acetylcysteine and Acute Brain Injuries

acetylcysteine has been researched along with Acute Brain Injuries in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.13)18.2507
2000's9 (28.13)29.6817
2010's16 (50.00)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Chang, S; Gao, W; Gao, YX; Liao, H; Pang, T; Qiu, WW; Wang, YJ; Wang, YY; Xu, Y; Xu, YZ; Yang, LF; Yu, LG; Zhang, LY1
André, C; Curioni, CC; da Silva, ACF; de Velasco, PC; Lamarca, F; Mocellin, MC; Ribas, SA; Tavares, MDS1
Bitsina, C; Chatzisotiriou, A; Dandi, E; Kesidou, E; Spandou, E; Tata, DA; Theotokis, P1
Beloosesky, R; Ginsberg, Y; Gutzeit, O; Khatib, N; Ross, MG; Weiner, Z; Zmora, O1
Aceti, A; Austin, T; Corvaglia, L; Faldella, G; Martini, S1
Beloosesky, R; Boulos, S; Fainaru, O; Ginsberg, Y; Gutzeit, O; Khatib, N; Millo, Z; Ross, MG; Segal, L; Weiner, Z; Zmora, O1
Acosta, G; Andrews, KD; Cao, J; Dietrich, AD; Liu, Z; Lu, KH; Lungwitz, EA; Majumdar, S; Race, NS; Shekhar, A; Shi, R; Truitt, WA; Vega Alvarez, SM; Warner, TR1
Beloosesky, R; Efrat, S; Ginsberg, Y; Khatib, N; Mordechai, H; Ross, MG; Sharabi, H; Tamar, BK; Weiner, Z1
Liu, BH; Wu, W; Xia, XD; Xie, CL; Zhang, YM1
Antkiewicz-Michaluk, L; Nalepa, I; Romańska, I; Wąsik, A; Zelek-Molik, A1
Beloosesky, R; Ginsberg, Y; Itskovitz-Eldor, J; Khatib, N; Maravi, N; Ross, MG; Weiner, Z1
Abdel Baki, SG; Bergold, PJ; Dash, P; Ershova, A; Grill, RJ; Grin'kina, NM; Haber, M; Irizarry, R; Orsi, S1
Baumgartner, WA; Beaty, CA; Blue, ME; Johnston, MV; Kambhampati, SP; Kannan, RM; Kannan, S; Lesniak, WG; Mishra, MK; Troncoso, JC; Wilson, MA; Zhang, F1
Nazıroğlu, M; Senol, N; Yürüker, V1
Balaban, CD; Baratz-Goldstein, R; Eakin, K; Hoffer, BJ; Hoffer, ME; Lockwood, M; Miller, J; Pick, CG; Zindel, O1
Goldstein, GA; Pandya, JD; Patel, SP; Pauly, JR; Rabchevsky, AG; Readnower, RD; Sullivan, PG; Yonutas, HM1
Ghazizadeh, V; Nazıroğlu, M; Senol, N; Yürüker, V1
Semple, BD1
Davidsson, J; Günther, M; Mathiesen, T; Norgren, S; Plantman, S; Risling, M1
Deng, H; Jankovic, J; Le, W; Pan, T; Xie, W; Zhao, H; Zhu, W1
Chang, E; Jenkins, DD; Singh, I1
Abdel Baki, SG; Bergold, PJ; Fenton, AA; Haber, M; Schwab, B1
Chang, EY; Newman, R; Singh, I; Sullivan, S; Zhang, J1
Balaban, C; Hoffer, B; Hoffer, ME; Slade, MD; Tsao, JW1
Hazell, AS; Yi, JH1
Griebenow, M; Kroppenstedt, SN; Stover, JF; Thomale, UW; Unterberg, AW2
Hazell, AS; Hoover, R; McIntosh, TK; Yi, JH1
Contreras, MA; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Chen, G; Hang, C; Hu, Z; Shi, J1
Lee, CP; Peterson, PL; Xiong, Y1
Chen, BD; Lee, CP; Lin, H; Peterson, PL; Xiong, Y1

Reviews

2 review(s) available for acetylcysteine and Acute Brain Injuries

ArticleYear
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials.
    Nutrition reviews, 2022, 10-10, Volume: 80, Issue:11

    Topics: Acetylcysteine; Brain Injuries; Cerebral Palsy; Child; Choline; Docosahexaenoic Acids; Female; Fetal Alcohol Spectrum Disorders; Humans; Infant; Infant, Newborn; Infant, Premature; Magnesium Sulfate; Pregnancy; Randomized Controlled Trials as Topic; Uridine Monophosphate; Vitamin A; Vitamin D

2022
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectives.
    Pediatric research, 2020, Volume: 87, Issue:5

    Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Asphyxia Neonatorum; Biomarkers; Brain Injuries; Clinical Trials as Topic; DNA; Erythropoietin; Free Radicals; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Malondialdehyde; Melatonin; Nitric Oxide; Oxidative Stress; Prostaglandins; Proteins; Uric Acid

2020

Trials

2 trial(s) available for acetylcysteine and Acute Brain Injuries

ArticleYear
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.
    Experimental neurology, 2014, Volume: 257

    Topics: Acetylcysteine; Aldehydes; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Double-Blind Method; Energy Metabolism; Glutathione; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine

2014
Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Acetylcysteine; Adolescent; Adult; Blast Injuries; Brain Injuries; Cognition Disorders; Double-Blind Method; Female; Free Radical Scavengers; Humans; Iraq War, 2003-2011; Male; Memory Disorders; Military Personnel; Neuropsychological Tests; Placebos; Severity of Illness Index; Sleep Initiation and Maintenance Disorders

2013

Other Studies

28 other study(ies) available for acetylcysteine and Acute Brain Injuries

ArticleYear
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; Glutamic Acid; Molecular Structure; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2015
N-Acetylcysteine Administration Attenuates Sensorimotor Impairments Following Neonatal Hypoxic-Ischemic Brain Injury in Rats.
    International journal of molecular sciences, 2022, Dec-19, Volume: 23, Issue:24

    Topics: Acetylcysteine; Animals; Animals, Newborn; Brain; Brain Injuries; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2022
Intestine and brain TLR-4 modulation following N-acetyl-cysteine treatment in NEC rodent model.
    Scientific reports, 2023, 05-22, Volume: 13, Issue:1

    Topics: Acetylcysteine; Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Enterocolitis, Necrotizing; Glutathione; Ileum; Intestines; Rats; Rats, Sprague-Dawley; Rodentia; Toll-Like Receptor 4

2023
Maternal N-acetyl-cysteine prevents neonatal brain injury associated with necrotizing enterocolitis in a rat model.
    Acta obstetricia et gynecologica Scandinavica, 2021, Volume: 100, Issue:5

    Topics: Acetylcysteine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain Injuries; Caspase 3; Disease Models, Animal; Enterocolitis, Necrotizing; Female; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Interleukin-6; Nitric Oxide Synthase Type I; Oxidative Stress; Pregnancy; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2021
Psychosocial impairment following mild blast-induced traumatic brain injury in rats.
    Behavioural brain research, 2021, 08-27, Volume: 412

    Topics: Acetylcysteine; Acrolein; Animals; Blast Injuries; Brain; Brain Concussion; Brain Injuries; Disease Models, Animal; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Psychosocial Functioning; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2021
Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI).
    Neuroscience, 2019, 04-01, Volume: 403

    Topics: Acetylcysteine; Animals; Brain; Brain Injuries; Disease Models, Animal; Escherichia coli; Female; Inflammation; Lipopolysaccharides; Male; Neuroprotective Agents; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Sprague-Dawley

2019
Neuroprotective effects of N-acetyl cysteine on primary hippocampus neurons against hydrogen peroxide-induced injury are mediated via inhibition of mitogen-activated protein kinases signal transduction and antioxidative action.
    Molecular medicine reports, 2018, Volume: 17, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Brain Injuries; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydrogen Peroxide; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2018
The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.
    Neurotoxicity research, 2018, Volume: 34, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Analysis of Variance; Animals; Brain; Brain Injuries; Cysteine Proteinase Inhibitors; Dopamine; Exploratory Behavior; Functional Laterality; Locomotion; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Wistar; Tetrahydroisoquinolines

2018
Prophylactic maternal N-acetylcysteine in rats prevents maternal inflammation-induced offspring cerebral injury shown on magnetic resonance imaging.
    American journal of obstetrics and gynecology, 2013, Volume: 208, Issue:3

    Topics: Acetylcysteine; Animals; Animals, Newborn; Brain; Brain Injuries; Female; Infectious Disease Transmission, Vertical; Inflammation; Lipopolysaccharides; Magnetic Resonance Imaging; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley

2013
Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury.
    Experimental neurology, 2013, Volume: 249

    Topics: Acetylcysteine; Animals; Avoidance Learning; Brain Injuries; Cognition Disorders; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Inflammation; Memory Disorders; Minocycline; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2013
Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest.
    ACS nano, 2014, Mar-25, Volume: 8, Issue:3

    Topics: Acetylcysteine; Animals; Biological Transport; Brain; Brain Injuries; Circulatory Arrest, Deep Hypothermia Induced; Dendrimers; Disease Models, Animal; Dogs; Drug Carriers; Male; Microglia; Nanomedicine; Neurons; Rabbits; Treatment Outcome; Valproic Acid

2014
N-acetylcysteine and selenium modulate oxidative stress, antioxidant vitamin and cytokine values in traumatic brain injury-induced rats.
    Neurochemical research, 2014, Volume: 39, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Brain Injuries; Cytokines; Male; Neuroprotective Agents; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Selenium; Vitamin A

2014
Efficacy of N-acetyl cysteine in traumatic brain injury.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Brain Injuries; Drug Evaluation, Preclinical; Male; Maze Learning; Mice; Mice, Inbred ICR; Rats, Sprague-Dawley; Recognition, Psychology

2014
Neuroprotection induced by N-acetylcysteine and selenium against traumatic brain injury-induced apoptosis and calcium entry in hippocampus of rat.
    Cellular and molecular neurobiology, 2014, Volume: 34, Issue:6

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Brain Injuries; Calcium; Caspase 3; Hippocampus; Male; Neurons; Rats, Sprague-Dawley; Selenium

2014
Early preservation of mitochondrial bioenergetics supports both structural and functional recovery after neurotrauma.
    Experimental neurology, 2014, Volume: 261

    Topics: Acetylcysteine; Animals; Brain Injuries; Energy Metabolism; Humans; Mitochondria; Models, Biological; Neuroprotective Agents; Oxidative Stress

2014
Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:9

    Topics: Acetylcysteine; Animals; Apoptosis; Brain; Brain Injuries; Head Injuries, Penetrating; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2015
Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.
    Brain research, 2008, Jul-30, Volume: 1222

    Topics: Acetylcysteine; Analysis of Variance; Animals; Apoptosis; Brain Injuries; Causality; Cell Line, Tumor; DNA-Binding Proteins; Dopamine; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Neuroblastoma; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase

2008
Neuroprotective interventions: is it too late?
    Journal of child neurology, 2009, Volume: 24, Issue:9

    Topics: Acetylcysteine; Animals; Animals, Newborn; Brain Injuries; Disease Models, Animal; Female; Humans; Hypothermia, Induced; Male; Myelin Sheath; Neuroprotective Agents; Oligodendroglia; Oxidative Stress; Polysaccharides; Pregnancy; Prenatal Exposure Delayed Effects; Research Design; Time Factors

2009
Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats.
    PloS one, 2010, Aug-31, Volume: 5, Issue:8

    Topics: Acetylcysteine; Animals; Avoidance Learning; Brain Injuries; Cognition; Conditioning, Psychological; Drug Synergism; Interleukin-1beta; Memory; Minocycline; Myelin Sheath; Perception; Rats; Rats, Sprague-Dawley; Task Performance and Analysis; Time Factors

2010
N-acetylcysteine attenuates the maternal and fetal proinflammatory response to intrauterine LPS injection in an animal model for preterm birth and brain injury.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:5

    Topics: Acetylcysteine; Animals; Animals, Newborn; Brain; Brain Injuries; Female; Fetal Diseases; Free Radical Scavengers; Mice; Pregnancy; Premature Birth

2011
N-acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury.
    Brain research, 2005, Feb-01, Volume: 1033, Issue:1

    Topics: Acetylcysteine; Animals; Blotting, Western; Brain Injuries; Disease Models, Animal; Enzyme Induction; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Immunohistochemistry; Male; Oxygenases; Percussion; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrazolium Salts; Time Factors

2005
The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats.
    Intensive care medicine, 2006, Volume: 32, Issue:1

    Topics: Acetylcysteine; Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Free Radical Scavengers; Male; Random Allocation; Rats; Rats, Sprague-Dawley

2006
Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
    Journal of neurotrauma, 2006, Volume: 23, Issue:1

    Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; SNARE Proteins; Synaptic Membranes; Synaptic Transmission; Time Factors; Up-Regulation

2006
The antioxidant effect of N-acethylcysteine on experimental contusion in rats.
    Acta neurochirurgica. Supplement, 2005, Volume: 95

    Topics: Acetylcysteine; Animals; Antioxidants; Brain Edema; Brain Injuries; Disease Models, Animal; Injections, Intraperitoneal; Intracranial Pressure; Rats; Rats, Sprague-Dawley; Treatment Outcome

2005
Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine.
    Experimental neurology, 2008, Volume: 210, Issue:2

    Topics: Acetylcysteine; Acyltransferases; Analysis of Variance; Animals; Brain Injuries; Case-Control Studies; Cells, Cultured; Child, Preschool; Drug Interactions; Female; Fetus; Flow Cytometry; Free Radical Scavengers; Humans; In Vitro Techniques; Infant; Lipopolysaccharides; Neuroglia; Peroxisomal Disorders; Peroxisomes; Pregnancy; Prenatal Exposure Delayed Effects; Reactive Oxygen Species; RNA, Small Interfering; Time Factors; Transfection

2008
Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine.
    Mediators of inflammation, 2008, Volume: 2008

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Blood-Brain Barrier; Brain Injuries; DNA; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Male; Neuroprotective Agents; NF-kappa B; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2008
Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats.
    Journal of neurotrauma, 1999, Volume: 16, Issue:11

    Topics: Acetylcysteine; Animals; Brain Injuries; Free Radical Scavengers; Glutathione; Male; Mitochondria; Rats; Rats, Sprague-Dawley

1999
Appearance of shortened Bcl-2 and Bax proteins and lack of evidence for apoptosis in rat forebrain after severe experimental traumatic brain injury.
    Biochemical and biophysical research communications, 2001, Aug-17, Volume: 286, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Brain Injuries; Cytochrome c Group; Free Radical Scavengers; Male; Mitochondria; Prosencephalon; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2001