acetylcarnitine has been researched along with Obesity in 12 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy." | 7.01 | L-carnitine and Acetyl-L Carnitine: A Possibility for Treating Alterations Induced by Obesity in the Central Nervous System. ( Abel, JDS; da Silva, LE; da Silva, MR; de Aguiar da Costa, M; de Oliveira, MP; Ludvig Gonçalves, C; Rezin, GT; Tartari, G, 2023) |
| "NR supplementation of 1000 mg/d for 6 wk in healthy overweight or obese men and women increased skeletal muscle NAD+ metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced minor changes in body composition and sleeping metabolic rate." | 5.34 | Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. ( Aarts, SABM; Auwerx, J; Connell, NJ; de Wit, VHW; Elfrink, HL; Havekes, B; Hoeks, J; Houtkooper, RH; Lindeboom, L; Lutgens, E; Mevenkamp, J; Moonen, MPB; Phielix, E; Remie, CME; Roumans, KHM; Schomakers, BV; Schrauwen, P; Schrauwen-Hinderling, VB; van de Weijer, T; Zapata-Pérez, R, 2020) |
| "The main aim of this study was to research new treatments following peripheral nerve injury involving melatonin (Mel), acetyl-l-carnitine (ALCAR), and leptin (Lep) using updated unbiased methods at the stereological and electron microscopic levels." | 3.85 | Possible effects of some agents on the injured nerve in obese rats: A stereological and electron microscopic study. ( Altun, G; Altunkaynak, BZ; Geuna, S; Kaplan, S; Muratori, L; Onger, ME; Türkmen, AP, 2017) |
| "Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity." | 3.80 | Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. ( Brouwers, B; Hesselink, MK; Hoeks, J; Kooi, ME; Koves, T; Lindeboom, L; Muoio, DM; Nabuurs, CI; Phielix, E; Schrauwen, P; Schrauwen-Hinderling, VB; Stevens, RD; Wildberger, JE, 2014) |
| "Betaine (BET) reduces diet-induced liver lipid accumulation, and may relieve obesity-related metabolic disturbances." | 3.79 | Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. ( Auriola, S; Hanhineva, K; Huotari, A; Keski-Rahkonen, P; Kolehmainen, M; Lehtonen, M; Mykkänen, H; Olli, K; Pekkinen, J; Poutanen, K; Tiihonen, K, 2013) |
| "Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy." | 3.01 | L-carnitine and Acetyl-L Carnitine: A Possibility for Treating Alterations Induced by Obesity in the Central Nervous System. ( Abel, JDS; da Silva, LE; da Silva, MR; de Aguiar da Costa, M; de Oliveira, MP; Ludvig Gonçalves, C; Rezin, GT; Tartari, G, 2023) |
| "Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary metabolism." | 1.36 | Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. ( Adams, SH; Fiehn, O; Garvey, WT; Hoppel, CL; Lok, KH; Newman, JW, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, H | 1 |
| Wang, Y | 1 |
| Zhang, X | 1 |
| Li, P | 1 |
| Shang, L | 1 |
| Chen, X | 1 |
| Zeng, J | 1 |
| da Silva, LE | 1 |
| de Oliveira, MP | 1 |
| da Silva, MR | 1 |
| Abel, JDS | 1 |
| Tartari, G | 1 |
| de Aguiar da Costa, M | 1 |
| Ludvig Gonçalves, C | 1 |
| Rezin, GT | 1 |
| Remie, CME | 1 |
| Roumans, KHM | 1 |
| Moonen, MPB | 1 |
| Connell, NJ | 1 |
| Havekes, B | 1 |
| Mevenkamp, J | 1 |
| Lindeboom, L | 3 |
| de Wit, VHW | 1 |
| van de Weijer, T | 1 |
| Aarts, SABM | 1 |
| Lutgens, E | 1 |
| Schomakers, BV | 1 |
| Elfrink, HL | 1 |
| Zapata-Pérez, R | 1 |
| Houtkooper, RH | 1 |
| Auwerx, J | 1 |
| Hoeks, J | 2 |
| Schrauwen-Hinderling, VB | 3 |
| Phielix, E | 2 |
| Schrauwen, P | 3 |
| Fluharty, NT | 1 |
| Brenner, C | 1 |
| Onger, ME | 1 |
| Kaplan, S | 1 |
| Geuna, S | 1 |
| Türkmen, AP | 1 |
| Muratori, L | 1 |
| Altun, G | 1 |
| Altunkaynak, BZ | 1 |
| Pekkinen, J | 1 |
| Olli, K | 1 |
| Huotari, A | 1 |
| Tiihonen, K | 1 |
| Keski-Rahkonen, P | 1 |
| Lehtonen, M | 1 |
| Auriola, S | 1 |
| Kolehmainen, M | 1 |
| Mykkänen, H | 1 |
| Poutanen, K | 1 |
| Hanhineva, K | 1 |
| Nabuurs, CI | 1 |
| Brouwers, B | 1 |
| Kooi, ME | 1 |
| Hesselink, MK | 2 |
| Wildberger, JE | 2 |
| Stevens, RD | 1 |
| Koves, T | 1 |
| Muoio, DM | 1 |
| Bruls, YM | 1 |
| van Ewijk, PA | 1 |
| Fiehn, O | 1 |
| Garvey, WT | 1 |
| Newman, JW | 1 |
| Lok, KH | 1 |
| Hoppel, CL | 2 |
| Adams, SH | 1 |
| Ringseis, R | 1 |
| Mooren, FC | 1 |
| Keller, J | 1 |
| Couturier, A | 1 |
| Wen, G | 1 |
| Hirche, F | 1 |
| Stangl, GI | 1 |
| Eder, K | 1 |
| Krüger, K | 1 |
| Colón-Soto, M | 1 |
| Peredo, RA | 1 |
| Vilá, LM | 1 |
| Genuth, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Nicotinamide Riboside on Metabolic Health in (Pre)Obese Humans[NCT02835664] | 15 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients[NCT03670693] | 45 participants (Actual) | Interventional | 2018-08-01 | Completed | |||
| Effects of Almond Consumption on Cardiovascular, Metabolomic, and Microbiome Profiles in Millennials: Implications of Systemic Glucoregulatory Mechanisms[NCT03084003] | 74 participants (Actual) | Interventional | 2016-02-18 | Completed | |||
| Correlation Between Carnitine Deficiency and Hypoglycemic Events in Type I Diabetes; Effects of Carnitine Supplementation on Hypoglycemic Events in Type I Diabetes[NCT00351234] | 200 participants (Actual) | Observational | 2004-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetylcarnitine and Obesity
| Article | Year |
|---|---|
L-carnitine and Acetyl-L Carnitine: A Possibility for Treating Alterations Induced by Obesity in the Central Nervous System.
Topics: Acetylcarnitine; Carnitine; Central Nervous System; Humans; Obesity; Oxidative Stress | 2023 |
1 trial available for acetylcarnitine and Obesity
| Article | Year |
|---|---|
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.
Topics: Acetylcarnitine; Aged; Body Composition; Dietary Supplements; Female; Humans; Male; Middle Aged; Mus | 2020 |
10 other studies available for acetylcarnitine and Obesity
| Article | Year |
|---|---|
Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Fatty Acids; Fatty Liv | 2023 |
Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it's time to test with exercise.
Topics: Acetylcarnitine; Body Composition; Dietary Supplements; Humans; Muscle, Skeletal; Niacinamide; Obesi | 2020 |
Possible effects of some agents on the injured nerve in obese rats: A stereological and electron microscopic study.
Topics: Acetylcarnitine; Animals; Female; Leptin; Melatonin; Microscopy, Electron; Nerve Regeneration; Obesi | 2017 |
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach.
Topics: Acetylcarnitine; Adipose Tissue; Adiposity; Animals; Betaine; Blood Glucose; Carnitine; Chromatograp | 2013 |
Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.
Topics: Acetylcarnitine; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Male; M | 2014 |
Longitudinal relaxation time editing for acetylcarnitine detection with
Topics: Acetylcarnitine; Adult; Aged; Algorithms; Female; Humans; Lipids; Magnetic Resonance Imaging; Male; | 2017 |
Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women.
Topics: Acetylcarnitine; Alleles; Amino Acids; Biomarkers; Black or African American; Diabetes Mellitus, Typ | 2010 |
Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.
Topics: Acetylcarnitine; Animals; Body Weight; Carnitine; Diet, High-Fat; Fatty Acids; Gene Expression Regul | 2011 |
Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine.
Topics: Acetylcarnitine; Adult; Autoimmune Diseases; Female; Humans; Lupus Erythematosus, Systemic; Obesity; | 2006 |
Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis.
Topics: Acetylcarnitine; Acidosis; Adolescent; Adult; Aged; Body Weight; Carnitine; Child; Diabetic Ketoacid | 1982 |