Page last updated: 2024-10-15

acetylcarnitine and Electron Transport Chain Deficiencies, Mitochondrial

acetylcarnitine has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 6 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Research Excerpts

ExcerptRelevanceReference
"A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid."7.71Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001)
"A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid."3.71Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001)
"Rhabdomyolysis is common in very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) and other metabolic myopathies, but its pathogenic basis is poorly understood."1.43Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency. ( de Sain-van der Velden, M; Diekman, EF; Houten, SM; Jeneson, JA; Nievelstein, RA; Schmitz, JP; Takken, T; Van der Pol, WL; van Riel, NA; Visser, G; Wardrop, M, 2016)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wei, X1
Qi, Y1
Zhang, X1
Gu, X1
Cai, H1
Yang, J1
Zhang, Y1
Mehrotra, A1
Kanwal, A1
Banerjee, SK1
Sandhir, R1
Diekman, EF1
Visser, G1
Schmitz, JP1
Nievelstein, RA1
de Sain-van der Velden, M1
Wardrop, M1
Van der Pol, WL1
Houten, SM1
van Riel, NA1
Takken, T1
Jeneson, JA1
Alves, E1
Binienda, Z1
Carvalho, F1
Alves, CJ1
Fernandes, E1
de Lourdes Bastos, M1
Tavares, MA1
Summavielle, T1
Shen, W1
Liu, K1
Tian, C1
Yang, L1
Li, X1
Ren, J1
Packer, L1
Head, E1
Sharman, E1
Liu, J1
Kottlors, M1
Jaksch, M1
Ketelsen, UP1
Weiner, S1
Glocker, FX1
Lücking, CH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Nutritional Ketosis and Exercise in Glycogen Storage Disease Type IIIa[NCT03011203]6 participants (Actual)Interventional2017-02-10Completed
Acute Nutritional Ketosis in VLCAD Deficiency: Testing the Metabolic Base for Therapeutic Use[NCT03531554]5 participants (Actual)Interventional2016-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for acetylcarnitine and Electron Transport Chain Deficiencies, Mitochondrial

ArticleYear
ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain.
    Neurotoxicology, 2015, Volume: 46

    Topics: Acetylcarnitine; Acetylcysteine; Analysis of Variance; Animals; Brain; Cadmium; Collagenases; Dose-R

2015
Mitochondrial modulators in experimental Huntington's disease: reversal of mitochondrial dysfunctions and cognitive deficits.
    Neurobiology of aging, 2015, Volume: 36, Issue:6

    Topics: Acetylcarnitine; Animals; Cognition Disorders; Drug Therapy, Combination; Female; Huntington Disease

2015
Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adenosine Triphosphate; Adolescent; Adult; Case

2016
Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adenosine Triphosphate; Adolescent; Adult; Case

2016
Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adenosine Triphosphate; Adolescent; Adult; Case

2016
Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adenosine Triphosphate; Adolescent; Adult; Case

2016
Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.
    Neuroscience, 2009, Jan-23, Volume: 158, Issue:2

    Topics: Acetylcarnitine; Animals; Body Weight; Brain; Cyclooxygenase 1; DNA, Mitochondrial; Fever; Hallucino

2009
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.
    Journal of cellular biochemistry, 2008, Jul-01, Volume: 104, Issue:4

    Topics: Acetylcarnitine; Animals; Cell Line, Tumor; Insulinoma; Islets of Langerhans; Mitochondrial Diseases

2008
Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.
    Neuromuscular disorders : NMD, 2001, Volume: 11, Issue:8

    Topics: Acetylcarnitine; Acute Disease; Antimanic Agents; Bipolar Disorder; Carnitine O-Palmitoyltransferase

2001