acetylcysteine and Adverse Drug Event

acetylcysteine has been researched along with Adverse Drug Event in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (23.26)	29.6817
2010's	11 (25.58)	24.3611
2020's	21 (48.84)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Thanacoody, HKR	1
Bateman, DN	1
Berland, NG; Calello, DP; Leonard, J	1
Baum, RA; Su, MK; Weant, KA	1
Camarena-Michel, A; Hoyte, C; Leonard, J; Pennington, S; Sudanagunta, S; Wang, GS	1
Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H	1
Motohashi, K; Thanacoody, RH	1
Gales, BJ; Gales, MA; Parli, GM	1
Balinski, A; Bower, R; Lee, M; McCarron, J	1
Filip, AB; Mullins, ME	1
Anderson, M; Gray, L; Kelgeri, C; Rajaraman, N	1
He, Z; Li, M; Li, Y; Mahai, G; Qian, X; Wan, Y; Wang, A; Xia, W; Xu, S	1
Haar, I; Strehle, EM	1
Albert, K; Hasara, S; Wilson, K	1
Banner, W; Beuhler, MC; Burns, MM; Cantrell, LF; Cole, JB; Dart, RC; Funk, AR; Heard, KJ; Hendrickson, RG; Lucyk, SN; Matoushek, T; Mazer-Amirshahi, M; Mullins, ME; Nelson, LS; Ruha, AM; Rumack, BH; Simone, K; Sivilotti, MLA; Stolbach, AI; Stork, CM; Su, MK; Varney, SM	1
Abdul Rouf, PV; Abushanab, D; Ahmed, N; Azad, A; Devi, D; Elbdairy, M; Elgassim, M; Elkassem, W; Elmoheen, A; Elqasass, H; Gasim, M; Hail, MA; Hanssens, Y; Mohammed, HR; Mohammed, S; Salem, W; Thomas, B; Vincent, M	1
Hayden, JC; Kelly, L; McNicholas, F	1
Blind, F; Hall, B; Wilson, K	1
Loubani, O; McDougall, G; Murphy, NG	1
Beitler, JR; Dzierba, AL; Furfaro, D; Muir, J; Shah, J	1
Graudins, A; O'Callaghan, C; Wong, A	1
Graudins, A; Gunja, N; McNulty, R; Sivilotti, MLA; Wong, A	1
Harmouche, E; Howland, MA; K Su, M	1
Howard, L; Reynard, C	1
Harmouche, E; Hoffman, RS; Howland, MA	1
Altemani, JMC; Amaral, LS; Calonga, L; Chone, CT; Curi, SFBB; de F L Ambrósio, R; de Sousa, VM; de T Leme, MF; Lima, CSP; Malaguti, C; Mazzola, PG; Moriel, P; Quintanilha, JCF; Vercesi, AE; Visacri, MB	1
Graudins, A; Wong, A	2
Busuttil, RW; Chun, LJ; Hiatt, JR; Tong, MJ	1
Athuraliya, TN; Jones, AL	1
Chan, GM; Greller, HA; Gupta, AK; Su, MK	1
Bavoux, F; Boyer-Gervoise, M; Chalumeau, M; Dubus, JC; Jean-Pastor, MJ; Mourdi, N	1
Chen, N; Hanly, L; Koren, G; Rieder, M; Yeger, H	1
Kwok, CS; Loke, YK; Pang, CL; Yeong, JK	1
Anton, C; Ferner, RE	1
Cui, X; Hayakawa, T; Hirano, S; Kanno, S; Kobayashi, Y; Li, S; Shraim, A	1
Venkataraman, R	1
Khashab, M; Kwo, PY; Tector, AJ	1
Corcoran, GB; Hughes, H; Lauterburg, BH; Mitchell, JR; Smith, CV	1
Butler, AY; Chyka, PA; Herman, MI; Holliman, BJ	1
Lee, WM; Ostapowicz, G	1

Reviews

12 review(s) available for acetylcysteine and Adverse Drug Event

Article	Year
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review. Drug safety, 2022, Volume: 45, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid	2022
Toxicology in the emergency department: what's new? British journal of hospital medicine (London, England : 2005), 2022, Sep-02, Volume: 83, Issue:9 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Emergency Service, Hospital; Humans	2022
"N-Acetylcysteine for Obsessive-Compulsive and Related Disorders in Children and Adolescents: A Review". The Annals of pharmacotherapy, 2023, Volume: 57, Issue:7 Topics: Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Cognitive Behavioral Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Obsessive-Compulsive Disorder; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Young Adult	2023
A clinician's guide to self-poisoning with paracetamol in youth: The what, when and why? Acta paediatrica (Oslo, Norway : 1992), 2020, Volume: 109, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2020
Use of N-Acetylcysteine for Clozapine-Induced Acute Liver Injury: A Case Report and Literature Review. Journal of pharmacy practice, 2023, Volume: 36, Issue:2 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Clozapine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute; Middle Aged	2023
Acetaminophen hepatotoxicity and acute liver failure. Journal of clinical gastroenterology, 2009, Volume: 43, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; United Kingdom; United States	2009
[Mucolytic drugs: towards a contraindication in infants]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:6 Topics: Acetylcysteine; Bronchitis; Carbocysteine; Contraindications; Cross-Cultural Comparison; Drug-Related Side Effects and Adverse Reactions; Europe; Expectorants; France; Humans; Infant; Respiratory Tract Infections; Risk Factors	2010
Measures used to treat contrast-induced nephropathy: overview of reviews. The British journal of radiology, 2013, Volume: 86, Issue:1021 Topics: Acetylcysteine; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Prevalence; Risk Assessment; Sodium Bicarbonate; Theophylline; Treatment Outcome	2013
Prevention of acute renal failure. Critical care clinics, 2005, Volume: 21, Issue:2 Topics: Acetylcysteine; Acute Kidney Injury; Diuretics; Dopamine Agents; Drug-Related Side Effects and Adverse Reactions; Fluid Therapy; Humans; Natriuretic Peptides; Theophylline	2005
Epidemiology of acute liver failure. Current gastroenterology reports, 2007, Volume: 9, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Hepatitis, Autoimmune; Hepatitis, Viral, Human; Humans; Liver Failure, Acute; Liver Transplantation; Metabolic Diseases; Neoplasms; Prognosis; Vascular Diseases	2007
Utility of acetylcysteine in treating poisonings and adverse drug reactions. Drug safety, 2000, Volume: 22, Issue:2 Topics: Acetylcysteine; Animals; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Poisoning	2000
Acute hepatic failure: a Western perspective. Journal of gastroenterology and hepatology, 2000, Volume: 15, Issue:5 Topics: Acetaminophen; Acetylcysteine; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; Health Care Costs; Hepatitis, Viral, Human; Humans; Liver Failure, Acute; Liver Transplantation; Prevalence; Prostaglandins	2000

Trials

1 trial(s) available for acetylcysteine and Adverse Drug Event

Article	Year
Can acetylcysteine ameliorate cisplatin-induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double-blind, placebo-controlled trial involving patients with head and neck cancer. Cancer medicine, 2019, Volume: 8, Issue:5 Topics: Acetylcysteine; Administration, Oral; Aged; Chemoradiotherapy; Cisplatin; Double-Blind Method; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Oxidative Stress; Treatment Outcome	2019

Article

Year

Can acetylcysteine ameliorate cisplatin-induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double-blind, placebo-controlled trial involving patients with head and neck cancer.

Cancer medicine, 2019, Volume: 8, Issue:5

Topics: Acetylcysteine; Administration, Oral; Aged; Chemoradiotherapy; Cisplatin; Double-Blind Method; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Oxidative Stress; Treatment Outcome

2019

Other Studies

30 other study(ies) available for acetylcysteine and Adverse Drug Event

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Large paracetamol overdose - Higher dose NAC is NOT required. British journal of clinical pharmacology, 2023, Volume: 89, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies	2023
Large paracetamol overdose-Higher dose acetylcysteine is required. British journal of clinical pharmacology, 2023, Volume: 89, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2023
Should the Dosage Cap Be Used in Patients Greater than 100 kg Receiving N-acetylcysteine for Acetaminophen Toxicity? Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2022, Volume: 18, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Humans	2022
The Cents of the Dosage Cap in Patients Greater than 100 Kilograms Receiving N-Acetylcysteine for Acetaminophen Toxicity. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2022, Volume: 18, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Humans	2022
Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity. The Annals of pharmacotherapy, 2023, Volume: 57, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Cohort Studies; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies	2023
Intravenous acetaminophen associated with acute liver failure. BMJ case reports, 2022, Nov-22, Volume: 15, Issue:11 Topics: Acetaminophen; Acetylcysteine; Brain Diseases; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute	2022
Fomepizole should be used more liberally in paracetamol overdose. British journal of clinical pharmacology, 2023, Volume: 89, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fomepizole; Humans	2023
Paracetamol overdose in children: management following an initial N-acetylcysteine regimen. Archives of disease in childhood. Education and practice edition, 2023, Volume: 108, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies	2023
Urinary metabolites of multiple volatile organic compounds among pregnant women across pregnancy: Variability, exposure characteristics, and associations with selected oxidative stress biomarkers. Environment international, 2023, Volume: 173 Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Biomarkers; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Oxidative Stress; Parity; Pregnancy; Pregnant Women; Volatile Organic Compounds	2023
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline. Archives of disease in childhood, 2023, Volume: 108, Issue:5 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2023
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose. Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacists; Retrospective Studies	2023
Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement. JAMA network open, 2023, 08-01, Volume: 6, Issue:8 Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Canada; Child; Drug-Related Side Effects and Adverse Reactions; Evidence-Based Medicine; Humans; Poisons	2023
Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study. Medicine, 2023, Sep-22, Volume: 102, Issue:38 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Qatar; Retrospective Studies; Young Adult	2023
Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity. Journal of hospital medicine, 2021, Volume: 16, Issue:6 Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Goals; Humans; Motivation	2021
N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer - a case report. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Risk Factors; Treatment Outcome	2021
A two-bag acetylcysteine regimen is associated with shorter delays and interruptions in the treatment of paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies	2022
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Young Adult	2018
In response to: "Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning". European journal of clinical pharmacology, 2018, Volume: 74, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2018
Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions. Emergency medicine journal : EMJ, 2018, Volume: 35, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2018
In response to: fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:10 Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2018
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Anaphylaxis; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Retrospective Studies; Young Adult	2016
N-acetylcysteine regimens for paracetamol overdose: Time for a change? Emergency medicine Australasia : EMA, 2016, Volume: 28, Issue:6 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Incidence	2016
Prolonged N-acetylcysteine therapy in late acetaminophen poisoning associated with acute liver failure--a need to be more cautious? Critical care (London, England), 2009, Volume: 13, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Liver Failure, Acute; Mice	2009
NAC: still the way to go. Critical care (London, England), 2009, Volume: 13, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug-Related Side Effects and Adverse Reactions; Humans; Liver Failure; Mice	2009
The effect of N-acetylcysteine on the antitumor activity of ifosfamide. Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:5 Topics: Acetylcysteine; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Ifosfamide; Mesna; Neuroblastoma; Phosphoramide Mustards; Rhabdomyosarcoma	2011
Medication errors detected in infusions. Archives of internal medicine, 2003, Apr-28, Volume: 163, Issue:8 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Humans; Infusions, Intravenous; Medication Errors	2003
Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells. Archives of toxicology, 2003, Volume: 77, Issue:6 Topics: Acetylcysteine; Animals; Antioxidants; Arsenates; Arsenites; Biological Transport; Buthionine Sulfoximine; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Drug-Related Side Effects and Adverse Reactions; Endothelium, Vascular; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; NADP; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Thioredoxins	2003
Alkylation and peroxidation injury from chemically reactive metabolites. Advances in experimental medicine and biology, 1981, Volume: 136 Pt A Topics: Acetaminophen; Acetylcysteine; Alkylation; Animals; Antioxidants; Biotransformation; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glutathione Disulfide; Humans; Lipid Peroxides; Liver; Microsomes, Liver; Peroxides; Pharmaceutical Preparations; Vitamin E	1981