acetylcarnitine has been researched along with Diabetic Neuropathies in 26 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Animals with 4 weeks of hyperglycemia and reduced NCV treated with an aldose reductase inhibitor (sorbinil) or a short-chain acyl-carnitine (acetyl-L-carnitine [ALC]) daily for 16 weeks showed an improvement in NCV." | 3.69 | The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetes. ( Carver, J; Korthals, JK; Lowitt, S; Malone, JI; Miranda, C; Salem, AF, 1996) |
| " LAC (or placebo) was started intramuscularly at a dosage of 1000 mg/day for 10 days and continued orally at a dosage of 2000 mg/day for the remainder of the study (355 days)." | 2.70 | Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. ( De Grandis, D; Minardi, C, 2002) |
| "Flurbiprofen treatment of ND rats replicated many of the biochemical and physiological abnormalities of EDN, i." | 1.31 | Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. ( Greene, DA; Larkin, D; Li, F; Marinescu, V; Pop-Busui, R; Stevens, MJ; Sullivan, K; Van Huysen, C, 2002) |
| "Sorbinil treatment was associated with normalized sciatic nerve sorbitol and myo-inositol; ALC treatment did not reduce the elevated sorbitol levels, but sciatic nerve myo-inositol content was no different from nondiabetic levels." | 1.29 | Acetyl-L-carnitine corrects the altered peripheral nerve function of experimental diabetes. ( Benford, S; Korthals, J; Lowitt, S; Malone, JI; Salem, AF, 1995) |
| "Treatment with sorbinil was associated with normalization of the tissue sorbitol (0." | 1.28 | Altered neuroexcitability in experimental diabetic neuropathy: effect of acetyl-L-carnitine. ( Corsico, N; Lowitt, S; Malone, JI; Orfalian, Z, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sergi, G | 1 |
| Pizzato, S | 1 |
| Piovesan, F | 1 |
| Trevisan, C | 1 |
| Veronese, N | 1 |
| Manzato, E | 1 |
| Rolim, LC | 1 |
| da Silva, EM | 1 |
| Flumignan, RL | 1 |
| Abreu, MM | 1 |
| Dib, SA | 1 |
| Li, S | 1 |
| Chen, X | 1 |
| Li, Q | 2 |
| Du, J | 1 |
| Liu, Z | 1 |
| Peng, Y | 1 |
| Xu, M | 1 |
| Lei, M | 1 |
| Wang, C | 1 |
| Zheng, S | 1 |
| Zhang, X | 1 |
| Yu, H | 1 |
| Shi, J | 1 |
| Tao, S | 1 |
| Feng, P | 1 |
| Tian, H | 1 |
| Evans, JD | 1 |
| Jacobs, TF | 1 |
| Evans, EW | 1 |
| Kuritzky, L | 1 |
| Pop-Busui, R | 1 |
| Marinescu, V | 1 |
| Van Huysen, C | 1 |
| Li, F | 1 |
| Sullivan, K | 1 |
| Greene, DA | 3 |
| Larkin, D | 1 |
| Stevens, MJ | 3 |
| De Grandis, D | 1 |
| Minardi, C | 1 |
| Defani, MA | 1 |
| Zanoni, JN | 1 |
| Natali, MR | 1 |
| Bazotte, RB | 1 |
| de Miranda-Neto, MH | 1 |
| Sima, AA | 4 |
| Calvani, M | 1 |
| Mehra, M | 1 |
| Amato, A | 1 |
| Ohsawa, M | 1 |
| Miyata, S | 1 |
| Carlsson, A | 1 |
| Kamei, J | 1 |
| Quatraro, A | 1 |
| Roca, P | 1 |
| Donzella, C | 1 |
| Acampora, R | 1 |
| Marfella, R | 1 |
| Giugliano, D | 1 |
| Lowitt, S | 3 |
| Malone, JI | 3 |
| Salem, AF | 2 |
| Korthals, J | 1 |
| Benford, S | 1 |
| Ido, Y | 1 |
| McHowat, J | 1 |
| Chang, KC | 1 |
| Arrigoni-Martelli, E | 1 |
| Orfalian, Z | 2 |
| Kilo, C | 1 |
| Corr, PB | 1 |
| Williamson, JR | 1 |
| Ristic, H | 1 |
| Merry, A | 1 |
| Kamijo, M | 1 |
| Lattimer, SA | 2 |
| Feldman, EL | 1 |
| Helton, ED | 1 |
| Millington, DS | 1 |
| Miranda, C | 1 |
| Korthals, JK | 1 |
| Carver, J | 1 |
| Nakamura, J | 1 |
| Koh, N | 1 |
| Sakakibara, F | 1 |
| Hamada, Y | 1 |
| Hara, T | 1 |
| Sasaki, H | 1 |
| Chaya, S | 1 |
| Komori, T | 1 |
| Nakashima, E | 1 |
| Naruse, K | 1 |
| Kato, K | 1 |
| Takeuchi, N | 1 |
| Kasuya, Y | 1 |
| Hotta, N | 1 |
| Scarpini, E | 1 |
| Doneda, P | 1 |
| Pizzul, S | 1 |
| Chiodi, P | 1 |
| Ramacci, MT | 4 |
| Baron, P | 1 |
| Conti, G | 1 |
| Sacilotto, G | 1 |
| Arduini, A | 1 |
| Scarlato, G | 1 |
| Lo Giudice, P | 1 |
| Careddu, A | 1 |
| Magni, G | 1 |
| Quagliata, T | 1 |
| Pacifici, L | 2 |
| Carminati, P | 1 |
| Gorio, A | 3 |
| Di Giulio, AM | 2 |
| Tenconi, B | 1 |
| Donadoni, L | 1 |
| Germani, E | 1 |
| Bertelli, A | 2 |
| Mantegazza, P | 2 |
| Maccari, F | 2 |
| Ferraris, L | 1 |
| Bellucci, A | 1 |
| Piovesan, P | 1 |
| Corsico, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial.[NCT02141035] | Phase 2/Phase 3 | 20 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for acetylcarnitine and Diabetic Neuropathies
| Article | Year |
|---|---|
Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Analgesics; Diabetic Neuropathies; Humans; Mitochondria; P | 2018 |
Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy.
Topics: Acetylcarnitine; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropa | 2019 |
Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy.
Topics: Acetylcarnitine; Diabetic Neuropathies; Humans; Vitamin B Complex | 2008 |
Acetyl-L-carnitine. Monograph.
Topics: Acetylcarnitine; Alcoholism; Alzheimer Disease; Attention Deficit Disorder with Hyperactivity; Cogni | 2010 |
Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data.
Topics: Acetylcarnitine; Animals; Diabetic Neuropathies; Humans; Nootropic Agents | 2007 |
4 trials available for acetylcarnitine and Diabetic Neuropathies
| Article | Year |
|---|---|
Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial.
Topics: Acetylcarnitine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double | 2016 |
Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Diabetic Neuropathies; Double-Blind Method; Female; Humans | 2002 |
Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.
Topics: Acetylcarnitine; Diabetic Neuropathies; Dose-Response Relationship, Drug; Double-Blind Method; Human | 2005 |
Acetyl-L-carnitine for symptomatic diabetic neuropathy.
Topics: Acetylcarnitine; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Human | 1995 |
17 other studies available for acetylcarnitine and Diabetic Neuropathies
| Article | Year |
|---|---|
Managing diabetic peripheral neuropathic pain in primary care.
Topics: Acetylcarnitine; Analgesics; Antidepressive Agents; Diabetic Neuropathies; Drug Therapy, Combination | 2010 |
Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration.
Topics: Acetylcarnitine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats.
Topics: Acetylcarnitine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Die | 2003 |
Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice.
Topics: Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Mice; Mice, | 2008 |
Acetyl-L-carnitine corrects the altered peripheral nerve function of experimental diabetes.
Topics: Acetylcarnitine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies | 1995 |
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic | 1994 |
Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcarnitine; Alprostadil; Animals; Diabetic Neuropathies; Dinopros | 1996 |
Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat.
Topics: Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Rela | 1996 |
The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetes.
Topics: Acetylcarnitine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies | 1996 |
Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats.
Topics: Acetylcarnitine; Aldehyde Reductase; Animals; Body Weight; Carnitine; Diabetes Mellitus, Experimenta | 1998 |
Acetyl-L-carnitine.
Topics: Acetylcarnitine; Alzheimer Disease; Animals; Depressive Disorder; Diabetic Neuropathies; HIV Infecti | 1999 |
L-carnitine and acetyl-L-carnitine in human nerves from normal and diabetic subjects.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Carnitine; Diabetic Neuropathies; Female; Humans; I | 1996 |
Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Autonomic Nervous System Diseases; Blood Glucose; Body Weight; Diabetes Me | 2002 |
Peptide alterations in autonomic diabetic neuropathy prevented by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabet | 1992 |
Acetyl-L-carnitine prevents substance P loss in the sciatic nerve and lumbar spinal cord of diabetic animals.
Topics: Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Lumbar Vertebrae; | 1992 |
Counteraction on experimentally induced diabetic neuropathy by levocarnitine acetyl.
Topics: Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Motor Activi | 1992 |
Altered neuroexcitability in experimental diabetic neuropathy: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidaz | 1992 |