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acetylcarnitine and Disease Models, Animal

acetylcarnitine has been researched along with Disease Models, Animal in 68 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"Prophylactic treatment with acetyl-L-carnitine (ALCAR) prevents the neuropathic pain syndrome that is evoked by the chemotherapeutic agent, paclitaxel."7.74Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. ( Bennett, GJ; Flatters, SJ; Jin, HW; Mulhern, HL; Xiao, WH, 2008)
"Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population."5.91Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023)
" Evidence from animal models of chemotherapy-induced painful peripheral neuropathy produced by the taxane agent, paclitaxel, and the platinum-complex agent, oxaliplatin, indicate that they produce neuropathy via a common mechanism-a toxic effect on the mitochondria in primary afferent sensory neurons."5.38Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. ( Bennett, GJ; Xiao, WH; Zheng, H, 2012)
"Fatigue is an indispensable sense for ordering rest."5.31Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain. ( Evengård, B; Hagberg, G; Iwase, M; Kanakura, Y; Kitani, T; Kuratsune, H; Långström, B; Lindh, G; Machii, T; Matsumura, K; Onoe, H; Takahashi, M; Watanabe, Y; Yamaguti, K, 2002)
"The effects of chronic hypoxia on cardiac membrane fatty acids and on lipid peroxidation were examined, as well as the effect of l-carnitine (LCAR), which suppresses lipid peroxidation, on this process."3.74Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. ( Hamaoka, K; Itoi, T; Nakanishi, H; Oka, T; Taguchi, R; Terada, N, 2008)
"Prophylactic treatment with acetyl-L-carnitine (ALCAR) prevents the neuropathic pain syndrome that is evoked by the chemotherapeutic agent, paclitaxel."3.74Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. ( Bennett, GJ; Flatters, SJ; Jin, HW; Mulhern, HL; Xiao, WH, 2008)
"Current therapy of mood disorders has several limitations."2.55l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug. ( Canonico, PL; Chiechio, S; Grilli, M, 2017)
"Epilepsy is a prevalent neurological disease, affecting approximately 1-2% of the global population."1.91Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish. ( Benvenutti, R; Chitolina, R; Herrmann, AP; Linazzi, A; Marcon, M; Piato, A; Reis, CG; Stahlhofer-Buss, T, 2023)
"ALC properly attenuated intensity of seizures and also incidence of kainate-induced status epilepticus (SE)."1.72Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy. ( Baluchnejadmojarad, T; Hashemi, P; Nazari-Serenjeh, M; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M, 2022)
"Pancreatitis was induced with 6 hly intraperitoneal (i."1.62Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry. ( High, AE; McIlwrath, SL; Saito, H; Starr, ME; Westlund, KN, 2021)
"L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord."1.46Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017)
"Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration."1.46Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor. ( Kazak, F; Yarim, GF, 2017)
"Neuroinflammation was induced by lipopolysaccharide (LPS)."1.46Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor. ( Kazak, F; Yarim, GF, 2017)
" Despite intensive research, the quest for promising neuroprotective drugs has largely failed, not only because of ineffectiveness, but also because of serious side-effects and dosing difficulties."1.40Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia. ( Farkas, T; Gellért, L; Iwamori, N; Kis, Z; Knapp, L; Kocsis, K; Oláh, G; Ono, E; Takakuwa, H; Toldi, J, 2014)
"Pain was measured in animals submitted to MIA model by paw pressure and compression behavioral tests in the presence or absence of ALC."1.40Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. ( Aglianò, M; Bianchi, E; Di Cesare Mannelli, L; Ghelardini, C; Lorenzoni, P; Menicacci, C, 2014)
"The development of pulmonary hypertension is a common accompaniment of congenital heart disease (CHD) with increased pulmonary blood flow."1.38Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. ( Aramburo, A; Black, SM; Fineman, JR; Kalkan, G; Kallarackal, S; Kumar, S; Rafikov, R; Rehmani, I; Sharma, S; Sun, X; Tian, J, 2012)
" Evidence from animal models of chemotherapy-induced painful peripheral neuropathy produced by the taxane agent, paclitaxel, and the platinum-complex agent, oxaliplatin, indicate that they produce neuropathy via a common mechanism-a toxic effect on the mitochondria in primary afferent sensory neurons."1.38Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. ( Bennett, GJ; Xiao, WH; Zheng, H, 2012)
" Female Wistar Hanover rats were dosed daily for 12 days (oral gavage) with either vehicle (control, 0."1.38Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. ( Constantin-Teodosiu, D; Davies, WJ; Glaves, PD; Greenhaff, PL; Mallinson, JE; Martin, EA; Sidaway, JE; Westwood, FR, 2012)
"ALCAR completely prevented mechanical hyperalgesia and provoked in the nerve a c-Jun increment only."1.36The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain. ( Bartolini, A; Di Cesare Mannelli, L; Ghelardini, C; Pacini, A; Toscano, A, 2010)
" The inhibition of TNF-alpha could be improved by ALC and in a dose-response relation."1.36[Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor necrosis factor-alpha]. ( Dai, X; Ding, Y; Li, Y; Wang, J; Zhang, Z; Zhao, M, 2010)
"Caerulein induced acute pancreatitis that was well-characterized morphologically and biochemically."1.35Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats. ( Abdel-Wahab, MH; Arafa, HM; Badary, OA; Hamada, FM; Hassan, MI; Hemeida, RA, 2009)
" Compared to a saline-injected control group, chronic administration of ALCAR at doses of 10 and 100 mg/kg (tested 24 h after the last dose administration) showed no effects, whereas doses of 50 and 75 mg/kg significantly reduced anxiety-like behaviours in the elevated plus-maze."1.33Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats. ( Buriakovsky, I; Cohen, H; Gershon, S; Kaplan, Z; Levine, J; McClure, RJ; Pettegrew, JW, 2005)
"Treatment with acetylcarnitine (AcCN) increases the activity of cytochrome oxidase in the aged heart."1.33Reversal of mitochondrial defects before ischemia protects the aged heart. ( He, D; Hoppel, CL; Lesnefsky, EJ; Moghaddas, S, 2006)
"Flurbiprofen treatment of ND rats replicated many of the biochemical and physiological abnormalities of EDN, i."1.31Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. ( Greene, DA; Larkin, D; Li, F; Marinescu, V; Pop-Busui, R; Stevens, MJ; Sullivan, K; Van Huysen, C, 2002)
"Fatigue is an indispensable sense for ordering rest."1.31Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain. ( Evengård, B; Hagberg, G; Iwase, M; Kanakura, Y; Kitani, T; Kuratsune, H; Långström, B; Lindh, G; Machii, T; Matsumura, K; Onoe, H; Takahashi, M; Watanabe, Y; Yamaguti, K, 2002)

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.47)18.7374
1990's3 (4.41)18.2507
2000's21 (30.88)29.6817
2010's37 (54.41)24.3611
2020's6 (8.82)2.80

Authors

AuthorsStudies
Tashakori-Miyanroudi, M1
Ramazi, S1
Hashemi, P1
Nazari-Serenjeh, M1
Baluchnejadmojarad, T1
Roghani, M1
Wang, J2
Song, J1
Song, G1
Feng, Y1
Pan, J1
Yang, X1
Xin, Z1
Hu, P1
Sun, T1
Liu, K1
Xu, W1
Wang, T1
Wang, S1
Liu, J5
Ruan, Y1
Qutob, HMH1
Saad, RA1
Bali, H1
Osailan, A1
Jaber, J1
Alzahrani, E1
Alyami, J1
Elsayed, H1
Alserihi, R1
Shaikhomar, OA1
Divya, KM1
Savitha, DP1
Krishna, GA1
Dhanya, TM1
Mohanan, PV1
Shah, SF1
Jafry, AT1
Hussain, G1
Kazim, AH1
Ali, M1
Rivani, E1
Endraswari, PD1
Widodo, ADW1
Khalil, MR1
Guldberg, R1
Nørgård, BM1
Uldbjerg, N1
Wehberg, S1
Fowobaje, KR1
Mashood, LO1
Ekholuenetale, M1
Ibidoja, OJ1
Romagnoli, A1
D'Agostino, M1
Pavoni, E1
Ardiccioni, C1
Motta, S1
Crippa, P1
Biagetti, G1
Notarstefano, V1
Rexha, J1
Perta, N1
Barocci, S1
Costabile, BK1
Colasurdo, G1
Caucci, S1
Mencarelli, D1
Turchetti, C1
Farina, M1
Pierantoni, L1
La Teana, A1
Al Hadi, R1
Cicconardi, F1
Chinappi, M1
Trucchi, E1
Mancia, F1
Menzo, S1
Morozzo Della Rocca, B1
D'Annessa, I1
Di Marino, D1
Choya, A1
de Rivas, B1
Gutiérrez-Ortiz, JI1
López-Fonseca, R1
Xu, S2
Cheng, B1
Huang, Z1
Liu, T1
Li, Y2
Jiang, L1
Guo, W1
Xiong, J1
Amirazodi, M1
Daryanoosh, F1
Mehrabi, A1
Gaeini, A1
Koushkie Jahromi, M1
Salesi, M1
Zarifkar, AH1
Studeny, P1
Netukova, M1
Nemcokova, M1
Klimesova, YM1
Krizova, D1
Kang, H2
Tao, Y1
Zhang, Q1
Sha, D1
Chen, Y1
Yao, J1
Gao, Y1
Ji, L1
Shi, P1
Shi, C1
Wu, YL1
Wright, AI1
M El-Metwaly, N1
A Katouah, H1
El-Desouky, MG1
El-Bindary, AA1
El-Bindary, MA1
Kostakis, ID1
Raptis, DA1
Davidson, BR1
Iype, S1
Nasralla, D1
Imber, C1
Sharma, D1
Pissanou, T1
Pollok, JM1
Hughes, AM1
Sanderson, E1
Morris, T1
Ayorech, Z1
Tesli, M1
Ask, H1
Reichborn-Kjennerud, T1
Andreassen, OA1
Magnus, P1
Helgeland, Ø1
Johansson, S1
Njølstad, P1
Davey Smith, G1
Havdahl, A1
Howe, LD1
Davies, NM1
Amrillah, T1
Prasetio, A1
Supandi, AR1
Sidiq, DH1
Putra, FS1
Nugroho, MA1
Salsabilla, Z1
Azmi, R1
Grammatikopoulos, P1
Bouloumis, T1
Steinhauer, S1
Mironov, VS2
Bazhenova, TA2
Manakin, YV2
Yagubskii, EB2
Yakushev, IA1
Gilmutdinov, IF1
Simonov, SV1
Lan, K1
Yang, H1
Zheng, J2
Hu, H1
Zhu, T1
Zou, X1
Hu, B1
Liu, H2
Olokede, O1
Wu, H1
Holtzapple, M1
Gungor, O1
Kose, M1
Ghaemi, R1
Acker, M1
Stosic, A1
Jacobs, R1
Selvaganapathy, PR1
Ludwig, N1
Yerneni, SS1
Azambuja, JH1
Pietrowska, M1
Widłak, P1
Hinck, CS1
Głuszko, A1
Szczepański, MJ1
Kärmer, T1
Kallinger, I1
Schulz, D1
Bauer, RJ1
Spanier, G1
Spoerl, S1
Meier, JK1
Ettl, T1
Razzo, BM1
Reichert, TE1
Hinck, AP1
Whiteside, TL1
Wei, ZL1
Juan, W1
Tong, D1
Juan, LX1
Sa, LY1
Jie, HFM1
Xiao, G1
Xiang, LG1
Jie, HM1
Xu, C1
Yu, DN1
Yao, ZX1
Bigdeli, F1
Gao, XM1
Cheng, X1
Li, JZ1
Zhang, JW1
Wang, W3
Guan, ZJ1
Bu, Y1
Liu, KG1
Morsali, A1
Das, R1
Paul, R1
Parui, A1
Shrotri, A1
Atzori, C1
Lomachenko, KA1
Singh, AK1
Mondal, J1
Peter, SC1
Florimbio, AR1
Coughlin, LN1
Bauermeister, JA1
Young, SD1
Zimmerman, MA1
Walton, MA1
Bonar, EE1
Demir, D1
Balci, AB1
Kahraman, N1
Sunbul, SA1
Gucu, A1
Seker, IB1
Badem, S1
Yuksel, A1
Ozyazicioglu, AF1
Goncu, MT1
Zhang, H1
Zhou, H1
Deng, Z1
Luo, L1
Ong, SP1
Wang, C2
Xin, H1
Whittingham, MS1
Zhou, G1
Maemura, R1
Wakamatsu, M1
Matsumoto, K1
Sakaguchi, H1
Yoshida, N1
Hama, A1
Yoshida, T1
Miwata, S1
Kitazawa, H1
Narita, K1
Kataoka, S1
Ichikawa, D1
Hamada, M1
Taniguchi, R1
Suzuki, K1
Kawashima, N1
Nishikawa, E1
Narita, A1
Okuno, Y1
Nishio, N1
Kato, K1
Kojima, S1
Morita, K1
Muramatsu, H1
Takahashi, Y1
Yirgu, A1
Mekonnen, Y1
Eyado, A1
Staropoli, A1
Vinale, F1
Zac, J1
Zac, S1
Pérez-Padilla, R1
Remigio-Luna, A1
Guzmán-Boulloud, N1
Gochicoa-Rangel, L1
Guzmán-Valderrábano, C1
Thirión-Romero, I1
Statsenko, ME1
Turkina, SV1
Barantsevich, ER1
Karakulova, YV1
Baranova, NS1
Morzhukhina, MV1
Wang, Q4
Gu, Y1
Chen, C1
Qiao, L1
Pan, F1
Song, C1
Canetto, SS1
Entilli, L1
Cerbo, I1
Cipolletta, S1
Wu, Y2
Zhu, P1
Jiang, Y1
Zhang, X1
Wang, Z1
Xie, B1
Song, T1
Zhang, F1
Luo, A1
Li, S1
Xiong, X1
Han, J1
Peng, X1
Li, M1
Huang, L1
Chen, Q1
Fang, W1
Hou, Y1
Zhu, Y1
Ye, J1
Liu, L1
Islam, MR1
Sanderson, P1
Johansen, MP1
Payne, TE1
Naidu, R1
Cao, J1
Yang, J1
Niu, X1
Liu, X1
Zhai, Y1
Qiang, C1
Niu, Y1
Li, Z1
Dong, N1
Wen, B1
Ouyang, Z1
Zhang, Y2
Li, J2
Zhao, M2
Zhao, J2
Morici, P1
Rizzato, C1
Ghelardi, E1
Rossolini, GM1
Lupetti, A1
Gözüküçük, R1
Cakiroglu, B1
He, X1
Li, R1
Zhao, D1
Zhang, L2
Ji, X1
Fan, X1
Chen, J1
Wang, Y1
Luo, Y1
Zheng, D1
Xie, L1
Sun, S1
Cai, Z1
Liu, Q1
Ma, K1
Sun, X2
Drinkwater, JJ1
Davis, TME1
Turner, AW1
Davis, WA1
Suzuki, Y1
Mizuta, Y1
Mikagi, A1
Misawa-Suzuki, T1
Tsuchido, Y1
Sugaya, T1
Hashimoto, T1
Ema, K1
Hayashita, T1
Chitolina, R1
Reis, CG1
Stahlhofer-Buss, T1
Linazzi, A1
Benvenutti, R1
Marcon, M1
Herrmann, AP1
Piato, A1
Ardizzone, A1
Fusco, R1
Casili, G1
Lanza, M1
Impellizzeri, D1
Esposito, E1
Cuzzocrea, S1
McIlwrath, SL1
Starr, ME1
High, AE1
Saito, H1
Westlund, KN1
Notartomaso, S1
Mascio, G1
Bernabucci, M1
Zappulla, C1
Scarselli, P1
Cannella, M1
Imbriglio, T1
Gradini, R1
Battaglia, G1
Bruno, V1
Nicoletti, F1
Kazak, F1
Yarim, GF1
Truong, T1
Gardner, DK1
Chiechio, S1
Canonico, PL1
Grilli, M1
Sung, Y1
Spagou, K1
Kafeza, M1
Kyriakides, M1
Dharmarajah, B1
Shalhoub, J1
Diaz, JA1
Wakefield, TW1
Holmes, E1
Davies, AH1
Evans, E1
Piccio, L1
Cross, AH1
Gibbs, KL1
Kalmar, B1
Rhymes, ER1
Fellows, AD1
Ahmed, M1
Whiting, P1
Davies, CH1
Greensmith, L1
Schiavo, G1
Chen, DQ1
Cao, G1
Chen, H1
Argyopoulos, CP1
Yu, H1
Su, W1
Chen, L1
Samuels, DC1
Zhuang, S1
Bayliss, GP1
Zhao, S1
Yu, XY1
Vaziri, ND1
Wang, M1
Liu, D2
Mao, JR1
Ma, SX1
Shang, YQ1
Ye, F1
Cheng, XH1
Li, XR1
Meng, MX1
Guo, Y1
Zhao, YY1
Kathirvel, E1
Morgan, K1
French, SW1
Morgan, TR1
Mehrotra, A2
Sandhir, R2
Karalija, A1
Novikova, LN1
Kingham, PJ1
Wiberg, M2
Novikov, LN1
Kocsis, K2
Knapp, L2
Gellért, L1
Oláh, G1
Kis, Z2
Takakuwa, H1
Iwamori, N1
Ono, E1
Toldi, J2
Farkas, T2
Bianchi, E1
Di Cesare Mannelli, L4
Menicacci, C1
Lorenzoni, P1
Aglianò, M1
Ghelardini, C4
Dodd, MS1
Atherton, HJ1
Carr, CA1
Stuckey, DJ1
West, JA1
Griffin, JL1
Radda, GK1
Clarke, K1
Heather, LC1
Tyler, DJ1
Mészáros, J1
Vécsei, L1
Lu, Y1
Xue, Z1
Li, C1
Zhao, X1
Zhang, J1
Wei, X1
Chen, X1
Cui, W1
Zhou, W1
Singh, S1
Mishra, A1
Shukla, S1
Sood, A1
Ewan, EE1
Hagg, T1
Snigdha, S1
de Rivera, C1
Milgram, NW1
Cotman, CW1
Bigio, B1
Mathé, AA1
Sousa, VC1
Zelli, D1
Svenningsson, P1
McEwen, BS1
Nasca, C1
Tang, S1
Lu, X1
Gullapalli, RP1
McKenna, MC2
Waddell, J1
Oka, T1
Itoi, T1
Terada, N1
Nakanishi, H1
Taguchi, R1
Hamaoka, K1
Calvani, M1
Nicolai, R3
Mosconi, L1
Toscano, A2
Pacini, A2
Bartolini, A3
Kostopoulos, VK1
Davis, CL1
Terzis, JK2
Shenk, JC1
Fischbach, K1
Xu, K1
Puchowicz, M1
Obrenovich, ME1
Gasimov, E1
Alvarez, LM1
Ames, BN1
Lamanna, JC1
Aliev, G1
Arafa, HM1
Hemeida, RA1
Hassan, MI1
Abdel-Wahab, MH1
Badary, OA1
Hamada, FM1
Kokkalis, ZT1
Soucacos, PN1
Yin, YY1
Cong, XB1
Liu, Z1
Wang, JZ2
Zhu, LQ2
Ruggenenti, P1
van der Meer, IM1
Remuzzi, G1
Zhang, Z1
Ding, Y1
Dai, X1
Abdul Muneer, PM1
Alikunju, S1
Szlachetka, AM1
Haorah, J1
Scafidi, S1
Racz, J1
Hazelton, J1
Fiskum, G3
Vivoli, E1
Salvicchi, A1
Schiavone, N1
Koverech, A1
Messano, M1
Benatti, P1
Zhou, P1
Chen, Z1
Zhao, N1
Guo, ZY1
Tan, L1
Hu, J1
Karsidag, S2
Akcal, A1
Sahin, S1
Kabukcuoglu, F1
Ugurlu, K1
Du, X1
Chen, K1
Choi, CH1
Li, W1
Cheng, W1
Stewart, C1
Hu, N1
Floyd, RA1
Kopke, RD2
Sharma, S1
Kumar, S1
Rafikov, R1
Aramburo, A1
Kalkan, G1
Tian, J1
Rehmani, I1
Kallarackal, S1
Fineman, JR1
Black, SM1
Zheng, H1
Xiao, WH2
Bennett, GJ2
Mallinson, JE1
Constantin-Teodosiu, D1
Glaves, PD1
Martin, EA1
Davies, WJ1
Westwood, FR1
Sidaway, JE1
Greenhaff, PL1
Schaevitz, LR1
Lopez, CM1
D'Iddio, S1
Iannoni, E1
Berger-Sweeney, JE1
Ferreira, MR1
Camberos, Mdel C1
Selenscig, D1
Martucci, LC1
Chicco, A1
Lombardo, YB1
Cresto, JC1
Pop-Busui, R1
Marinescu, V1
Van Huysen, C1
Li, F1
Sullivan, K1
Greene, DA1
Larkin, D1
Stevens, MJ1
Coleman, JK2
Campbell, KC1
Riffenburgh, RH1
Kuratsune, H1
Yamaguti, K1
Lindh, G1
Evengård, B1
Hagberg, G1
Matsumura, K1
Iwase, M1
Onoe, H1
Takahashi, M1
Machii, T1
Kanakura, Y1
Kitani, T1
Långström, B1
Watanabe, Y1
Yasui, F1
Matsugo, S1
Ishibashi, M1
Kajita, T1
Ezashi, Y1
Oomura, Y1
Kojo, S1
Sasaki, K1
McKay Hart, A1
Terenghi, G1
Tafti, M1
Petit, B1
Chollet, D1
Neidhart, E1
de Bilbao, F1
Kiss, JZ1
Wood, PA1
Franken, P1
Levine, J1
Kaplan, Z1
Pettegrew, JW1
McClure, RJ1
Gershon, S1
Buriakovsky, I1
Cohen, H1
Rosenthal, RE2
Bogaert, YE1
Kopke, R1
Bielefeld, E1
Jackson, R1
Henderson, D1
Lesnefsky, EJ1
He, D1
Moghaddas, S1
Hoppel, CL1
Al-Majed, AA1
Sayed-Ahmed, MM1
Al-Omar, FA1
Al-Yahya, AA1
Aleisa, AM1
Al-Shabanah, OA1
Kotil, K1
Kirali, M1
Eras, M1
Bilge, T1
Uzun, H1
Elanchezhian, R1
Ramesh, E1
Sakthivel, M1
Isai, M1
Geraldine, P1
Rajamohan, M1
Jesudasan, CN1
Thomas, PA1
Jin, HW1
Flatters, SJ1
Mulhern, HL1
Martens, ME1
Lee, CP1
Visentin, M1
Bellasio, R1
Tacconi, MT1
Lolic, MM1
El Banani, H1
Bernard, M1
Cozzone, P1
James, F1
Feuvray, D1
Benzerrouk, R1
Qureshi, IA1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations[NCT05919186]293 participants (Actual)Interventional2021-10-12Completed
Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059]Phase 4504 participants (Anticipated)Interventional2021-02-25Recruiting
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]Phase 1/Phase 260 participants (Anticipated)Interventional2023-11-01Recruiting
Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369]Phase 10 participants (Actual)Interventional2014-12-31Withdrawn (stopped due to Changes to cardiac surgery program)
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial.[NCT02141035]Phase 2/Phase 320 participants (Actual)Interventional2015-09-30Completed
Antioxidation Medication for Noise-induced Hearing Loss[NCT00552786]Phase 253 participants (Actual)Interventional2007-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Temporary Threshold Changes Measurement by Distortion Product Otoacoustic Emissions (DPOAE) (A Total of Four Hearing Assessments Were Completed for Each Formulation Period on the 1st Day Pre- and Post-shift, and the 14th Day Pre- and Post-shift)

Distortion product otoacoustic emissions (DPOAE) is an objective measure to assess the cochlear changes. DPOAE response threshold at high frequency (HF) was defined as the average of response levels (dB SPL) at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by DPOAE were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of DPOAE temporary threshold change was calculated by subtracting the pre-shift DPOAE response threshold from the post-shift DPOAE response threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift

Interventiondecibels (dB SPL) (Mean)
N-acetylcysteine (NAC)-0.85
Placebo-0.89

Temporary Threshold Shift Measurement by Pure Tone Audiometry (A Total of Four Hearing Assessments Were Completed for Each Formulation Period on the 1st Day Pre- and Post-shift, and the 14th Day Pre- and Post-shift)

The hearing threshold level (HL) at high frequency (HF) by pure-tone audiometry (PTA) was defined as the average of HLs at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by PTA were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of temporary threshold change was calculated by subtracting the pre-shift hearing threshold from the post-shift hearing threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift

Interventiondecibels (Mean)
N-acetylcysteine (NAC)3.4
Placebo2.7

Reviews

3 reviews available for acetylcarnitine and Disease Models, Animal

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022
l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug.
    International journal of molecular sciences, 2017, Dec-21, Volume: 19, Issue:1

    Topics: Acetylcarnitine; Analgesics; Animals; Antidepressive Agents; Chronic Pain; Disease Models, Animal; H

2017
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
    JAMA neurology, 2018, 08-01, Volume: 75, Issue:8

    Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements;

2018

Trials

1 trial available for acetylcarnitine and Disease Models, Animal

ArticleYear
Impact of dexamethasone and tocilizumab on hematological parameters in COVID-19 patients with chronic disease.
    Medicina clinica (English ed.), 2022, Dec-23, Volume: 159, Issue:12

    Topics: Acetaminophen; Acetylcarnitine; Acetylcholinesterase; Acids; Acinetobacter baumannii; Acinetobacter

2022

Other Studies

65 other studies available for acetylcarnitine and Disease Models, Animal

ArticleYear
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy.
    Journal of molecular neuroscience : MN, 2022, Volume: 72, Issue:6

    Topics: Acetylcarnitine; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocam

2022
Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration.
    Andrology, 2022, Volume: 10, Issue:5

    Topics: Acetylcarnitine; Animals; Disease Models, Animal; Erectile Dysfunction; Fibrosis; Humans; Male; Nerv

2022
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:6

    Topics: Acetylcarnitine; Acetylcysteine; Adult; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy;

2023
Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain.
    International journal of molecular sciences, 2021, Feb-17, Volume: 22, Issue:4

    Topics: Acetylcarnitine; Amides; Animals; Carrageenan; Cell Count; Cyclooxygenase 2; Disease Models, Animal;

2021
Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry.
    World journal of gastroenterology, 2021, Mar-07, Volume: 27, Issue:9

    Topics: Acetylcarnitine; Acute Disease; Animals; Brain; Ceruletide; Disease Models, Animal; Male; Mice; Mice

2021
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
    Molecular pain, 2017, Volume: 13

    Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen

2017
Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor.
    Neuroscience letters, 2017, Sep-29, Volume: 658

    Topics: Acetylcarnitine; Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Inflamma

2017
Antioxidants improve IVF outcome and subsequent embryo development in the mouse.
    Human reproduction (Oxford, England), 2017, Dec-01, Volume: 32, Issue:12

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Blastocyst; Culture Media; Disease Models, A

2017
Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2018, Volume: 55, Issue:5

    Topics: Acetylcarnitine; Adenosine; Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Ene

2018
Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.
    Cell death & disease, 2018, 05-22, Volume: 9, Issue:6

    Topics: Acetylcarnitine; Amyotrophic Lateral Sclerosis; Animals; Axonal Transport; Disease Models, Animal; E

2018
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
    Nature communications, 2019, 04-01, Volume: 10, Issue:1

    Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disea

2019
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
    Nutrition research (New York, N.Y.), 2013, Volume: 33, Issue:11

    Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe

2013
Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.
    Behavioural brain research, 2014, Mar-15, Volume: 261

    Topics: Acetylcarnitine; Animals; Antioxidants; Behavior, Animal; Brain; Chromatography, Thin Layer; Disease

2014
The effects of N-acetyl-cysteine and acetyl-L-carnitine on neural survival, neuroinflammation and regeneration following spinal cord injury.
    Neuroscience, 2014, Jun-06, Volume: 269

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Apoptosis; Axons; Cell Survival; Cervical Ve

2014
Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia.
    Neuroscience, 2014, Jun-06, Volume: 269

    Topics: Acetylcarnitine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carotid Artery Diseases; Dendriti

2014
Prophylactic role of acetyl-l-carnitine on knee lesions and associated pain in a rat model of osteoarthritis.
    Life sciences, 2014, Jun-13, Volume: 106, Issue:1-2

    Topics: Acetylcarnitine; Animals; Chondrocytes; Disease Models, Animal; Male; Osteoarthritis, Knee; Pain; Pa

2014
Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.
    Circulation. Cardiovascular imaging, 2014, Volume: 7, Issue:6

    Topics: Acetylcarnitine; Animals; Biomarkers; Citric Acid; Citric Acid Cycle; Disease Models, Animal; Female

2014
Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:6

    Topics: Acetylcarnitine; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug;

2015
Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice.
    Neuroscience, 2015, Jan-29, Volume: 285

    Topics: Acetylcarnitine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chromones; Depre

2015
ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats.
    Molecular neurobiology, 2016, Volume: 53, Issue:7

    Topics: Acetylcarnitine; Animals; Antioxidants; Ataxia; Axons; Behavior, Animal; Brain; Cell Nucleus; Diseas

2016
Mitochondrial modulators improve lipid composition and attenuate memory deficits in experimental model of Huntington's disease.
    Molecular and cellular biochemistry, 2015, Volume: 410, Issue:1-2

    Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Cholesterol; Chromatography, Thin Layer; Cognitio

2015
Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats.
    Journal of neurotrauma, 2016, Feb-01, Volume: 33, Issue:3

    Topics: Acetylcarnitine; Animals; Behavior, Animal; Disease Models, Animal; Female; Infusions, Spinal; Motor

2016
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
    Neurobiology of aging, 2016, Volume: 37

    Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes

2016
Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 07-12, Volume: 113, Issue:28

    Topics: Acetylcarnitine; Animals; Antidepressive Agents; Dentate Gyrus; Depression; Disease Models, Animal;

2016
Neuroprotective Effects of Acetyl-L-Carnitine on Neonatal Hypoxia Ischemia-Induced Brain Injury in Rats.
    Developmental neuroscience, 2016, Volume: 38, Issue:5

    Topics: Acetylcarnitine; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Hypoxi

2016
Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:8

    Topics: Acetylcarnitine; Age Factors; Animals; Antioxidants; Carnitine; Catalase; Cell Membrane; Chronic Dis

2008
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor.
    Journal of neuroscience research, 2009, Volume: 87, Issue:1

    Topics: Acetylcarnitine; Animals; Apoptosis; Atropine; Caspase 3; Cytochromes c; Disease Models, Animal; In

2009
Effects of acetylo-L-carnitine in end-to-side neurorrhaphy: a pilot study.
    Microsurgery, 2009, Volume: 29, Issue:6

    Topics: Acetylcarnitine; Analysis of Variance; Anastomosis, Surgical; Animals; Behavior, Animal; Brachial Pl

2009
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
    Journal of the neurological sciences, 2009, Aug-15, Volume: 283, Issue:1-2

    Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov

2009
Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:1

    Topics: Acetylcarnitine; Amylases; Animals; Calcium; Ceruletide; Disease Models, Animal; Glutathione; Glutat

2009
Effect of acetyl-L-carnitine on axonal sprouting following donor nerve injury distal to an end-to-side neurorrhaphy model.
    Journal of reconstructive microsurgery, 2009, Volume: 25, Issue:8

    Topics: Acetylcarnitine; Animals; Axons; Disease Models, Animal; Electromyography; Male; Motor Endplate; Ner

2009
The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain.
    Neuroscience, 2010, Feb-17, Volume: 165, Issue:4

    Topics: Acetylcarnitine; Animals; Disease Models, Animal; Enzyme Activation; Functional Laterality; Hyperalg

2010
Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 19, Issue:2

    Topics: Acetylcarnitine; Analysis of Variance; Animals; Disease Models, Animal; Hippocampus; Lipid Peroxidat

2010
Oral acetyl-L-carnitine therapy and insulin resistance.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:6

    Topics: Acetylcarnitine; Administration, Oral; Animals; Blood Glucose; Cardiovascular Diseases; Diabetes Mel

2010
[Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor necrosis factor-alpha].
    Wei sheng yan jiu = Journal of hygiene research, 2010, Volume: 39, Issue:2

    Topics: Acetylcarnitine; Animals; Cell Line; Disease Models, Animal; Insulin Receptor Substrate Proteins; In

2010
Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitine.
    Psychopharmacology, 2011, Volume: 214, Issue:3

    Topics: Acetylcarnitine; Alcohols; Animals; Biological Transport; Blood-Aqueous Barrier; Cells, Cultured; Ce

2011
Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain.
    Developmental neuroscience, 2010, Volume: 32, Issue:5-6

    Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain; Brain Injuries; Disease Models, Animal; Male; Neu

2010
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression.
    Psychopharmacology, 2011, Volume: 218, Issue:2

    Topics: Acetylcarnitine; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Gene Knockdown

2011
Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities.
    Rejuvenation research, 2011, Volume: 14, Issue:6

    Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain

2011
Neurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary data.
    The Journal of hand surgery, European volume, 2012, Volume: 37, Issue:6

    Topics: Acetylcarnitine; Action Potentials; Animals; Disease Models, Animal; Electromyography; Male; Neural

2012
Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment.
    Hearing research, 2012, Volume: 283, Issue:1-2

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Auditory Threshold; Biomarkers; Chinchilla;

2012
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
    Free radical biology & medicine, 2012, Jul-15, Volume: 53, Issue:2

    Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopteri

2012
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; An

2012
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
    The Journal of physiology, 2012, Dec-15, Volume: 590, Issue:24

    Topics: Acetylcarnitine; Animals; Body Weight; Carbohydrate Metabolism; Cathepsin L; Cytoprotection; Dichlor

2012
Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Acetylcarnitine; Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cog

2012
Changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis induced by an acetyl-L-carnitine and nicotinamide treatment in dyslipidaemic insulin-resistant rats.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:3

    Topics: Acetyl-CoA Carboxylase; Acetylcarnitine; Animals; Body Weight; Carnitine O-Palmitoyltransferase; Dis

2013
Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration.
    Diabetes, 2002, Volume: 51, Issue:8

    Topics: Acetylcarnitine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase

2002
Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss.
    The Laryngoscope, 2002, Volume: 112, Issue:9

    Topics: Acetylcarnitine; Analysis of Variance; Animals; Audiometry; Auditory Threshold; Chinchilla; Cochlea;

2002
Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain.
    NeuroImage, 2002, Volume: 17, Issue:3

    Topics: Acetylcarnitine; Adult; Animals; Brain; Brain Mapping; Cerebral Cortex; Disease Models, Animal; Fati

2002
Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice.
    Neuroscience letters, 2002, Dec-16, Volume: 334, Issue:3

    Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Brain; Disease Models, Animal; Dose-Response Re

2002
Pharmacological enhancement of peripheral nerve regeneration in the rat by systemic acetyl-L-carnitine treatment.
    Neuroscience letters, 2002, Dec-16, Volume: 334, Issue:3

    Topics: Acetylcarnitine; Animals; Axons; Axotomy; Cell Count; Disease Models, Animal; Immunochemistry; Male;

2002
Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.
    Nature genetics, 2003, Volume: 34, Issue:3

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase; Animals; Brain; Disease Models, Animal; Electroencephalogra

2003
Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats.
    The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:1

    Topics: Acetylcarnitine; Animals; Anti-Anxiety Agents; Anxiety; Arousal; Disease Models, Animal; Dose-Respon

2005
Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs.
    Neuroscience letters, 2005, Apr-18, Volume: 378, Issue:2

    Topics: Acetylcarnitine; Analysis of Variance; Animals; Brain Ischemia; Disease Models, Animal; Dogs; Heart

2005
Prevention of impulse noise-induced hearing loss with antioxidants.
    Acta oto-laryngologica, 2005, Volume: 125, Issue:3

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Chinchilla; Disease Models, Animal; Evoked P

2005
Reversal of mitochondrial defects before ischemia protects the aged heart.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:9

    Topics: Acetylcarnitine; Aging; Animals; Disease Models, Animal; Heart; L-Lactate Dehydrogenase; Male; Mitoc

2006
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:8

    Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Energy Metaboli

2006
Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and placebo-control trials.
    Turkish neurosurgery, 2007, Volume: 17, Issue:2

    Topics: Acetylcarnitine; Animals; Axons; Chronic Disease; Decompression, Surgical; Disease Models, Animal; F

2007
Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model.
    Current eye research, 2007, Volume: 32, Issue:11

    Topics: Acetylcarnitine; Animals; Antioxidants; Catalase; Cataract; Disease Models, Animal; Electrophoresis,

2007
Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells.
    Experimental neurology, 2008, Volume: 210, Issue:1

    Topics: Acetylcarnitine; Animals; Axons; Behavior, Animal; Disease Models, Animal; Drug Interactions; Langer

2008
Fatty acid metabolism in skeletal muscle mitochondria from two strains of dystrophic mice.
    Canadian journal of biochemistry, 1980, Volume: 58, Issue:7

    Topics: Acetylcarnitine; Animals; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase

1980
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2

    Topics: Acetylcarnitine; Acyl Coenzyme A; Animals; Aspirin; Carnitine; Coenzyme A; Disease Models, Animal; K

1995
Neuroprotective effects of acetyl-L-carnitine after stroke in rats.
    Annals of emergency medicine, 1997, Volume: 29, Issue:6

    Topics: Acetylcarnitine; Animals; Cerebral Infarction; Disease Models, Animal; Drug Evaluation, Preclinical;

1997
Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury.
    The American journal of cardiology, 1998, Sep-03, Volume: 82, Issue:5A

    Topics: Acetylcarnitine; Animals; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Fatty Acid

1998
Hepatic mitochondrial proteins in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:3

    Topics: Acetylcarnitine; Animals; Disease Models, Animal; Extracellular Matrix Proteins; Female; Hyperammone

2001