acetylcarnitine has been researched along with Nerve Degeneration in 17 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " GSH plays a key role in antioxidant defense, and HNE exposure causes an initial depletion of GSH that leads to gradual toxic accumulation of reactive oxygen species." | 1.34 | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. ( Abdul, HM; Butterfield, DA, 2007) |
| "Peripheral neuropathies are widespread disorders induced by autoimmune diseases, drug or toxin exposure, infections, metabolic insults or trauma." | 1.34 | Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy. ( Bartolini, A; Calvani, M; Di Cesare Mannelli, L; Ghelardini, C; Mosconi, L; Nicolai, R; Pacini, A; Vivoli, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Zhang, C | 1 |
| Zhang, X | 1 |
| Wang, S | 1 |
| Meng, Q | 1 |
| Wu, S | 1 |
| Yang, H | 1 |
| Xia, Y | 1 |
| Chen, R | 1 |
| Traina, G | 1 |
| Calabrese, V | 1 |
| Cornelius, C | 1 |
| Mancuso, C | 1 |
| Lentile, R | 1 |
| Stella, AM | 1 |
| Butterfield, DA | 2 |
| Binienda, ZK | 1 |
| Beaudoin, MA | 1 |
| Gough, B | 1 |
| Ali, SF | 1 |
| Virmani, A | 1 |
| Terenghi, G | 1 |
| Hart, A | 1 |
| Wiberg, M | 1 |
| Al-Majed, AA | 1 |
| Sayed-Ahmed, MM | 1 |
| Al-Omar, FA | 1 |
| Al-Yahya, AA | 1 |
| Aleisa, AM | 1 |
| Al-Shabanah, OA | 1 |
| Abdul, HM | 1 |
| Di Cesare Mannelli, L | 1 |
| Ghelardini, C | 1 |
| Calvani, M | 3 |
| Nicolai, R | 1 |
| Mosconi, L | 1 |
| Vivoli, E | 1 |
| Pacini, A | 1 |
| Bartolini, A | 1 |
| Piovesan, P | 1 |
| Pacifici, L | 1 |
| Taglialatela, G | 1 |
| Ramacci, MT | 2 |
| Angelucci, L | 2 |
| Scorziello, A | 1 |
| Meucci, O | 1 |
| Schettini, G | 1 |
| Rao, KV | 1 |
| Mawal, YR | 1 |
| Qureshi, IA | 1 |
| Fernandez, E | 3 |
| Pallini, R | 3 |
| Lauretti, L | 2 |
| La Marca, F | 1 |
| Scogna, A | 1 |
| Rossi, GF | 3 |
| Marchese, E | 1 |
| Gangitano, C | 2 |
| Del Fa, A | 2 |
| Olivieri-Sangiacomo, C | 2 |
| Sbriccoli, A | 2 |
| De Angelis, C | 1 |
| Scarfò, C | 1 |
| Falcinelli, M | 1 |
| Reda, E | 1 |
| Carta, A | 1 |
| Caruso, G | 1 |
| Benedetti, N | 1 |
| Iannuccelli, M | 1 |
| Rampello, L | 1 |
| Giammona, G | 1 |
| Aleppo, G | 1 |
| Favit, A | 1 |
| Fiore, L | 1 |
| Ricoy, J | 1 |
2 reviews available for acetylcarnitine and Nerve Degeneration
| Article | Year |
|---|---|
The neurobiology of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Apoptosis; Brain; Dietary Supplements; Energy Metabolism; Epigenesi | 2016 |
The nerve injury and the dying neurons: diagnosis and prevention.
Topics: Acetylcarnitine; Acetylcysteine; Animals; Axons; Cell Death; Cell Dedifferentiation; Humans; Nerve D | 2011 |
1 trial available for acetylcarnitine and Nerve Degeneration
| Article | Year |
|---|---|
Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Double-Blind Method; Female; Humans; Male; Nerve Degenerat | 1992 |
14 other studies available for acetylcarnitine and Nerve Degeneration
| Article | Year |
|---|---|
An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles.
Topics: Acetylcarnitine; Aluminum Oxide; Animals; Antioxidants; Apoptosis; Cell Line; Cytoprotection; Dose-R | 2016 |
Redox homeostasis and cellular stress response in aging and neurodegeneration.
Topics: Acetylcarnitine; Aging; Animals; Carbon Monoxide; Gene Regulatory Networks; Heme Oxygenase-1; Homeos | 2010 |
Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol.
Topics: Acetylcarnitine; Animals; Antioxidants; Axons; Environmental Pollutants; Male; Nerve Degeneration; N | 2010 |
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Energy Metaboli | 2006 |
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
Topics: Acetylcarnitine; Aldehydes; Alzheimer Disease; Animals; Apoptosis; Cell Survival; Cerebral Cortex; C | 2007 |
Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy.
Topics: Acetylcarnitine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cytochromes c; Cytosol; DNA Fragm | 2007 |
Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection.
Topics: Acetylcarnitine; Aging; Animals; Autonomic Pathways; Basal Ganglia; Brain Chemistry; Choline O-Acety | 1994 |
Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells.
Topics: Acetylcarnitine; Amyloid beta-Peptides; Animals; Arginine; Basal Metabolism; Cells, Cultured; Cerebe | 1997 |
Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion.
Topics: Acetylcarnitine; Ammonia; Animals; Brain; Electron Transport Complex IV; Energy Metabolism; Female; | 1997 |
Motonuclear changes after cranial nerve injury and regeneration.
Topics: Acetylcarnitine; Animals; Axons; Cell Nucleus; Facial Nerve; Facial Nerve Injuries; Guinea Pigs; Mot | 1997 |
Levocarnitine acetyl prevents cell death following long-term section of the vagus nerve in rats.
Topics: Acetylcarnitine; Animals; Cell Death; Denervation; Male; Medulla Oblongata; Motor Neurons; Nerve Deg | 1992 |
Levocarnitine acetyl stimulates peripheral nerve regeneration and neuromuscular junction remodelling following sciatic nerve injury.
Topics: Acetylcarnitine; Animals; Male; Nerve Crush; Nerve Degeneration; Nerve Regeneration; Neuromuscular J | 1992 |
Trophic action of acetyl-L-carnitine in neuronal cultures.
Topics: Acetylcarnitine; Animals; Cells, Cultured; Cellular Senescence; Cerebellum; Nerve Degeneration; Neur | 1992 |
Studies on the degenerative and regenerative phenomena occurring after transection and repair of the sciatic nerve in rats: effects of acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Axons; Carnitine; Horseradish Peroxidase; Male; Motor Neurons; Nerve Degen | 1990 |