acetylcarnitine has been researched along with Diseases, Occupational in 1 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coleman, JK | 1 |
| Kopke, RD | 1 |
| Liu, J | 1 |
| Ge, X | 1 |
| Harper, EA | 1 |
| Jones, GE | 1 |
| Cater, TL | 1 |
| Jackson, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antioxidation Medication for Noise-induced Hearing Loss[NCT00552786] | Phase 2 | 53 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distortion product otoacoustic emissions (DPOAE) is an objective measure to assess the cochlear changes. DPOAE response threshold at high frequency (HF) was defined as the average of response levels (dB SPL) at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by DPOAE were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of DPOAE temporary threshold change was calculated by subtracting the pre-shift DPOAE response threshold from the post-shift DPOAE response threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift
| Intervention | decibels (dB SPL) (Mean) |
|---|---|
| N-acetylcysteine (NAC) | -0.85 |
| Placebo | -0.89 |
The hearing threshold level (HL) at high frequency (HF) by pure-tone audiometry (PTA) was defined as the average of HLs at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by PTA were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of temporary threshold change was calculated by subtracting the pre-shift hearing threshold from the post-shift hearing threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift
| Intervention | decibels (Mean) |
|---|---|
| N-acetylcysteine (NAC) | 3.4 |
| Placebo | 2.7 |
1 other study available for acetylcarnitine and Diseases, Occupational
| Article | Year |
|---|---|
Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Auditory Threshold; Chinchilla; Female; Hair | 2007 |