acetylcarnitine has been researched along with Hepatic Encephalopathy in 11 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fatigue is frequently reported in hepatic encephalopathy (HE) and may be related to hyperammonemia." | 2.76 | Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. ( Bella, R; Galvano, F; Giordano, M; Li Volti, G; Malaguarnera, M; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "Minimal hepatic encephalopathy (MHE) represents a common complication present in well-compensated cirrhotic patients that impairs patients' daily functioning and health-related quality of life (HRQL)." | 2.76 | Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. ( Bella, R; Gargante, MP; Giordano, M; Malaguarnera, G; Malaguarnera, M; Mistretta, A; Motta, M; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "61 patients with severe hepatic encephalopathy were recruited to the study." | 2.76 | Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. ( Bella, R; Giordano, M; Malaguarnera, G; Malaguarnera, M; Motta, M; Nunnari, G; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "Minimal hepatic encephalopathy was diagnosed with the Trail Making Test (TMT), Symbol Digit Modalities Test (SDMT) and Auditory Verbal Learning Test (AVL) and cognitive function with the Mini Mental State Examination (MMSE)." | 2.73 | Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008) |
| "Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function." | 2.73 | Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008) |
| "L: -Acetylcarnitine (LAC) is a physiologically active substance that improves both the energetic and the neurotransmission profiles." | 2.72 | Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. ( Astuto, M; Lo Giudice, E; Malaguarnera, M; Pistone, G; Raffaele, R; Rampello, L; Vecchio, I, 2006) |
| "Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Treatment for hepatic encephalopathy is complex." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Hence, we have no data on the drug for hepatic encephalopathy in acute liver failure." | 2.61 | Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019) |
| "Hepatic encephalopathy is a common complication of hepatic cirrhosis." | 2.49 | Acetyl-L-carnitine in hepatic encephalopathy. ( Malaguarnera, M, 2013) |
| "The pathogenesis of hepatic encephalopathy has not been clearly defined." | 2.49 | Acetyl-L-carnitine in hepatic encephalopathy. ( Malaguarnera, M, 2013) |
| "Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response." | 1.48 | Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials. ( Cai, XJ; Hu, CM; Wang, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Alimirah, M | 1 |
| Sadiq, O | 1 |
| Gordon, SC | 1 |
| Cai, XJ | 1 |
| Wang, L | 1 |
| Hu, CM | 1 |
| Martí-Carvajal, AJ | 1 |
| Gluud, C | 1 |
| Arevalo-Rodriguez, I | 1 |
| Martí-Amarista, CE | 1 |
| Malaguarnera, M | 8 |
| Risino, C | 2 |
| Cammalleri, L | 2 |
| Malaguarnera, L | 1 |
| Astuto, M | 2 |
| Vecchio, I | 2 |
| Rampello, L | 6 |
| Vacante, M | 4 |
| Giordano, M | 3 |
| Pennisi, G | 4 |
| Bella, R | 3 |
| Li Volti, G | 1 |
| Galvano, F | 1 |
| Malaguarnera, G | 2 |
| Gargante, MP | 2 |
| Motta, M | 2 |
| Mistretta, A | 1 |
| Nunnari, G | 1 |
| Pistone, G | 1 |
| Raffaele, R | 1 |
| Lo Giudice, E | 1 |
| Cristaldi, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ORAL ACETYL-L-CARNITINE THERAPY REDUCES FATIGUE IN HEPATIC ENCEPHALOPATHY[NCT01223742] | 0 participants | Interventional | 2002-06-30 | Completed | |||
| Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy[NCT01223729] | 67 participants | Interventional | 2002-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetylcarnitine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Novel Therapies in Hepatic Encephalopathy.
Topics: Acetylcarnitine; Albumins; Ammonia; Dipeptides; Fecal Microbiota Transplantation; Flumazenil; GABA M | 2020 |
Acetyl-L-carnitine for patients with hepatic encephalopathy.
Topics: Acetylcarnitine; Ammonia; Chelating Agents; Fatigue; Female; Hepatic Encephalopathy; Humans; Liver C | 2019 |
Acetyl-L-carnitine. Monograph.
Topics: Acetylcarnitine; Alcoholism; Alzheimer Disease; Attention Deficit Disorder with Hyperactivity; Cogni | 2010 |
Acetyl-L-carnitine in hepatic encephalopathy.
Topics: Acetylcarnitine; Animals; Hepatic Encephalopathy; Humans; Hyperammonemia | 2013 |
6 trials available for acetylcarnitine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study.
Topics: Acetylcarnitine; Amino Acids, Branched-Chain; Ammonia; Double-Blind Method; Electroencephalography; | 2009 |
Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
Topics: Acetylcarnitine; Adult; Aged; Ammonia; Double-Blind Method; Fatigue; Female; Hepatic Encephalopathy; | 2011 |
Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
Topics: Acetylcarnitine; Adult; Aged; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Female; H | 2011 |
Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
Topics: Acetylcarnitine; Adult; Alanine Transaminase; Ammonia; Bilirubin; Cognition; Double-Blind Method; El | 2011 |
Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.
Topics: Acetylcarnitine; Adult; Ammonia; Blood Urea Nitrogen; Double-Blind Method; Electroencephalography; F | 2006 |
Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
Topics: Acetylcarnitine; Adult; Ammonia; Bilirubin; Cognition; Double-Blind Method; Female; Hepatic Encephal | 2008 |
1 other study available for acetylcarnitine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Topics: Acetylcarnitine; Adult; Ammonia; Dipeptides; Female; Hepatic Encephalopathy; Humans; Lactulose; Male | 2018 |