expectorants; Humans; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Theophylline; Treatment Outcome	2002
[Acetylcysteine in chronic obstructive pulmonary disease. Secretolytic, antioxidant or placebo?]. Medizinische Monatsschrift fur Pharmazeuten, 2003, Volume: 26, Issue:11 Topics: Acetylcysteine; Expectorants; Free Radical Scavengers; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive	2003
Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. The European respiratory journal, 2004, Volume: 23, Issue:4 Topics: Acetylcysteine; Antioxidants; Disease Progression; Free Radical Scavengers; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species	2004
[Other drugs (not bronchodilators) in COPD]. Archivos de bronconeumologia, 2004, Volume: 40 Suppl 1 Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Aged; Antioxidants; Bronchodilator Agents; Clinical Trials as Topic; Cohort Studies; Drug Therapy, Combination; Expectorants; Forced Expiratory Volume; Humans; Middle Aged; Pulmonary Disease, Chronic Obstructive	2004
Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:1 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Dose-Response Relationship, Drug; Humans; Models, Biological; Pulmonary Disease, Chronic Obstructive	2007
[Pharmacological treatment of COPD and future of anti-inflammatory therapy]. Medizinische Klinik (Munich, Germany : 1983), 2006, Apr-15, Volume: 101, Issue:4 Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Dyspnea; Expectorants; Forced Expiratory Volume; Forecasting; Humans; Inflammation; Infliximab; Lung; Macrolides; Nitriles; Phosphodiesterase Inhibitors; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Research; Respiratory Function Tests; Simvastatin; Smoking Cessation; Tetracycline; Theophylline; Tumor Necrosis Factor-alpha	2006
[Acetylcysteine in the treatment of severe COPD]. Nederlands tijdschrift voor geneeskunde, 2006, Jun-03, Volume: 150, Issue:22 Topics: Acetylcysteine; Free Radical Scavengers; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Treatment Outcome	2006
N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD, 2006, Volume: 3, Issue:4 Topics: Acetylcysteine; Free Radical Scavengers; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome	2006
[New pharmacological options in the therapy of COPD]. Pneumologie (Stuttgart, Germany), 2007, Volume: 61, Issue:6 Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Bacterial Agents; Biomarkers; C-Reactive Protein; Forced Expiratory Volume; Humans; Inflammation; Macrolides; Pulmonary Disease, Chronic Obstructive; Reference Values	2007
Role of N-acetylcysteine in the management of COPD. International journal of chronic obstructive pulmonary disease, 2006, Volume: 1, Issue:4 Topics: Acetylcysteine; Cost-Benefit Analysis; Dyspnea; Expectorants; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Quality of Life; Respiratory Function Tests; Treatment Outcome	2006
The role for N-acetylcysteine in the management of COPD. International journal of chronic obstructive pulmonary disease, 2006, Volume: 1, Issue:2 Topics: Acetylcysteine; Biomarkers; Exhalation; Free Radical Scavengers; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive	2006
[Histone dependent signalization during pharmacotherapy of chronic obstructive pulmonary disease]. Pneumonologia i alergologia polska, 2007, Volume: 75, Issue:4 Topics: Acetylcysteine; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Histones; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Theophylline	2007

Trials

25 trial(s) available for acetylcysteine and Airflow Obstruction, Chronic

Article	Year
Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:9 Topics: Acetylcysteine; Cough; Humans; Propolis; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Quality of Life	2022
Efficacy and Safety of N-Acetylcysteine for Chronic Obstructive Pulmonary Disease and Chronic Bronchitis. BioMed research international, 2022, Volume: 2022 Topics: Acetylcysteine; Bronchitis, Chronic; Double-Blind Method; Humans; Pulmonary Disease, Chronic Obstructive; Surveys and Questionnaires	2022
A randomized, double-blind, placebo-controlled study evaluating the efficacy of propolis and N-acetylcysteine in exacerbations of chronic obstructive pulmonary disease. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:13 Topics: Acetylcysteine; Disease Progression; Double-Blind Method; Humans; Propolis; Pulmonary Disease, Chronic Obstructive	2022
High-dose N-acetylcysteine for long-term, regular treatment of early-stage chronic obstructive pulmonary disease (GOLD I-II): study protocol for a multicenter, double-blinded, parallel-group, randomized controlled trial in China. Trials, 2020, Sep-11, Volume: 21, Issue:1 Topics: Acetylcysteine; China; Double-Blind Method; Forced Expiratory Volume; Humans; Multicenter Studies as Topic; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Respiratory Function Tests; Treatment Outcome	2020
N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1 BioMed research international, 2021, Volume: 2021 Topics: Acetylcysteine; Administration, Oral; Aged; Down-Regulation; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-10; Interleukin-17; Lymphocyte Count; Male; Pulmonary Disease, Chronic Obstructive; T-Lymphocytes, Regulatory; Th17 Cells; Up-Regulation	2021
Impact of smoking status and concomitant medications on the effect of high-dose N-acetylcysteine on chronic obstructive pulmonary disease exacerbations: A post-hoc analysis of the PANTHEON study. Respiratory medicine, 2019, Volume: 147 Topics: Acetylcysteine; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Aged; Bronchodilator Agents; China; Disease Progression; Expectorants; Female; Humans; Male; Middle Aged; Placebos; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Smoking	2019
Priming of beta-2 agonist and antimuscarinic induced physiological responses induced by 1200mg/day NAC in moderate to severe COPD patients: A pilot study. Respiratory physiology & neurobiology, 2014, Jan-15, Volume: 191 Topics: Acetylcysteine; Aged; Albuterol; Antioxidants; Bronchodilator Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Ipratropium; Male; Middle Aged; Muscarinic Antagonists; Pilot Projects; Plethysmography; Pulmonary Disease, Chronic Obstructive; Spirometry; Statistics, Nonparametric; Total Lung Capacity	2014
Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. International journal of chronic obstructive pulmonary disease, 2013, Volume: 8 Topics: Acetylcysteine; Aged; Airway Resistance; Antioxidants; Computer Simulation; Cross-Over Studies; Female; Forced Expiratory Volume; Functional Residual Capacity; Glutathione; Glutathione Peroxidase; Humans; Lung; Male; Middle Aged; Models, Biological; Multidetector Computed Tomography; Oxidative Stress; Phenotype; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Time Factors; Treatment Outcome	2013
Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:3 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; China; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Free Radical Scavengers; Humans; Male; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Treatment Outcome; Vital Capacity	2014
Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD. Chest, 2014, Volume: 146, Issue:3 Topics: Acetylcysteine; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Free Radical Scavengers; Hong Kong; Humans; Male; Physical Endurance; Pulmonary Disease, Chronic Obstructive; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2014
N-acetylcysteine in patients with COPD exacerbations associated with increased sputum. Wiener klinische Wochenschrift, 2015, Volume: 127, Issue:7-8 Topics: Acetylcysteine; Aged; Double-Blind Method; Expectorants; Female; Humans; Male; Placebo Effect; Pulmonary Disease, Chronic Obstructive; Sputum; Treatment Outcome	2015
Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients. Journal of nutritional science and vitaminology, 2016, Volume: 62, Issue:1 Topics: Acetylcysteine; Adult; Aged; Antioxidants; Ascorbic Acid; Body Mass Index; Dietary Carbohydrates; Dietary Supplements; Glutathione; Humans; Malaysia; Male; Middle Aged; Nutritional Status; Pulmonary Disease, Chronic Obstructive; Single-Blind Method; Treatment Outcome; Vitamin A	2016
High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial. International journal of chronic obstructive pulmonary disease, 2016, Volume: 11 Topics: Acetylcysteine; Aged; Bronchitis, Chronic; Double-Blind Method; Female; Health Status; Humans; Male; Pulmonary Disease, Chronic Obstructive; Treatment Failure	2016
The effect of different treatment modalities on oxidative stress in COPD. Advances in therapy, 2008, Volume: 25, Issue:7 Topics: Acetylcysteine; Adrenergic beta-Antagonists; Aged; Drug Therapy, Combination; Female; Free Radical Scavengers; Glucocorticoids; Humans; Ipratropium; Male; Malondialdehyde; Methylprednisolone; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Superoxide Dismutase	2008
Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis. Respiratory medicine, 2009, Volume: 103, Issue:4 Topics: Acetylcysteine; Adult; Aged; Androstadienes; Bronchitis, Chronic; Bronchodilator Agents; Expectorants; Female; Fluticasone; Forced Expiratory Volume; Humans; Male; Middle Aged; Netherlands; Primary Health Care; Pulmonary Disease, Chronic Obstructive; Quality of Life; Smoking; Treatment Outcome	2009
Effect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled study. Chest, 2009, Volume: 136, Issue:2 Topics: Acetylcysteine; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Probability; Pulmonary Disease, Chronic Obstructive; Reference Values; Respiratory Function Tests; Risk Assessment; Severity of Illness Index; Total Lung Capacity; Treatment Outcome	2009
High-dose N-acetylcysteine in the prevention of COPD exacerbations: rationale and design of the PANTHEON Study. COPD, 2013, Volume: 10, Issue:2 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Disease Progression; Double-Blind Method; Expectorants; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Research Design; Time Factors; Vital Capacity	2013
High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest, 2013, Volume: 144, Issue:1 Topics: Acetylcysteine; Aged; Aged, 80 and over; Antioxidants; Asian People; Dose-Response Relationship, Drug; Double-Blind Method; Dyspnea; Female; Hong Kong; Humans; Incidence; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Surveys and Questionnaires; Treatment Outcome; Walking	2013
Does oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease? American journal of respiratory and critical care medicine, 2004, May-01, Volume: 169, Issue:9 Topics: Acetylcysteine; Administration, Oral; Aged; Antioxidants; Biological Availability; Cross-Over Studies; Double-Blind Method; Drug Monitoring; Forced Expiratory Volume; Humans; Lipid Peroxidation; Male; Middle Aged; Muscle, Skeletal; Oxidative Stress; Physical Endurance; Pulmonary Disease, Chronic Obstructive; Thigh; Thiobarbituric Acid Reactive Substances; Time Factors; Treatment Outcome; Vital Capacity	2004
Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD. Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:1 Topics: Acetylcysteine; Administration, Oral; Aged; Breath Tests; Drug Administration Schedule; Exhalation; Female; Humans; Hydrogen Peroxide; Male; Pulmonary Disease, Chronic Obstructive; Spirometry; Time Factors	2005
New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56 Suppl 4 Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Androstadienes; Anti-Inflammatory Agents; Antioxidants; Double-Blind Method; Eosinophil Cationic Protein; Expectorants; Female; Fluticasone; Forced Expiratory Volume; Glutathione Peroxidase; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Male; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Sputum; Treatment Outcome	2005
Oxygen therapy at low flow causes oxidative stress in chronic obstructive pulmonary disease: Prevention by N-acetyl cysteine. Free radical research, 2005, Volume: 39, Issue:10 Topics: Acetylcysteine; Blood Proteins; Erythrocytes; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen Inhalation Therapy; Pulmonary Disease, Chronic Obstructive	2005
Quality control of spirometry: a lesson from the BRONCUS trial. The European respiratory journal, 2005, Volume: 26, Issue:6 Topics: Acetylcysteine; Aged; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality Control; Reference Values; Respiratory Function Tests; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Spirometry	2005
Increased hydrogen peroxide concentration in the exhaled breath condensate of stable COPD patients after nebulized N-acetylcysteine. Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:3 Topics: Acetylcysteine; Aged; Analysis of Variance; Breath Tests; Cross-Over Studies; Double-Blind Method; Exhalation; Expectorants; Expiratory Reserve Volume; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Hydrogen Peroxide; Male; Middle Aged; Nebulizers and Vaporizers; Nitrates; Nitrites; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Sulfhydryl Compounds	2007
The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design. BRONCUS-trial Committee. The European respiratory journal, 2001, Volume: 17, Issue:3 Topics: Acetylcysteine; Cost-Benefit Analysis; Double-Blind Method; Expectorants; Female; Follow-Up Studies; Forced Expiratory Volume; Functional Residual Capacity; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Randomized Controlled Trials as Topic; Spirometry; Vital Capacity	2001

Other Studies

52 other study(ies) available for acetylcysteine and Airflow Obstruction, Chronic

Article	Year
N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN- Computational and mathematical methods in medicine, 2021, Volume: 2021 Topics: Acetylcysteine; Aged; Animals; Case-Control Studies; Computational Biology; Cytokines; Disease Models, Animal; Female; Humans; Interferon-gamma; Interleukin-18; Killer Cells, Natural; Lung; Macrophages; Male; Mice; Mice, Inbred C57BL; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Disease, Chronic Obstructive	2021
A combination of N-acetyl cysteine and propolis attenuates oxidative-inflammatory parameters during COPD exacerbation. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:7 Topics: Acetylcysteine; Antioxidants; Aryldialkylphosphatase; Biomarkers; Humans; Oxidation-Reduction; Oxidative Stress; Propolis; Pulmonary Disease, Chronic Obstructive; Serum Albumin	2022
EFFICIENT COMPREHENSIVE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION AND POSTCOVIDAL SYNDROME IN ELDERLY PATIENTS. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2022, Volume: 75, Issue:6 Topics: Acetylcysteine; Aged; COVID-19; COVID-19 Drug Treatment; Glycine; Humans; Middle Aged; Pulmonary Disease, Chronic Obstructive; Quality of Life; Sodium Chloride	2022
Efficacy of treatment with N-acetylcysteine inhalation for AECOPD: A propensity-score-matched cohort study. The clinical respiratory journal, 2023, Volume: 17, Issue:10 Topics: Acetylcysteine; Cohort Studies; Disease Progression; Humans; Propensity Score; Pulmonary Disease, Chronic Obstructive; Retrospective Studies	2023
N-acetycysteine: A potential therapeutic agent in COVID-19 infection. Medical hypotheses, 2020, Volume: 144 Topics: Acetylcysteine; Antioxidants; COVID-19 Drug Treatment; Glutathione; Humans; Oxidation-Reduction; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Respiratory Distress Syndrome	2020
Clinical value of N-acetylcysteine combined with terbutaline sulfate in elderly patients with chronic obstructive pulmonary disease and its effect on apoptosis/anti-apoptosis mechanism. Annals of palliative medicine, 2020, Volume: 9, Issue:5 Topics: Acetylcysteine; Aged; Apoptosis; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Terbutaline	2020
Use of mucolytics in COPD: A Delphi consensus study. Respiratory medicine, 2020, Volume: 175 Topics: Acetylcysteine; Carbocysteine; Consensus; Drug Therapy, Combination; Expectorants; Female; Health Status; Humans; Internationality; Male; Practice Guidelines as Topic; Pulmonary Disease, Chronic Obstructive; Surveys and Questionnaires; Symptom Flare Up; Thioglycolates; Thiophenes; Treatment Outcome	2020
S-Allylmercapto-N-acetylcysteine ameliorates elastase-induced chronic obstructive pulmonary disease in mice via regulating autophagy. Biochemical and biophysical research communications, 2021, 07-12, Volume: 562 Topics: A549 Cells; Acetylcysteine; Allyl Compounds; Animals; Autophagy; Disease Models, Animal; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Pancreatic Elastase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Disease, Chronic Obstructive; Swine; TOR Serine-Threonine Kinases; Up-Regulation; Weight Loss	2021
Effects of N-acetyl-L-cysteine on the membrane vesicle release and growth of respiratory pathogens. FEMS microbiology letters, 2017, 05-01, Volume: 364, Issue:9 Topics: Acetylcysteine; Anti-Bacterial Agents; Bacteria; Cytoplasmic Vesicles; Expectorants; Haemophilus influenzae; Humans; Macrophages; Moraxella catarrhalis; Pseudomonas aeruginosa; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections; Streptococcus pneumoniae	2017
N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103 Topics: Acetylcysteine; Biological Availability; Bronchi; Disease Progression; Female; Humans; Inflammation; Lipopolysaccharides; Male; Middle Aged; Models, Biological; Neurokinin A; Oxidative Stress; Protective Agents; Pulmonary Disease, Chronic Obstructive; Regression Analysis	2018
N-acetylcysteine (NAC) in COPD: benefits often lost in trials. QJM : monthly journal of the Association of Physicians, 2019, May-01, Volume: 112, Issue:5 Topics: Acetylcysteine; Clinical Trials as Topic; Humans; Oxidative Stress; Pulmonary Disease, Chronic Obstructive	2019
An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases. American journal of respiratory and critical care medicine, 2019, 01-15, Volume: 199, Issue:2 Topics: Acetylcysteine; Animals; Asthma; Cystic Fibrosis; Disease Models, Animal; Dithiothreitol; Expectorants; Humans; In Vitro Techniques; Male; Mice; Mucociliary Clearance; Mucus; Pulmonary Disease, Chronic Obstructive	2019
The effect of diesel emission exposure on primary human bronchial epithelial cells from a COPD cohort: N-acetylcysteine as a potential protective intervention. Environmental research, 2019, Volume: 170 Topics: Acetylcysteine; Antioxidants; Epithelial Cells; Humans; Particulate Matter; Pulmonary Disease, Chronic Obstructive; Vehicle Emissions	2019
The COPD Pipeline XXI. COPD, 2013, Volume: 10, Issue:2 Topics: Acetylcysteine; Clinical Trials as Topic; Cyclosporine; Drug Discovery; Humans; Orphan Drug Production; Pulmonary Disease, Chronic Obstructive; Research Design; Research Report; Rosiglitazone; Thiazolidinediones	2013
Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model. PloS one, 2013, Volume: 8, Issue:11 Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Apoptosis; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Deoxyguanosine; Disease Models, Animal; Emphysema; Expectorants; Gene Expression; Lung; Malondialdehyde; Mice; Ozone; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests	2013
[N-acetylcysteine reduces exacerbation frequency in COPD]. Praxis, 2013, Nov-27, Volume: 102, Issue:24 Topics: Acetylcysteine; Antioxidants; Asian People; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive	2013
N-Acetylcysteine Protection in COPD: An Alternative Mechanism of Action. Chest, 2014, Volume: 145, Issue:1 Topics: Acetylcysteine; Antioxidants; Asian People; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive	2014
Response. Chest, 2014, Volume: 145, Issue:1 Topics: Acetylcysteine; Antioxidants; Asian People; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive	2014
High-dose N-acetylcysteine in chronic obstructive pulmonary disease, prone positioning in acute respiratory distress syndrome, and continuous positive airway pressure and exhaled nitric oxide in obstructive sleep apnea. American journal of respiratory and critical care medicine, 2014, 01-15, Volume: 189, Issue:2 Topics: Acetylcysteine; Continuous Positive Airway Pressure; Free Radical Scavengers; Humans; Nitric Oxide; Prone Position; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Sleep Apnea, Obstructive	2014
N-acetylcysteine in COPD may be beneficial, but for whom? The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:3 Topics: Acetylcysteine; Female; Free Radical Scavengers; Humans; Male; Pulmonary Disease, Chronic Obstructive	2014
N-acetylcysteine for COPD: the evidence remains inconclusive. The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:4 Topics: Acetylcysteine; Female; Free Radical Scavengers; Humans; Male; Pulmonary Disease, Chronic Obstructive	2014
N-acetylcysteine for COPD: the evidence remains inconclusive--authors' reply. The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:4 Topics: Acetylcysteine; Female; Free Radical Scavengers; Humans; Male; Pulmonary Disease, Chronic Obstructive	2014
2014 American Thoracic Society International Conference. The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:7 Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Asthma; Congresses as Topic; Eosinophilia; Expectorants; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Idiopathic Pulmonary Fibrosis; Indoles; Lung Neoplasms; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyridones; Respiratory Distress Syndrome	2014
[The efficacy of N-acetylcysteine of pneumoconiosis patients in taye III with chronic obstructive pulmonary disease]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2015, Volume: 33, Issue:1 Topics: Acetylcysteine; Humans; Pneumoconiosis; Pulmonary Disease, Chronic Obstructive; Treatment Outcome	2015
[Cigarette smoke extract induces senescence of murine skeletal muscle cells by oxidative stress-induced down-regulation of histone deacetylase 2]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2015, Volume: 31, Issue:5 Topics: Acetylcysteine; Animals; beta-Galactosidase; Cell Line; Cellular Senescence; Down-Regulation; Histone Deacetylase 2; Mice; Muscle, Skeletal; Nicotiana; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; RNA, Messenger; Smoke	2015
Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes. International journal of chronic obstructive pulmonary disease, 2015, Volume: 10 Topics: Acetylcysteine; Aged; Antioxidants; Disease Progression; Drug Administration Schedule; Epoxide Hydrolases; Female; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Pulmonary Disease, Chronic Obstructive; Recovery of Function; Severity of Illness Index; Spirometry; Surveys and Questionnaires; Time Factors; Treatment Outcome	2015
Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells. Respiratory investigation, 2015, Volume: 53, Issue:4 Topics: Acetylcysteine; Antibodies; Antioxidants; Bronchi; Cell Line, Tumor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Ligands; Molecular Targeted Therapy; Mucin 5AC; Nicotiana; Oxidative Stress; Phosphorylation; Poly I-C; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smoke; Toll-Like Receptor 3; Virus Diseases	2015
Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter. Drug design, development and therapy, 2015, Volume: 9 Topics: Acetylcysteine; Administration, Oral; Aged; Alleles; DNA; Dose-Response Relationship, Drug; Female; Genotype; Heme Oxygenase-1; Humans; Male; Microsatellite Repeats; Polymorphism, Genetic; Promoter Regions, Genetic; Pulmonary Disease, Chronic Obstructive	2015
S-allylmercapto-l-cysteine modulates MUC5AC and AQP5 secretions in a COPD model via NF-кB signaling pathway. International immunopharmacology, 2016, Volume: 39 Topics: Acetylcysteine; Allyl Compounds; Aquaporin 5; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelial Cells; Garlic; Gene Expression Regulation; Humans; Lipopolysaccharides; Mucin 5AC; NF-kappa B; Pulmonary Disease, Chronic Obstructive; Signal Transduction	2016
Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation. Respiratory research, 2017, 01-24, Volume: 18, Issue:1 Topics: Acetylcysteine; Aged; Airway Resistance; Anti-Inflammatory Agents; Antioxidants; Disease Progression; Female; Humans; Lung; Male; Organ Culture Techniques; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Treatment Outcome	2017
Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione. American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 295, Issue:4 Topics: Acetylcysteine; Cell Death; Fibroblasts; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase-1; Humans; Inflammation; Lung; NF-E2 Transcription Factor; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Smoke	2008
Simultaneous detection of N-acetyl-L-cysteine and physiological low molecular mass thiols in plasma by capillary electrophoresis. Amino acids, 2009, Volume: 37, Issue:2 Topics: Acetylcysteine; Electrophoresis, Capillary; Expectorants; Humans; Molecular Weight; Pulmonary Disease, Chronic Obstructive; Sulfhydryl Compounds	2009
Compatibility and aerosol characteristics of formoterol fumarate mixed with other nebulizing solutions. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:10 Topics: Acetylcysteine; Aerosols; Anti-Asthmatic Agents; Bronchodilator Agents; Budesonide; Chromatography, High Pressure Liquid; Cromolyn Sodium; Drug Incompatibility; Drug Stability; Ethanolamines; Expectorants; Formoterol Fumarate; Humans; Hydrogen-Ion Concentration; Ipratropium; Nebulizers and Vaporizers; Osmolar Concentration; Particle Size; Pulmonary Disease, Chronic Obstructive; Time Factors	2008
Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells. International journal of chronic obstructive pulmonary disease, 2008, Volume: 3, Issue:3 Topics: Acetylcysteine; Biological Transport; Bronchi; Bronchodilator Agents; Budesonide; Cholinergic Antagonists; Drug Resistance, Multiple; Epithelial Cells; Ethanolamines; Expectorants; Flow Cytometry; Formoterol Fumarate; Humans; In Vitro Techniques; Ipratropium; Multidrug Resistance-Associated Proteins; Oxidative Stress; Pulmonary Disease, Chronic Obstructive	2008
Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats. Respirology (Carlton, Vic.), 2009, Volume: 14, Issue:3 Topics: Acetylcysteine; Administration, Oral; Animals; Antioxidants; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Male; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Rats; Rats, Sprague-Dawley; Smoking; Vascular Endothelial Growth Factor A	2009
Plastic bronchitis as an unusual cause of mucus plugging in cystic fibrosis. Pediatric pulmonology, 2009, Volume: 44, Issue:9 Topics: Acetylcysteine; Administration, Inhalation; Bronchitis; Child, Preschool; Cystic Fibrosis; Expectorants; Humans; Male; Mucus; Pulmonary Disease, Chronic Obstructive	2009
Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:4 Topics: Acetylcysteine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Aged; Bronchoalveolar Lavage; Cell Proliferation; Cyclic AMP; Cytokines; Down-Regulation; Female; Free Radical Scavengers; Gene Knockdown Techniques; Humans; Macrophages, Alveolar; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Receptor, Adenosine A2B; RNA, Small Interfering; Smoking; U937 Cells; Vasodilator Agents	2010
N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV). Biochemical pharmacology, 2011, Sep-01, Volume: 82, Issue:5 Topics: Acetylcysteine; Cell Line; Humans; Inflammation Mediators; Influenza A virus; Influenza B virus; Mucin 5AC; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Respiratory Syncytial Viruses; Virus Replication	2011
[Anti-inflammatory efficacy of N-acetylcysteine and therapeutic usefulness]. Pneumologie (Stuttgart, Germany), 2011, Volume: 65, Issue:9 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arthritis; Bronchitis; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Expectorants; Free Radical Scavengers; Humans; Lung Diseases; Lung Diseases, Interstitial; Pulmonary Disease, Chronic Obstructive	2011
Neutrophil activation in severe, early-onset COPD patients versus healthy non-smoker subjects in vitro: effects of antioxidant therapy. Respiration; international review of thoracic diseases, 2012, Volume: 83, Issue:2 Topics: Acetylcysteine; Apoptosis; Case-Control Studies; Chemotaxis; Female; Free Radical Scavengers; Humans; Interleukin-8; Leukocyte Elastase; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Sulfhydryl Compounds	2012
Neutrophil-mediated lung damage: a new COPD phenotype? Respiration; international review of thoracic diseases, 2012, Volume: 83, Issue:2 Topics: Acetylcysteine; Female; Free Radical Scavengers; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Pulmonary Disease, Chronic Obstructive	2012
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:5 Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adult; Antigens, CD34; Asthma; Blood Cells; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Collagen Type I; ErbB Receptors; Female; Fibroblasts; Follow-Up Studies; Gefitinib; Humans; Hydrogen Peroxide; Leukocyte Common Antigens; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Function Tests; Signal Transduction; Stem Cells; Tyrphostins	2012
Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine. PloS one, 2012, Volume: 7, Issue:10 Topics: Acetylcysteine; Antiviral Agents; Axonemal Dyneins; Bronchi; Cell Differentiation; Cells, Cultured; Cilia; Epithelial Cells; Forkhead Transcription Factors; Free Radical Scavengers; Gene Expression Regulation; Humans; Interleukin-13; Microscopy, Video; Mucin 5AC; Pulmonary Disease, Chronic Obstructive; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Tubulin; Virus Replication	2012
[Is systemic administration of N-acetylcysteine effective?]. Deutsche medizinische Wochenschrift (1946), 2003, Mar-21, Volume: 128, Issue:12 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Overdose; Expectorants; Humans; Injections, Intravenous; Pulmonary Disease, Chronic Obstructive	2003
N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. The European respiratory journal, 2003, Volume: 21, Issue:5 Topics: Acetylcysteine; Administration, Oral; Aged; Dose-Response Relationship, Drug; Expectorants; Female; Hospitalization; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive	2003
N-acetylcysteine is unlikely to reduce hospitalisation for chronic obstructive pulmonary disease. The European respiratory journal, 2003, Volume: 22, Issue:5 Topics: Acetylcysteine; Expectorants; Humans; Patient Readmission; Pulmonary Disease, Chronic Obstructive	2003
[Influence of N-acetylcysteine on the cytokines and matrix metalloproteinases in chronic obstructive pulmonary disease rat models]. Zhonghua nei ke za zhi, 2004, Volume: 43, Issue:8 Topics: Acetylcysteine; Animals; Disease Models, Animal; Interferon-gamma; Interleukin-4; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 9; Metalloendopeptidases; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-1; Tobacco Smoke Pollution	2004
Pathogenesis of cigarette smoke-induced chronic obstructive pulmonary disease and therapeutic effects of glucocorticoids and N-acetylcysteine in rats. Chinese medical journal, 2004, Volume: 117, Issue:11 Topics: Acetylcysteine; Animals; Forced Expiratory Volume; Glucocorticoids; Interferon-gamma; Interleukin-4; Lung; Male; Matrix Metalloproteinase 12; Metalloendopeptidases; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Wistar; Smoking; Tissue Inhibitor of Metalloproteinase-1; Vital Capacity	2004
[Efficacy of nebulizer therapy with acetylcystein in outpatients with chronic obstructive lung disease]. Klinicheskaia meditsina, 2005, Volume: 83, Issue:4 Topics: Acetylcysteine; Administration, Inhalation; Adult; Exercise Tolerance; Follow-Up Studies; Forced Expiratory Volume; Humans; Middle Aged; Nebulizers and Vaporizers; Outpatients; Pulmonary Disease, Chronic Obstructive; Treatment Outcome	2005
N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3 Topics: Acetylcysteine; Antioxidants; Cells, Cultured; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Macrophages, Alveolar; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Pulmonary Disease, Chronic Obstructive; Pyrrolidines; Thiocarbamates; Tumor Necrosis Factor-alpha	2006
[Cell oxidative processes and antioxidant mucoactive drugs]. Archivos de bronconeumologia, 2001, Volume: 37, Issue:10 Topics: Acetylcysteine; Animals; Expectorants; Free Radical Scavengers; Humans; Models, Animal; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Rats; Smoking	2001
Acute exacerbations of chronic obstructive pulmonary disease. Annals of internal medicine, 2002, Apr-02, Volume: 136, Issue:7 Topics: Acetylcysteine; Evidence-Based Medicine; Expectorants; Humans; Pulmonary Disease, Chronic Obstructive	2002