acetylcysteine and Acute Liver Injury, Drug-Induced

acetylcysteine has been researched along with Acute Liver Injury, Drug-Induced in 481 studies

Research

Studies (481)

Timeframe	Studies, this research(%)	All Research%
pre-1990	70 (14.55)	18.7374
1990's	51 (10.60)	18.2507
2000's	100 (20.79)	29.6817
2010's	183 (38.05)	24.3611
2020's	77 (16.01)	2.80

Authors

Authors	Studies
Goon, DJ; Nagasawa, HT; Yuzon, DL; Zera, RT	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Albertson, TE; Chenoweth, JA; Lai, L; Lewis, JC; Lim, M; Mendoza, E	1
Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ	1
Graudins, A; Syafira, N; Wong, A; Yarema, M	1
Hodgson, SE; Wong, A	1
Beuhler, MC; Shah, KR	2
Chellan, N; Dludla, PV; Gabuza, KB; Marcheggiani, F; Mazibuko-Mbeje, SE; Nkambule, BB; Ntamo, Y; Nyambuya, TM; Tiano, L; Ziqubu, K	1
Thanacoody, HKR	1
Bateman, DN	2
Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH	1
Ağın, H; Atakul, G; Çağlar, A; Çolak, M; Karaarslan, U; Soydan, E; Topal, S	1
Björnsson, ES	1
Chomchai, C; Chomchai, S; Mekavuthikul, P; Phuditshinnapatra, J	1
Akakpo, JY; Begher-Tibbe, B; Brackhagen, L; Brecklinghaus, T; Canbay, A; Copple, IM; Curry, SC; Friebel, A; Ghallab, A; Goldring, C; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Hofmann, U; Jaeschke, H; Kappenberg, F; Longerich, T; Luedde, T; Marchan, R; Murad, W; Myllys, M; Olyaee, M; Overbeck, N; Rahnenführer, J; Reinders, J; Schreiter, T; Seddek, AL; Sezgin, S; Sowa, JP; Trauner, M; Urban, S; Vucur, M; Zühlke, S	1
Duan, L; Jaeschke, H; Ramachandran, A; Sanchez-Guerrero, G	1
Jia, C; Li, J; Li, W; Peng, Y; Shi, J; Zheng, J	1
Berg, SE; Filip, AB; Mullins, ME; Schwarz, ES	1
Guan, C; Hu, Y; Li, W; Peng, Y; Sun, C; Zhang, M; Zheng, J	1
Abbas, AA; Ahmed, AE; Hamdy, A	1
Chen, Y; Ge, W; Song, W; Yan, R	1
Wong, A	1
Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H	1
Abhyankar, S; Adelusi, O; Apte, U; Dawn, B; Duan, L; Jaeschke, H; Nguyen, NT; Ramachandran, A; Robarts, DR; Soder, RP; Umbaugh, DS; Woolbright, B	1
Cai, X; Chen, Z; Deng, J; Du, Z; Hua, S; Khan, NU; Liu, Z; Zhang, D; Zhou, M	1
Ding, KN; Guo, YN; He, YM; Liang, SS; Lu, MH; Shen, XL; Tang, LP	1
Chen, M; Du, J; Wu, B; Xiao, Y; Zhang, F; Zhang, L; Zhang, X	1
Cumaoğlu, B; Günay, N; Oğuz Cumaoğlu, M; Tekin, Y	1
Janković, SM	1
Chang, X; Guo, M; Niu, S; Shang, M; Tang, M; Wu, T; Xue, Y; Zhang, T; Zhang, W	1
Dear, JW	1
Carr, D; Cohen, K; Costello, E; Dorfman, JR; Goldring, C; Gunter, H; Maartens, G; Moosa, MS; Patel, C; Pirmohamed, M; Russomanno, G	1
Huang, L; Luo, G; Zhang, Z	1
Fu, G; Gao, Y; Huang, H; Jin, L; Kom, MC; Shen, J; Tang, Y; Xie, Y; Yan, J	1
Albert, K; Hasara, S; Wilson, K	1
Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P	1
Akradi, L; Mokhtari, Z; Raeeszadeh, M	1
Capossela, L; Chiaretti, A; Curatola, A; Ferretti, S; Gatto, A; Graglia, B; Pansini, V	1
Ezhilarasan, D; Gayatri Devi, R	1
Aki, T; Funakoshi, T; Tanaka, H; Uemura, K; Unuma, K	1
Abid Ali, M; Paramjyothi, GK; Sireesha, K; Subbalaxmi, MVS; Sukumaran, D; Usharani, P	1
Bai, H; Chang, X; Dong, W; Feng, C; Ma, Q; Wu, Z; Yang, J	1
Chao, L; Hu, L; Huang, R; Kang, Z; Li, Y; Ning, Z; Pan, J; Tang, Z; Wan, F; Wang, C; Yang, F; Zhong, G	1
Awad, NI; Bridgeman, PJ; Cocchio, C; Geib, AJ; Roy, A	1
Chen, HY; Cheng, HT; Lu, JX; Seak, CJ; Smollin, C; Yu, JH	1
Chen, Q; Chen, YH; Li, J; Li, Z; Lin, L; Shen, E; Wan, X; Xia, M; Yan, D; Zhan, W; Zhang, G; Zhang, Q	1
Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW	1
Buckley, NA; Chiew, AL; Isoardi, KZ; Pomerleau, A; Reith, D; Soderstrom, J; Wong, A	1
Colle, I; Debacker, PJ; Devisscher, L; Geerts, A; Lefere, S; Raevens, S; Van Campenhout, S; Van Vlierberghe, H; Verhelst, X	1
Ishitsuka, Y; Kadowaki, D; Kondo, Y	1
Bahadır, A; Erduran, E; Eroglu, N; Reis, GP	1
Azandaryani, MT; Firozian, F; Karami, S; Nili-Ahmadabadi, A; Ranjbar, A	1
Aamir, M; Fatima, S; Naz, S	1
Abdallah, FR; Atteia, HH; Elswefy, SE; Hasan, RA; Wahba, AS	1
Allie, S; Chughlay, MF; Cohen, K; Gunter, H; Hickman, N; Maartens, G; Moosa, MS; Setshedi, M; Sonderup, M; Spearman, CW; Stead, DF; Stewart, A; Wasserman, S	1
Akakpo, JY; Jaeschke, H; Ramachandran, A	1
Autry, MT; Fox, AN; Johnson, PN; Nation, BE	1
Akgun, E; Boyacioglu, M; Kum, S	1
Eshrati, R; Ghafourian Hesami, M; Gudarzi, S; Jafari, M; Nazari, A; Samizadeh, E	1
Ilan, Y; Lichtenstein, Y; Shabat, Y	1
Kumar-M, P; Patil, A; Sharma, S; Sharma, V; Singh, AK; Soni, H; Verma, S	1
Hampannavar, MS; Roy, A; Singh, V	1
Antonucci, R; Capobianco, G; Cuzzolin, L; Locci, C	1
Ezhilarasan, D; Raghunandhakumar, S	1
Büyük, B; Coşkun, Ö; Öztopuz, Ö	1
Loubani, O; McDougall, G; Murphy, NG	1
Enver Ozan, İ; Erdem Güzel, E; Gül, M; Kavak Balgetir, M; Kaya Tektemur, N; Ozan Kocamüftüoğlu, G; Özcan Yıldırım, S; Tektemur, A; Yalçın, T	1
Wang, J	1
Cumpston, KL; Downs, JW; Kershner, EK; Rose, SR; Troendle, MM; Wills, BK	1
Bateman, DN; Choi, H; Dear, JW; Drum, CL; Ibrahim, B; Khoo, BBJ; Leroy Sivappiragasam, P; Ng, ML	1
Bashir, DW; Galal, MK; Hashim, AR; M, ES; Yasin, NAE	1
Abd-Eldayem, AM; Ahmed, E; Ahmed, EA	1
Akpunonu, P; Bailey, AM; Baum, RA; Geraghty, L; Howell, MM; Mohan, S; Su, MK; Weant, KA; Webb, AN; Woolum, JA	1
Buckley, NA; Chiew, AL	1
Kewcharoen, J; Narimasu, T; Nishimura, Y	1
Deye, N; Diallo, A; Gourlain, H; Goury, A; Malissin, I; Mégarbane, B; Nuzzo, A; Péron, N; Salem, S; Vicaut, E; Voicu, S	1
Burnham, K; Knight, S; Smith, H; Yang, T	1
Beitler, JR; Dzierba, AL; Furfaro, D; Muir, J; Shah, J	1
Akakpo, JY; Curry, SC; Jaeschke, H; Jaeschke, MW; Ramachandran, A; Rumack, BH	1
Graudins, A; Sivilotti, MLA; Wong, A	1
Graudins, A; Wong, A	1
Antelava, N; Ghonghadze, M; Liluashvili, K; Okujava, M; Pachkoria, K	2
Heidarian, E; Nikoukar, M; Nouri, A	1
Graudins, A; Landersdorfer, C; Wong, A	1
Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Kirby, KA; Page, CB	1
Goldberger, D; Vearrier, D	1
Antoine, DJ; Brillant, N; Burton, NC; Elmasry, M; Fenwick, S; Goldring, CE; Kipar, A; Kitteringham, NR; Park, BK; Poptani, H; Rodriguez, JM; Sharkey, JW	1
Berg, T; Borlak, J; van Bömmel, F	1
Graudins, A; Gunja, N; McNulty, R; Wong, A	1
Bunchorntavakul, C; Reddy, KR	2
Allen, L; Antoine, DJ; Clarke, JI; Cooper, J; Dargan, PI; Dear, JW; Francis, B; Jorgensen, AL; Park, BK; Pirmohamed, M; Shen, J; Thomas, SHL; Wood, D; Wraight, J	1
Chomchai, C; Chomchai, S	2
Dervay, K; Fixl, AN; Woods, RM	1
Chandru, P; Gunja, N; Lim, JME; McNulty, R	1
Janega, P; Luha, J; Muchová, J; Otrubová, O; Turecký, L; Uličná, O	1
Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A	1
Arianto, L; Bisgaard, AS; Dan-Nielsen, S; Heedeland, RL; Jans, SR; Jørgensen, MH	1
Hu, H; Huo, Y; Yan, M; Yin, S	1
Bao, YQ; Gu, LL; Li, YL; Lu, H; Shen, ZL	1
Blomgren, A; Grundemar, L; Högestätt, ED; Nilsson, JLÅ; Nilsson, UJ	1
Fontana, RJ; Hassan, A	1
Graudins, A; Greene, S; Gunja, N; Koutsogiannis, Z; McNulty, R; Sivilotti, M; Taylor, D; Wong, A	1
Chao, X; Ding, WX; Du, K; Jaeschke, AH; Jaeschke, H; Ramachandran, A; Weemhoff, JL; Woolbright, BL	1
Choy, KW; Dear, JW; Doery, J; Graudins, A; Homer, N; Wong, A	1
Coudert, C; Dualé, C; Macian, N; Papet, I; Pereira, B; Pickering, G	1
Batista, ÂG; Cadore, S; Cruz-Höfling, MAD; da Silva, EDN; de Jesus, MB; Durán, N; Ferreira, LB; Maróstica Júnior, MR; Mendonça, MCP; Rizoli, C	1
Dear, J	1
Chattipakorn, N; Kobroob, A; Palee, S; Peerapanyasut, W; Wongmekiat, O	1
Green, JP; Johnson, DW; Mutsaers, A; Rumack, BH; Sivilotti, MLA; Spyker, DA; Tucker, D; Yarema, MC	1
Hendrickson, RG	1
Ho, SM; Jiang, W; Khanal, T; Kim, K; Leung, YK; Timchenko, N	1
Altinbas, A; Ayhan, S; Canakci, E; Kokturk, S; Noyan, T; Tas, N	1
Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ	1
Huang, J; Huang, W; Nisar, MF; Wan, C; Yan, T	1
Kubo, T; Lee, SH; Oe, T; Ozawa, M	1
Abdelmegeed, MA; Banerjee, A; Hardwick, JP; Jang, S; Song, BJ	1
Alatas, O; Sahin, S	1
Dargan, PI; Hitchings, AW; Wood, DM	1
Al-Hourani, K; Bateman, DN; Dear, JW; Dow, M; Mansi, R; Pettie, J	1
Barosa, R; Fonseca, C; Freitas, J; Ramos, LR	1
Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Suntres, ZE; Szabo, M	1
Amathieu, R; Chemit, M; Compagnon, P; Costentin, C; Dhonneur, G; Levesque, E; Merle, JC	1
Downey, KJ; Gavin, T; Geohagen, BC; Liu, Q; LoPachin, RM; Zhang, L	1
Kam, RY	1
Ding, B; Hou, Y; Li, J; Liu, Y; Long, M; Wang, L; Wu, G; Yang, Z; Yi, D	1
Jiang, S; Ni, SZ; Xia, J; Zhao, Y; Zhou, XL; Zhu, YQ	1
Agilli, M; Altayli, E; Aydin, FN; Aydin, I; Cayci, T; Eyi, YE; Kaldirim, U; Macit, E; Taslipinar, MY; Toygar, M; Tuncer, SK; Ucar, F; Yigit, N	1
Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD	1
Marti, C; Ramlawi, M; Sarasin, F	1
Sanaei-Zadeh, H	1
Koch, A; Streetz, KL; Tacke, F; Trautwein, C	1
Duffull, SB; Isbister, GK	2
Berman, AJ; Gilberti, B; Rahman, S	1
Atli, Y; Bulbuloglu, E; Cetinkaya, A; Ciralik, H; Kantarceken, B; Kurutas, EB	1
Carbajo-Pescador, S; Carvalho, NR; da Rosa, EF; da Silva, MH; Dalla Corte, CL; González-Gallego, J; Mauriz, JL; Soares, FA; Tassi, CC	1
Antoine, DJ; Dear, JW	2
Beger, RD; Bhattacharyya, S; Gill, P; James, LP; Kearns, GL; Letzig, LG; Marshall, JD; Pence, L; Reed, MD; Simpson, PM; Sullivan, JE; Van Den Anker, JN; Yan, K	1
Burda, G; Gole, J; Hermon, M; Mostafa, G; Trittenwein, G; Vargha, R	1
Bronstein, AC; Bucher-Bartelson, B; Dart, RC; Green, JL; Heard, K; Heard, S; Rumack, BH	1
Chomchai, C; Chomchai, S; Lawattanatrakul, N	1
Abdelmoula, J; Ahmed, MB; Annabi, A; Belhadjhmida, N; Bouzid, K; Dhouib, IB; El Fazaa, S; Gharbi, N; Lamine, AJ; Lasram, MM	1
Aksit, H; Bildik, A	1
Andersen, J; Askbo, N; Hedeland, RL; Iskandar, A; Jørgensen, MH	1
Akbulut, S; Dogan, Z; Elbe, H; Erdemli, E; Eris, C; Otan, E; Toprak, G; Turkoz, Y	1
Eisenbach, C; Hoyler, B; Mogler, C; Sandig, C; Steinebrunner, N; Stremmel, W; Vittas, S	1
Avellini, C; De Vita, S; Maset, M; Quartuccio, L; Soardo, G	1
Fukami, T; Iwamura, A; Kume, T; Nakajima, M; Sasaki, E; Tsuneyama, K; Yokoi, T	1
Brito, MV; Costa, FD; Costa, LA; Teixeira, RK; Vasconcelos, DM; Yamaki, VN; Yasojima, EY	1
Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Qu, A; Tan, H; Wang, Y; Zeng, H	1
Azarpira, N; Bazyari, M; Heidari, R; Jamshidzadeh, A; Najibi, A; Niknahad, H	1
Culpepper-Morgan, JA; Ferstenberg, R; Lukšič, M; Sheikh, IA	1
Jones, DL; McGovern, AJ; Mullins, ME; Vitkovitsky, IV	1
de Wolff, JF; Jiad, E; Palipane, N	1
Arai, T; Kitamura, D; Koyama, R; Mizuta, R; Yuasa, M	1
Dave, KP; Hummel, JP; Mudalel, ML; Solga, SF	1
Altinoz, E; Turkoz, Y; Vardi, N	1
De Hoyos, P; El Rahi, C; Mejia, P; Thompson-Moore, N	1
Annabi, A; El-Bini Dhouib, I; El-Fazaa, S; El-Golli, N; Gharbi, N; Jrad, A; Lasram, MM	1
Chughlay, MF; Cohen, K; Engel, ME; Kramer, N; Spearman, W; Werfalli, M	1
Jaeschke, H	1
Dargan, PI; Greene, SL; Sivilotti, ML; Wong, A; Wood, DM	1
Andrus, JP; Herzenberg, LA; Owumi, SE	1
Curtis, RM; Sivilotti, ML	1
Cai, Z; Fang, H; Ju, L; Li, E; Lou, Q; Sun, J; Wang, F; Xi, J	1
Gerkin, RD; Levine, M; O'Connor, AD; Padilla-Jones, A	1
Dağlı, B; Demirci, B; Gökçimen, A; Kahyaoğlu, F; Ömürlü, İK; Uysal, HB; Yılmaz, M	1
Durgun, HM; Dursun, R; Guloglu, C; Gunduz, E; İçer, M; Turkcu, G; Üstündağ, M; Yuksel, H; Zengin, Y	1
Hernandez, SH; Hoffman, RS; Howland, M; Schiano, TD	1
Chien, CC; Chiu, YT; Lin, TH; Liu, CC; Liu, RH; Su, HL; Tsai, MS; Wang, SH	1
Dawson, AH; Galappatthy, P	1
Gerkin, R; Levine, M; O'Connor, AD; Padilla-Jones, A	1
Jacobitz, KL; Kirschner, RI; Rozier, CM; Smith, LM	1
Fernandez, D; Nelson, LS	1
Ercal, N; Hart, M; Khayyat, A; Tobwala, S	1
Lewis, JH; Stine, JG	1
Hovda, LR; Schmid, RD	1
Berling, I; Downes, MA; Isbister, GK; Mcnamara, K; Page, CB; Whyte, IM	1
Angus, P; Elliott, TR; Kannourakis, G; Symes, T	1
Coen, M; Foster, J; Holmes, E; Kavanagh, TJ; Kyriakides, M; Maitre, L; Mohar, I; Nelson, SD; Stamper, BD; Wilson, ID	1
Chughlay, MF; Cohen, K; Kramer, N; Spearman, CW; Werfalli, M	1
Chen, JX; Long, CY; Wang, JL; Xu, LL; Yu, M	1
Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, AE; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ	1
Donnelly, MC; Hayes, PC; Simpson, KJ	1
Fix, OK; Hameed, B; Karvellas, CJ; Lee, WM; Leung, AA; McGuire, BM; Schilsky, ML; Stravitz, RT; Tillman, H	1
Ghanem, CI; Manautou, JE; Mottino, AD; Pérez, MJ	1
Al-Hourani, K; Bateman, DN; Beckwith, HK; Cairney, DG; Dear, JW; Eddleston, M	1
Personne, M	1
Ahmadian, E; Azarmi, Y; Eftekhari, A; Eghbal, MA; Hamishehkar, H; Parvizpur, A	1
Bogaerts, E; Colle, I; Devisscher, L; Geerts, A; Hoorens, A; Paridaens, A; Raevens, S; van Grunsven, LA; Van Vlierberghe, H; Vandewynckel, YP; Verhelst, X	1
Antoine, DJ; Bateman, DN; Clarke, JI; Cooper, JG; Dargan, PI; Dear, JW; Eddleston, M; Gray, A; Homer, NZ; Kimmitt, RA; Lewis, SC; Seymour, JH; Vliegenthart, A; Webb, DJ; Wood, DM	1
Broska, J; Cowie, C; Gunja, N; Isbister, GK; Islam, S; Jayaweera, D; Poojara, L; Roberts, MS	1
Abdel-Moneim, AM; Abu El-Saad, AM; Al-Kahtani, MA	1
Archer, JRH; Dargan, PI; Davies, CL; Dines, AM; Greene, SL; Marks, DJB; Wood, DM	1
Ali, DA; Katary, MA; Soliman, NA; Zineldeen, DH	1
Evans, J; Petchey, WG; Sampaziotis, F; Serjeant, L	1
Brenner, CE; Bressan, CA; Brittes, PC; Cheiran, G; da Veiga, M; Finamor, I; Pavanato, MA; Pérez, S; Rius-Pérez, S; Rocha, MI; Sastre, J	1
Hoffman, RS; Howland, MA; Nelson, LS; Smith, SW	1
Danel, V; Saviuc, P	1
Bilgili, A; Eraslan, G; Onbasilar, I; Ozdemir, M; Yalçin, S	1
Doyon, S; Klein-Schwartz, W	2
Cohen, R; Cooke, A; Deshpande, AV; Wong, CK	1
Chang, CY; Martin, P; Tan, HH	1
Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A	1
Bateman, DN; Sandilands, EA	1
Bockewitz, E; Burda, AM; Kubic, A; Wahl, M	1
Carlson, GP; Mahlapuu, R; Meszka-Jordan, A; Soomets, U	1
Ariyananda, PL; Fernando, WK	1
Krishnan, GP; Majlesi, N; Nelson, L; Olsen, A; Olsen, D	1
Bailey, B; Berlin, RJ; Brant, RF; Chalut, D; Dart, RC; Johnson, DW; Lee, JS; Nettel-Aguirre, A; Plint, AC; Purssell, RA; Rumack, BH; Rutledge, T; Seviour, CA; Sivilotti, ML; Spyker, DA; Stiell, IG; Thompson, M; Tyberg, J; Yarema, MC	1
Chen, Y; Ji, L; Liu, T; Wang, Z	1
Bond, GR	2
Bhatnagar, A; Conklin, DJ; Haberzettl, P; Lesgards, JF; Prough, RA; Srivastava, S	1
Lopez, DP	1
Jaeschke, H; Saito, C; Zwingmann, C	1
Betten, DP; Burner, EE; Clark, RF; Thomas, SC; Tomaszewski, C	1
Marchetti, A; Rossiter, R	1
Chan, GM; Greller, HA; Gupta, AK; Lee, DC; Su, MK	1
Krenzelok, EP; Martello, JL; Pummer, TL	1
He, J; Ji, JM; Wang, P; Wu, G; Xue, Y; Zhu, JQ	1
Bateman, DN; Dear, J	1
Mehrpour, O; Sanaei-Zadeh, H; Shadnia, S	1
Carvalho, AC; Guedes, MM; Lima, PR; Lira, SR; Maciel, MA; Rabelo, AF; Rao, VS; Santos, FA; Tomé, Ada R	1
Avizeh, R; Najafzadeh, H; Razijalali, M; Shirali, S	1
Baniasadi, S; Eftekhari, P; Fahimi, F; Masjedi, MR; Raoufy, MR; Tabarsi, P; Velayati, AA	1
Kamijo, Y	1
Hirose, Y	1
Dehpour, AR; Golestan Jahromi, M; Nabavizadeh, F; Nahrevanian, H; Vahedian, J; Zare-Mehrjardi, A	1
Acharya, M; Lau-Cam, CA	1
Babu, IR; Goessling, W; Lord, AM; North, TE; Tannenbaum, SR; Vedder, LM; Wishnok, JS; Zon, LI	1
Offerman, SR	1
Abdelwahab, SA; Elbitar, HI; Ibrahim, SA; Morsy, MA; Zedan, MZ	1
Ji, L; Jiang, P; Liang, Q; Min, Y; Sheng, Y; Wang, Z; Xia, Y	1
Beringer, RM; Parry, S; Stoddart, PA; Thompson, JP	1
Abdel-Rahman, SM; Brown, A; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Milesi-Hallé, A	1
He, W; Liu, T; Qi, Y; Yan, C; Zhang, Y	1
El-Agamy, DS; Said, SA	1
Filik, L	1
Chandrasekaran, VR; Chien, SP; Hsu, DZ; Liu, MY	1
Bisschops, LA; Bisschops, WA; Kramers, C; van Rossum, LK; Vroegop, MP	1
James, LP; Khandelwal, N; Larson, AM; Lee, WM; Sanders, C	1
Mishra, A; Paul, S; Swarnakar, S	1
Masubuchi, Y; Nakayama, J; Sadakata, Y	1
Bateman, DN; Dear, JW; Ferner, RE	1
Karthikeyan, S; Priya, S; Vijayalakshmi, P; Vivekanandan, P	1
Halcomb, SE; Johnson, MT; McCammon, CA; Mullins, ME	1
Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Smith, MG; Suntres, ZE	1
Dougherty, PP; Klein-Schwartz, W	1
Anusornsuwan, T; Chomchai, C; Chomchai, S	1
Bockus, A; Boggess, N; Ding, WX; Jaeschke, H; Ni, HM	1
Cash, WJ; Iqbal, M; McCormick, PA; Sarwar, S	1
Anscombe, M; Berling, I; Isbister, GK	1
García, C; Martínez, M; Nicolás, M; Porta, R; Sánchez, L	1
Amarapurkar, DN; Gupta, VH; Rai, G; Sasi, P; Singh, M; Wangikar, PP	1
Green, J; Heard, K	1
Buckley, N; Fernandopulle, R; Senarathna, SM; Sri Ranganathan, S	1
Hewawasam, RP; Jayatilaka, KA; Pathirana, C	1
Grant, LM; Rockey, DC	1
Dargan, PI; Keep, J; McQuade, DJ; Wood, DM	1
Andersen, ME; Clewell, HJ; Harrill, AH; Howell, BA; Siler, SQ; Watkins, PB; Woodhead, JL; Yang, Y	1
Aydogan, T; Erdogan, D; Eren, MA; Iraz, M; Koksal, M; Kurcer, Z; Tas, M; Ulas, T	1
Waring, WS	2
Betto, MR; Campos, MM; Driemeier, D; Lazarotto, LF; Leite, CE; Watanabe, TT	1
Dhakal, K; Gadupudi, GS; Lai, IK; Li, M; Ludewig, G; Olivier, AK; Robertson, LW	1
Jiang, R; Lu, H; Peng, X; Wan, J; Xie, J; Zhang, L	1
Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S	1
De Capadocia Rosell, J; Jiménez Vizuete, JM; Lozano Serrano, B; Mateo Cerdá, CM	1
Baltaci, D; Colakoglu, S; Kandis, H; Kara, IH; Karakus, A; Kaya, H; Memisogullari, R; Saritas, A; Yildirim, U	1
Rollstin, AD; Seifert, SA	1
Hoppu, K	1
Lebray, P; Pol, S	1
Bendtsen, F; Dalhoff, K; Knudsen, TT; Schmidt, LE	1
Forkert, PG; Martin, EJ; Racz, WJ	1
Hori, Y; Iwasaki, Y; Komiyayama, Y; Kuroki, Y; Nakatani, H; Namera, A	1
Abbott, F; Farrell, K; Gopaul, S	1
Altintas, E; Kiykim, A; Pata, C; Sezer, K; Uyar, B; Yazar, A	1
Berkeley, LI; Cohen, JF; Crankshaw, DL; Nagasawa, HT; Shirota, FN	1
Ahmad, M; Al-Shabanah, OA; Gado, A; Raza, M	1
Bharadwaj, LA; Davies, GF; Ovsenek, N; Roesler, WJ	1
Hinson, JA; James, LP; Lamps, LW; McCullough, SS	1
Bozek, P; Galbavý, S; Greksák, M; Nakano, M; Ulicná, O; Vancová, O; Zlatos, L	1
Kociancic, T; Reed, MD	1
El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E	1
Tepel, M	1
Juurlink, DN	1
Hinson, JA; James, LP; Mayeux, PR	1
Donald, S; Gescher, AJ; Greaves, P; Jimeno, J; Orr, S; Verschoyle, RD	1
Drobnik, W; Fischereder, M; Hoffmann, U; Krämer, BK; Krüger, B	1
Friedlander, M; Kurtovic, J; Riordan, SM; Singh-Grewal, I; Webster, GJ	1
Taylor, SE	1
Chatterjee, AK; Pal, S	1
Bendtsen, F; Dalhoff, KP; Knudsen, TT; Schmidt, LE	1
Garg, U; Wasserman, GS	1
Chang, WT; Chen, WJ; Fang, CC; Tsai, CL; Weng, TI	1
Boyer, EW; Brush, DE	1
Buckley, N; Chan, B; Dawson, A; Graudins, A; Kerr, F; Murray, L; Trudinger, B; Whyte, IM	1
Prescott, L	1
Marzullo, L	1
Chang, WT; Fang, CC; Tsai, CL; Walson, PD; Weng, TI	1
Dambach, DM; Durham, SK; Laskin, DL; Laskin, JD	1
Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC	1
Elfarra, AA; Sprague, CL	1
Clark, LE; Herrera, JL; Wilkes, JM	1
Frumin, I; Iancu, TC; Manov, I; Motanis, H	1
Bilodeau, M; Zwingmann, C	1
Baba, A; Itoh, Y; Matsuo, M; Mishima, K; Oishi, R	1
Meng, Q; Shen, C; Wu, YT; Yin, J; Yu, JP	1
Cairon, E; Mian, P; Moling, O; Pristerá, R; Rimenti, G; Rizza, F	1
Bulbuloglu, E; Cetinkaya, A; Kantarceken, B; Kurutas, EB	1
Meng, Q; Shen, C; Zhang, G; Zhang, H	1
Lovecchio, F; Pizon, AF	1
Betten, DP; Cantrell, FL; Clark, RF; Thomas, SC; Williams, SR	1
Aladag, M; Ara, C; Ciralik, H; Demirel, U; Firat, S; Harputluoglu, MM; Hilmioglu, F; Karincaoglu, M; Temel, I	1
Biswas, A; Chowdhury, A; Dhali, GK; Ghatak, S; Santra, A	1
Akiyama, S; Aoyama, K; Furukawa, T; Ikeda, R; Keppler, D; Komatsu, M; Nong, Q; Takeuchi, T; Takumi, S	1
Baek, MW; Kim, DJ; Lee, BH; Lee, HK; Lee, HY; Na, YR; Noh, KJ; Park, JH; Park, SH; Ryu, DY; Seok, SH	1
Dart, RC; Rumack, BH	1
Durgut, R; Duru, M; Kaya, H; Koc, A; Sogut, S; Uz, E; Yilmaz, HR	1
Callelo, DP; Henretig, FM; Osterhoudt, KC	1
Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC	1
Sawyer, TS; Spiller, HA	1
Ayata, A; Bayram, D; Cim, A; Gokcimen, A; Kocak, A; Ozgüner, F; Tola, HT	1
Heard, K; Jagoda, AS; Sloan, EP; Wolf, SJ	1
Larson, AM	1
Kimball, T	1
Lu, JW; Wang, H; Wei, W; Xu, DX; Zhang, C; Zhao, L	1
Joshi, D; Shrivastava, S; Shukla, S; Singh, V	1
Jin, Y; Li, G; Liao, Y; Lu, C; Lu, X; Tang, H	1
Björnsson, E	1
Ali, FM; Bird, SB; Boyer, EW	1
Fang, CC; Tsai, CL; Walson, PD	1
Chan, GM; Greller, HA; Majlesi, N; Su, M	1
Cheng, X; Li, D; Meng, Q; Shen, C	1
Cocking, G; Keaney, NP	1
Miller, LF; Rumack, BH	1
Critchley, JA; Prescott, LF	1
Rumack, BH	4
Linden, CH; Rumack, BH	1
Poulsen, HE; Ranek, L	1
Lake, BG	1
Delaforge, M; Hall, DE; Ioannides, C; Mulder, DE; Parke, DV; Spickett, J; Steele, CM	1
Berman, ML; Harbison, RD; James, RC; Smith, AC	1
Anundi, I; Dawson, JR; Moldéus, P; Norbeck, K	1
Corcoran, GB; Lauterburg, BH; Mitchell, JR	1
Arnold, TH; Cook, HR; Epps, JM; Hamrick, ME	1
Cameron, AM; Hinson, JA; Mays, JB	1
Oehme, FW; Savides, MC	1
Black, M	1
Goulding, R; Meredith, TJ	1
Freedman, F; Sellers, EM	1
Breen, KJ; Bury, RW; Desmond, PV; Forge, BH; Mashford, ML; Whelan, G	1
Ruffalo, RL; Thompson, JF	1
Bailey, BO	1
Massey, TE; McElligott, TF; Racz, WJ; Walker, RM	1
Frankl, O; Kaplinsky, N; Shnaps, Y; Tirosh, M	1
Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT	1
Nagasawa, HT; Zera, RT	1
Oh, TE; Shenfield, GM	1
Heathcote, J; Wanless, IR	1
Esteban, A; Graells, ML; Mayol, MJ; Pérez-Mateo, M; Satorres, J	1
Kirsh, BM; Lam, N; Layden, TJ; Wiley, TE	1
Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW	1
Alcaraz, MJ; Bustos, G; Ferrándiz, ML; Gunasegaran, R; Payá, M	1
Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T	1
Døssing, M; Sonne, J	1
De Wit, N; Gillet, R; Huyghens, L; Spapen, H; Zhang, H	1
al-Khalil, I; Douidar, SM; Habersang, RW	1
Burroughs, AK; Hansing, RL; Monto, GL; Scheuer, PJ	1
Donnelly, PJ; Racz, WJ; Walker, RM	1
Colin, R; Ducrotté, P; François, A; Laffineur, G; Lerebours, E; Michel, P; Riachi, G	1
Hegarty, JE; Mulcahy, HE	1
Jones, AF; Vale, JA	1
Grewal, KK; Racz, WJ	1
Fuller, SH; Larsen, LC	1
Canizares, LL; Fernandez, OU	1
Cho, CH; Kaan, SK; Woo, PC	1
Fellay, M; Kehtari, R	1
Kalafatis, N; Macrides, TA; Naylor, LM; Shihata, A; Wright, PF	1
Belpaire, F; Buylaert, W; Calle, P; De Paepe, P; Samyn, N; Vandenbulcke, M; Verstraete, A; Vogelaers, D	1
Lisa Catón, V; Monzón Marín, JL; Ochoa Gómez, FJ; Saralegui Reta, I	1
Astrup, LB; Clemmesen, JO; Dalhoff, KP; Ott, P; Poulsen, HE; Tage-Jensen, U	1
Dietrich, A; Ehrlich, W; Kröger, H; Kurpisz, M; Lange, R; Ohde, M	1
Dunlevy, TM; Wall, MP	1
Kearns, GL; Leeder, JS; Wasserman, GS	2
Perry, HE; Shannon, MW	1
Anders, MW; Baggs, RB; Iyer, RA; Uttamsingh, V	1
Tucker, JR	1
Schmidt, WE; Wronski, R	1
Padar, S; Smith, TJ	1
Ben Ayed, H; Descotes, J; Testud, F; Vial, T	1
Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM	1
Akbay, A; Bozdayi, M; Bozkaya, H; Cinar, K; Eranil, S; Uzunalimoğlu, O; Yurdaydin, C	1
Hudson, M; James, OF; Prince, MI; Thomas, SH	1
Barbet, J; d'Athis, P; Ferracci, G; Pons, G; Rey, E; Tran, A; Tréluyer, JM; Vincent, J	1
Attri, S; Goel, RC; Katyal, R; Nain, CK; Rana, SV; Singh, K; Sodhi, CP; Vaiphei, K	1
Damián, FJ; Jaramillo, F; Llamas, J; Loarca-Piña, MG; Martínez, A; Martínez, C; Ortíz, R; Quezada, T; Reyes, JL; Rodríguez, ML; Valdivia, AG; Yamamoto, L	1
Koren, G; Kozer, E	1
Darville, TL; Farrar, HC; Givens, TG; Hinson, JA; James, LP; Kearns, GL; Simpson, PM; Sullivan, JE; Wasserman, GS	1
Gómez, E; Nogué, S; Recasens, M	1
Attali, M; Borchardt, J; Mahlab, K; Malnick, SD; Sokolowski, N	1
Dargan, PI; Jones, AL	1
Gyamlani, GG; Parikh, CR	1
Kearns, GL	1
Beard, RH; Farrar, HC; James, LP; Wells, E	1
Gerber, JG; Harbison, RD; MacDonald, JS; Nies, AS; Villeneuve, JP; Wood, AJ	1
Adriaenssens, P; Ballantyne, A; Park, J; Prescott, LF; Proudfoot, AT	1
Macy, AM	1
van Zwieten, PA	1
Dillman, RO; Kim, HS; Stewart, DM; Stewart, K	1
Adam, RD; Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT; Stewart, MJ	1
Prescott, LF	2
Conner, CS; Scalley, RD	1
Austin, F; Carloss, H; Forrester, J; Fuson, T	1
Best, L; Krenzelok, EP; Manoguerra, AS	1
Davis, M; Harrison, NG; Simmons, CJ; Williams, R	1
Ema, S; Hayashi, M; Horii, S; Yamakawa, M	1
Chan, HM; Cherian, MG; Tabarrok, R; Tamura, Y	1
Block, R; Jankowski, JA; Lacoux, P; Pennington, CR	1
Batey, RG; Brotodihardjo, AE; Byth, K; Farrell, GC	1
Halkin, H; Winkler, E	1
Gustafson, DL; Pritsos, CA; Sokoloff, M	1
Katz, J; Michael, S; Oberstein, E; Popescu, A; Simko, V	1
De Majo, W; Levy, GA; Sheiner, P	1
Lewis, RK; Paloucek, FP	1
Bray, GP; Mowat, C; Muir, DF; Tredger, JM; Williams, R	1
Cesarone, CF; D'Agostini, F; Perrone, MC; Serra, D	1
Alexander, GJ; Gimson, AE; Harrison, PM; Wendon, JA; Williams, R	1
Hansen, RM; Hanson, GA; Varma, RR	1
Bourcier, DR; Kulkarni, AP; Mitra, A; Ravikumar, VC	1
Alexander, GJ; Forbes, A; Gove, C; Harrison, PM; Keays, R; Wendon, JA; Williams, R	1
Lubec, G	1
Beckett, GJ; Donovan, JW; Hussey, AJ; Prescott, LF; Proudfoot, AT	1
Harvey, JM; Jones, AF; Vale, JA	1
Donovan, JW; Jarvie, DR; Prescott, LF; Proudfoot, AT	1
Chiesura, P; Gioffrè, F; Rizzi, E; Scapinello, A; Trevisan, A	1
Bartle, WR; Derry, JE; Livingstone, DJ; Paradiso, FL	1
Abdel Aal, SF; Badawy, AH; Samour, SA	1
Corcoran, GB; Wong, BK	1
Yeung, JH	1
Bailey, D; Blake, KV; Hendeles, L; Zientek, GM	1
Gescher, A; Mráz, J; Shaw, AJ	1
Flesch, F; Jaeger, A; Kopferschmitt, J; Sauder, P	1
Corcoran, GB; Neese, BL; Wong, BK	1
Levy, G	1
Tenenbein, M	1
Davis, M	1
Zarro, VJ	1
Andrews, C; Jellett, L	1
Axworthy, DB; Baillie, TA; Farmer, PB; Farrow, KC; Gescher, A; Kestell, P; Pearson, PG; Shaw, AJ; Threadgill, MD	1
Brodeur, J; Goyal, R	1
Hall, AH; Rumack, BH	1
Flanagan, RJ; Mant, TG	1
Corcoran, GB; Galinsky, RE; Wong, BK	1
Andres, JM; Bailey, DJ	1
Hayashi, S; Nakai, T	1
Beckett, GJ; Chapman, BJ; Dyson, EH; Hayes, JD	1
Corcoran, GB; Hughes, H; Mitchell, JR; Racz, WJ; Smith, CV; Todd, EL	1
Corcoran, GB; Mitchell, JR; Racz, WJ; Smith, CV	1
Pakuts, A; Paul, CJ; Solomonraj, G; Whitehouse, LW; Wong, LT	1
Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1

Reviews

73 review(s) available for acetylcysteine and Acute Liver Injury, Drug-Induced

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-Induced Liver Injury: Clinical Evidence of N-Acetyl Cysteine Protective Effects. Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Humans	2021
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of toxicology, 2022, Volume: 96, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Mice	2022
Clinical management of patients with drug-induced liver injury (DILI). United European gastroenterology journal, 2021, Volume: 9, Issue:7 Topics: Acetylcysteine; Aged; Anti-Bacterial Agents; Anticholesteremic Agents; Atorvastatin; Azithromycin; Checklist; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Middle Aged; Pruritus; Symptom Assessment	2021
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review. Drug safety, 2022, Volume: 45, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid	2022
The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. Experimental biology and medicine (Maywood, N.J.), 2023, Volume: 248, Issue:5 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Oxidative Stress	2023
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. The Medical journal of Australia, 2020, Volume: 212, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; New Zealand; Practice Guidelines as Topic	2020
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug? Biological & pharmaceutical bulletin, 2020, Volume: 43, Issue:2 Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Female; Glutathione; Humans; Male; Mitochondria, Liver; Oxidative Stress; Pregnancy	2020
Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:11 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Edetic Acid; Fomepizole; Hepatocytes; Humans; Liver Failure, Acute; Pyridoxal Phosphate	2020
Appropriate chemopreventive strategy for anti-tubercular therapy related liver injury is unsettled: Results from a systematic review and network meta-analysis. Expert review of clinical pharmacology, 2020, Volume: 13, Issue:11 Topics: Acetylcysteine; Antitubercular Agents; Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Randomized Controlled Trials as Topic; Research Design	2020
Paracetamol overdose in the newborn and infant: a life-threatening event. European journal of clinical pharmacology, 2021, Volume: 77, Issue:6 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects	2021
Acetaminophen Poisoning. Critical care clinics, 2021, Volume: 37, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans	2021
A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose. Expert review of clinical pharmacology, 2021, Volume: 14, Issue:10 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans	2021
Use of N-Acetylcysteine for Clozapine-Induced Acute Liver Injury: A Case Report and Literature Review. Journal of pharmacy practice, 2023, Volume: 36, Issue:2 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Clozapine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute; Middle Aged	2023
Risk prediction of hepatotoxicity in paracetamol poisoning. Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:8 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antioxidants; Biomarkers; Blood Coagulation; Chemical and Drug Induced Liver Injury; Decision Support Techniques; Humans; Liver; Liver Function Tests; Nomograms; Predictive Value of Tests; Prognosis; Prothrombin Time; Risk Assessment; Risk Factors; Severity of Illness Index	2017
Acute Liver Failure. Clinics in liver disease, 2017, Volume: 21, Issue:4 Topics: Acetylcysteine; Brain Edema; Chemical and Drug Induced Liver Injury; Clinical Protocols; Critical Care; Disease Management; Diuretics, Osmotic; Free Radical Scavengers; Hepatic Encephalopathy; Humans; Intracranial Hypertension; Liver Failure, Acute; Liver Transplantation; Mannitol; Saline Solution, Hypertonic; Time Factors	2017
Therapeutic effects of N-acetyl-L-cysteine on liver damage induced by long-term CCl4 administration. General physiology and biophysics, 2018, Volume: 37, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Liver; Male; Rats; Rats, Wistar; Treatment Outcome	2018
Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox biology, 2018, Volume: 17 Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Humans; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Oxidative Stress; Reactive Oxygen Species	2018
The diagnosis and management of idiosyncratic drug-induced liver injury. Liver international : official journal of the International Association for the Study of the Liver, 2019, Volume: 39, Issue:1 Topics: Acetylcysteine; Adrenal Cortex Hormones; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Failure, Acute; Liver Transplantation; Randomized Controlled Trials as Topic; Risk Factors	2019
What is the most appropriate dose of Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:8 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Humans	2019
The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury. Oxidative medicine and cellular longevity, 2019, Volume: 2019 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Humans; Saponins; Sirtuin 1; Triterpenes	2019
[Severe toxic acute liver failure: etiology and treatment]. Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:6 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Cholestasis; Combined Modality Therapy; Diagnosis, Differential; Disease Management; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Illicit Drugs; Liver Failure, Acute; Liver Function Tests; Liver Transplantation; Mushroom Poisoning; Neurologic Examination; Occupational Diseases; Respiratory Insufficiency; Sepsis; Shock; Time Factors; Valproic Acid	2013
Acetaminophen-related hepatotoxicity. Clinics in liver disease, 2013, Volume: 17, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liver Injury; Humans; Liver Failure, Acute; Risk Factors	2013
[Acute liver failure. Diagnosis and therapy]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2013, Volume: 108, Issue:8 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Liver Transplantation; Multiple Organ Failure; Nucleosides; Nucleotides; Organ Dysfunction Scores; Prognosis	2013
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. Expert review of clinical pharmacology, 2014, Volume: 7, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Overdose; Humans	2014
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. Digestive diseases (Basel, Switzerland), 2015, Volume: 33, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Free Radical Scavengers; Hepatocytes; Humans; Liver; Liver Failure, Acute; Mice	2015
Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert review of gastroenterology & hepatology, 2016, Volume: 10, Issue:4 Topics: Acetylcysteine; Adrenal Cortex Hormones; Antidotes; Antioxidants; Chelating Agents; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Genetic Predisposition to Disease; Humans; Liver Transplantation; Liver, Artificial; Patient Selection; Pharmacogenomic Testing; Phenotype; Precision Medicine; Risk Factors; Therapeutic Irrigation; Treatment Outcome	2016
N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review. British journal of clinical pharmacology, 2016, Volume: 81, Issue:6 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Humans	2016
The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2016, Volume: 22, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Contraindications; Free Radical Scavengers; Humans; Liver Failure, Acute; Liver Transplantation; Prognosis; Quality of Life; Rare Diseases; Survival Rate; Treatment Outcome; Waiting Lists	2016
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacological research, 2016, Volume: 109 Topics: Acetaminophen; Acetylcysteine; Animals; Brain; Chemical and Drug Induced Liver Injury; Humans; Liver	2016
Adverse reactions associated with acetylcysteine. Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagulation; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Risk Factors	2009
Emergency: acetaminophen poisoning. The American journal of nursing, 2009, Volume: 109, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Labeling; Emergencies; Emergency Treatment; Female; Humans; Liver Diseases; Nonprescription Drugs; Patient Education as Topic; Risk Factors; Substance Abuse Detection; Suicide, Attempted; Time Factors	2009
Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Injections, Intravenous; Time Factors; Treatment Outcome	2011
[Intentional paracetamol intoxication in children]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans	2011
Management of paracetamol poisoning. BMJ (Clinical research ed.), 2011, Apr-19, Volume: 342 Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Transplantation; Nomograms; Physical Examination	2011
Lack of toxicity after paracetamol overdose in a extremely preterm neonate. European journal of clinical pharmacology, 2012, Volume: 68, Issue:5 Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Infusions, Intravenous; Medication Errors; Metabolic Clearance Rate; Sepsis; Treatment Outcome	2012
Acetylcysteine therapy for acetaminophen poisoning. Current pharmaceutical biotechnology, 2012, Volume: 13, Issue:10 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Emergency Treatment; Humans; Molecular Structure; Structure-Activity Relationship; Treatment Outcome	2012
Drug-induced liver injury. Current opinion in gastroenterology, 2012, Volume: 28, Issue:3 Topics: Acetylcysteine; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Disease Susceptibility; Europe; Female; Genome-Wide Association Study; Genotype; HLA-DRB1 Chains; Humans; Male; Protective Agents; Risk Factors; United States	2012
Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning. Expert review of clinical pharmacology, 2012, Volume: 5, Issue:3 Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Humans; Risk Factors	2012
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage]. Duodecim; laaketieteellinen aikakauskirja, 2002, Volume: 118, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Poisoning; Time Factors; Treatment Outcome	2002
[Practical analysis of toxic substances useful for clinical toxicology--4--Acetaminophen]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2002, Volume: 15, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Liver Diseases; Predictive Value of Tests; Severity of Illness Index; Suicide, Attempted; Ultraviolet Rays	2002
Acetaminophen intoxication and length of treatment: how long is long enough? Pharmacotherapy, 2003, Volume: 23, Issue:8 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Time Factors	2003
Acetylcysteine for the prevention of radiocontrast -induced nephropathy. Minerva cardioangiologica, 2003, Volume: 51, Issue:5 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Contrast Media; Free Radical Scavengers; Humans	2003
Acetaminophen-induced hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:12 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cytokines; Humans; Kupffer Cells; Liver Diseases; Mitochondria, Liver; Oxidative Stress; Tyrosine	2003
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Current opinion in pediatrics, 2005, Volume: 17, Issue:2 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Exanthema; Humans; Infusions, Intravenous; Liver Diseases; Practice Guidelines as Topic; Pruritus	2005
Acetaminophen overdose in pregnancy. Southern medical journal, 2005, Volume: 98, Issue:11 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fetus; Humans; Liver; Pregnancy; Pregnancy Complications	2005
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil	2006
Acetaminophen hepatotoxicity. Clinics in liver disease, 2007, Volume: 11, Issue:3 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver	2007
Hepatotoxicity associated with antiepileptic drugs. Acta neurologica Scandinavica, 2008, Volume: 118, Issue:5 Topics: Acetylcysteine; Animals; Anticonvulsants; Autoimmune Diseases; Carnitine; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Hepatic Encephalopathy; Hepatocytes; Humans; Liver; Liver Diseases	2008
The treatment of acetaminophen poisoning. Annual review of pharmacology and toxicology, 1983, Volume: 23 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Glutathione; Humans; Liver; Methionine; Necrosis; Sulfhydryl Compounds	1983
Acetaminophen overdose. The American journal of medicine, 1983, Nov-14, Volume: 75, Issue:5A Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Chemical and Drug Induced Liver Injury; Child; Ethanol; Humans; Infusions, Parenteral	1983
Acetaminophen overdose. Emergency medicine clinics of North America, 1984, Volume: 2, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors	1984
Acetaminophen hepatotoxicity. Gastroenterology, 1980, Volume: 78, Issue:2 Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Glutathione; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine	1980
Paracetamol. Postgraduate medical journal, 1980, Volume: 56, Issue:657 Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Cysteamine; Dextropropoxyphene; Humans; Infant; Kidney Diseases; Methionine	1980
Treatment of acetaminophen poisoning. Canadian Medical Association journal, 1981, Oct-15, Volume: 125, Issue:8 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Liver	1981
Hepatotoxicity: newer aspects of pathogenesis and treatment. The Gastroenterologist, 1995, Volume: 3, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Contraceptives, Oral; Female; Humans; Isoniazid; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Nonprescription Drugs; Propylthiouracil; Rifampin	1995
Diagnosis and management of fulminant hepatic failure. Comprehensive therapy, 1995, Volume: 21, Issue:4 Topics: Acetylcysteine; Adrenal Cortex Hormones; Artificial Organs; Blood Coagulation Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Liver; Prognosis; Renal Insufficiency; Risk Factors	1995
Drug-induced hepatic disorders. Incidence, management and avoidance. Drug safety, 1993, Volume: 9, Issue:6 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Humans; Jaundice; Liver; Liver Diseases; Liver Transplantation; Risk Factors	1993
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders]. Nederlands tijdschrift voor geneeskunde, 1994, Apr-02, Volume: 138, Issue:14 Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug Induced Liver Injury; Humans; Myocardial Reperfusion Injury; Nitrates; Reactive Oxygen Species; Respiratory Distress Syndrome	1994
Paracetamol hepatotoxicity. Irish journal of medical science, 1993, Volume: 162, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalopathy; Humans; Intubation; Liver Diseases; Prognosis; Stomach	1993
Paracetamol poisoning and the kidney. Journal of clinical pharmacy and therapeutics, 1993, Volume: 18, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Kidney	1993
Management of acetaminophen toxicity. American family physician, 1996, Volume: 53, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Poisoning	1996
[Focus: fulminant and subfulminant hepatic insufficiency]. Revue medicale de la Suisse romande, 1996, Volume: 116, Issue:6 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Critical Care; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Hypoxia; Liver Failure, Acute; Liver Transplantation; Prognosis	1996
[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver]. Ugeskrift for laeger, 1996, Nov-25, Volume: 158, Issue:48 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Denmark; Humans; Infusions, Intravenous; Poisoning	1996
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:6 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Infant; Injections, Intravenous; Liver Diseases; Male; Middle Aged; Poisoning; Transaminases	1999
Acetaminophen intoxication during treatment: what you don't know can hurt you. Clinical pediatrics, 2000, Volume: 39, Issue:3 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Risk Factors	2000
Management of paracetamol overdose: current controversies. Drug safety, 2001, Volume: 24, Issue:7 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Drug Overdose; Female; Humans; Liver Diseases; Pregnancy; Risk Factors	2001
Acetaminophen poisoning: an update for the intensivist. Critical care (London, England), 2002, Volume: 6, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Critical Care; Humans; Liver Transplantation; Prognosis	2002
Assessment and treatment of acetaminophen overdose. Clinical pharmacy, 1991, Volume: 10, Issue:10 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Gastric Lavage; Humans; Ipecac	1991
[Paracetamol hepatotoxicity]. Padiatrie und Padologie, 1990, Volume: 25, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant	1990
Pediatric toxicology: current controversies and recent advances. Current problems in pediatrics, 1986, Volume: 16, Issue:4 Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child Abuse; Child, Preschool; Digitoxin; Digoxin; Emetics; Female; Gastric Lavage; Humans; Hydrocarbons; Immunoglobulin Fab Fragments; Infant; Male; Naloxone; Narcotics; Poisoning	1986
Protective agents for acetaminophen overdose. Seminars in liver disease, 1986, Volume: 6, Issue:2 Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine; Cysteamine; Glucuronates; Glutathione; Humans; Inactivation, Metabolic; Lipid Peroxides; Liver; Methionine; Necrosis; Propylthiouracil	1986
[Therapy of toxic hepatitis]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adrenal Cortex Hormones; Age Factors; Aged; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Male; Middle Aged; Prognosis; Sex Factors	1985

Trials

20 trial(s) available for acetylcysteine and Acute Liver Injury, Drug-Induced

Article	Year
Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury. British journal of clinical pharmacology, 2023, Volume: 89, Issue:6 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antibiotics, Antitubercular; Chemical and Drug Induced Liver Injury; Female; Humans; Male; MicroRNAs; Placebos	2023
A study to evaluate the hepatoprotective effect of N- acetylcysteine on anti tuberculosis drug induced hepatotoxicity and quality of life. The Indian journal of tuberculosis, 2023, Volume: 70, Issue:3 Topics: Acetylcysteine; Bilirubin; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Prospective Studies; Quality of Life; Tuberculosis	2023
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). Journal of hepatology, 2020, Volume: 72, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult	2020
A Randomized Controlled Trial of Intravenous N-Acetylcysteine in the Management of Anti-tuberculosis Drug-Induced Liver Injury. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 11-02, Volume: 73, Issue:9 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Chemical and Drug Induced Liver Injury; Double-Blind Method; Female; Humans	2021
A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose. Clinical and translational science, 2021, Volume: 14, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Metabolomics; Middle Aged; Oxidation-Reduction; ROC Curve; Sulfhydryl Compounds	2021
The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose. Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Creatinine; Feasibility Studies; Female; Free Radical Scavengers; Humans; Male; Young Adult	2019
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion. Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poisoning; Treatment Outcome; Victoria; Young Adult	2019
N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects. Fundamental & clinical pharmacology, 2019, Volume: 33, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Double-Blind Method; Drug Interactions; Expectorants; Glutathione; Humans; Male; Pain; Pain Measurement; Young Adult	2019
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi Trials, 2019, Jan-08, Volume: 20, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase I as Topic; Data Interpretation, Statistical; Drug Overdose; Drug Therapy, Combination; Edetic Acid; Female; Humans; Male; Outcome Assessment, Health Care; Pyridoxal Phosphate; Randomized Controlled Trials as Topic; Research Design	2019
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial). EBioMedicine, 2019, Volume: 46 Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Overdose; Edetic Acid; Female; Humans; Male; Protective Agents; Pyridoxal Phosphate; Time Factors; Young Adult	2019
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:5 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Humans; Male; Prospective Studies; Time Factors; Transaminases; Treatment Outcome; Young Adult	2014
Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats. Journal of veterinary pharmacology and therapeutics, 2010, Volume: 33, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Bilirubin; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Liver; Male; Methemoglobinemia; Protective Agents; Silymarin	2010
Protective effect of N-acetylcysteine on antituberculosis drug-induced hepatotoxicity. European journal of gastroenterology & hepatology, 2010, Volume: 22, Issue:10 Topics: Acetylcysteine; Aged; Aged, 80 and over; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Therapy, Combination; Ethambutol; Female; Free Radical Scavengers; Humans; Isoniazid; Liver; Male; Pyrazinamide; Rifampin; Tuberculosis, Pulmonary	2010
The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:2 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Contrast Media; Female; Humans; Liver Diseases; Male; Prospective Studies; Radiopharmaceuticals	2004
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Annals of emergency medicine, 2005, Volume: 45, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Male; Nausea	2005
Clinical safety of high oral doses of acetylcysteine. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Diarrhea; Drug Administration Schedule; Electrocardiography; Electrolytes; Humans; Liver; Liver Diseases; Rats; Vomiting	1983
Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. The Journal of pediatrics, 1998, Volume: 132, Issue:1 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drugs, Investigational; Female; Free Radical Scavengers; Humans; Injections, Intravenous; Male; Statistics, Nonparametric	1998
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. The New England journal of medicine, 1991, Jun-27, Volume: 324, Issue:26 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hemodynamics; Hepatic Encephalopathy; Hepatitis C; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Oxygen; Oxygen Consumption	1991
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ (Clinical research ed.), 1991, Oct-26, Volume: 303, Issue:6809 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Diseases; London; Male; Middle Aged; Prospective Studies; Prothrombin Time; Survival Rate	1991
Letter: Cysteamine for paracetamol overdosage. Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864 Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Clinical Trials as Topic; Cysteamine; Dimercaprol; Humans; Penicillamine; Poisoning; Time Factors	1974

Other Studies

388 other study(ies) available for acetylcysteine and Acute Liver Injury, Drug-Induced

Article	Year
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine. Journal of medicinal chemistry, 1982, Volume: 25, Issue:5 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cysteine; Magnetic Resonance Spectroscopy; Mice; Thiazoles	1982
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests	2011
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Eating; Humans; Retrospective Studies	2022
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:4 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans	2022
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies; Victoria	2022
Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eating; Humans	2022
Authors' reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eating; Humans	2022
Large paracetamol overdose - Higher dose NAC is NOT required. British journal of clinical pharmacology, 2023, Volume: 89, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies	2023
Large paracetamol overdose-Higher dose acetylcysteine is required. British journal of clinical pharmacology, 2023, Volume: 89, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans	2023
The association between N-acetylcysteine treatment and hepatic healing in patients with non-acetaminophen-induced liver injury in pediatric intensive care: A single-center retrospective study. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2022, Volume: 29, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Critical Care; Female; Humans; Liver Failure, Acute; Male; Retrospective Studies; Transaminases; Treatment Outcome	2022
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram. Pharmacology research & perspectives, 2022, Volume: 10, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Nomograms; Retrospective Studies; Sensitivity and Specificity; Young Adult	2022
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. Journal of hepatology, 2022, Volume: 77, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Mice; Mice, Inbred C57BL	2022
Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, Volume: 163 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Liver; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A2B	2022
Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6. Chemical research in toxicology, 2022, 05-16, Volume: 35, Issue:5 Topics: Acetylcysteine; Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2D6; Glutathione; Microsomes, Liver; Propafenone; Quinones; Rats	2022
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020. Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Databases, Factual; Fomepizole; Humans	2022
Chemical research in toxicology, 2022, 06-20, Volume: 35, Issue:6 Topics: Acetylcysteine; Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Environmental Pollutants; Glutathione; Mice; Xylenes	2022
Compromised blood-bile barrier after acetaminophen overdose. Archives of toxicology, 2022, Volume: 96, Issue:10 Topics: Acetaminophen; Acetylcysteine; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver	2022
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning. Toxicological sciences : an official journal of the Society of Toxicology, 2022, 09-24, Volume: 189, Issue:2 Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Imines; Larva; Liver; Mammals; Sulfates; Zebrafish	2022
Comment: Comparison of 2-Bag Versus 3-Bag The Annals of pharmacotherapy, 2023, Volume: 57, Issue:4 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans	2023
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts. Archives of toxicology, 2022, Volume: 96, Issue:12 Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Fibroblasts; Hepatocytes; Humans; Liver; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Wharton Jelly	2022
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury. ACS applied materials & interfaces, 2022, Sep-28, Volume: 14, Issue:38 Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Ferroptosis; Heme Oxygenase-1; Hereditary Sensory and Motor Neuropathy; Humans; Liver; NF-E2-Related Factor 2; Oxidative Stress; Silicon Dioxide; Xanthophylls	2022
Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling. Ecotoxicology and environmental safety, 2022, Oct-01, Volume: 244 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Kelch-Like ECH-Associated Protein 1; Liver; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; RNA, Messenger; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases	2022
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity. Xenobiotica; the fate of foreign compounds in biological systems, 2022, Volume: 52, Issue:6 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Liver; Luciferases; Mice; Receptors, Cytoplasmic and Nuclear	2022
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:20 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver Diseases; Mice; Nitrates; Nitrites	2022
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert opinion on drug metabolism & toxicology, 2022, Volume: 18, Issue:11 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans	2022
Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury. Chemico-biological interactions, 2023, Jan-05, Volume: 369 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Humans; Metal Nanoparticles; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Silver	2023
Fomepizole should not be used more liberally in paracetamol overdose. British journal of clinical pharmacology, 2023, Volume: 89, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COVID-19; Drug Overdose; Fomepizole; Humans	2023
Role of NF-κB signaling pathway in hexavalent chromium-induced hepatotoxicity. Environmental toxicology, 2023, Volume: 38, Issue:6 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Chromium; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Reactive Oxygen Species; Signal Transduction	2023
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose. Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacists; Retrospective Studies	2023
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7). Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:6 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies	2023
Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity. Analytical cellular pathology (Amsterdam), 2023, Volume: 2023 Topics: Acetaminophen; Acetylcysteine; Animals; Bone Marrow; Chemical and Drug Induced Liver Injury; Liver; Rats; Rats, Wistar; Thymus Plant	2023
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning. Acta bio-medica : Atenei Parmensis, 2023, 05-29, Volume: 94, Issue:S1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; COVID-19; Digestive System Diseases; Drug Overdose; Female; Humans	2023
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice. Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:11 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Farnesol; Glutathione; Liver; Mice; Necrosis; NF-kappa B; Transaminases	2023
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochemical and biophysical research communications, 2023, 10-08, Volume: 676 Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Glutathione; Homeostasis; Humans; Liver; Liver Neoplasms; Oxidation-Reduction	2023
Aflatoxin B1-induced early developmental hepatotoxicity in larvae zebrafish. Chemosphere, 2023, Volume: 340 Topics: Acetylcysteine; Aflatoxin B1; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Larva; Zebrafish	2023
Characterization of the cellular effects and mechanism of arsenic trioxide-induced hepatotoxicity in broiler chickens. Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 61 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenic Trioxide; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chickens; Hepatocytes; Methionine Sulfoxide Reductases; Oxidative Stress; Reactive Oxygen Species	2019
Protocol deviations in intravenous acetylcysteine therapy for acetaminophen toxicity. The American journal of emergency medicine, 2020, Volume: 38, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Clinical Protocols; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult	2020
N-acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion. Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:1 Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Chromium; Drug Therapy, Combination; Humans; Male; Middle Aged; Oxidative Stress; Treatment Outcome	2020
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL. Biochimica et biophysica acta. Molecular basis of disease, 2020, 01-01, Volume: 1866, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Hepatocytes; Humans; Inflammation; Leukocytes; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand	2020
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity. The American journal of emergency medicine, 2020, Volume: 38, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans; Male; Treatment Outcome	2020
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury. Journal of leukocyte biology, 2020, Volume: 107, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Free Radical Scavengers; Glycine; Inflammation; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides	2020
Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury. Irish journal of medical science, 2020, Volume: 189, Issue:4 Topics: Acetylcysteine; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Disease Models, Animal; Female; Humans; Liver; Male; Retrospective Studies	2020
Improvement of therapeutic potential N-acetylcysteine in acetaminophen hepatotoxicity by encapsulation in PEGylated nano-niosomes. Life sciences, 2020, Aug-15, Volume: 255 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Liposomes; Male; Nanoparticles; Particle Size; Polyethylene Glycols; Rats; Rats, Wistar; Surface-Active Agents	2020
Late Diagnosis of Paracetamol Poisoning is Always Lethal in Young Adult. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2020, Volume: 30, Issue:6 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Delayed Diagnosis; Humans; Male; Young Adult	2020
Antifibrotic effect of curcumin, N-acetyl cysteine and propolis extract against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment. Life sciences, 2020, Nov-01, Volume: 260 Topics: Acetylcysteine; Animals; Apoptosis; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Curcumin; Drug Therapy, Combination; Inflammation; Interleukins; Liver; Liver Cirrhosis; Male; Phenols; Propolis; Rats; Rats, Wistar	2020
Possible role for acetylcysteine as a treatment for acute liver failure secondary to antitubercular medication use. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2020, 09-04, Volume: 77, Issue:18 Topics: Acetylcysteine; Administration, Oral; Adult; Antidotes; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Failure, Acute; Tuberculosis	2020
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats. Experimental animals, 2021, Feb-06, Volume: 70, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Folic Acid; Free Radical Scavengers; Oxidative Stress; Rats, Sprague-Dawley	2021
Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in rat liver and kidney. Journal of biochemistry, 2021, Apr-18, Volume: 169, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Ethanol; Free Radical Scavengers; Glutathione; Humans; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Taraxacum	2021
Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage. Inflammation, 2021, Volume: 44, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Concanavalin A; Coprophagia; Dexamethasone; Ecosystem; Gastrointestinal Microbiome; Hepatitis, Autoimmune; Housing, Animal; Male; Mice; Mice, Inbred C57BL; Treatment Outcome	2021
N-Acetyl Cysteine in Antitubercular Drug-Induced Liver Injury: In Search of Homogenous Evidence. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 10-05, Volume: 73, Issue:7 Topics: Acetylcysteine; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Humans; Liver	2021
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:4 Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokines; Gene Expression Regulation; Liver; Male; Mice; Necrosis	2021
Possible protective activity of n-acetyl cysteine against cisplatin‑induced hepatotoxicity in rats. Molecular biology reports, 2021, Volume: 48, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cisplatin; Humans; Inflammation; Liver; Neoplasms; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar	2021
N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer - a case report. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Risk Factors; Treatment Outcome	2021
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice. Ultrastructural pathology, 2021, Jan-02, Volume: 45, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Liver; Mice	2021
Repetitive drug-induced liver injury with kedaling tablets. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:9 Topics: Acetylcysteine; Alkaloids; Berberine Alkaloids; Chemical and Drug Induced Liver Injury; China; Corydalis; Free Radical Scavengers; Humans; Magnoliopsida; Male; Medicine, Chinese Traditional; Middle Aged; Plant Extracts; Treatment Outcome	2021
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:10 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poison Control Centers; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult	2021
Ameliorative effect of N-acetylcysteine against glyphosate-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies. Environmental science and pollution research international, 2021, Volume: 28, Issue:31 Topics: Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glycine; Glyphosate; Liver; Male; Oxidative Stress; Rats; Rats, Wistar	2021
Can granulocyte colony stimulating factor (G-CSF) ameliorate acetaminophen-induced hepatotoxicity? Human & experimental toxicology, 2021, Volume: 40, Issue:10 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; L-Lactate Dehydrogenase; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar	2021
Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used? Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2021, Volume: 17, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Obesity; Retrospective Studies	2021
Extremely Elevated Procalcitonin in a Case of Acetaminophen Overdose and Acute Liver Injury. Internal medicine (Tokyo, Japan), 2022, Jan-01, Volume: 61, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Male; Middle Aged; Procalcitonin	2022
Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study. United European gastroenterology journal, 2021, Volume: 9, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Multivariate Analysis; Nomograms; Paris; Predictive Value of Tests; Procalcitonin; Prospective Studies; ROC Curve; Young Adult	2021
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Archives of toxicology, 2021, Volume: 95, Issue:10 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Time Factors	2021
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studies; Sensitivity and Specificity; Young Adult	2017
[EFFECT OF ACETYLCYSTEINE, CORVITIN AND THEIR COMBINATION ON THE FUNCTIONAL STATE OF LIVER IN RATS WITH PARACETAMOL INDUCED TOXIC HEPATITIS]. Georgian medical news, 2017, Issue:263 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Flavonoids; Liver; Male; Protective Agents; Rats, Wistar	2017
[ACTION OF L-CARNITINE, CORVITIN AND THEIR COMBINATION ON FUNCTIONAL STATE OF LIVER IN EXPERIMENTAL MODEL OF REYE SYNDROME IN RATS]. Georgian medical news, 2017, Issue:263 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Flavonoids; Liver; Male; Protective Agents; Random Allocation; Rats, Wistar; Reye Syndrome	2017
Effects of N-acetyl cysteine on oxidative stress and TNF-α gene expression in diclofenac-induced hepatotoxicity in rats. Toxicology mechanisms and methods, 2017, Volume: 27, Issue:8 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Catalase; Chemical and Drug Induced Liver Injury; Diclofenac; Gene Expression; Lipids; Liver; Liver Function Tests; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Silymarin; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2017
Acetylcysteine (Cetylev) for acetaminophen overdose. The Medical letter on drugs and therapeutics, 2017, 06-19, Volume: 59, Issue:1523 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Compounding; Drug Overdose; Humans; Tablets; Treatment Outcome	2017
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. European journal of clinical pharmacology, 2017, Volume: 73, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Overdose; Humans; Infusions, Intravenous; Models, Biological	2017
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:10 Topics: Acetaminophen; Acetylcysteine; Adult; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Databases, Factual; Dose-Response Relationship, Drug; Drug Overdose; Early Medical Intervention; Female; Humans; Male; Poison Control Centers; Prospective Studies; Retrospective Studies; Treatment Outcome	2017
Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug and Narcotic Control; Drug Approval; Drug Combinations; Drug Compounding; Drug Overdose; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Poison Control Centers; Policy Making; Pregnancy; Prescription Drugs; Program Evaluation; Protective Factors; Risk Factors; Time Factors; United States; United States Food and Drug Administration; Young Adult	2017
Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo. Toxicology and applied pharmacology, 2017, 10-01, Volume: 332 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; HMGB1 Protein; Liver; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Photoacoustic Techniques	2017
N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury. Liver international : official journal of the International Association for the Study of the Liver, 2018, Volume: 38, Issue:2 Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Antidotes; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Glutathione; Hepatocytes; Humans; Infusions, Intravenous; Liver; Liver Transplantation; Male; Middle Aged; Prednisolone; Recovery of Function; Retrospective Studies; Severity of Illness Index; Treatment Outcome	2018
Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Prospective Studies; Retrospective Studies	2018
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Glutamate Dehydrogenase; HMGB1 Protein; Humans; Keratin-18; Male; MicroRNAs; Middle Aged; Prospective Studies; Risk Assessment; Young Adult	2018
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose. Pharmacoepidemiology and drug safety, 2018, Volume: 27, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Obesity; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult	2018
Intravenous AACN advanced critical care, 2017,Winter, Volume: 28, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Education, Nursing, Continuing; Humans; United States	2017
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:7 Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged	2018
Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:10 Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Cystic Fibrosis; Drug Overdose; Female; Humans; MicroRNAs; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult	2018
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury. Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child, Preschool; Denmark; Female; Humans; Incidence; Infant; Male; Retrospective Studies	2018
Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells. Molecules and cells, 2018, May-31, Volume: 41, Issue:5 Topics: Acetylcysteine; Alkaloids; Amino Acid Chloromethyl Ketones; Anthracenes; Antioxidants; Antiviral Agents; Apoptosis; Butylamines; Cell Line; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Free Radical Scavengers; Gene Expression Regulation; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Quinolizines; Reactive Oxygen Species	2018
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity. Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:5 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Benzene Derivatives; Benzoquinones; Chelating Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Imines; Mice; Sulfhydryl Compounds	2018
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Archives of toxicology, 2019, Volume: 93, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Mice, Inbred C57BL; Necrosis; Organophosphorus Compounds; Piperidines; Receptor-Interacting Protein Serine-Threonine Kinases	2019
N-Acetylcysteine reverses silver nanoparticle intoxication in rats. Nanotoxicology, 2019, Volume: 13, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Humans; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Metal Nanoparticles; Rats; Silver	2019
Activation of Sirtuin 3 and Maintenance of Mitochondrial Integrity by International journal of molecular sciences, 2019, Jan-11, Volume: 20, Issue:2 Topics: Acetylcysteine; Animals; Apoptosis; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Kidney Diseases; Male; Mitochondria; Mitochondrial Dynamics; Oxidative Stress; Phenols; Rats; Rats, Wistar; Signal Transduction; Sirtuins; Superoxide Dismutase	2019
Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clinical toxicology (Philadelphia, Pa.), 2019, Volume: 57, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Clinical Decision-Making; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Patient Selection; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Time-to-Treatment; Young Adult	2019
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:7 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Epigenesis, Genetic; Hep G2 Cells; Humans; Liver Failure, Acute; Mice; Mice, Knockout; Orphan Nuclear Receptors; RNA, Long Noncoding; Signal Transduction; Tumor Suppressor Protein p53	2019
Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine. Bratislavske lekarske listy, 2019, Volume: 120, Issue:4 Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dexmedetomidine; Glutathione; Liver; Oxidative Stress; Rats	2019
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash. The Journal of toxicological sciences, 2019, Volume: 44, Issue:8 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry	2019
Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury. Free radical biology & medicine, 2013, Volume: 60 Topics: Acetaminophen; Acetanilides; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Mice; Mitochondria, Liver; Nitrates; Oxidative Stress; Proteins; Superoxide Dismutase	2013
The protective effects of n-acetylcysteine against acute hepatotoxicity. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2013, Volume: 32, Issue:5 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley	2013
Dissemination and uptake of a new treatment pathway for paracetamol poisoning in the UK: a survey of healthcare professionals. British journal of clinical pharmacology, 2013, Volume: 76, Issue:6 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Delivery of Health Care; Government Regulation; Health Care Surveys; Health Knowledge, Attitudes, Practice; Health Personnel; Health Plan Implementation; Humans; Information Dissemination; Injections, Intravenous; Pilot Projects; Practice Guidelines as Topic; Surveys and Questionnaires; United Kingdom	2013
The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose. QJM : monthly journal of the Association of Physicians, 2013, Volume: 106, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Hospitalization; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Young Adult	2013
Acute hepatitis in a young woman with systemic lupus erythematosus: a diagnostic challenge. BMJ case reports, 2013, Apr-05, Volume: 2013 Topics: Acetylcysteine; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Autoimmune; Humans; Liver Function Tests; Lupus Erythematosus, Systemic; Middle Aged	2013
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. Journal of drug targeting, 2013, Volume: 21, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Body Weight; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Liposomes; Liver; Male; Peroxidase; Rats; Rats, Sprague-Dawley	2013
Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Hepatocytes; Injections, Intraperitoneal; Ketones; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Quantum Theory	2013
How safe is acetaminophen? HDA now, 2013,Spring Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Safety	2013
Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets. The British journal of nutrition, 2014, Jan-14, Volume: 111, Issue:1 Topics: Acetylcysteine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Female; HSP70 Heat-Shock Proteins; Inflammation Mediators; Lipopolysaccharides; Liver; NF-kappa B; Random Allocation; Swine	2014
Roles of lipoxin A4 in preventing paracetamol-induced acute hepatic injury in a rabbit model. Inflammation, 2013, Volume: 36, Issue:6 Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; Hepatocytes; Inflammation; Interleukin-10; Lipoxins; Liver; Male; Rabbits; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2013
Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Human & experimental toxicology, 2013, Volume: 32, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hyperbaric Oxygenation; Interleukin-6; Liver; Male; Neopterin; Protective Agents; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	2013
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Archives of toxicology, 2014, Volume: 88, Issue:2 Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria	2014
[Paracetamol overdose]. Revue medicale suisse, 2013, Aug-14, Volume: 9, Issue:394 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nonprescription Drugs	2013
Reliability of the reported ingested dose for predicting the requirement of N-acetylcysteine in paracetamol overdose patients. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male	2013
Understanding probability and exposure in paracetamol overdose risk assessment. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male	2013
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male	2013
Letter in response to Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:10 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male	2013
The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats. Bratislavske lekarske listy, 2013, Volume: 114, Issue:12 Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Carnitine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Free Radical Scavengers; Liver; Oxidative Stress; Rats; Rats, Wistar; Vitamin B Complex	2013
New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure. PloS one, 2013, Volume: 8, Issue:12 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzene Derivatives; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Reactive Oxygen Species	2013
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children. Biomarkers in medicine, 2014, Volume: 8, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Sex Factors	2014
Treatment with N-acetylcystein and total plasma exchange for extracorporeal liver support in children with paracetamol intoxication. Klinische Padiatrie, 2014, Volume: 226, Issue:2 Topics: Acetaminophen; Acetylcysteine; Ammonia; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Infant; Intensive Care Units, Pediatric; Liver Failure, Acute; Liver Function Tests; Plasma; Plasma Exchange; Respiratory Tract Infections	2014
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nomograms; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Thailand	2014
Antioxidant and anti-inflammatory effects of N-acetylcysteine against malathion-induced liver damages and immunotoxicity in rats. Life sciences, 2014, Jun-27, Volume: 107, Issue:1-2 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytokines; Flow Cytometry; Free Radical Scavengers; Inflammation; Insecticides; Leukocytes; Lipid Peroxidation; Liver; Lymphocytes; Malathion; Male; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2014
Determination of DNA damage in experimental liver intoxication and role of N-acetyl cysteine. Cell biochemistry and biophysics, 2014, Volume: 70, Issue:2 Topics: Acetylation; Acetylcysteine; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Damage; Histone Acetyltransferases; Histone Deacetylases; Histones; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley	2014
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter. Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Likelihood Functions; Male; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Thailand; Time Factors; Young Adult	2014
Early predictors of severe acetaminophen-induced hepatotoxicity in a paediatric population referred to a tertiary paediatric department. Acta paediatrica (Oslo, Norway : 1992), 2014, Volume: 103, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Female; Hospital Departments; Humans; Male; Pediatrics; Referral and Consultation; Retrospective Studies; Severity of Illness Index; Suicide, Attempted; Tertiary Care Centers; Time Factors	2014
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World journal of gastroenterology, 2014, Aug-07, Volume: 20, Issue:29 Topics: Acetylcysteine; Amifostine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Male; Methotrexate; Oxidative Stress; Rats, Sprague-Dawley; Time Factors	2014
Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse. BMC gastroenterology, 2014, Aug-19, Volume: 14 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Disease Models, Animal; Free Radical Scavengers; Interleukin-1beta; Lactate Dehydrogenases; Liver; Liver Failure, Acute; Mice; Mice, Inbred BALB C; Neostigmine; Tumor Necrosis Factor-alpha	2014
Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2014, Volume: 20, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fever; Glucocorticoids; Humans; Liver; Lupus Erythematosus, Systemic; Prednisone; Treatment Outcome	2014
Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury. Toxicology letters, 2015, Jan-05, Volume: 232, Issue:1 Topics: Acetylcysteine; Activation, Metabolic; Alanine Transaminase; Animals; Anticonvulsants; Bile; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Glutathione; Liver; Mice, Inbred C57BL; Phenytoin; Sulfhydryl Compounds; Time Factors	2015
Attenuation of copaiba oil in hepatic damage in rats. Acta cirurgica brasileira, 2014, Volume: 29, Issue:12 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Corn Oil; Disease Models, Animal; Fabaceae; gamma-Glutamyltransferase; Male; Plant Oils; Random Allocation; Rats, Wistar; Treatment Outcome	2014
Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Plant Extracts; Schisandra; Signal Transduction; Tablets	2015
Carbonyl traps as potential protective agents against methimazole-induced liver injury. Journal of biochemical and molecular toxicology, 2015, Volume: 29, Issue:4 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and Drug Induced Liver Injury; Male; Metformin; Methimazole; Mice; Necrosis; Oxidative Stress; Protective Agents	2015
Spice/K2 synthetic marijuana-induced toxic hepatitis treated with N-acetylcysteine. The American journal of case reports, 2014, Dec-30, Volume: 15 Topics: Acetylcysteine; Antiviral Agents; Cannabinoids; Chemical and Drug Induced Liver Injury; Humans; Illicit Drugs; Male; Middle Aged; Spices	2014
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Humans; Predictive Value of Tests; Recovery of Function; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome	2015
Paracetamol overdose. British journal of hospital medicine (London, England : 2005), 2015, Volume: 76, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Practice Guidelines as Topic; Time Factors	2015
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose. Biomedical research (Tokyo, Japan), 2014, Volume: 35, Issue:6 Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Mesna; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction	2014
N-acetylcysteine treats intravenous amiodarone induced liver injury. World journal of gastroenterology, 2015, Mar-07, Volume: 21, Issue:9 Topics: Acetylcysteine; Aged; Amiodarone; Anti-Arrhythmia Agents; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Liver; Liver Function Tests; Oxidative Stress; Time Factors; Treatment Outcome	2015
The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues. Bratislavske lekarske listy, 2015, Volume: 116, Issue:4 Topics: Acetylcysteine; Acrylamide; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Free Radical Scavengers; Intestinal Diseases; Intestine, Large; Liver; Male; Rats; Rats, Wistar	2015
Successful use of N-acetylcysteine to treat severe hepatic injury caused by a dietary fitness supplement. Pharmacotherapy, 2015, Volume: 35, Issue:6 Topics: Acetylcysteine; Antioxidants; Chemical and Drug Induced Liver Injury; Dietary Supplements; Humans; Male; Physical Fitness; Vasodilator Agents; Young Adult	2015
Carbosulfan-induced oxidative damage following subchronic exposure and the protective effects of N-acetylcysteine in rats. General physiology and biophysics, 2015, Volume: 34, Issue:3 Topics: Acetylcysteine; Animals; Carbamates; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Synergism; Kidney Diseases; Oxidative Stress; Pesticides; Rats; Rats, Wistar; Reactive Oxygen Species; Treatment Outcome	2015
N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol. Systematic reviews, 2015, Jun-12, Volume: 4 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Protocols; Free Radical Scavengers; Humans; Research Design; Systematic Reviews as Topic	2015
External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:8 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitals, Teaching; Humans; Likelihood Functions; Male; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; United Kingdom	2015
Changing the Management of Paracetamol Poisoning. Clinical therapeutics, 2015, Volume: 37, Issue:9 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Antiemetics; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Protocols; Free Radical Scavengers; HMGB1 Protein; Humans; MicroRNAs; Ondansetron; Vomiting	2015
Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity. Drug development research, 2015, Volume: 76, Issue:5 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Gene Expression Regulation, Enzymologic; Male; Mice; Transaminases	2015
A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Decision Support Techniques; Drug Overdose; Female; Humans; Kaplan-Meier Estimate; Liver Transplantation; Male; Middle Aged; Models, Biological; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult	2015
N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:7 Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Heme Oxygenase (Decyclizing); Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Up-Regulation	2015
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Blood Coagulation; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Humans; Male; Predictive Value of Tests; Prothrombin Time; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Young Adult	2016
Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity. Basic & clinical pharmacology & toxicology, 2016, Volume: 118, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glutathione; Liver; Liver Function Tests; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxidase; Rats, Wistar; Thiamine Pyrophosphate	2016
Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats? Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2016, Volume: 68, Issue:1 Topics: Acetaminophen; Acetates; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclopropanes; Cytochrome P-450 CYP1A2 Inducers; Disease Models, Animal; Free Radical Scavengers; Male; Quinolines; Rats; Rats, Wistar; Sulfides	2016
The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies. Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:10 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Half-Life; Hemofiltration; Humans; Infusions, Intravenous; Prospective Studies; Renal Dialysis; Tissue Distribution	2015
Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice. Journal of medicinal food, 2015, Volume: 18, Issue:11 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alpinia; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Disease Models, Animal; Flavonoids; Glutathione; Helichrysum; Liver; Male; Mice, Inbred BALB C; Oxidative Stress; Phytotherapy; Plant Extracts; Protective Agents; Silymarin	2015
Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka. The Ceylon medical journal, 2015, Volume: 60, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Disease Management; Drug Overdose; Free Radical Scavengers; Humans; Sri Lanka	2015
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time	2016
Nomogram line crossing after acetaminophen combination product overdose. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; Chemical and Drug Induced Liver Injury; Child; Decision Support Techniques; Drug Combinations; Drug Overdose; Female; Histamine Antagonists; Humans; Male; Middle Aged; Nomograms; Poison Control Centers; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; Young Adult	2016
In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.". Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time	2016
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity. Toxicology letters, 2016, Jan-22, Volume: 241 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Glutamate Dehydrogenase; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Oxidative Stress; Survival Analysis	2016
Acute Hepatic Failure in a Dog after Xylitol Ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2 Topics: Acetylcysteine; Animals; Animals, Inbred Strains; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Disseminated Intravascular Coagulation; Dogs; Hypoglycemia; Liver Failure, Acute; Male; S-Adenosylmethionine; Sweetening Agents; Treatment Outcome; Xylitol	2016
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Liver; Male; Middle Aged; Prospective Studies; Young Adult	2016
Resolution of norfloxacin-induced acute liver failure after N-acetylcysteine therapy: further support for the use of NAC in drug-induced ALF? BMJ case reports, 2016, Jan-06, Volume: 2016 Topics: Acetylcysteine; Aged; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Failure, Acute; Norfloxacin	2016
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer. Archives of toxicology, 2016, Volume: 90, Issue:12 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Energy Metabolism; Eosinophilia; Glutathione; Isomerism; Liver; Magnetic Resonance Imaging; Male; Metabolomics; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Specific Pathogen-Free Organisms; Tissue Distribution	2016
Involvement of oxidative stress in tri-ortho-cresyl phosphate-induced liver injury in male mice. Human & experimental toxicology, 2016, Volume: 35, Issue:10 Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glutathione Peroxidase; Lipid Peroxidation; Liver Function Tests; Male; Mice, Inbred Strains; Oxidative Stress; Plasticizers; Superoxide Dismutase; Tritolyl Phosphates	2016
N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:3 Topics: Acetaminophen; Acetylcysteine; Age Factors; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Random Allocation	2016
Acute liver injury and acute liver failure from mushroom poisoning in North America. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:7 Topics: Acetylcysteine; Adult; Amanitins; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Mushroom Poisoning; North America; Penicillins; Registries; Silybin; Silymarin	2016
How to treat paracetamol overdose and when to do it. Expert review of clinical pharmacology, 2016, Volume: 9, Issue:5 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans	2016
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:5 Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Retrospective Studies; Risk Factors; United Kingdom	2016
[Paracetamol 665 mg has caused several cases of difficult-to-treat poisoning – New treatment recommendations to prevent liver damage]. Lakartidningen, 2016, 05-27, Volume: 113 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Humans; Practice Guidelines as Topic	2016
In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine. Toxicology mechanisms and methods, 2016, Volume: 26, Issue:7 Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hepatocytes; Lipid Peroxidation; Liver; Male; Membrane Potential, Mitochondrial; Oxidative Stress; Rats; Rats, Sprague-Dawley; Risperidone; Ubiquinone	2016
Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication. Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Endoplasmic Reticulum Stress; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Taurochenodeoxycholic Acid; Unfolded Protein Response	2017
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury. Clinical pharmacology and therapeutics, 2017, Volume: 101, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antiemetics; Area Under Curve; Biomarkers; Chemical and Drug Induced Liver Injury; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Overdose; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Ondansetron; Reproducibility of Results; ROC Curve; Toxicokinetics; Young Adult	2017
Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations. Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:2 Topics: Abdominal Pain; Acetylcysteine; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Chloroform; Drug Eruptions; Drug Overdose; Female; Gastrointestinal Diseases; Half-Life; Humans; Liver Function Tests; Models, Biological; Respiratory Insufficiency	2017
N-acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats. Drug design, development and therapy, 2016, Volume: 10 Topics: Acetylcysteine; Animals; Arsenites; Chemical and Drug Induced Liver Injury; Male; Oxidative Stress; Rats; Rats, Wistar; Sodium Compounds; Succimer	2016
Outcomes from massive paracetamol overdose: a retrospective observational study. British journal of clinical pharmacology, 2017, Volume: 83, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Creatinine; Drug Overdose; Female; Humans; Male; Prevalence; Retrospective Studies; Treatment Outcome; Young Adult	2017
N-acetylcysteine a possible protector against indomethacin-induced peptic ulcer: crosstalk between antioxidant, anti-inflammatory, and antiapoptotic mechanisms. Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Chemokines, CXC; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric Mucosa; Glucosephosphate Dehydrogenase; Humans; Indomethacin; Interferon-gamma; Interleukin-1beta; Male; Oxidation-Reduction; Pain; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Ranitidine; Rats; Rats, Wistar; Stomach Ulcer	2017
Haemodialysis in acute paracetamol poisoning. BMJ case reports, 2017, Jan-17, Volume: 2017 Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fluid Therapy; Free Radical Scavengers; Humans; Renal Dialysis; Young Adult	2017
Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox biology, 2017, Volume: 11 Topics: Acetylcysteine; Animals; Aspartame; Chemical and Drug Induced Liver Injury; Cystathionine gamma-Lyase; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Humans; Liver; Methionine Adenosyltransferase; Mice; Sweetening Agents	2017
Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:9 Topics: Acetaminophen; Acetylcysteine; Aged; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Half-Life; Humans; Male; Time Factors	2008
[Acute acetaminophen overdose]. La Revue du praticien, 2008, Apr-30, Volume: 58, Issue:8 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans	2008
Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage. Human & experimental toxicology, 2008, Volume: 27, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Drug Synergism; Free Radical Scavengers; L-Lactate Dehydrogenase; Male; Mice; Sodium Selenite	2008
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009, Volume: 16, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Observation; Retrospective Studies	2009
Hepatic derangement following N-Acetylcysteine enemas in an infant with cystic fibrosis. Journal of paediatrics and child health, 2008, Volume: 44, Issue:11 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Cystic Fibrosis; Enema; Fecal Impaction; Free Radical Scavengers; Humans; Ileus; Infant, Newborn; Meconium	2008
Acetaminophen hepatotoxicity: current management. The Mount Sinai journal of medicine, New York, 2009, Volume: 76, Issue:1 Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidine; Comorbidity; Disease Progression; Drug and Narcotic Control; Free Radical Scavengers; Humans; Liver Failure; Liver Transplantation; Prognosis; Renal Dialysis; Severity of Illness Index; Treatment Outcome	2009
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:5 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin	2009
Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours. Seminars in diagnostic pathology, 2009, Volume: 26, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver; Male; Poison Control Centers	2009
Oxidative stress due to (R)-styrene oxide exposure and the role of antioxidants in non-Swiss albino (NSA) mice. Journal of toxicology and environmental health. Part A, 2009, Volume: 72, Issue:10 Topics: Acetylcysteine; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cell Count; Chemical and Drug Induced Liver Injury; Epoxy Compounds; Glutathione; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Lung Diseases; Male; Mice; Oxidative Stress; Quinolines; Reactive Oxygen Species; Stereoisomerism; Trans-Activators	2009
Paracetamol poisoning below toxic level causing liver damage in a fasting adult. The Ceylon medical journal, 2009, Volume: 54, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fasting; Female; Free Radical Scavengers; Humans; Liver; Liver Diseases; Risk Factors; Young Adult	2009
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009, Volume: 16, Issue:6 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans	2009
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Annals of emergency medicine, 2009, Volume: 54, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Critical Pathways; Drug Administration Schedule; Drug Overdose; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk; United States; Young Adult	2009
Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. Journal of cellular biochemistry, 2009, Oct-01, Volume: 108, Issue:2 Topics: Acetylcysteine; Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochromes c; Cytotoxins; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione; Glutathione Peroxidase; Glutathione Synthase; Glutathione Transferase; Hepatocytes; Humans; Pyrrolizidine Alkaloids; Reactive Oxygen Species; Thioredoxins	2009
Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning? Annals of emergency medicine, 2009, Volume: 54, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Time Factors	2009
Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2 Topics: Acetylcysteine; Acrolein; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cystitis; Glutathione Transferase; Hemorrhage; Immunohistochemistry; In Situ Nick-End Labeling; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder; Urinary Bladder Diseases	2009
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation	2010
A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; California; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Poison Control Centers; Poisoning; Practice Guidelines as Topic; Retrospective Studies; Treatment Outcome; Young Adult	2009
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis. Journal of medical economics, 2009, Volume: 12, Issue:4 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Drug Overdose; Humans; Injections, Intravenous; Length of Stay; Models, Economic; Time Factors; United States	2009
IV versus oral N-acetylcysteine. Annals of emergency medicine, 2009, Volume: 54, Issue:6 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous	2009
Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity. Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:1 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Cohort Studies; Cost-Benefit Analysis; Costs and Cost Analysis; Drug Overdose; Female; Humans; Infusions, Intravenous; Length of Stay; Liver Function Tests; Male; Middle Aged; Retrospective Studies	2010
Role of urinary biomarkers of N,N-dimethylformamide in the early detection of hepatic injury among occupational exposed workers. International archives of occupational and environmental health, 2010, Volume: 83, Issue:4 Topics: Acetylcysteine; Adult; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; China; Dimethylformamide; Environmental Monitoring; Female; Formamides; Humans; Hyaluronoglucosaminidase; Liver Function Tests; Male; Middle Aged; Occupational Exposure; Textile Industry	2010
Medicine, poison, and mystic potion: a personal perspective on paracetamol Louis Roche lecture, Stockholm, 2009. Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Risk Factors	2010
Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose. Human & experimental toxicology, 2011, Volume: 30, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Delayed Diagnosis; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Intensive Care Units; Liver Failure, Acute; Male; Treatment Outcome	2011
Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice. Natural product communications, 2010, Volume: 5, Issue:4 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Diterpenes, Clerodane; Drug Interactions; Glutathione; Histocytochemistry; Male; Mice; Thiobarbituric Acid Reactive Substances; Vitamin E	2010
[Are nomograms available for the treatment of acetaminophen poisoning?]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2010, Volume: 23, Issue:2 Topics: Acetaminophen; Acetylcysteine; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Nomograms	2010
[Are nomograms available for the treatment of acetaminophen poisoning? Pros: usefullness of nomogram-based decision-making in the treatment of acute acetaminophen overdose in Japan: single center experience with 61 consecutive patients in Niigata City Gen Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2010, Volume: 23, Issue:2 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hospitals, General; Humans; Japan; Liver Function Tests; Male; Nomograms; Young Adult	2010
Protective effect of ghrelin on acetaminophen-induced liver injury in rat. Peptides, 2010, Volume: 31, Issue:11 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ghrelin; Liver; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2010
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. Journal of biomedical science, 2010, Aug-24, Volume: 17 Suppl 1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Glutathione Transferase; Humans; Liver; Liver Diseases; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Taurine	2010
PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proceedings of the National Academy of Sciences of the United States of America, 2010, Oct-05, Volume: 107, Issue:40 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Animals, Genetically Modified; Chemical and Drug Induced Liver Injury; Dinoprostone; Genes, Reporter; Glutathione; Liver; Liver Failure, Acute; Proteome; Signal Transduction; Zebrafish	2010
The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:1 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; California; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Overdose; Female; Hospitals, Community; Humans; Infusions, Intravenous; Length of Stay; Male; Medical Records; Poison Control Centers; Practice Patterns, Physicians'; Retrospective Studies	2011
Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice. Life sciences, 2010, Dec-18, Volume: 87, Issue:23-26 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Glutathione; Hepatocytes; Hydrogen Sulfide; Male; Malondialdehyde; Mice; Nitric Oxide; Tumor Necrosis Factor-alpha	2010
The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. Toxicology, 2011, Feb-04, Volume: 280, Issue:1-2 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Female; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolizidine Alkaloids; Sex Characteristics	2011
Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines. Archives of disease in childhood, 2011, Volume: 96, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Injections, Intravenous; Male; Practice Guidelines as Topic; United Kingdom	2011
Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chemico-biological interactions, 2011, Feb-01, Volume: 189, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Coloring Agents; Disease Models, Animal; Indocyanine Green; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred Strains; Time Factors	2011
Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells. Toxicology and industrial health, 2011, Volume: 27, Issue:3 Topics: Acetylcarnitine; Acetylcysteine; Animals; Cadmium Chloride; Chemical and Drug Induced Liver Injury; DNA Breaks, Single-Stranded; Drug Antagonism; Environmental Pollutants; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Hepatocytes; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2011
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats. Arzneimittel-Forschung, 2010, Volume: 60, Issue:11 Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convulsants; Curcumin; Eating; Fatty Liver; Free Radical Scavengers; Hypoglycemic Agents; Liver; Liver Function Tests; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rosiglitazone; Seizures; Thiazolidinediones; Valproic Acid	2010
Protective effect of N-acetyl cystein on antituberculosis drug-induced hepatotoxicity. European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:2 Topics: Acetylcysteine; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Humans; Tuberculosis, Pulmonary	2011
Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice. Human & experimental toxicology, 2011, Volume: 30, Issue:10 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Benzodioxoles; Chemical and Drug Induced Liver Injury; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred C3H; Phenols	2011
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver Failure, Acute; Male; Middle Aged; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Transaminases	2011
Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice. Biochimie, 2011, Volume: 93, Issue:5 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cytokines; Dimethyl Sulfoxide; Down-Regulation; Ethanol; Female; I-kappa B Proteins; Liver; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; NF-kappa B; Peroxidase	2011
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Female; Furosemide; Glutathione; Interleukin-6; Liver; Male; Mice; Mice, Inbred Strains	2011
Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats. Toxicology and industrial health, 2011, Volume: 27, Issue:10 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Disease Models, Animal; Free Radical Scavengers; Lipid Peroxidation; Liver; Liver Function Tests; Male; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar	2011
Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity. The Annals of pharmacotherapy, 2011, Volume: 45, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Administration Schedule; Drug Approval; Female; Humans; Male; Medication Errors; Middle Aged; Off-Label Use; Retrospective Studies; United States; United States Food and Drug Administration; Young Adult	2011
Treatment of ricin A-chain-induced hepatotoxicity with liposome-encapsulated N-acetylcysteine. Journal of drug targeting, 2011, Volume: 19, Issue:9 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemical Warfare Agents; Inflammation; Lipid Peroxidation; Liposomes; Male; Rats; Rats, Sprague-Dawley; Ricin	2011
Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses. The Journal of emergency medicine, 2012, Volume: 43, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Interactions; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Nomograms; Poisoning; Retrospective Studies; Risk Assessment; Time Factors; Young Adult	2012
Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose. Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:7 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Logistic Models; Male; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult	2011
Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adenine; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Green Fluorescent Proteins; Hepatocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Primary Cell Culture; TOR Serine-Threonine Kinases	2012
Paracetamol overdose: the liver unit perspective. Irish journal of medical science, 2012, Volume: 181, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Early Diagnosis; Humans; Liver Failure, Acute; Liver Transplantation; Time Factors	2012
Intravenous paracetamol toxicity in a malnourished child. Clinical toxicology (Philadelphia, Pa.), 2012, Volume: 50, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child Nutrition Disorders; Child, Preschool; Delayed Diagnosis; Humans; Infusions, Intravenous; Male; Medication Errors	2012
Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model. Human & experimental toxicology, 2012, Volume: 31, Issue:8 Topics: Acetylcysteine; Antitubercular Agents; Cell Cycle; Cell Survival; Chemical and Drug Induced Liver Injury; Curcumin; Hep G2 Cells; Humans; Isoniazid; Membrane Potential, Mitochondrial; Protective Agents; Pyrazinamide; Silymarin	2012
A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka. BMC clinical pharmacology, 2012, Feb-22, Volume: 12 Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Decision Trees; Humans; Methionine; Sri Lanka; Time Factors	2012
Effect of Asparagus falcatus on acetaminophen toxicity in mice: a comparison of antioxidative effect with N-acetyl cysteine. Journal of dietary supplements, 2008, Volume: 5, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Asparagus Plant; Chemical and Drug Induced Liver Injury; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts	2008
Paracetamol toxicity: What would be the implications of a change in UK treatment guidelines? European journal of clinical pharmacology, 2012, Volume: 68, Issue:11 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Costs; Drug Overdose; Emergency Service, Hospital; Free Radical Scavengers; Health Care Costs; Hospitals, Urban; Humans; London; Practice Guidelines as Topic; Retrospective Studies; Risk; Risk Assessment; United Kingdom	2012
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Benzoquinones; Chemical and Drug Induced Liver Injury; Cohort Studies; Computer Simulation; Hepatocytes; Humans; Imines; Infusions, Intravenous; Liver; Prescription Drug Misuse; Risk Factors	2012
Effect of melatonin and n-acetylcysteine on hepatic injury in rat induced by methanol intoxication: a comparative study. European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:4 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Male; Melatonin; Methanol; Microscopy, Electron; Protective Agents; Rats; Rats, Wistar; Time Factors	2012
Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice. Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:9 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Enalapril; Female; Glutathione; Male; Mice; Mice, Inbred C57BL	2012
N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology, 2012, Dec-08, Volume: 302, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; CD36 Antigens; Chemical and Drug Induced Liver Injury; Fatty Liver; Gene Expression Regulation; Glutathione; Injections, Intraperitoneal; Male; Organ Size; Polychlorinated Biphenyls; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Severity of Illness Index	2012
Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single '150-line'? British journal of clinical pharmacology, 2012, Volume: 74, Issue:6 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Practice Guidelines as Topic; Risk Assessment; Risk Factors; United Kingdom	2012
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice. Toxicology mechanisms and methods, 2012, Volume: 22, Issue:8 Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Liver; Male; Mice; Oxidative Stress; Thioctic Acid	2012
Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2013, Volume: 50, Issue:6 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cleft Palate; Humans; Infusions, Intravenous; Liver Failure, Acute	2013
[Presentation of a case of Paraquat poisoning]. Revista espanola de anestesiologia y reanimacion, 2012, Volume: 59, Issue:3 Topics: Acetylcysteine; Acute Kidney Injury; Adult; Ascorbic Acid; Charcoal; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Diuretics; Fatal Outcome; Furosemide; Gastric Lavage; Hemoperfusion; Humans; Immunosuppressive Agents; Male; Paraquat; Poisoning; Pulmonary Fibrosis; Respiration, Artificial; Respiratory Insufficiency; Rhabdomyolysis; Suicide, Attempted; Vitamin E	2012
N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage. Toxicology and industrial health, 2014, Volume: 30, Issue:7 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Antipyretics; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; International Normalized Ratio; Oxidants; Prothrombin Time; Rats; Rats, Wistar; Thioglycolates; Thiophenes	2014
Acetaminophen/diphenhydramine overdose in profound hypothermia. Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholinergic Antagonists; Diphenhydramine; Drug Combinations; Drug Overdose; Female; Humans; Hypothermia; Infusions, Intravenous; Nonprescription Drugs; Rewarming; Treatment Outcome	2013
N-acetylcysteine for paracetamol poisoning: effect on prothrombin. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans; Liver Failure; Prothrombin Time	2002
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies	2002
Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1 Topics: Acetylcysteine; Adenosine Diphosphate; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dichloroethylenes; Dose-Response Relationship, Drug; Female; Glutathione; In Vitro Techniques; Indicators and Reagents; Mice; Mitochondria, Liver; Oxygen Consumption; Polarography; Time Factors	2003
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. Epilepsia, 2003, Volume: 44, Issue:3 Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Humans; Liver Diseases; Male; Risk Factors; Valproic Acid	2003
Successful treatment of acute hepatic injury caused by paracetamol intoxication in a late-referral patient by N-acetylcysteine. Journal of clinical gastroenterology, 2003, Volume: 36, Issue:4 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Infusions, Intravenous; Liver; Liver Function Tests; Male; Middle Aged; Severity of Illness Index; Suicide, Attempted; Treatment Outcome	2003
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione. Journal of biochemical and molecular toxicology, 2003, Volume: 17, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Free Radical Scavengers; Glutathione; Mice; Prodrugs	2003
A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 134, Issue:4 Topics: Acetylcysteine; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Guanidines; Liver; Liver Diseases; Male; Rats; Rats, Wistar	2003
Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism. Pharmacological research, 2003, Volume: 48, Issue:1 Topics: Acetylcysteine; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression; Heat-Shock Proteins; Hepatocytes; Histones; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazolidinediones; Troglitazone; Ubiquitin	2003
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemokines; Drug Interactions; Immunoenzyme Techniques; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Necrosis; Nitric Oxide; Reactive Nitrogen Species; Up-Regulation	2003
Hepatoprotective effect of rooibos tea (Aspalathus linearis) on CCl4-induced liver damage in rats. Physiological research, 2003, Volume: 52, Issue:4 Topics: Acetylcysteine; Animals; Aspalathus; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholesterol; Free Radical Scavengers; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Malondialdehyde; Rats; Rats, Wistar; Triglycerides	2003
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. Toxicology, 2003, Sep-30, Volume: 191, Issue:2-3 Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts	2003
Drug-induced hepatotoxicity. The New England journal of medicine, 2003, Nov-13, Volume: 349, Issue:20 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Humans; Liver; Liver Diseases	2003
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro. Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:4 Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; beta-Naphthoflavone; Cell Survival; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Female; Hepatocytes; Inactivation, Metabolic; Isoquinolines; Liver; Phenobarbital; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin	2004
Prevention of hepatotoxicity but loss of antimelanoma effect with combined fotemustine and anti-oxidant treatment. Internal medicine journal, 2004, Volume: 34, Issue:5 Topics: Acetylcysteine; Adult; Antineoplastic Agents; Antioxidants; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Treatment Outcome	2004
Acetaminophen intoxication and length of treatment: how long is long enough?--A comment. Pharmacotherapy, 2004, Volume: 24, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Confidence Intervals; Drug Administration Schedule; Free Radical Scavengers; Humans	2004
Protective effect of N-acetylcysteine against arsenic-induced depletion in vivo of carbohydrate. Drug and chemical toxicology, 2004, Volume: 27, Issue:2 Topics: Acetylcysteine; Animals; Arsenites; Blood Glucose; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glucose-6-Phosphatase; Hypoglycemia; Kidney; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Sodium Compounds	2004
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning]. Ugeskrift for laeger, 2004, Sep-27, Volume: 166, Issue:40 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies	2004
Intravenous administration of N-acetylcysteine: interference with coagulopathy testing. Annals of emergency medicine, 2004, Volume: 44, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Injections, Intravenous; International Normalized Ratio; Liver Diseases; Male; Prothrombin Time	2004
Acute acetaminophen intoxication in Taiwan: outcomes and risk factors. Journal of the Formosan Medical Association = Taiwan yi zhi, 2004, Volume: 103, Issue:11 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Retrospective Studies; Risk Factors; Taiwan	2004
Intravenous N-acetylcysteine for children. Pediatric emergency care, 2004, Volume: 20, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Humans; Injections, Intravenous	2004
Oral or intravenous N-acetylcysteine for acetaminophen poisoning? Annals of emergency medicine, 2005, Volume: 45, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; Liver Diseases; Time Factors	2005
A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication. Clinical therapeutics, 2005, Volume: 27, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Retrospective Studies	2005
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity. Toxicology and applied pharmacology, 2006, Mar-01, Volume: 211, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokines; Gene Expression; Glutathione; Humans; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1; Interleukin-10; Interleukin-4; Liver; Macrophage Inflammatory Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Necrosis; NF-kappa B p50 Subunit; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2006
A new acetaminophen nomogram with a different purpose. Annals of emergency medicine, 2005, Volume: 46, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Emergency Medicine; Humans; Liver Diseases; Nomograms; Outcome and Process Assessment, Health Care; Risk Assessment	2005
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine. Annals of emergency medicine, 2005, Volume: 46, Issue:3 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Overdose; Emergency Medicine; Female; Humans; Liver Diseases; Logistic Models; Male; Models, Theoretical; Outcome and Process Assessment, Health Care; Retrospective Studies; Risk Assessment; Risk Factors; Transaminases	2005
Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine. Toxicology and applied pharmacology, 2005, Sep-15, Volume: 207, Issue:3 Topics: Acetophenones; Acetylcysteine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Free Radical Scavengers; Glutathione; Glycols; Hypoglycemia; Insulin; Lactates; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley	2005
Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver. Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Citric Acid Cycle; Cytoprotection; Disease Models, Animal; Glutathione; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Nitro Compounds; Oxidative Stress; Propionates; Pyruvate Carboxylase; Pyruvate Dehydrogenase Complex; Taurine; tert-Butylhydroperoxide	2006
Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity. Free radical biology & medicine, 2006, May-01, Volume: 40, Issue:9 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cisplatin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Lipid Peroxidation; Liver Diseases; Male; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2006
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid. Phytotherapy research : PTR, 2006, Volume: 20, Issue:8 Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Humans; Immunosuppressive Agents; Male; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Species Specificity	2006
Severe hepatotoxicity after therapeutic doses of acetaminophen. Clinical therapeutics, 2006, Volume: 28, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Hepatitis B; Hepatitis C; HIV Seropositivity; Humans; Italy; Male; Middle Aged; Risk Factors; Substance Abuse, Intravenous	2006
N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Medical science monitor : international medical journal of experimental and clinical research, 2006, Volume: 12, Issue:8 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Methotrexate; Oxidants; Oxidative Stress; Rats; Rats, Wistar	2006
Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture. Toxicology letters, 2006, Nov-01, Volume: 167, Issue:1 Topics: Acetylcysteine; Animals; Antidotes; Antitubercular Agents; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Ditiocarb; Female; Glutathione; Glycyrrhiza; Glycyrrhizic Acid; Hepatocytes; Isoniazid; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin	2006
Adverse reaction from use of intravenous N-acetylcysteine. The Journal of emergency medicine, 2006, Volume: 31, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Transplantation	2006
A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Confidence Intervals; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Prospective Studies; Risk Assessment; Surveys and Questionnaires; Treatment Outcome	2007
Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats. Human & experimental toxicology, 2006, Volume: 25, Issue:12 Topics: Acetylcysteine; Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drugs, Chinese Herbal; Free Radical Scavengers; Ginkgo biloba; Hepatic Encephalopathy; Liver; Male; Necrosis; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Severity of Illness Index; Thioacetamide; Thiobarbituric Acid Reactive Substances	2006
Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicology and applied pharmacology, 2007, Apr-15, Volume: 220, Issue:2 Topics: Acetylcysteine; Alanine Transaminase; Animals; Apoptosis; Arsenic; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Glutathione; Hepatocytes; In Situ Nick-End Labeling; Liver; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Oxidative Stress; Poly(ADP-ribose) Polymerases; Triglycerides	2007
Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 97, Issue:2 Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; Indicators and Reagents; Liver-Specific Organic Anion Transporter 1; Marine Toxins; Microcystins; Mitogen-Activated Protein Kinases; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Signal Transduction; Solute Carrier Organic Anion Transporter Family Member 1B3	2007
Arsenite-induced apoptosis is prevented by antioxidants in zebrafish liver cell line. Toxicology in vitro : an international journal published in association with BIBRA, 2007, Volume: 21, Issue:5 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenites; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Dithiothreitol; Dose-Response Relationship, Drug; Genes, Reporter; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Liver; Oxidative Stress; Plasmids; Transfection; Trypan Blue; Zebrafish	2007
Patient-tailored acetylcysteine administration. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Function Tests	2007
The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats. Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar; Superoxide Dismutase	2008
Erratum in intravenous n-acetylcysteine dosing. Pediatric emergency care, 2007, Volume: 23, Issue:5 Topics: Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Infusions, Intraosseous; Liver Diseases	2007
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Male; Mice; Mushroom Poisoning; Penicillin G; Random Allocation; Silybin; Silymarin; Thioctic Acid	2007
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine. The Journal of emergency medicine, 2007, Volume: 33, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Registries; Retrospective Studies	2007
Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity. Human & experimental toxicology, 2007, Volume: 26, Issue:6 Topics: Acetylcysteine; Administration, Oral; Animals; Antibiotics, Antineoplastic; Caffeic Acids; Chemical and Drug Induced Liver Injury; Doxorubicin; Drug Therapy, Combination; Free Radical Scavengers; Hepatocytes; Injections, Intraperitoneal; Leukocytes, Mononuclear; Liver Diseases; Male; Microscopy, Polarization; Protective Agents; Random Allocation; Rats; Rats, Wistar; Vitamin E; Vitamins	2007
Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose. Annals of emergency medicine, 2007, Volume: 50, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Emergency Service, Hospital; Humans; Poisoning	2007
Clinical excellence exemplar. The Florida nurse, 2007, Volume: 55, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Patient Care Management; Physician-Nurse Relations; Poison Control Centers	2007
N-acetylcysteine attenuates lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice. Acta pharmacologica Sinica, 2007, Volume: 28, Issue:11 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Galactosamine; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Tumor Necrosis Factor-alpha	2007
Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat. Indian journal of experimental biology, 2007, Volume: 45, Issue:12 Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drug Therapy, Combination; Liver Diseases; Magnesium; Male; Mercury Poisoning; Oxidative Stress; Penicillamine; Rats; Rats, Sprague-Dawley; Sodium Selenite; Treatment Outcome; Zinc	2007
Selection of agents for prevention of cisplatin-induced hepatotoxicity. Pharmacological research, 2008, Volume: 57, Issue:2 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antineoplastic Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Cisplatin; Drug Therapy, Combination; Fosfomycin; Glutathione; Injections, Intraperitoneal; Male; Malondialdehyde; Methionine; Mice; Pilot Projects; Selenium; Taurine; Thiosulfates; Zinc	2008
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics. Alcohol (Fayetteville, N.Y.), 2008, Volume: 42, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Liver; Models, Statistical; Registries; Risk	2008
Key features of the patient-tailored N-acetylcysteine protocol. Annals of emergency medicine, 2008, Volume: 51, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Risk Assessment; Surveys and Questionnaires; Treatment Outcome	2008
Comment on "Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose". Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2008, Volume: 15, Issue:5 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethanol; Free Radical Scavengers; Humans; International Normalized Ratio	2008
Investigation of rifampicin-induced hepatotoxicity in rat hepatocytes maintained in gel entrapment culture. Cell biology and toxicology, 2009, Volume: 25, Issue:3 Topics: Acetylcysteine; Albumins; Animals; Antitubercular Agents; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Drug Antagonism; Enzyme Inhibitors; Glutathione; Glycyrrhizic Acid; Hepatocytes; Lipid Metabolism; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rifampin; Tetrazolium Salts; Thiazoles	2009
N-acetylcysteine protection against halothane hepatotoxicity:experiments in rats. Lancet (London, England), 1981, Jul-11, Volume: 2, Issue:8237 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Halothane; Liver; Male; Rats	1981
[Paracetamol poisoning]. Ugeskrift for laeger, 1984, Dec-17, Volume: 146, Issue:51 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Risk; Suicide, Attempted	1984
Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Kinetics; Liver; Liver Diseases; Male; Microsomes, Liver; Naphthalenes; Necrosis; Rats; Rats, Inbred Strains; Sulfhydryl Compounds	1984
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity. Toxicology, 1983, Volume: 28, Issue:4 Topics: Acetaminophen; Acetylcysteine; Animals; Carbocysteine; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteine; Humans; In Vitro Techniques; Kidney; Male; Mesocricetus; Microsomes, Liver; Protein Binding	1983
Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. American journal of diseases of children (1960), 1984, Volume: 138, Issue:5 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Ethanol; Humans; Infant; Liver Function Tests; Poison Control Centers; Prospective Studies	1984
Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Liver; Male; Maleates; Rats; Sulfhydryl Compounds; Time Factors; Triiodothyronine	1984
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat. Archives of toxicology, 1984, Volume: 55, Issue:1 Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Maleates; Paraquat; Phenobarbital; Rats; Rats, Inbred Strains	1984
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. The Journal of clinical investigation, 1983, Volume: 71, Issue:4 Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Glucuronates; Glutathione; Male; Rats; Rats, Inbred Strains; Sulfates	1983
Dantrolene sodium: urinary metabolites and hepatotoxicity. Research communications in chemical pathology and pharmacology, 1983, Volume: 39, Issue:3 Topics: Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cricetinae; Cytochrome P-450 Enzyme System; Dantrolene; Ethylmorphine; Glutathione; Kinetics; Male; Mesocricetus; Mice; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Species Specificity	1983
Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice. Biochemical pharmacology, 1983, Jul-01, Volume: 32, Issue:13 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hyperglycemia; Liver Glycogen; Male; Mice	1983
Acetaminophen and its toxicity. Journal of applied toxicology : JAT, 1983, Volume: 3, Issue:2 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Cats; Chemical and Drug Induced Liver Injury; Cricetinae; Dogs; Ethanol; Glutathione; Guinea Pigs; Humans; Kinetics; Liver; Mice; Rats	1983
Paracetamol self-poisoning: diagnosis, management, and outcome. The Medical journal of Australia, 1982, Jan-23, Volume: 1, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Australia; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Hospitalization; Humans; Injections, Intravenous; Liver Diseases; Liver Function Tests; Methionine; Middle Aged; Suicide, Attempted; Time Factors	1982
Cimetidine and acetylcysteine as antidote for acetaminophen overdose. Southern medical journal, 1982, Volume: 75, Issue:8 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Guanidines; Humans; Liver Diseases; Time Factors	1982
Acetaminophen poisoning and its treatment. Comprehensive therapy, 1982, Volume: 8, Issue:12 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans	1982
Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice. Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Body Temperature; Chemical and Drug Induced Liver Injury; Hemoglobins; Male; Mice; Time Factors	1981
[Acute hepatocellular damage due to paracetamol]. Harefuah, 1981, Dec-15, Volume: 101, Issue:12 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests	1981
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. British medical journal, 1980, Jan-05, Volume: 280, Issue:6206 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Injections, Intravenous; Liver Diseases	1980
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:9 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis; Penicillamine	1980
Intravenous N-acetylcysteine for paracetamol poisoning. The Medical journal of Australia, 1980, Jun-28, Volume: 1, Issue:13 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged	1980
Protective effect of diltiazem against acetaminophen hepatotoxicity in mice. Liver, 1995, Volume: 15, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Survival; Chemical and Drug Induced Liver Injury; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Liver; Mice	1995
Paracetamol poisoning. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1993, Volume: 83, Issue:11 Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines	1993
Hispidulin protection against hepatotoxicity induced by bromobenzene in mice. Life sciences, 1994, Volume: 55, Issue:8 Topics: Acetylcysteine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Flavones; Flavonoids; Glutathione; Lipid Peroxides; Liver Diseases; Male; Mice	1994
Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases. Acta clinica Belgica, 1993, Volume: 48, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adult; Charcoal; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Female; Gastric Lavage; Humans; Liver Function Tests; Male; Poisoning; Suicide, Attempted	1993
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing. Clinical pediatrics, 1994, Volume: 33, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Female; Humans; Pancytopenia; Peritoneal Dialysis	1994
Attenuation of acetaminophen hepatitis by prostaglandin E2. A histopathological study. Digestive diseases and sciences, 1994, Volume: 39, Issue:5 Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Acetylcysteine; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Rats; Rats, Sprague-Dawley	1994
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity. Archives of toxicology, 1994, Volume: 68, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Mice, Inbred Strains; Mitochondria, Liver; Oxygen Consumption	1994
[Acute hepatic disorders after exposure to dimethylformamide. Clinical and histological aspects]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9 Topics: Acetylcysteine; Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Dimethylformamide; Humans; Liver Function Tests; Male; Occupational Diseases	1993
Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity. Canadian journal of physiology and pharmacology, 1993, Volume: 71, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Membrane; Chelating Agents; Chemical and Drug Induced Liver Injury; Dithiothreitol; Fura-2; In Vitro Techniques; Male; Mice; Sulfhydryl Compounds	1993
Acute hepatotoxicity from ingestion of yellow phosphorus-containing fireworks. Journal of clinical gastroenterology, 1995, Volume: 21, Issue:2 Topics: Acetylcysteine; Acute Disease; Adult; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Phosphorus; Prothrombin Time	1995
Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity. European journal of pharmacology, 1995, Oct-06, Volume: 293, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Glutathione; Liver; Malondialdehyde; Mice; Mice, Inbred ICR; Sulfates; Zinc Compounds; Zinc Sulfate	1995
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1996, Volume: 33, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestanols; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Necrosis	1996
Hepatotoxicity of N, N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61. Human & experimental toxicology, 1996, Volume: 15, Issue:8 Topics: Acetylcysteine; Adult; Amides; Animals; Chemical and Drug Induced Liver Injury; Dimethylformamide; Drug Combinations; Free Radical Scavengers; Humans; L-Iditol 2-Dehydrogenase; Liver Diseases; Male; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Suicide, Attempted; Tetracaine	1996
[Carbon tetrachloride poisoning]. Anales de medicina interna (Madrid, Spain : 1984), 1996, Volume: 13, Issue:8 Topics: Acetylcysteine; Acute Kidney Injury; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Humans; Male; Middle Aged; Occupational Diseases	1996
Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine. General pharmacology, 1997, Volume: 28, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Male; Methionine; Mice; Mice, Inbred Strains; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors	1997
Pediatric subacute acetaminophen toxicity. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1997, Volume: 116, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans; Male	1997
Acetaminophen overdose with therapeutic intent. The Journal of pediatrics, 1998, Volume: 132, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans	1998
Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats. Anesthesiology, 1998, Volume: 89, Issue:5 Topics: Acetylcysteine; Acyltransferases; Anesthetics, Inhalation; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytosol; Dealkylation; Drug Contamination; Ethers; Hydrocarbons, Fluorinated; Kidney Diseases; Magnetic Resonance Spectroscopy; Male; Methyl Ethers; Rats; Rats, Inbred F344; Sevoflurane	1998
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine. Pediatric emergency care, 1998, Volume: 14, Issue:6 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Drug Overdose; Humans; Liver Diseases; Risk Factors; Time Factors	1998
[ACC in liver failure]. Der Internist, 1999, Volume: 40, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans	1999
Transformation of an acetaminophen toxicity nomogram to an artificial neural network. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Gastrointestinal Transit; Liver Diseases; Neural Networks, Computer	1999
[No N-acetylcysteine in the absence of verified paracetamol intoxication]. Presse medicale (Paris, France : 1983), 1999, Sep-25, Volume: 28, Issue:28 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Humans; Poisoning	1999
Serum cytotoxin and oxidant stress markers in N-acetylcysteine treated thioacetamide hepatotoxicity of rats. Human & experimental toxicology, 1999, Volume: 18, Issue:11 Topics: Acetylcysteine; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cytotoxins; Disease Models, Animal; Free Radical Scavengers; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thioacetamide	1999
Reduction in incidence of severe paracetamol poisoning. Lancet (London, England), 2000, Jun-10, Volume: 355, Issue:9220 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Humans; Incidence; Legislation, Drug; Liver Diseases; Male; Poisoning; Severity of Illness Index; United Kingdom	2000
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat. Toxicology and applied pharmacology, 2001, Feb-01, Volume: 170, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dioxolanes; Drug Combinations; Drug Overdose; Liver; Male; Rats; Rats, Sprague-Dawley; Time Factors	2001
Isoniazid- and rifampicin-induced oxidative hepatic injury--protection by N-acetylcysteine. Human & experimental toxicology, 2000, Volume: 19, Issue:9 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Catalase; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Interactions; Injections, Intraperitoneal; Isoniazid; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Rifampin; Superoxide Dismutase	2000
Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poultry science, 2001, Volume: 80, Issue:6 Topics: Acetylcysteine; Aflatoxin B1; Alanine Transaminase; Animal Feed; Animals; Aspartate Aminotransferases; Blood Proteins; Body Weight; Chemical and Drug Induced Liver Injury; Chickens; Free Radical Scavengers; Glutathione; Glutathione Transferase; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Poultry Diseases; Random Allocation; Treatment Outcome	2001
Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Interleukin-8; Liver Function Tests; Male; Prothrombin Time	2001
[Anaphylactoid reaction in relation to the use of N-acetylcysteine the prevention of paracetamol hepatotoxicity]. Medicina clinica, 2001, Nov-03, Volume: 117, Issue:14 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Suicide, Attempted	2001
Acute cholestatic hepatitis after exposure to isoflurane. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:2 Topics: Acetylcysteine; Acute Disease; Aged; Anesthetics, Inhalation; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Isoflurane; Liver; Liver Function Tests; Ursodeoxycholic Acid	2002
Acetaminophen toxicity: suicidal vs. accidental. Critical care (London, England), 2002, Volume: 6, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Female; Hospitalization; Hospitals, Urban; Humans; Male; Middle Aged; New York; Retrospective Studies; Suicide, Attempted	2002
Acetaminophen hepatotoxicity: the first 35 years. Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspartate Aminotransferases; Barbiturates; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Therapy, Combination; Enzyme Induction; Ethanol; Humans; Liver; Liver Diseases; Nutritional Physiological Phenomena; Phenytoin	2002
Acetaminophen poisoning in children: treat early and long enough. The Journal of pediatrics, 2002, Volume: 140, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Time Factors	2002
Predictors of outcome after acetaminophen poisoning in children and adolescents. The Journal of pediatrics, 2002, Volume: 140, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Male; Predictive Value of Tests; Prothrombin Time; Retrospective Studies; Sensitivity and Specificity	2002
Effect of N-acetylcysteine on hepatic covalent binding of paracetamol (acetaminophen) Lancet (London, England), 1977, Mar-19, Volume: 1, Issue:8012 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Inactivation, Metabolic; Liver; Male; Mice; Protein Binding	1977
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (London, England), 1977, Aug-27, Volume: 2, Issue:8035 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Drug Evaluation; Female; Follow-Up Studies; Humans; Infusions, Parenteral; Male; Methionine; Middle Aged	1977
Preventing hepatotoxicity in acetaminophen overdose. The American journal of nursing, 1979, Volume: 79, Issue:2 Topics: Acetaminophen; Acetylcysteine; Charcoal; Chemical and Drug Induced Liver Injury; Diuretics; Glutathione; Hemoperfusion; Humans; Peritoneal Dialysis; Poisoning; Renal Dialysis	1979
[Therapy of paracetamol poisoning]. Nederlands tijdschrift voor geneeskunde, 1979, Feb-24, Volume: 123, Issue:8 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Methionine	1979
Acetaminophen overdose: a growing health care hazard. Clinical toxicology, 1979, Volume: 14, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Gastric Lavage; Humans; Liver Diseases; Middle Aged; Time Factors	1979
Acetylcysteine for acetaminophen overdose. The Medical letter on drugs and therapeutics, 1979, Nov-30, Volume: 21, Issue:24 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Liver; Methionine	1979
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. British medical journal, 1979, Nov-03, Volume: 2, Issue:6198 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Infusions, Parenteral; Kidney Diseases; Liver Diseases; Male; Methionine; Middle Aged; Risk; Time Factors	1979
Paracetamol poisoning. Prevention of liver damage. Medecine & chirurgie digestives, 1979, Volume: 8, Issue:5 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis	1979
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage. Health bulletin, 1978, Volume: 36, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver Diseases; Male; Methionine; Middle Aged; Scotland	1978
Acetaminophen poisoning: a case report of the use of acetylcysteine. American journal of hospital pharmacy, 1978, Volume: 35, Issue:8 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Codeine; Female; Humans; Liver Function Tests; Meperidine; Promethazine	1978
Acute acetaminophen intoxication. Southern medical journal, 1978, Volume: 71, Issue:8 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver; Male; Methionine; Suicide, Attempted	1978
Acetaminophen toxity. American journal of hospital pharmacy, 1977, Volume: 34, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Necrosis; Sulfhydryl Compounds	1977
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage. The Quarterly journal of medicine, 1976, Volume: 45, Issue:178 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronates; Humans; Liver Diseases; Male; Suicide; Sulfates	1976
[Two cases of severe liver injuries induced by acetaminophen]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1992, Dec-10, Volume: 81, Issue:12 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Glucagon; Humans; Insulin; Liver; Male; Plasma Exchange; Suicide, Attempted	1992
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats. Chemico-biological interactions, 1992, Sep-28, Volume: 84, Issue:2 Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Metallothionein; Methionine Sulfoximine; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley; Sulfates; Vitamin K; Zinc; Zinc Sulfate	1992
Does hypothermia protect against the development of hepatitis in paracetamol overdose? Anaesthesia, 1992, Volume: 47, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypothermia; Intermittent Positive-Pressure Ventilation; Liver Function Tests; Time Factors	1992
Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge. The Medical journal of Australia, 1992, Sep-21, Volume: 157, Issue:6 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Function Tests; Male; New South Wales; Patient Admission; Prognosis; Retrospective Studies	1992
Paracetamol overdose in Israel--1992. Israel journal of medical sciences, 1992, Volume: 28, Issue:11 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Glutathione; Humans; Inactivation, Metabolic; Israel	1992
PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity. Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4 Topics: Acetylcysteine; Animals; Antioxidants; Azoles; Body Weight; Chemical and Drug Induced Liver Injury; Creatine Kinase; Doxorubicin; Drug Interactions; Female; Heart Diseases; Isoindoles; Lipid Peroxidation; Liver Diseases; Mice; Mice, Inbred BALB C; Organoselenium Compounds	1992
Protective effect of oral acetylcysteine against the hepatorenal toxicity of carbon tetrachloride potentiated by ethyl alcohol. Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:4 Topics: Acetylcysteine; Alcoholism; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Creatinine; Ethanol; Glutathione; Kidney; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Male; Rats; Rats, Inbred Strains	1992
Acetylcysteine and fulminant hepatic failure. Hepatology (Baltimore, Md.), 1992, Volume: 15, Issue:3 Topics: Acetaminophen; Acetylcysteine; Biological Transport; Chemical and Drug Induced Liver Injury; Hemodynamics; Humans; Liver Circulation; Liver Diseases; Oxygen	1992
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose. Human & experimental toxicology, 1991, Volume: 10, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical and Drug Induced Liver Injury; Creatinine; Dialysis; Ethanol; Female; Humans; Hydrogen-Ion Concentration; Liver Diseases; Male; Platelet Count; Positive-Pressure Respiration; Prognosis; Thrombin Time	1991
[Evaluation of blood chemistry parameters of rats treated with 2-acetylaminofluorene and N-acetylcysteine]. Bollettino della Societa italiana di biologia sperimentale, 1991, Volume: 67, Issue:9 Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury; Lipids; Liver Function Tests; Male; Rats; Rats, Inbred Strains	1991
Gold induced hepatitis and pure red cell aplasia. Complete recovery after corticosteroid and N-acetylcysteine therapy. The Journal of rheumatology, 1991, Volume: 18, Issue:8 Topics: Acetylcysteine; Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury; Gold; Hepatitis; Humans; Injections; Male; Middle Aged; Red-Cell Aplasia, Pure	1991
Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen. Journal of biochemical toxicology, 1991,Summer, Volume: 6, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Isocitrate Dehydrogenase; Liver; Male; Mice; Sulfobromophthalein	1991
Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage. Human & experimental toxicology, 1990, Volume: 9, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Glutathione Transferase; Humans; Infusions, Intravenous; Male; Middle Aged	1990
Hypophosphataemia and phosphaturia in paracetamol poisoning. Lancet (London, England), 1989, Sep-09, Volume: 2, Issue:8663 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Evaluation Studies as Topic; Female; Glucose; Hepatic Encephalopathy; Humans; Male; Phosphates; Potassium; Severity of Illness Index	1989
The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. European journal of clinical pharmacology, 1989, Volume: 37, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Injections, Intravenous; Liver Function Tests; Male	1989
Liver toxicity due to 1,2-dichloropropane in the rat. Archives of toxicology, 1989, Volume: 63, Issue:6 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Glutathione Transferase; Liver Diseases; Male; Propane; Rats; Rats, Inbred Strains; Solvents; Time Factors	1989
Delayed acetaminophen toxicity despite acetylcysteine use. DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:6 Topics: Acetaminophen; Acetylcysteine; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Humans	1989
Liver injury associated with N-acetylcysteine administration. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Liver Function Tests; Male; Rats	1989
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine. Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride	1987
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice. Drug metabolism and drug interactions, 1988, Volume: 6, Issue:3-4 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds	1988
Death of a child associated with multiple overdoses of acetaminophen. Clinical pharmacy, 1988, Volume: 7, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Organ Size; Renal Dialysis	1988
Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes. Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Carbamates; Chemical and Drug Induced Liver Injury; Formamides; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Structure-Activity Relationship	1988
[Acute paracetamol poisoning]. La Revue du praticien, 1987, Dec-03, Volume: 37, Issue:47 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Prognosis	1987
Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice. Research communications in chemical pathology and pharmacology, 1987, Volume: 58, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Organ Size; Proteins; Spectrophotometry, Atomic; Time Factors	1987
Sulfate conjugation in drug metabolism: role of inorganic sulfate. Federation proceedings, 1986, Volume: 45, Issue:8 Topics: Acetaminophen; Acetylcysteine; Animals; Arylsulfotransferase; Biotransformation; Chemical and Drug Induced Liver Injury; Computers; Humans; Kidney Failure, Chronic; Kinetics; Rats; Salicylamides; Sulfates; Sulfurtransferases	1986
Acetaminophen overdose. American family physician, 1987, Volume: 35, Issue:4 Topics: Acetaminophen; Acetylcysteine; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; Humans; Kinetics; Risk; Time Factors	1987
Paracetamol overdose. Australian family physician, 1987, Volume: 16, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Female; Gastric Lavage; Humans	1987
Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Deuterium; Formamides; Glutathione; Kinetics; Male; Mass Spectrometry; Methylamines; Mice; Mice, Inbred BALB C	1987
Effect of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the metabolism and toxicity of bromobenzene: an acute study. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:5 Topics: Acetylcysteine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Phenols; Sulfates; Transaminases	1987
Management of acute acetaminophen overdose. American family physician, 1986, Volume: 33, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Intubation, Gastrointestinal; Liver; Male; Risk; Time Factors	1986
Coma and metabolic acidosis early in severe acute paracetamol poisoning. Human toxicology, 1986, Volume: 5, Issue:3 Topics: Acetaminophen; Acetylcysteine; Acidosis; Adolescent; Aged; Blood Gas Analysis; Chemical and Drug Induced Liver Injury; Coma; Female; Half-Life; Humans; Male; Middle Aged	1986
Dissociation of increased sulfation from sulfate replenishment and hepatoprotection in acetaminophen-poisoned mice by N-acetylcysteine stereoisomers. Journal of pharmaceutical sciences, 1986, Volume: 75, Issue:9 Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Mice, Inbred ICR; Stereoisomerism; Sulfates	1986
Liver injury after oral and rectal administration of N-acetylcysteine for meconium ileus equivalent in a patient with cystic fibrosis. Pediatrics, 1987, Volume: 79, Issue:2 Topics: Acetylcysteine; Administration, Oral; Administration, Rectal; Chemical and Drug Induced Liver Injury; Cystic Fibrosis; Humans; Infant; Intestinal Obstruction; Liver Function Tests; Male	1987
Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage. Gut, 1985, Volume: 26, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Glutathione Transferase; Humans; Liver Diseases	1985
Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3 Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Glutathione; Inactivation, Metabolic; Male; Mass Spectrometry; Metabolic Clearance Rate; Mice; Mice, Inbred ICR	1985
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Necrosis; Rats; Rats, Inbred F344; Time Factors	1985
Postabsorption antidotal effects of N-acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse. Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:5 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Body Weight; Chemical and Drug Induced Liver Injury; Glutathione; Indocyanine Green; Liver; Liver Function Tests; Male; Mice; Time Factors	1985
Acetaminophen: acute overdose toxicity in children. Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:12 Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Ethanol; Humans; Time Factors	1985
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium	1974