acetylcarnitine has been researched along with Down Syndrome in 2 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "People with Down syndrome are vulnerable to developing dementia at an earlier age than the general population." | 2.52 | Pharmacological interventions for cognitive decline in people with Down syndrome. ( Hanratty, J; Livingstone, N; Macdonald, G; McShane, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Livingstone, N | 1 |
| Hanratty, J | 1 |
| McShane, R | 1 |
| Macdonald, G | 1 |
| De Falco, FA | 1 |
| D'Angelo, E | 1 |
| Grimaldi, G | 1 |
| Scafuro, F | 1 |
| Sachez, F | 1 |
| Caruso, G | 1 |
1 review available for acetylcarnitine and Down Syndrome
| Article | Year |
|---|---|
Pharmacological interventions for cognitive decline in people with Down syndrome.
Topics: Acetylcarnitine; Adult; Antioxidants; Cognition; Cognition Disorders; Donepezil; Down Syndrome; Huma | 2015 |
1 trial available for acetylcarnitine and Down Syndrome
| Article | Year |
|---|---|
[Effect of the chronic treatment with L-acetylcarnitine in Down's syndrome].
Topics: Acetylcarnitine; Adolescent; Adult; Child; Double-Blind Method; Down Syndrome; Female; Humans; Intel | 1994 |