Page last updated: 2024-10-15

acetylcarnitine and Hepatic Encephalopathy

acetylcarnitine has been researched along with Hepatic Encephalopathy in 11 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Fatigue is frequently reported in hepatic encephalopathy (HE) and may be related to hyperammonemia."2.76Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. ( Bella, R; Galvano, F; Giordano, M; Li Volti, G; Malaguarnera, M; Pennisi, G; Rampello, L; Vacante, M, 2011)
"Minimal hepatic encephalopathy (MHE) represents a common complication present in well-compensated cirrhotic patients that impairs patients' daily functioning and health-related quality of life (HRQL)."2.76Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. ( Bella, R; Gargante, MP; Giordano, M; Malaguarnera, G; Malaguarnera, M; Mistretta, A; Motta, M; Pennisi, G; Rampello, L; Vacante, M, 2011)
"61 patients with severe hepatic encephalopathy were recruited to the study."2.76Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. ( Bella, R; Giordano, M; Malaguarnera, G; Malaguarnera, M; Motta, M; Nunnari, G; Pennisi, G; Rampello, L; Vacante, M, 2011)
"Minimal hepatic encephalopathy was diagnosed with the Trail Making Test (TMT), Symbol Digit Modalities Test (SDMT) and Auditory Verbal Learning Test (AVL) and cognitive function with the Mini Mental State Examination (MMSE)."2.73Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008)
"Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function."2.73Acetyl-L-carnitine treatment in minimal hepatic encephalopathy. ( Cammalleri, L; Cristaldi, E; Gargante, MP; Malaguarnera, M; Pennisi, G; Rampello, L; Risino, C; Vacante, M, 2008)
"L: -Acetylcarnitine (LAC) is a physiologically active substance that improves both the energetic and the neurotransmission profiles."2.72Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. ( Astuto, M; Lo Giudice, E; Malaguarnera, M; Pistone, G; Raffaele, R; Rampello, L; Vecchio, I, 2006)
"Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease."2.61Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019)
"Treatment for hepatic encephalopathy is complex."2.61Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019)
"Hence, we have no data on the drug for hepatic encephalopathy in acute liver failure."2.61Acetyl-L-carnitine for patients with hepatic encephalopathy. ( Arevalo-Rodriguez, I; Gluud, C; Martí-Amarista, CE; Martí-Carvajal, AJ, 2019)
"Hepatic encephalopathy is a common complication of hepatic cirrhosis."2.49Acetyl-L-carnitine in hepatic encephalopathy. ( Malaguarnera, M, 2013)
"The pathogenesis of hepatic encephalopathy has not been clearly defined."2.49Acetyl-L-carnitine in hepatic encephalopathy. ( Malaguarnera, M, 2013)
"Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response."1.48Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials. ( Cai, XJ; Hu, CM; Wang, L, 2018)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Alimirah, M1
Sadiq, O1
Gordon, SC1
Cai, XJ1
Wang, L1
Hu, CM1
Martí-Carvajal, AJ1
Gluud, C1
Arevalo-Rodriguez, I1
Martí-Amarista, CE1
Malaguarnera, M8
Risino, C2
Cammalleri, L2
Malaguarnera, L1
Astuto, M2
Vecchio, I2
Rampello, L6
Vacante, M4
Giordano, M3
Pennisi, G4
Bella, R3
Li Volti, G1
Galvano, F1
Malaguarnera, G2
Gargante, MP2
Motta, M2
Mistretta, A1
Nunnari, G1
Pistone, G1
Raffaele, R1
Lo Giudice, E1
Cristaldi, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
ORAL ACETYL-L-CARNITINE THERAPY REDUCES FATIGUE IN HEPATIC ENCEPHALOPATHY[NCT01223742]0 participants Interventional2002-06-30Completed
Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy[NCT01223729]67 participants Interventional2002-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for acetylcarnitine and Hepatic Encephalopathy

ArticleYear
Novel Therapies in Hepatic Encephalopathy.
    Clinics in liver disease, 2020, Volume: 24, Issue:2

    Topics: Acetylcarnitine; Albumins; Ammonia; Dipeptides; Fecal Microbiota Transplantation; Flumazenil; GABA M

2020
Acetyl-L-carnitine for patients with hepatic encephalopathy.
    The Cochrane database of systematic reviews, 2019, 01-05, Volume: 1

    Topics: Acetylcarnitine; Ammonia; Chelating Agents; Fatigue; Female; Hepatic Encephalopathy; Humans; Liver C

2019
Acetyl-L-carnitine. Monograph.
    Alternative medicine review : a journal of clinical therapeutic, 2010, Volume: 15, Issue:1

    Topics: Acetylcarnitine; Alcoholism; Alzheimer Disease; Attention Deficit Disorder with Hyperactivity; Cogni

2010
Acetyl-L-carnitine in hepatic encephalopathy.
    Metabolic brain disease, 2013, Volume: 28, Issue:2

    Topics: Acetylcarnitine; Animals; Hepatic Encephalopathy; Humans; Hyperammonemia

2013

Trials

6 trials available for acetylcarnitine and Hepatic Encephalopathy

ArticleYear
Branched chain amino acids supplemented with L-acetylcarnitine versus BCAA treatment in hepatic coma: a randomized and controlled double blind study.
    European journal of gastroenterology & hepatology, 2009, Volume: 21, Issue:7

    Topics: Acetylcarnitine; Amino Acids, Branched-Chain; Ammonia; Double-Blind Method; Electroencephalography;

2009
Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    The American journal of clinical nutrition, 2011, Volume: 93, Issue:4

    Topics: Acetylcarnitine; Adult; Aged; Ammonia; Double-Blind Method; Fatigue; Female; Hepatic Encephalopathy;

2011
Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:6

    Topics: Acetylcarnitine; Adult; Aged; Anxiety Disorders; Depressive Disorder; Double-Blind Method; Female; H

2011
Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
    Metabolic brain disease, 2011, Volume: 26, Issue:4

    Topics: Acetylcarnitine; Adult; Alanine Transaminase; Ammonia; Bilirubin; Cognition; Double-Blind Method; El

2011
Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:12

    Topics: Acetylcarnitine; Adult; Ammonia; Blood Urea Nitrogen; Double-Blind Method; Electroencephalography; F

2006
Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:11

    Topics: Acetylcarnitine; Adult; Ammonia; Bilirubin; Cognition; Double-Blind Method; Female; Hepatic Encephal

2008

Other Studies

1 other study available for acetylcarnitine and Hepatic Encephalopathy

ArticleYear
Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:10

    Topics: Acetylcarnitine; Adult; Ammonia; Dipeptides; Female; Hepatic Encephalopathy; Humans; Lactulose; Male

2018