acetylcarnitine has been researched along with Fragile X Syndrome in 9 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The fragile X syndrome is caused by a >200 CGG repeat expansion within the FMR1 gene promoter, with consequent DNA hypermethylation and inactivation of its expression." | 1.33 | Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. ( Chiurazzi, P; Moscato, U; Neri, G; Oostra, BA; Pietrobono, R; Tabolacci, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rueda, JR | 2 |
| Guillén, V | 1 |
| Ballesteros, J | 2 |
| Tejada, MI | 2 |
| Solà, I | 1 |
| Hall, SS | 1 |
| Calvani, M | 4 |
| D'Iddio, S | 2 |
| de Gaetano, A | 2 |
| Mariotti, P | 2 |
| Mosconi, L | 1 |
| Pomponi, MG | 3 |
| Tabolacci, E | 3 |
| Torrioli, MG | 3 |
| Vernacotola, S | 3 |
| Neri, G | 6 |
| Pascale, E | 1 |
| Battiloro, E | 1 |
| Cimino Reale, G | 1 |
| Pietrobono, R | 2 |
| Chiurazzi, P | 4 |
| Nicolai, R | 1 |
| D'Ambrosio, E | 1 |
| Moscato, U | 2 |
| Oostra, BA | 1 |
| Peruzzi, L | 1 |
| Mila, M | 1 |
| Militerni, R | 1 |
| Musumeci, S | 1 |
| Ramos, FJ | 1 |
| Frontera, M | 1 |
| Sorge, G | 1 |
| Marzullo, E | 1 |
| Romeo, G | 1 |
| Vallee, L | 1 |
| Veneselli, E | 1 |
| Cocchi, E | 1 |
| Garbarino, E | 1 |
| Bianchi, E | 1 |
3 reviews available for acetylcarnitine and Fragile X Syndrome
| Article | Year |
|---|---|
L-acetylcarnitine for treating fragile X syndrome.
Topics: Acetylcarnitine; Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Ch | 2015 |
Systematic review of pharmacological treatments in fragile X syndrome.
Topics: Acetylcarnitine; Dioxoles; Folic Acid; Fragile X Syndrome; Humans; Methylphenidate; Piperidines; Tre | 2009 |
Treatments for fragile X syndrome: a closer look at the data.
Topics: Acetylcarnitine; Adrenergic alpha-Agonists; Behavior Therapy; Central Nervous System Stimulants; Clo | 2009 |
3 trials available for acetylcarnitine and Fragile X Syndrome
| Article | Year |
|---|---|
[L-acetylcarnitine treatment on fragile X patients hyperactive behaviour].
Topics: Acetylcarnitine; Child; Child Behavior Disorders; Clinical Trials as Topic; Fragile X Syndrome; Huma | 2001 |
A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
Topics: Acetylcarnitine; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Double-Blind Meth | 2008 |
Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome.
Topics: Acetylcarnitine; Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Double-Blind Meth | 1999 |
3 other studies available for acetylcarnitine and Fragile X Syndrome
| Article | Year |
|---|---|
Modulation of methylation in the FMR1 promoter region after long term treatment with L-carnitine and acetyl-L-carnitine.
Topics: Acetylcarnitine; Carnitine; Cells, Cultured; DNA Methylation; Fragile X Mental Retardation Protein; | 2003 |
Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments.
Topics: Acetylation; Acetylcarnitine; Azacitidine; Cell Line; Chromatin Immunoprecipitation; Decitabine; DNA | 2005 |
Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro.
Topics: Acetylation; Acetylcarnitine; Adolescent; Adult; Aged; Butyrates; Butyric Acid; Cells, Cultured; Chi | 1994 |