acetylcarnitine has been researched along with Epilepsy in 5 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is a severe neurological disorder characterized by altered electrical activity in the brain." | 6.53 | Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine. ( Borges, K; Eloqayli, H; Hadera, MG; Jaradat, S; McDonald, T; Meisingset, TW; Smeland, OB; Sonnewald, U, 2016) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 5.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| " Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)." | 5.22 | Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016) |
| "Carnitine metabolism was monitored in seven children started on a KD for pharmacoresistant epilepsy after a conventional initial fasting period." | 2.72 | Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. ( Baumeister, FA; Bieger, I; Busch, R; Busch, V; Gempel, K; Hack, A; Pascher, B, 2006) |
| "Epilepsy is a severe neurological disorder characterized by altered electrical activity in the brain." | 2.53 | Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine. ( Borges, K; Eloqayli, H; Hadera, MG; Jaradat, S; McDonald, T; Meisingset, TW; Smeland, OB; Sonnewald, U, 2016) |
| "Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population." | 1.91 | Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chitolina, R | 1 |
| Reis, CG | 1 |
| Stahlhofer-Buss, T | 1 |
| Linazzi, A | 1 |
| Benvenutti, R | 1 |
| Marcon, M | 1 |
| Herrmann, AP | 1 |
| Piato, A | 1 |
| Schoeler, NE | 1 |
| Bell, G | 1 |
| Yuen, A | 1 |
| Kapelner, AD | 1 |
| Heales, SJR | 1 |
| Cross, JH | 1 |
| Sisodiya, S | 1 |
| Hadera, MG | 1 |
| McDonald, T | 1 |
| Smeland, OB | 1 |
| Meisingset, TW | 1 |
| Eloqayli, H | 1 |
| Jaradat, S | 1 |
| Borges, K | 1 |
| Sonnewald, U | 1 |
| Maldonado, C | 1 |
| Guevara, N | 1 |
| Queijo, C | 1 |
| González, R | 1 |
| Fagiolino, P | 1 |
| Vázquez, M | 1 |
| Hack, A | 1 |
| Busch, V | 1 |
| Pascher, B | 1 |
| Busch, R | 1 |
| Bieger, I | 1 |
| Gempel, K | 1 |
| Baumeister, FA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test the Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced by Glucose Deprivation[NCT04513002] | Phase 2 | 30 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetylcarnitine and Epilepsy
| Article | Year |
|---|---|
Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine.
Topics: Acetylcarnitine; Amino Acids; Animals; Anticonvulsants; Astrocytes; Epilepsy; Humans; Mice; Neurotra | 2016 |
2 trials available for acetylcarnitine and Epilepsy
| Article | Year |
|---|---|
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E | 2016 |
Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.
Topics: 3-Hydroxybutyric Acid; Acetylcarnitine; Biological Transport; Carnitine; Child; Child, Preschool; Di | 2006 |
2 other studies available for acetylcarnitine and Epilepsy
| Article | Year |
|---|---|
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; | 2023 |
An examination of biochemical parameters and their association with response to ketogenic dietary therapies.
Topics: Acetylcarnitine; Adolescent; Adult; Age Factors; Biomarkers; Child; Child, Preschool; Diet, Ketogeni | 2017 |