acetylcysteine and Aging

acetylcysteine has been researched along with Aging in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (4.81)	18.7374
1990's	14 (13.46)	18.2507
2000's	40 (38.46)	29.6817
2010's	35 (33.65)	24.3611
2020's	10 (9.62)	2.80

Authors

Authors	Studies
Huang, J; Huang, Y; Li, J; Ma, L; Su, L; Tang, Y; Wang, R; Wu, YH; Yang, GX; Zhang, L; Zheng, LL; Zhou, LC	1
Bosch, RJ; Cook, A; Delgado-Marín, M; Mínguez-Moratinos, M; Moreno-Gómez-Toledano, R; Ramírez-Carracedo, R; Reventún, P; Sánchez-Esteban, S; Saura, M	1
Kim, UJ; Lee, KH	1
Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE	1
Cui, Y; Flaker, GC; Hao, H; Jiang, M; Liu, Q; Liu, X; Liu, Z; Xiao, Y; Zhou, S; Zhu, Q	1
Abrigo, J; Aguirre, F; Arrese, M; Cabello-Verrugio, C; Cabrera, D; Marín, T; Simon, F; Tacchi, F; Vilos, C	1
Kacena, MA; Orschell, CM; Pelus, LM; Singh, P	1
Hashimoto, M; Kawaguchi, K; Sugimoto, M	1
Chen, G; Guo, Q; Guo, W; Tian, W; Xu, M; Xu, Y; Yang, Y; Zhang, Y; Zheng, J	1
Chacko, S; Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, C; Sekhar, RV	1
Eremina, S; Gautier, L; Gusarov, I; Katkova-Zhukotskaya, O; Makarov, AА; Mironov, A; Nudler, E; Pani, B; Shamovsky, I	1
Cieslik, KA; Entman, ML; Granillo, A; Gupte, AA; Hamilton, DJ; Heredia, CP; Li, S; Medrano, G; Reddy, A; Reineke, E; Sekhar, RV; Taffet, GE; Zhang, A	1
Aldunate, R; Alfaro, IE; Arriagada, H; Bravo-Zehnder, M; Minniti, AN; Zúñiga, S	1
Forster, MJ; Ikonne, US; Sumien, N; Vann, PH; Wong, JM	1
Fan, LH; Hou, Y; Jing, Y; Li, J; Li, L; Ouyang, YC; Sun, QY; Wang, Y; Wang, ZB	1
Jung, JU; Mei, L; Shi, XM; Shun, C; Xia, WF; Xiong, L; Xiong, S; Xiong, WC	1
Chen, BY; Chen, LW; Duan, L; Gao, GD; Sun, XL; Wang, JJ; Xia, Y; Yung, KK	1
Bagh, MB; Banerjee, P; Chakrabarti, S; Chattopadhyay, S; Ghosh, A; Sahoo, A; Thakurta, IG	1
Hong, W; Lin, F; Liu, D; Lu, L; Wang, S; Xu, A; Zhou, M; Zhu, Y	1
Chang, NS; Chen, BH; Cheng, NW; Chu, CY; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH	1
Chen, H; Guo, Y; Li, L; Li, N; Liu, R; Wang, L; Xia, Y; Yin, Y; Zhai, H; Zhang, J	1
Oh, SI; Park, JK; Park, SK	1
Le, W; Xiao, Q; Yang, S	1
Banerjee, A; Bhowmick, P; Bir, A; Chakrabarti, S; Sinha, M	1
Martínez-Banaclocha, M	1
Deb, I; Paul, S; Poddar, R; Rajagopal, S	1
Chattopadhyay, S; Khatri, R; Krishnan, S; Kumar, V; Mukhopadhyay, A; Roy, S	1
Bernard, K; Breton, L; Cacho-Valadez, B; Desjardins, D; Hekimi, S; Khaki, A; Liu, JL; Wang, Y; Yee, C	1
Butler, JA; Hagen, TM; Kelley, AR; Shay, KP; Thomas, NO	1
Baker, EH; Levin, SW; Mukherjee, AB; Zhang, Z	1
Bacman, SR; Dillon, LM; Hida, A; Malek, TR; Moraes, CT; Morton, PD; Pickrell, AM; Pinto, M; Wang, X; Williams, SL; Yu, A	1
Grubeck-Loebenstein, B; Koziel, R; Krismer, M; Lair, J; Meryk, A; Naismith, E; Pangrazzi, L; Trieb, K	1
Angerer, J; Boettcher, MI; Drexler, H; Fromme, H; Hartmann, EC; Schettgen, T	1
Aboulkassim, T; Fernandes, P; Hamel, E; Lecrux, C; Nicolakakis, N; Ongali, B; Rosa-Neto, P; Tong, XK	1
Bagh, MB; Chakrabarti, S; Maiti, AK; Roy, A	1
de Diego-Otero, Y; Decara, J; del Arco-Herrera, I; el Bekay, R; Rodriguez-de Fonseca, F; Romero-Zerbo, Y; Sanchez, L	1
Castaño, A; Gavilán, E; Gavilán, MP; Jiménez, S; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J	1
Chen, F; Chen, PS; Fishbein, MC; Garfinkel, A; Karagueuzian, HS; Lin, SF; Mandel, WJ; Morita, N; Qu, Z; Sovari, AA; Weiss, JN; Xie, LH; Xie, Y	1
Endo, T; Hayakawa, M; Hisanaga, S; Miura, Y; Sakurai, Y; Sato, Y; Shimada, Y; Zempel, H	1
Malter, JS; Wang, DS; Wang, R	1
Hsieh, CC; Papaconstantinou, J	1
Fischer, DF; Hobo, B; van Leeuwen, FW; van Tijn, P; Verhage, MC	1
Bae, YS; Jeon, SM; Kim, KJ; Kwon, TK; Lee, SJ	1
Fan, X; Monnier, VM; Nemet, I; Potts, B; Strauch, CM; Xiaoqin, L	1
Artiukhina, ZE; Ekimova, IV; Guzhova, IV; Pastukhov, IuF; Romanova, IV	1
Barbanel, G; Billard, JM; Dutar, P; Haxaire, C; Kervern, M; Mothet, JP; Potier, B; Sinet, PM; Turpin, FR	1
Castaño, A; García-Cuervo, L; Gavilán, E; Gavilán, MP; Gutiérrez, A; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J	1
Broxmeyer, HE; Cooper, S; Fu, XY; Hangoc, G; Mantel, C; Messina-Graham, S; Moh, A	1
Cao, L; Li, L; Zuo, Z	1
Blackwell, JR; Damsgaard, R; Hellsten, Y; Jones, AM; Mortensen, SP; Nyberg, M	1
Kolosova, NG; Muraleva, NA; Skulachev, VP; Stefanova, NA	1
Andrade, L; Campos, R; Canale, D; de Bragança, AC; Sanches, TR; Seguro, AC; Shimizu, MH; Volpini, RA	1
Chung, JH; Eun, HC; Fisher, GJ; Kang, S; Lee, JH; Lee, MK; Seo, JY; Voorhees, JJ	1
Chung, JH; Duell, EA; Fisher, GJ; Kang, S; Lee, JH; Voorhees, JJ; Wan, YS	1
Bershtein, LM; Gamayunova, VB; Kovalenko, IG; Poroshina, TE; Rozanov, YM; Tsyrlina, EV; Vasil'ev, DA	1
Contestabile, A; Monti, B; Virgili, M	1
Dai, J; Ershler, WB; Hall, DE; Keller, ET; Lu, Y; Manolagas, SC; Murtha, JM; O'Brien, CA; Qi, W; Yao, Z; Zhang, J	1
Bershteĭn, LM; Kovalenko, IG; Poroshina, TE; Tsyrlina, EV; Vasil'ev, DA	1
Kishimoto, C; Miyamoto, M; Nakamura, H; Nimata, M; Yodoi, J	1
Chung, HY; Je, JH; Jung, KJ; Lee, JY; Yu, BP	1
Cocco, T; Di Paola, M; Grattagliano, I; Moschetta, A; Palasciano, G; Palmieri, VO; Portincasa, P	1
Clemente, M; Cocco, T; Di Paola, M; Grattagliano, I; Lopriore, B; Sgobbo, P; Villani, G	1
Morrison, DC; Papasian, CJ; Qureshi, AA; Qureshi, N; Van Way, C; Vogel, SN	1
Fisher, PB; Sarkar, D	1
Aunan, ES; Coleman, MC; Kregel, KC; Morrison, JP; Spitz, DR; Walsh, SA	1
Han, YH; Kim, HS; Kim, JM; Kim, SK; Moon, EY; Yu, DY	1
Dobesová, Z; Jendeková, L; Kojsová, S; Kunes, J; Pechánová, O; Zicha, J	1
Aoyama, K; Chan, WY; Chen, Y; Hamby, AM; Liu, J; Suh, SW; Swanson, RA	1
Kim, CH; Kwon, TK; Lee, JT; Lee, TJ; Moon, SK; Park, JW	1
Basile, I; Bonafe', F; Caldarera, CM; Carboni, M; Farruggia, G; Gamberini, C; Giordano, E; Guarnieri, C; Muscari, C; Stanic, I	1
Alagramam, KN; Canlon, B; Davis, RR; Krieg, E; Kuo, MW; Stanton, SG	1
Fujii, N; Hamamoto, T; Kagawa, Y; Kinouchi, T; Nishio, H; Nishiuchi, Y; Takada, K; Tsunemi, M	1
Barrett, B; Benko, A; Capusten, B; Fraser-Hill, M; Magner, P; Myers, A; Owen, RJ	1
Gendron, ME; Thorin, E	1
Zhang, J	1
Barajas, B; Kim, HJ; Nel, AE; Wang, M	1
Hook, JB; Ishmael, J; Lock, EA	1
Fischer, LJ; Green, MD	1
De Juan, E; Ferrándiz, ML; Martínez, M; Miquel, J; Sevila, I	1
Appenroth, D	1
Camerino, DC; Tricarico, D	1
Appenroth, D; Winnefeld, K	1
Kawase, M; Kinoshita, C; Murata, H; Nakata, K; Ogata, K; Ogino, S; Ohmori, S; Sakaue, T	1
Allameh, A; Vansoun, EY; Zarghi, A	1
Banaclocha, MM; Ferrándiz, ML; Hernández, AI; Martínez, N	1
Bechter-Thüring, E; Brack, C; Labuhn, M	1
Bärtsch, P; Benner, A; Breitkreutz, R; Dröge, W; Hack, V; Kinscherf, R; Röhrer, H; Taut, F	1
Martínez Banaclocha, M; Martínez, N	1
Correa, R; De la Fuente, M; Del Rio, M; Ferrández, MD	1
Hernández, AI; Martínez, M; Martínez, N	1
De la Fuente, M; Victor, VM	1
Martínez Banaclocha, M	1
Huang, FF; Keller, JN; Markesbery, WR	1
Baggio, G; Barbi, C; Bonafè, M; Botti, B; Capri, M; Cossarizza, A; Franceschi, C; Malorni, W; Monti, D; Piacentini, M; Salvioli, S; Straface, E; Valensin, S	1
Balbeur, L; Dumont, P; Remacle, J; Toussaint, O	1
Cantuti-Castelvetri, I; Denisova, NA; Hassan, WN; Joseph, JA; Paulson, KE	1
Banaclocha, MM	1
Catalán, MP; De La Fuente, M; Guayerbas, N; Miquel, J; Víctor, VM	1
James, SP; Pheasant, AE	1
Dutton, GJ	1
Baines, PJ; Bray, HG; James, SP	1
Tarentini Trojani, F	1
Chen, TS; Lang, CA; Richie, JP	1
Asensi, M; Ferrer, JV; Gascó, E; Pallardó, FV; Sastre, J; Viña, J	1

Reviews

4 review(s) available for acetylcysteine and Aging

Article	Year
Cysteine Network (CYSTEINET) Dysregulation in Parkinson's Disease: Role of N-acetylcysteine. Current drug metabolism, 2016, Volume: 17, Issue:4 Topics: Acetylcysteine; Aging; Amino Acid Transport System y+; Brain; Cysteine; Energy Metabolism; Glutathione; Homeostasis; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Parkinson Disease; Protein Processing, Post-Translational; Reactive Oxygen Species	2016
The proteasome: a central regulator of inflammation and macrophage function. Immunologic research, 2005, Volume: 31, Issue:3 Topics: Acetylcysteine; Aging; Animals; Atherosclerosis; Cholesterol; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Shock, Hemorrhagic; Signal Transduction; Toll-Like Receptor 2	2005
Molecular mechanisms of aging-associated inflammation. Cancer letters, 2006, May-08, Volume: 236, Issue:1 Topics: Acetylcysteine; Aging; Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cellular Senescence; Chemokines; Cytokines; Enzyme Inhibitors; Exoribonucleases; Free Radicals; Humans; Inflammation; Neurodegenerative Diseases; NF-kappa B; Reactive Oxygen Species	2006
Developmental aspects of drug conjugation, with special reference to glucuronidation. Annual review of pharmacology and toxicology, 1978, Volume: 18 Topics: Acetylation; Acetylcysteine; Acylation; Aging; Amino Acids; Animals; Chick Embryo; Enzyme Induction; Fetus; Glucuronates; Glucuronosyltransferase; Glutathione; Glutathione Transferase; Glycosides; Humans; Liver; Methylation; Pharmaceutical Preparations; Sulfates; Uridine Diphosphate Glucuronic Acid	1978

Trials

3 trial(s) available for acetylcysteine and Aging

Article	Year
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 2023, 01-26, Volume: 78, Issue:1 Topics: Acetylcysteine; Aged; Aging; Animals; Dietary Supplements; Glutathione; Glycine; Health Promotion; Humans; Inflammation; Insulin Resistance; Mice; Mitochondria; Oxidative Stress	2023
Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. The Journal of physiology, 2012, Nov-01, Volume: 590, Issue:21 Topics: Acetylcholine; Acetylcysteine; Adult; Aged; Aging; Antioxidants; Femoral Artery; Humans; Leg; Male; Middle Aged; Motor Activity; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Norepinephrine; Regional Blood Flow; Young Adult	2012
The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention. Blood, 1998, Jul-01, Volume: 92, Issue:1 Topics: Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cell Death; Child; Child, Preschool; Cystine; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Neoplasms; Oxidation-Reduction; Serum Albumin; Sulfhydryl Compounds	1998

Other Studies

97 other study(ies) available for acetylcysteine and Aging

Article	Year
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. European journal of medicinal chemistry, 2020, Feb-01, Volume: 187 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Carbamates; Cell Line, Tumor; Cell Survival; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Galactose; Humans; Inflammation; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Protein Aggregates; Structure-Activity Relationship	2020
Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium. Biomolecules, 2021, 09-29, Volume: 11, Issue:10 Topics: Acetylcysteine; Activating Transcription Factor 4; Aging; Animals; Aorta; Apoptosis; Benzhydryl Compounds; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; eIF-2 Kinase; Endothelium; Mice; Necroptosis; Oxidative Stress; Phenols; Transcription Factor CHOP	2021
Neuroprotective effects of N-acetylcysteine amide against oxidative injury in an aging model of organotypic hippocampal slice cultures. Neuroreport, 2022, 03-02, Volume: 33, Issue:4 Topics: Acetylcysteine; Aging; Animals; Hippocampus; Neuroprotective Agents; Oxidative Stress; Rats	2022
N-acetylcysteine attenuates atherosclerosis progression in aging LDL receptor deficient mice with preserved M2 macrophages and increased CD146. Atherosclerosis, 2022, Volume: 357 Topics: Acetylcysteine; Aging; Animals; Atherosclerosis; CD146 Antigen; Diet, High-Fat; Hyperlipidemias; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reactive Oxygen Species; Receptors, LDL	2022
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease. Current molecular medicine, 2019, Volume: 20, Issue:1 Topics: Acetylcysteine; Aging; Animals; Apoptosis; Disease Models, Animal; End Stage Liver Disease; Humans; Mice; Muscle Fibers, Skeletal; Muscular Atrophy; Oxidative Stress; Pyridines; Sarcopenia	2019
Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. Stem cell reviews and reports, 2020, Volume: 16, Issue:4 Topics: Acetylcysteine; Aging; Animals; Cell Count; Cell Cycle; Cells, Cultured; Clone Cells; Colony-Forming Units Assay; Free Radical Scavengers; Hematopoietic Stem Cells; Mesenchymal Stem Cells; Mice, Inbred C57BL; Phenotype; Reactive Oxygen Species; Receptors, CXCR4	2020
An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice. Biochemical and biophysical research communications, 2021, 02-19, Volume: 541 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Down-Regulation; Female; Gene Expression Profiling; Lung; Mice; Mice, Inbred C57BL; Oxidative Stress	2021
The Dual Effects of Reactive Oxygen Species on the Mandibular Alveolar Bone Formation in SOD1 Knockout Mice: Promotion or Inhibition. Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Acetylcysteine; Aging; Alveolar Process; Animals; Antioxidants; Jaw; Mandible; Mice, Knockout; Osteoclasts; Osteogenesis; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase-1; X-Ray Microtomography	2021
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Re Clinical and translational medicine, 2021, Volume: 11, Issue:3 Topics: Acetylcysteine; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Dietary Supplements; DNA Damage; Endothelium; Female; Free Radical Scavengers; Geriatric Assessment; Glutathione; Glycine; Glycine Agents; Humans; Inflammation; Insulin Resistance; Male; Mitochondria; Muscle Strength; Oxidative Stress; Pilot Projects; Young Adult	2021
Dietary thiols accelerate aging of C. elegans. Nature communications, 2021, 07-15, Volume: 12, Issue:1 Topics: Acetylcysteine; Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dietary Supplements; DNA-Binding Proteins; Escherichia coli; Female; Fibroblasts; Gene Expression Regulation; Glutathione; Humans; Male; Paraquat; Reactive Oxygen Species; Sulfhydryl Compounds; Transcription Factors; Unfolded Protein Response	2021
Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors. The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 08-10, Volume: 73, Issue:9 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cardiovascular Physiological Phenomena; Cellular Senescence; Diet Therapy; Dietary Supplements; Glutathione; Glycine; Inflammation; Mice; Mitochondria; Oxidative Stress	2018
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. Aging cell, 2019, Volume: 18, Issue:1 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Down-Regulation; Homeostasis; Insulin; Longevity; Models, Biological; Motor Activity; Mutation; Neurons; Oxidation-Reduction; Reproduction; Signal Transduction; Time Factors	2019
Supplementation with N-Acetyl Cysteine Affects Motor and Cognitive Function in Young but Not Old Mice. The Journal of nutrition, 2019, 03-01, Volume: 149, Issue:3 Topics: Acetylcysteine; Aging; Animal Feed; Animals; Cognition; Diet; Dietary Supplements; Memory; Mice; Motor Activity; Spatial Learning	2019
N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse. Aging, 2019, 04-12, Volume: 11, Issue:7 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cellular Senescence; Cytoplasmic Granules; Female; Mice; Mice, Inbred ICR; Mitochondria; Oocytes; Ovulation; Reactive Oxygen Species; Spindle Apparatus; Time-Lapse Imaging	2019
Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013, Volume: 28, Issue:10 Topics: Acetylcysteine; Acid Phosphatase; Adipogenesis; Aging; Amyloid beta-Peptides; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Cell Differentiation; Cell Lineage; Cells, Cultured; Cricetinae; Humans; Isoenzymes; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Organ Size; Osteoblasts; Osteogenesis; Osteoporosis; Tartrate-Resistant Acid Phosphatase	2013
Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults. International journal of molecular sciences, 2013, Jul-08, Volume: 14, Issue:7 Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Aging; Animals; Anti-Bacterial Agents; Apoptosis; Dopaminergic Neurons; Nerve Growth Factor; Nerve Tissue Proteins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase	2013
Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats. Experimental gerontology, 2014, Volume: 50 Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Calcium; Dietary Supplements; Drug Evaluation, Preclinical; Drug Therapy, Combination; Learning Disabilities; Maze Learning; Membrane Potentials; Memory Disorders; Oxidative Stress; Potassium; Rats; Sodium; Synaptosomes; Thioctic Acid	2014
Interferon-γ induces senescence in normal human melanocytes. PloS one, 2014, Volume: 9, Issue:3 Topics: Acetylcysteine; Aging; Apoptosis; beta-Galactosidase; Cell Cycle; Cell Cycle Checkpoints; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Humans; Interferon-gamma; Interleukin-6; Iron-Binding Proteins; Janus Kinase 1; Janus Kinase 2; Melanocytes; Phosphorylation; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor; Tumor Suppressor Protein p53	2014
Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases. Neurobiology of disease, 2014, Volume: 71 Topics: Acetylcysteine; Aging; Alzheimer Disease; Animals; Animals, Genetically Modified; Cathepsin B; Cell Movement; Embryo, Nonmammalian; Folic Acid; Folic Acid Deficiency; gamma-Glutamyl Hydrolase; Green Fluorescent Proteins; Hot Temperature; Microtubule-Associated Proteins; Neural Crest; Neural Tube Defects; Oxidative Stress; Time Factors; Zebrafish; Zebrafish Proteins	2014
Aging increases the susceptivity of MSCs to reactive oxygen species and impairs their therapeutic potency for myocardial infarction. PloS one, 2014, Volume: 9, Issue:11 Topics: Acetylcysteine; Aging; Animals; Apoptosis; Cell Adhesion; Free Radical Scavengers; Heart; Hydrogen Peroxide; Integrins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2014
Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo, Brazil), 2015, Volume: 70, Issue:5 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Caenorhabditis elegans; Fertility; Green Fluorescent Proteins; Longevity; Oxidative Stress; Stress, Physiological; Transcription Factors	2015
G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:12 Topics: Acetylcysteine; Aging; Animals; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopaminergic Neurons; Genetic Predisposition to Disease; Mice, Transgenic; Microglia; Motor Activity; Mutation; Neurodegenerative Diseases; Protein Serine-Threonine Kinases; Substantia Nigra; Tyrosine 3-Monooxygenase	2015
Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol. Neurochemistry international, 2016, Volume: 95 Topics: Acetylcysteine; Aging; alpha-Tocopherol; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Dietary Supplements; Drug Therapy, Combination; Maze Learning; Peptide Fragments; Rats; Rats, Wistar; Thioctic Acid	2016
Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP. Neurobiology of aging, 2016, Volume: 41 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Brain; Cells, Cultured; Enzyme Activation; Glutamates; Glutathione; Nervous System Diseases; Neuroprotection; Oxidative Stress; Protein Multimerization; Protein Tyrosine Phosphatases, Non-Receptor; Rats, Sprague-Dawley; Synaptic Transmission	2016
Reactive Oxygen Species Limit the Ability of Bone Marrow Stromal Cells to Support Hematopoietic Reconstitution in Aging Mice. Stem cells and development, 2016, 06-15, Volume: 25, Issue:12 Topics: Acetylcysteine; Aging; Animals; Apoptosis; Bone Marrow Cells; Cellular Senescence; Colony-Forming Units Assay; Curcumin; Gene Expression Regulation; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Mesenchymal Stem Cells; Mice, Inbred C57BL; Myeloid Cells; Reactive Oxygen Species; Stress, Physiological; Stromal Cells	2016
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging cell, 2017, Volume: 16, Issue:1 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Ascorbic Acid; Caenorhabditis elegans; Longevity; Mitochondria; Models, Biological; Mutation; Oxidative Stress; Paraquat; Reactive Oxygen Species; Resveratrol; Stilbenes; Superoxide Dismutase	2017
Glutathione maintenance mitigates age-related susceptibility to redox cycling agents. Redox biology, 2016, Volume: 10 Topics: Acetylcysteine; Aging; Animals; Gene Expression Regulation, Developmental; Glutathione; Glutathione Peroxidase; Hepatocytes; Lipid Peroxidation; Male; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Inbred F344; Vitamin K 3	2016
MRI Brain Volume Measurements in Infantile Neuronal Ceroid Lipofuscinosis. AJNR. American journal of neuroradiology, 2017, Volume: 38, Issue:2 Topics: Acetylcysteine; Aging; Brain; Brain Stem; Cerebellum; Cerebrum; Child; Child, Preschool; Cysteamine; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Magnetic Resonance Imaging; Male; Neuronal Ceroid-Lipofuscinoses; Thalamus	2017
Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner. Cell death and differentiation, 2017, Volume: 24, Issue:2 Topics: Acetylcysteine; Aging; Animals; Apoptosis; Cell Cycle Checkpoints; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Deoxyribonucleases, Type II Site-Specific; DNA Breaks, Double-Stranded; DNA, Mitochondrial; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mifepristone; Phenotype; Reactive Oxygen Species; Thymocytes; Tumor Suppressor Protein p53	2017
"Inflamm-aging" influences immune cell survival factors in human bone marrow. European journal of immunology, 2017, Volume: 47, Issue:3 Topics: Acetylcysteine; Aging; Animals; Ascorbic Acid; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Cytokines; Free Radical Scavengers; Humans; Immunologic Memory; Immunosenescence; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reactive Oxygen Species; Superoxide Dismutase-1	2017
Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population. Journal of agricultural and food chemistry, 2008, Aug-13, Volume: 56, Issue:15 Topics: Acetylcysteine; Acrylamide; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Diet; Epoxy Compounds; Female; Hemoglobins; Humans; Male; Middle Aged; Oxidation-Reduction; Valine	2008
Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Sep-10, Volume: 28, Issue:37 Topics: Acetylcholine; Acetylcysteine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Behavior, Animal; Cerebrovascular Disorders; Disease Models, Animal; Gene Expression Regulation; Humans; Hypoglycemic Agents; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Nitric Oxide Synthase; Peptide Fragments; Pioglitazone; PPAR gamma; Superoxide Dismutase; Thiazolidinediones	2008
Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age related decline in Na(+),K (+)-ATPase activity and associated peroxidative damage in rat brain synaptosomes. Biogerontology, 2008, Volume: 9, Issue:6 Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Dietary Supplements; Female; Free Radical Scavengers; Lipid Peroxidation; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Synaptosomes; Thioctic Acid	2008
Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:4 Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Enzyme Activation; Exploratory Behavior; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; Free Radicals; In Vitro Techniques; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phenotype; Protein Kinase C-alpha; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Stress, Psychological	2009
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition. Aging cell, 2009, Volume: 8, Issue:6 Topics: Acetylcysteine; Aging; Animals; Biomarkers; Caspase 3; Enzyme Inhibitors; Hippocampus; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Signal Transduction; Unfolded Protein Response	2009
Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5 Topics: Acetylcysteine; Action Potentials; Age Factors; Aging; Animals; Antioxidants; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Communication; Computer Simulation; Disease Models, Animal; Electrocardiography; Enzyme Activation; Fibrosis; Heart Ventricles; Hydrogen Peroxide; Male; Models, Cardiovascular; Myocytes, Cardiac; Oxidants; Oxidative Stress; Perfusion; Protein Kinase Inhibitors; Rabbits; Rats; Rats, Inbred F344; Sulfonamides; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation	2009
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:1 Topics: Acetylcysteine; Aging; Animals; Apoptosis; Astrocytes; Biological Transport; Cathepsin D; Cells, Cultured; Cytosol; Lysosomes; Neurons; Oxidative Stress; Proteasome Inhibitors; Rats; Rats, Wistar; tert-Butylhydroperoxide	2010
N-acetylcysteine prevents 4-hydroxynonenal- and amyloid-beta-induced modification and inactivation of neprilysin in SH-SY5Y cells. Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:1 Topics: Acetylcysteine; Aging; Aldehydes; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Enzyme Activation; Humans; Neprilysin; Neuroprotective Agents; Peptide Fragments; Protease Inhibitors	2010
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS). Aging, 2009, Jul-31, Volume: 1, Issue:9 Topics: Acetylcysteine; Activating Transcription Factor 2; Aging; Animals; Antimycin A; Cell Proliferation; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Fibroblasts; Hydrogen Peroxide; Longevity; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mitochondria; Nitro Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propionates; Protein Binding; Reactive Oxygen Species; Rotenone; Skin; Thioredoxins	2009
Low levels of mutant ubiquitin are degraded by the proteasome in vivo. Journal of neuroscience research, 2010, Aug-15, Volume: 88, Issue:11 Topics: Acetylcysteine; Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Immunohistochemistry; Mice; Mice, Transgenic; Proteasome Endopeptidase Complex; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Ubiquitin	2010
NADPH oxidase is involved in protein kinase CKII down-regulation-mediated senescence through elevation of the level of reactive oxygen species in human colon cancer cells. FEBS letters, 2010, Jul-16, Volume: 584, Issue:14 Topics: Acetophenones; Acetylcysteine; Aging; Antioxidants; Casein Kinase II; Cellular Senescence; Colonic Neoplasms; Down-Regulation; Genes, p53; HCT116 Cells; Humans; Hydrogen Peroxide; Mitochondria; NADPH Oxidases; Reactive Oxygen Species; RNA, Small Interfering; Superoxides	2010
Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice. Molecular vision, 2011, Volume: 17 Topics: Acetylcysteine; Administration, Topical; Aging; Animals; Arginine; Ascorbic Acid; Biological Transport, Active; Cataract; Crystallins; Gene Knock-In Techniques; Glycation End Products, Advanced; Guanidines; Humans; Lens, Crystalline; Mass Spectrometry; Mice; Mice, Transgenic; Ophthalmic Solutions; Penicillamine; Rabbits; Sodium-Coupled Vitamin C Transporters; Spectrometry, Fluorescence	2011
[Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:7 Topics: Acetylcysteine; Aging; Animals; Bacterial Proteins; Biotin; Blotting, Western; Catheterization; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Microinjections; Microscopy, Confocal; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase; Ubiquitin; Up-Regulation	2011
Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serine-dependent NMDA receptor activation. Aging cell, 2012, Volume: 11, Issue:2 Topics: Acetylcysteine; Aging; Animals; Hippocampus; Lysine; Male; Neuronal Plasticity; Oxidative Stress; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine	2012
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus. Journal of neuroinflammation, 2012, May-04, Volume: 9 Topics: Acetylcysteine; Aging; Animals; Drug Synergism; Hippocampus; Inflammation; Lipopolysaccharides; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitination	2012
Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood, 2012, Sep-27, Volume: 120, Issue:13 Topics: Acetylcysteine; Aging; Anemia; Animals; Bone Marrow; Cell Differentiation; Cell Proliferation; Cells, Cultured; Erythroid Cells; Female; Free Radical Scavengers; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Oxygen Consumption; Phenotype; Reactive Oxygen Species; Sequence Deletion; STAT3 Transcription Factor	2012
N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice. Neuroscience, 2012, Sep-18, Volume: 220 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Behavior, Animal; Brain; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Transporter 3; Glutathione; Male; Mice; Mice, Knockout; Oxidative Stress	2012
The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats. Aging, 2012, Volume: 4, Issue:10 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Biomarkers; Body Weight; Dehydroepiandrosterone; Growth Hormone; Insulin-Like Growth Factor I; Leukocyte Count; Male; Plastoquinone; Rats; Rats, Wistar; Testosterone	2012
N-acetylcysteine attenuates renal alterations induced by senescence in the rat. Experimental gerontology, 2013, Volume: 48, Issue:2 Topics: Acetylcysteine; Age Factors; Aging; Animals; Antioxidants; Aquaporin 2; Biomarkers; Blotting, Western; Cellular Senescence; Cholesterol; Ectodysplasins; Glucuronidase; Immunohistochemistry; Inulin; Kidney; Klotho Proteins; Male; Membrane Transport Proteins; Oxidative Stress; Phosphates; Rats; Rats, Wistar; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Thiobarbituric Acid Reactive Substances; Tumor Suppressor Protein p53; Urea Transporters	2013
Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo. The Journal of investigative dermatology, 2002, Volume: 119, Issue:2 Topics: Acetylcysteine; Adult; Aging; Cells, Cultured; Female; Fibroblasts; Humans; Keratinocytes; Male; Matrix Metalloproteinase 12; Metalloendopeptidases; RNA, Messenger; Skin; Ultraviolet Rays; Vitamin E	2002
Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. The Journal of investigative dermatology, 2003, Volume: 120, Issue:5 Topics: Acetylcysteine; Aging; Antioxidants; Collagenases; Enzyme Activation; Erythema; Free Radical Scavengers; Genistein; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Light; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin; Ultraviolet Rays	2003
Modification of the uterotropic effect produced by estrogens in aging rats. Bulletin of experimental biology and medicine, 2002, Volume: 134, Issue:5 Topics: Acetylcysteine; Aging; Animals; Ascorbic Acid; Carnosine; DNA Damage; Endometrium; Estradiol; Female; Melatonin; Organ Size; Rats; Receptors, Progesterone; Swimming; Uterus; Vitamin E	2002
Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation. Neurochemistry international, 2004, Volume: 44, Issue:8 Topics: Acetylcysteine; Aging; Animals; Biomarkers; Blotting, Western; Body Weight; Brain; Brain Chemistry; Choline O-Acetyltransferase; Densitometry; Diet; Free Radical Scavengers; Male; Ornithine Decarboxylase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses	2004
In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Experimental gerontology, 2004, Volume: 39, Issue:2 Topics: Acetylcysteine; Aging; Animals; Free Radical Scavengers; Gene Expression; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitosis; Muscle, Skeletal; NF-kappa B; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha	2004
[Switching off the estrogen effect and approaches to its correction]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2003, Volume: 89, Issue:8 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Ascorbic Acid; Carnosine; Cell Cycle; DNA Damage; Estradiol; Estrogen Receptor Modulators; Estrogens; Ethanol; Female; Fulvestrant; Gamma Rays; Melatonin; Organ Size; Ovariectomy; Physical Conditioning, Animal; Rats; Smoking; Swimming; Uterus; Vitamin D	2003
Thioredoxin, a redox-regulating protein, is expressed in spontaneous myocarditis in inbred strains of mice. International journal of cardiology, 2004, Volume: 95, Issue:2-3 Topics: Acetylcysteine; Aging; Animals; Biomarkers; Free Radical Scavengers; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Myocarditis; Myocardium; Oxidative Stress; Thioredoxins	2004
Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation. Free radical biology & medicine, 2004, Aug-15, Volume: 37, Issue:4 Topics: Acetylcysteine; Aging; Aldehydes; Animals; Apoptosis; Blotting, Western; Cell Nucleus; Cell Survival; Coloring Agents; Culture Media, Serum-Free; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Free Radicals; Gene Expression Regulation; Lipid Peroxidation; Luciferases; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Oxidation-Reduction; Oxidative Stress; Prostate; Rats; Sulfones; Tetrazolium Salts; Thiazoles; Time Factors; Transcription, Genetic; Transfection; Up-Regulation	2004
Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Experimental gerontology, 2004, Volume: 39, Issue:9 Topics: Acetylcysteine; Aging; Animals; Caloric Restriction; Colon; Dietary Supplements; Glutathione; Ileum; Intestinal Mucosa; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Wistar	2004
Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine. Free radical biology & medicine, 2005, Mar-15, Volume: 38, Issue:6 Topics: Acetylcysteine; Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Brain; Carbon; Cerebral Cortex; Citrate (si)-Synthase; Cytochromes; Cytosol; Diet; Glutathione; Male; Mitochondria; Mitochondria, Heart; Myocardium; Oxidative Phosphorylation; Oxidative Stress; Oxygen; Oxygen Consumption; Phosphorylation; Rats; Rats, Wistar; Spectrophotometry; Time Factors	2005
Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress. Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 99, Issue:6 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Enzyme Activation; Heat Stress Disorders; Heat-Shock Response; Injections, Intraperitoneal; Male; Oxidoreductases; Rats; Rats, Inbred F344; Sulfhydryl Compounds	2005
Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence. FEBS letters, 2005, Aug-29, Volume: 579, Issue:21 Topics: Acetylcysteine; Aging; Animals; Cell Cycle; Cells, Cultured; Cellular Senescence; Fibroblasts; Hydrogen Peroxide; Mice; Mice, Knockout; Oxidants; Peroxidases; Peroxiredoxins; Reactive Oxygen Species	2005
Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension. Clinical science (London, England : 1979), 2006, Volume: 110, Issue:2 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Glutathione; Heart Ventricles; Hypertension; Kidney; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species	2006
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nature neuroscience, 2006, Volume: 9, Issue:1 Topics: Acetylcysteine; Aging; Animals; Behavior, Animal; Bicuculline; Blotting, Western; Brain; Cysteine; Excitatory Amino Acid Transporter 3; GABA Antagonists; Genotype; Glutathione; Immunohistochemistry; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Oxidants; Oxidative Stress	2006
Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells. International journal of molecular medicine, 2006, Volume: 17, Issue:1 Topics: Acetylcysteine; Age Factors; Aging; Aldehydes; Animals; Aorta; Cell Cycle; Cell Death; Cell Proliferation; Cells, Cultured; Cyclin D1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Growth Inhibitors; MAP Kinase Signaling System; Mice; Myocytes, Smooth Muscle; Reactive Oxygen Species	2006
Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death. Experimental gerontology, 2006, Volume: 41, Issue:8 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Apoptosis; Caloric Restriction; Cell Death; Cell Proliferation; Drug Administration Schedule; Male; Mesenchymal Stem Cells; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2006
N-Acetyl L-cysteine does not protect against premature age-related hearing loss in C57BL/6J mice: a pilot study. Hearing research, 2007, Volume: 226, Issue:1-2 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Evoked Potentials, Auditory, Brain Stem; Female; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Mice; Mice, Inbred C57BL; Pilot Projects; Presbycusis	2007
Isolation and characterization of mammalian D-aspartyl endopeptidase. Amino acids, 2007, Volume: 32, Issue:1 Topics: Acetylcysteine; Aging; Alzheimer Disease; Animals; Aspartic Acid Endopeptidases; Caenorhabditis elegans; D-Aspartic Acid; Escherichia coli; Glutamate Dehydrogenase; Mice; Mitochondrial Membranes; Mitochondrial Proteins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Saccharomyces cerevisiae; Succinate Dehydrogenase	2007
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 2007, Volume: 58, Issue:2 Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Interactions; Fluid Therapy; Free Radical Scavengers; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Kidney Diseases; Metformin; Renal Dialysis; Risk Assessment	2007
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4 Topics: Acetylcholine; Acetylcysteine; Aging; Animals; Antioxidants; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Catechin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Hydrazines; Indomethacin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxidation-Reduction; Reactive Oxygen Species; Receptors, Thromboxane A2, Prostaglandin H2; Renal Artery; RNA, Messenger; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasodilator Agents	2007
Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level. Biochimica et biophysica acta, 2007, Volume: 1772, Issue:10 Topics: Acetylcysteine; Aging; Animals; Cell Line, Tumor; Diabetes Mellitus; Dithiothreitol; Energy Metabolism; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Gluconeogenesis; Glutathione; Hepatocytes; Homeostasis; Male; Obesity; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Sprague-Dawley; RNA, Messenger	2007
Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. The Journal of allergy and clinical immunology, 2008, Volume: 121, Issue:5 Topics: Acetylcysteine; Adoptive Transfer; Aging; Animals; Dendritic Cells; Dermatitis, Contact; Female; Flow Cytometry; Free Radical Scavengers; Glutathione; Interferon-gamma; Interleukin-4; Isothiocyanates; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidation-Reduction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfoxides; Th1 Cells; Thiocyanates	2008
Nephrotoxicity of hexachloro-1,3-butadiene in the mouse: the effect of age, sex, strain, monooxygenase modifiers, and the role of glutathione. Toxicology and applied pharmacology, 1984, Mar-15, Volume: 72, Issue:3 Topics: Acetylcysteine; Acute Kidney Injury; Aging; Animals; Butadienes; Female; Glutathione; Kidney Tubular Necrosis, Acute; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; p-Aminohippuric Acid; Sex Factors; Species Specificity; Tetraethylammonium; Tetraethylammonium Compounds; Urea	1984
Age- and sex-related differences in acetaminophen metabolism in the rat. Life sciences, 1981, Dec-07, Volume: 29, Issue:23 Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Female; Glucuronates; Liver; Male; Rats; Sex Factors; Sulfates	1981
N-acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria. European journal of pharmacology, 1995, Mar-16, Volume: 292, Issue:3-4 Topics: Acetylcysteine; Aging; Animals; Basal Metabolism; Female; Free Radical Scavengers; Mice; Mitochondria, Liver; Nerve Tissue Proteins; Oxidative Phosphorylation; Proton-Translocating ATPases	1995
Ontogenic changes in the nephrotoxicity of chromate correlate with the glutathione oxidoreduction system. Journal of trace elements and electrolytes in health and disease, 1994, Volume: 8, Issue:1 Topics: Acetylcysteine; Aging; Animals; Chromates; Female; Glutaredoxins; Glutathione; Kidney; Male; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Protein Disulfide Reductase (Glutathione); Proteinuria; Rats; Sodium Compounds	1994
ATP-sensitive K+ channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-related modifications of their biophysical and pharmacological properties. Molecular pharmacology, 1994, Volume: 46, Issue:4 Topics: Acetylcysteine; Adenosine Triphosphate; Aging; Animals; Cysteine; Glyburide; In Vitro Techniques; Male; Muscle, Skeletal; Oxidation-Reduction; Potassium Channels; Rats; Rats, Inbred WKY; Thimerosal	1994
Role of glutathione for cisplatin nephrotoxicity in young and adult rats. Renal failure, 1993, Volume: 15, Issue:2 Topics: Acetylcysteine; Aging; Animals; Antimetabolites; Buthionine Sulfoximine; Cisplatin; Drug Interactions; Female; Glutathione; Kidney; Methionine Sulfoximine; Rats; Rats, Wistar	1993
Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives. Mechanisms of ageing and development, 1996, Sep-30, Volume: 90, Issue:3 Topics: Acetylcysteine; Aging; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Cystine; Female; Glutathione; Glutathione Disulfide; Liver; Male; Maleates; Mice; Rats; Rats, Inbred F344; Species Specificity	1996
Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity. Mechanisms of ageing and development, 1997, Volume: 95, Issue:1-2 Topics: Acetaminophen; Acetylcysteine; Aging; Analgesics, Non-Narcotic; Animals; Glutathione; Inactivation, Metabolic; Liver; Male; Rats	1997
N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: Acetylcysteine; Aging; Animals; Female; Free Radical Scavengers; Glutathione; Mice; Mice, Inbred Strains; Mitochondria; Neurons; Oxidation-Reduction; Sulfhydryl Compounds; Synapses	1997
N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cellular and molecular life sciences : CMLS, 1997, Volume: 53, Issue:11-12 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Drosophila melanogaster; Gene Expression; Longevity; RNA, Messenger; RNA, Ribosomal	1997
N-acetylcysteine elicited increase in cytochrome c oxidase activity in mice synaptic mitochondria. Brain research, 1999, Sep-18, Volume: 842, Issue:1 Topics: Acetylcysteine; Aging; Animals; Electron Transport Complex IV; Male; Mice; Mitochondria; Oxidative Phosphorylation; Synapses	1999
Effects in vitro of several antioxidants on the natural killer function of aging mice. Experimental gerontology, 1999, Volume: 34, Issue:5 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Ascorbic Acid; Killer Cells, Natural; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Peritoneum; Spleen; Thiazoles; Thiazolidines; Thymus Gland; Vitamin E	1999
N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria. Brain research, 2000, Feb-07, Volume: 855, Issue:1 Topics: Acetylcysteine; Aging; Animals; Avoidance Learning; Behavior, Animal; Female; Free Radical Scavengers; Memory Disorders; Mice; Mice, Inbred Strains; Mitochondria; Oxidative Stress; Regression Analysis; Synapses	2000
Anti-oxidants as modulators of immune function. Immunology and cell biology, 2000, Volume: 78, Issue:1 Topics: Acetylcysteine; Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Antioxidants; Cell Adhesion; Disease Models, Animal; Female; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Shock, Septic; Vitamin E	2000
N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease. Brain research, 2000, Mar-17, Volume: 859, Issue:1 Topics: Acetylcysteine; Aging; Animals; Electron Transport Complex I; Free Radical Scavengers; Mice; Mitochondria; NADH, NADPH Oxidoreductases; Parkinson Disease; Sulfhydryl Compounds; Synapses; Synaptosomes	2000
Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience, 2000, Volume: 98, Issue:1 Topics: Acetylcysteine; Aging; Aldehydes; Amino Acid Chloromethyl Ketones; Animals; Cell Death; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutathione; Iron; Lipid Peroxidation; Lysosomes; Mice; Motor Neurons; Multienzyme Complexes; Neuroblastoma; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reactive Oxygen Species; Spinal Cord; Tumor Cells, Cultured	2000
Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mechanisms of ageing and development, 2000, Dec-20, Volume: 121, Issue:1-3 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Aging; Apoptosis; Cell Death; Deoxyribose; Dipeptides; Drug Resistance; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Monocytes; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Time Factors	2000
Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition. Journal of anatomy, 2000, Volume: 197 Pt 4 Topics: Acetylcysteine; Aging; beta-Galactosidase; Biomarkers; Cell Division; Cell Line; Cell Nucleus; Cell Size; Cytoplasm; Fibroblasts; Humans; Image Processing, Computer-Assisted; Interleukin-1; Reactive Oxygen Species; Stimulation, Chemical; Tumor Necrosis Factor-alpha	2000
Role of membrane lipids in regulation of vulnerability to oxidative stress in PC12 cells: implication for aging. Free radical biology & medicine, 2001, Mar-15, Volume: 30, Issue:6 Topics: Acetylcysteine; Aging; Animals; Calcium; Cell Membrane; Cholesterol; Enzyme Induction; Fluorescent Dyes; Glutathione; Hydrogen Peroxide; Membrane Lipids; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Sphingomyelin Phosphodiesterase; Sphingomyelins	2001
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. Medical hypotheses, 2001, Volume: 56, Issue:4 Topics: Acetylcysteine; Aging; Humans; Mitochondria; Neurodegenerative Diseases	2001
The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice. Free radical research, 2002, Volume: 36, Issue:2 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cell Adhesion; Chemotaxis, Leukocyte; Diet; Dose-Response Relationship, Drug; Female; Leukocytes; Lymphocytes; Mice; Phagocytosis; Sulfhydryl Compounds; Superoxides; Thiazoles; Thiazolidines	2002
Glutathione conjugation and mercapturic acid formation in the developing rat, in vivo and in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 1978, Volume: 8, Issue:4 Topics: Acetylcysteine; Acetyltransferases; Aging; Animals; Animals, Newborn; Female; gamma-Glutamyltransferase; Glutathione; Glutathione Transferase; In Vitro Techniques; Kidney; Liver; Male; Rats	1978
Mercapturic acid formation in the developing rat. Xenobiotica; the fate of foreign compounds in biological systems, 1977, Volume: 7, Issue:11 Topics: Acetylcysteine; Aging; Animals; Cysteine; Female; Glutathione Transferase; Liver; Male; Propane; Rats; Sulfoxides	1977
[Pulmonary aging. Meeting at the Istituto Superiore di Sanità in Rome]. La Clinica terapeutica, 1992, Volume: 140, Issue:5 Topics: Acetylcysteine; Adult; Aging; Bronchitis; Chronic Disease; Clinical Trials as Topic; Humans; Lung; Lung Diseases; Multicenter Studies as Topic; Smoking	1992
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. Biochemical pharmacology, 1992, Jul-07, Volume: 44, Issue:1 Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relationship, Drug; Glutathione; Kidney; Male; Mice; Mice, Inbred C57BL; Organ Size	1992
Age-related changes in glutathione synthesis in the eye lens. The Biochemical journal, 1990, Jul-15, Volume: 269, Issue:2 Topics: Acetylcysteine; Adenosine Triphosphate; Aging; Animals; Cystathionine gamma-Lyase; Glutathione; Lens, Crystalline; Methionine; Mice; Oxidation-Reduction; Peroxides; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide	1990