acetylcarnitine has been researched along with Liver Cirrhosis in 8 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Minimal hepatic encephalopathy was diagnosed with the Trail Making Test (TMT), Symbol Digit Modalities Test (SDMT) and Auditory Verbal Learning Test (AVL) and cognitive function with the Mini Mental State Examination (MMSE)." | 2.73 | Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008) |
| "Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function." | 2.73 | Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008) |
| "L: -Acetylcarnitine (LAC) is a physiologically active substance that improves both the energetic and the neurotransmission profiles." | 2.72 | Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. ( Astuto, M; Lo Giudice, E; Malaguarnera, M; Pistone, G; Raffaele, R; Rampello, L; Vecchio, I, 2006) |
| "Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Treatment for hepatic encephalopathy is complex." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Hence, we have no data on the drug for hepatic encephalopathy in acute liver failure." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Wang, Y | 1 |
| Ma, S | 1 |
| Zhang, C | 1 |
| Liu, H | 1 |
| Sun, D | 1 |
| Martí-Carvajal, AJ | 1 |
| Gluud, C | 1 |
| Arevalo-Rodriguez, I | 1 |
| Martí-Amarista, CE | 1 |
| Lu, Y | 1 |
| Li, N | 1 |
| Gao, L | 1 |
| Xu, YJ | 1 |
| Huang, C | 1 |
| Yu, K | 1 |
| Ling, Q | 1 |
| Cheng, Q | 1 |
| Chen, S | 1 |
| Zhu, M | 1 |
| Fang, J | 1 |
| Chen, M | 1 |
| Ong, CN | 1 |
| Malaguarnera, M | 4 |
| Risino, C | 2 |
| Cammalleri, L | 2 |
| Malaguarnera, L | 1 |
| Astuto, M | 2 |
| Vecchio, I | 2 |
| Rampello, L | 3 |
| Pistone, G | 1 |
| Raffaele, R | 1 |
| Lo Giudice, E | 1 |
| Gargante, MP | 1 |
| Cristaldi, E | 1 |
| Vacante, M | 1 |
| Pennisi, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy[NCT01223729] | 67 participants | Interventional | 2002-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for acetylcarnitine and Liver Cirrhosis
| Article | Year |
|---|---|
Acetyl-L-carnitine for patients with hepatic encephalopathy.
Topics: Acetylcarnitine; Ammonia; Chelating Agents; Fatigue; Female; Hepatic Encephalopathy; Humans; Liver C | 2019 |
Acetyl-L-carnitine. Monograph.
Topics: Acetylcarnitine; Alcoholism; Alzheimer Disease; Attention Deficit Disorder with Hyperactivity; Cogni | 2010 |
Carnitine derivatives: clinical usefulness.
Topics: Acetylcarnitine; Cardiotonic Agents; Cardiovascular Diseases; Carnitine; Cognition Disorders; Depres | 2012 |
3 trials available for acetylcarnitine and Liver Cirrhosis
| Article | Year |
|---|---|
Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study.
Topics: Acetylcarnitine; Amino Acids, Branched-Chain; Ammonia; Double-Blind Method; Electroencephalography; | 2009 |
Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.
Topics: Acetylcarnitine; Adult; Ammonia; Blood Urea Nitrogen; Double-Blind Method; Electroencephalography; F | 2006 |
Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
Topics: Acetylcarnitine; Adult; Ammonia; Bilirubin; Cognition; Double-Blind Method; Female; Hepatic Encephal | 2008 |
2 other studies available for acetylcarnitine and Liver Cirrhosis
| Article | Year |
|---|---|
Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury.
Topics: Acetylcarnitine; Adult; Biomarkers; Case-Control Studies; Female; Glycocholic Acid; Hepatitis B, Chr | 2021 |
Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma.
Topics: Acetylcarnitine; Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Fe | 2016 |