Page last updated: 2024-10-15

acetylcarnitine and Epilepsy

acetylcarnitine has been researched along with Epilepsy in 5 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Epilepsy is a severe neurological disorder characterized by altered electrical activity in the brain."6.53Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine. ( Borges, K; Eloqayli, H; Hadera, MG; Jaradat, S; McDonald, T; Meisingset, TW; Smeland, OB; Sonnewald, U, 2016)
"Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population."5.91Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023)
" Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)."5.22Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016)
"Carnitine metabolism was monitored in seven children started on a KD for pharmacoresistant epilepsy after a conventional initial fasting period."2.72Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. ( Baumeister, FA; Bieger, I; Busch, R; Busch, V; Gempel, K; Hack, A; Pascher, B, 2006)
"Epilepsy is a severe neurological disorder characterized by altered electrical activity in the brain."2.53Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine. ( Borges, K; Eloqayli, H; Hadera, MG; Jaradat, S; McDonald, T; Meisingset, TW; Smeland, OB; Sonnewald, U, 2016)
"Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population."1.91Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Chitolina, R1
Reis, CG1
Stahlhofer-Buss, T1
Linazzi, A1
Benvenutti, R1
Marcon, M1
Herrmann, AP1
Piato, A1
Schoeler, NE1
Bell, G1
Yuen, A1
Kapelner, AD1
Heales, SJR1
Cross, JH1
Sisodiya, S1
Hadera, MG1
McDonald, T1
Smeland, OB1
Meisingset, TW1
Eloqayli, H1
Jaradat, S1
Borges, K1
Sonnewald, U1
Maldonado, C1
Guevara, N1
Queijo, C1
González, R1
Fagiolino, P1
Vázquez, M1
Hack, A1
Busch, V1
Pascher, B1
Busch, R1
Bieger, I1
Gempel, K1
Baumeister, FA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002]Phase 230 participants (Actual)Interventional2022-03-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for acetylcarnitine and Epilepsy

ArticleYear
Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine.
    Neurochemical research, 2016, Volume: 41, Issue:1-2

    Topics: Acetylcarnitine; Amino Acids; Animals; Anticonvulsants; Astrocytes; Epilepsy; Humans; Mice; Neurotra

2016

Trials

2 trials available for acetylcarnitine and Epilepsy

ArticleYear
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
    BioMed research international, 2016, Volume: 2016

    Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E

2016
Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.
    Pediatric research, 2006, Volume: 60, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetylcarnitine; Biological Transport; Carnitine; Child; Child, Preschool; Di

2006

Other Studies

2 other studies available for acetylcarnitine and Epilepsy

ArticleYear
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:6

    Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy;

2023
An examination of biochemical parameters and their association with response to ketogenic dietary therapies.
    Epilepsia, 2017, Volume: 58, Issue:5

    Topics: Acetylcarnitine; Adolescent; Adult; Age Factors; Biomarkers; Child; Child, Preschool; Diet, Ketogeni

2017