acetylcarnitine has been researched along with Pregnancy in 32 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conclude that addition of ALC therapy is superior to metformin plus pioglitazone in ameliorating insulin resistance, polycystic ovaries, menstrual irregularities, and hypoadiponectinemia in women with PCOS." | 5.41 | Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial. ( Badshah, H; Ehtesham, E; Habib, SH; Israr, M; Malik, MO; Rauf, B; Raza, MA; Shah, FA; Shah, I; Shah, M; Tauqir, S; Usman, M, 2021) |
| "Insulin resistance was calculated by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)." | 3.01 | Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial. ( Badshah, H; Ehtesham, E; Habib, SH; Israr, M; Malik, MO; Rauf, B; Raza, MA; Shah, FA; Shah, I; Shah, M; Tauqir, S; Usman, M, 2021) |
| " Stimulation of spermatogenesis using the antioxidant complex SpermActin Forte is an effective and safe method of treating male infertility." | 2.90 | [Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility]. ( Gamidov, SI; Ovchinnikov, RI; Popova, AY, 2019) |
| "3." | 2.90 | [Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility]. ( Gamidov, SI; Ovchinnikov, RI; Popova, AY, 2019) |
| "Although male infertility affects 1:15 men, there is no obvious reason in the vast majority of cases." | 2.66 | l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility. ( Anderson, R; Khaw, SC; Martins da Silva, S; Wong, ZZ, 2020) |
| "Autism spectrum disorder is characterized by a variety of cellular and molecular abnormalities which leads to autism-associated behaviors." | 1.91 | Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism. ( Roghani, M; Sadr, SS; Sanaeierad, A; Zahedi, E, 2023) |
| "Infants born to mothers with preeclampsia with severe features and chronic hypertension with superimposed preeclampsia had alterations in acetylcarnitine, free carnitine, and ornithine levels." | 1.72 | Newborn screen metabolic panels reflect the impact of common disorders of pregnancy. ( Aghaeepour, N; Bianco, K; Chang, AL; Lee, HC; Mayo, JA; Reiss, JD; Shaw, GM; Stevenson, DK; Sylvester, KG, 2022) |
| "Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear." | 1.72 | Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes. ( Cao, Y; Chang, X; Dai, Y; Guo, J; Liang, W; Lu, D; Lv, S; Qi, X; Wang, Z; Wu, C; Zhang, J; Zhang, L; Zhou, Z, 2022) |
| "Whether intergenerational trauma transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother-infant interaction is unknown." | 1.62 | Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. ( Abbott, GW; Alachkar, A; Alhassen, L; Alhassen, S; Baldi, P; Barhoosh, H; Chen, S; De Silva, A; Henrich, C; Khoudari, M; Mutesa, L; Parrocha, C; Phan, A; Shapiro, E; Wang, Z, 2021) |
| "Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes." | 1.42 | Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy. ( Buss, C; Entringer, S; Hellmuth, C; Koletzko, B; Lindsay, KL; Uhl, O; Wadhwa, PD, 2015) |
| "Although vitamin B12 deficiency is not a primary target of newborn screening (NBS) programs, measurements of propionylcarnitine (C3) and its ratios with acetylcarnitine (C3/C2) and palmitoylcarnitine (C3/C16) may incidentally identify vitamin B12-deficient newborns." | 1.40 | Serum vitamin B12 levels during the first trimester of pregnancy correlate with newborn screening markers of vitamin B12 deficiency. ( Dayaldasani, A; Pérez-Valero, V; Rodríguez-Espinosa, M; Rueda, I; Ruiz-Escalera, J; Yahyaoui, R, 2014) |
| "The development of pulmonary hypertension is a common accompaniment of congenital heart disease (CHD) with increased pulmonary blood flow." | 1.38 | Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. ( Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J, 2012) |
| "L-Carnitine transfer was 20% that of the freely diffusing antipyrine and 40% that of L-lysine." | 1.27 | Transfer and metabolism of carnitine and carnitine esters in the in vitro perfused human placenta. ( Novak, M; Penn, D; Prögler, M; Schmidt-Sommerfeld, E; Schneider, H; Sodha, RJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (18.75) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 11 (34.38) | 2.80 |
| Authors | Studies |
|---|---|
| Sciascia, QL | 1 |
| Prehn, C | 1 |
| Adamski, J | 1 |
| Daş, G | 1 |
| Lang, IS | 1 |
| Otten, W | 1 |
| Görs, S | 1 |
| Metges, CC | 1 |
| Yaris, M | 1 |
| Akdogan, N | 1 |
| Öztürk, M | 1 |
| Bozkurt, A | 1 |
| Karabakan, M | 1 |
| Reiss, JD | 1 |
| Chang, AL | 1 |
| Mayo, JA | 1 |
| Bianco, K | 1 |
| Lee, HC | 1 |
| Stevenson, DK | 1 |
| Shaw, GM | 1 |
| Aghaeepour, N | 1 |
| Sylvester, KG | 1 |
| Khaw, SC | 1 |
| Wong, ZZ | 1 |
| Anderson, R | 1 |
| Martins da Silva, S | 1 |
| Neto, FTL | 1 |
| Marques, RA | 1 |
| Cavalcanti Filho, AF | 1 |
| Fonte, JEFD | 1 |
| Lima, SVC | 1 |
| Silva, RO | 1 |
| Zhang, J | 1 |
| Wang, Z | 4 |
| Dai, Y | 1 |
| Zhang, L | 2 |
| Guo, J | 1 |
| Lv, S | 1 |
| Qi, X | 1 |
| Lu, D | 1 |
| Liang, W | 1 |
| Cao, Y | 1 |
| Wu, C | 1 |
| Chang, X | 1 |
| Zhou, Z | 2 |
| Qutob, HMH | 1 |
| Saad, RA | 1 |
| Bali, H | 1 |
| Osailan, A | 1 |
| Jaber, J | 1 |
| Alzahrani, E | 1 |
| Alyami, J | 1 |
| Elsayed, H | 1 |
| Alserihi, R | 1 |
| Shaikhomar, OA | 1 |
| Divya, KM | 1 |
| Savitha, DP | 1 |
| Krishna, GA | 1 |
| Dhanya, TM | 1 |
| Mohanan, PV | 1 |
| Shah, SF | 1 |
| Jafry, AT | 1 |
| Hussain, G | 1 |
| Kazim, AH | 1 |
| Ali, M | 1 |
| Rivani, E | 1 |
| Endraswari, PD | 1 |
| Widodo, ADW | 1 |
| Khalil, MR | 1 |
| Guldberg, R | 1 |
| Nørgård, BM | 1 |
| Uldbjerg, N | 1 |
| Wehberg, S | 1 |
| Fowobaje, KR | 1 |
| Mashood, LO | 1 |
| Ekholuenetale, M | 1 |
| Ibidoja, OJ | 1 |
| Romagnoli, A | 1 |
| D'Agostino, M | 1 |
| Pavoni, E | 1 |
| Ardiccioni, C | 1 |
| Motta, S | 1 |
| Crippa, P | 1 |
| Biagetti, G | 1 |
| Notarstefano, V | 1 |
| Rexha, J | 1 |
| Perta, N | 1 |
| Barocci, S | 1 |
| Costabile, BK | 1 |
| Colasurdo, G | 1 |
| Caucci, S | 1 |
| Mencarelli, D | 1 |
| Turchetti, C | 1 |
| Farina, M | 1 |
| Pierantoni, L | 1 |
| La Teana, A | 1 |
| Al Hadi, R | 1 |
| Cicconardi, F | 1 |
| Chinappi, M | 1 |
| Trucchi, E | 1 |
| Mancia, F | 1 |
| Menzo, S | 1 |
| Morozzo Della Rocca, B | 1 |
| D'Annessa, I | 1 |
| Di Marino, D | 1 |
| Choya, A | 1 |
| de Rivas, B | 1 |
| Gutiérrez-Ortiz, JI | 1 |
| López-Fonseca, R | 1 |
| Xu, S | 1 |
| Cheng, B | 1 |
| Huang, Z | 2 |
| Liu, T | 1 |
| Li, Y | 1 |
| Jiang, L | 1 |
| Guo, W | 1 |
| Xiong, J | 1 |
| Amirazodi, M | 1 |
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| Tao, Y | 1 |
| Zhang, Q | 1 |
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| Guan, ZJ | 1 |
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| Rodríguez-Espinosa, M | 1 |
| Rueda, I | 1 |
| Pérez-Valero, V | 1 |
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| Hata, I | 1 |
| Nakai, A | 1 |
| Kikawa, Y | 1 |
| Sudo, M | 1 |
| Tanaka, Y | 1 |
| Yamaguchi, S | 1 |
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| Vicari, E | 1 |
| Calogero, AE | 1 |
| Novak, M | 2 |
| Wieser, PB | 1 |
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| Amenta, F | 1 |
| Cavallotti, C | 1 |
| De Rossi, M | 1 |
| Bossoni, G | 1 |
| Carpi, C | 1 |
| Schmidt-Sommerfeld, E | 2 |
| Penn, D | 2 |
| Sodha, RJ | 2 |
| Prögler, M | 2 |
| Schneider, H | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations[NCT05919186] | 293 participants (Actual) | Interventional | 2021-10-12 | Completed | |||
| Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress Response in Patients With PCOS: A Double Blind Randomized Clinical Trial[NCT04113889] | Phase 2 | 147 participants (Actual) | Interventional | 2019-10-15 | Completed | ||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Impact of Fish Oil or Probiotic Intake on Maternal Obesity and Molecular Biomarkers in the Placenta[NCT03215784] | 80 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | |||
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for acetylcarnitine and Pregnancy
| Article | Year |
|---|---|
l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility.
Topics: Acetylcarnitine; Antioxidants; Carnitine; Dietary Supplements; Female; Humans; Infertility, Male; Ma | 2020 |
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Carnitine; Female; Humans; Infertility, Male; Male; Meta-A | 2007 |
6 trials available for acetylcarnitine and Pregnancy
| Article | Year |
|---|---|
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter | 2022 |
[Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility].
Topics: Acetylcarnitine; Adult; Carnitine; Double-Blind Method; Female; Fumarates; Humans; Infertility, Male | 2019 |
Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media system with antioxidants versus standard G-Series media system.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Antioxidants; Culture Media; Embryo Culture Techniques; Embr | 2020 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia.
Topics: Acetylcarnitine; Analysis of Variance; Carnitine; Double-Blind Method; Drug Therapy, Combination; Fe | 2005 |
[A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia].
Topics: Acetylcarnitine; Administration, Oral; Adult; Carnitine; Double-Blind Method; Drug Administration Sc | 2005 |
24 other studies available for acetylcarnitine and Pregnancy
| Article | Year |
|---|---|
The Effect of Dietary Protein Imbalance during Pregnancy on the Growth, Metabolism and Circulatory Metabolome of Neonatal and Weaned Juvenile Porcine Offspring.
Topics: Acetylcarnitine; Animals; Animals, Newborn; Carnitine; Dietary Carbohydrates; Dietary Proteins; Fema | 2021 |
The effects of two different antioxidant combinations on sperm parameters.
Topics: Acetylcarnitine; Adult; Antioxidants; Ascorbic Acid; Carnitine; Citric Acid; Female; Folic Acid; Fru | 2022 |
Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.
Topics: Acetylcarnitine; Diabetes, Gestational; Female; Humans; Hypertension, Pregnancy-Induced; Nitric Oxid | 2022 |
Prediction of semen analysis parameter improvement after varicocoelectomy using 1 H NMR-based metabonomics assays.
Topics: Acetylcarnitine; Caprylates; Creatine; Female; Humans; Hydrogen; Infertility, Male; Isoleucine; Magn | 2022 |
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.
Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin; | 2022 |
Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism.
Topics: Acetylcarnitine; Animals; Autism Spectrum Disorder; Autistic Disorder; Encephalitis; Female; Microbi | 2023 |
Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction.
Topics: Acetylcarnitine; Animals; Brain; Computational Biology; Depression; Female; Historical Trauma; Human | 2021 |
Metabolomics reveals the role of acetyl-l-carnitine metabolism in γ-Fe
Topics: Acetylcarnitine; Animals; Embryo, Nonmammalian; Embryonic Development; Female; Ferric Compounds; Mem | 2019 |
Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine.
Topics: Acetylcarnitine; Animals; Anti-HIV Agents; Behavior, Animal; Birth Weight; Female; Hippocampus; Lipi | 2013 |
The influence of maternal disease on metabolites measured as part of newborn screening.
Topics: Acetylcarnitine; Alanine; Biomarkers; Female; Fetal Blood; Humans; Infant, Newborn; Male; Multivaria | 2013 |
Serum vitamin B12 levels during the first trimester of pregnancy correlate with newborn screening markers of vitamin B12 deficiency.
Topics: Acetylcarnitine; Adolescent; Adult; Biomarkers; Carnitine; Diet; Female; Gestational Age; Humans; In | 2014 |
Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy.
Topics: Acetylcarnitine; Adult; Amino Acids; Carnitine; Citric Acid Cycle; Fasting; Fatty Acids; Female; Hum | 2015 |
A case of holocarboxylase synthetase deficiency with insufficient response to prenatal biotin therapy.
Topics: Acetylcarnitine; Biotin; Carnitine; Female; Holocarboxylase Synthetase Deficiency; Humans; Infant, N | 2009 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopteri | 2012 |
A study of the acylcarnitine content of sows' colostrum, milk and newborn piglet tissues: demonstration of high amounts of isovalerylcarnitine in colostrum and milk.
Topics: Acetylcarnitine; Animals; Animals, Newborn; Carnitine; Colostrum; Female; Lactation; Liver; Milk; Pr | 1984 |
Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholinesterase; Ammonia; Animals; Brain; Carnitine; Choline; Choline O-Acetyl | 1995 |
Alterations of the thalamo-cortical system in rats prenatally exposed to ethanol are prevented by concurrent administration of acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ethanol; Female; Horseradish Peroxidase; Microinjections; Nootropic Agents | 1995 |
Prenatal diagnosis of organic acidemias based on amniotic fluid levels of acylcarnitines.
Topics: Acetylcarnitine; Acidosis; Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Fetal Disea | 1996 |
Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis.
Topics: Acetylcarnitine; Adult; Antioxidants; Carnitine; Epididymitis; Female; Genital Diseases, Male; Human | 2001 |
Acetylcarnitine and free carnitine in body fluids before and after birth.
Topics: Acetylcarnitine; Adult; Amniotic Fluid; Body Fluids; Carnitine; Female; Glycine max; Humans; Hydroxy | 1979 |
Effect of dietary lysine level and protein restriction on the lipids and carnitine levels in the liver of pregnant rats.
Topics: Acetylcarnitine; Animals; Carnitine; Cholesterol; Diet; Fatty Acids; Female; Indicators and Reagents | 1989 |
Effect of acetyl-L-carnitine treatment on some behavioural, histochemical and histological parameters of methylazoxymethanol microencephalic rats.
Topics: Acetylcarnitine; Acetylcholinesterase; Animals; Behavior, Animal; Brain; Carnitine; Female; Histocyt | 1986 |
Transfer and metabolism of carnitine and carnitine esters in the in vitro perfused human placenta.
Topics: Acetylcarnitine; Carnitine; Esters; Female; Glucose; Humans; In Vitro Techniques; Lactates; Lysine; | 1985 |
Transfer and metabolism of carnitine and carnitine esters in the in vitro perfused human placenta.
Topics: Acetylcarnitine; Biological Transport; Carnitine; Female; Humans; In Vitro Techniques; Maternal-Feta | 1985 |