Page last updated: 2024-10-15

acetylcarnitine and Chronic Disease

acetylcarnitine has been researched along with Chronic Disease in 12 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"A panel of gut-related biomarkers including metabolites of the choline/carnitine- pathway (acetyl-L-carnitine, betaine, choline, γ-butyrobetaine, L-carnitine and trimethylamine-N-oxide [TMAO]) and the gut peptide, Trefoil factor-3 (TFF-3), were investigated in 1,783 patients with worsening HF enrolled in the systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) cohort and associations with HF severity and outcomes, and use in risk stratification were assessed."4.12Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium. ( Anker, SD; Cleland, JG; Israr, MZ; Lang, CC; Metra, M; Ng, LL; Salzano, A; Samani, NJ; Suzuki, T; van Veldhuisen, DJ; Voors, AA; Zannad, F; Zhan, H, 2022)
"The effects of chronic hypoxia on cardiac membrane fatty acids and on lipid peroxidation were examined, as well as the effect of l-carnitine (LCAR), which suppresses lipid peroxidation, on this process."3.74Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. ( Hamaoka, K; Itoi, T; Nakanishi, H; Oka, T; Taguchi, R; Terada, N, 2008)
" dosage of 1."2.67Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. ( Cicerano, U; De Chiara, S; Gallotta, G; Mansi, L; Postiglione, A; Salvatore, M; Schettini, G; Soricelli, A, 1991)
"L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord."1.46Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017)
") at a dosage of 1."1.28Cerebral blood flow in patients with chronic cerebrovascular disease: effect of acetyl L-carnitine. ( Cicerano, U; De Chiara, S; Gallotta, G; Mancini, M; Postiglione, A; Salvatore, M; Soricelli, A, 1990)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's3 (25.00)29.6817
2010's2 (16.67)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Israr, MZ1
Zhan, H1
Salzano, A1
Voors, AA1
Cleland, JG1
Anker, SD1
Metra, M1
van Veldhuisen, DJ1
Lang, CC1
Zannad, F1
Samani, NJ1
Ng, LL1
Suzuki, T1
Skoromets, AA1
Kotov, SV1
Voronkov, PB1
Popova, VV1
Zubkova, TG1
Kiselev, AV1
Statsenko, ME1
Turkina, SV1
Notartomaso, S1
Mascio, G1
Bernabucci, M1
Zappulla, C1
Scarselli, P1
Cannella, M1
Imbriglio, T1
Gradini, R1
Battaglia, G2
Bruno, V1
Nicoletti, F2
Oka, T1
Itoi, T1
Terada, N1
Nakanishi, H1
Taguchi, R1
Hamaoka, K1
Chiechio, S1
Copani, A1
Zammataro, M1
Gereau, RW1
Kotil, K1
Kirali, M1
Eras, M1
Bilge, T1
Uzun, H1
Bidzinska, B2
Petraglia, F2
Angioni, S2
Genazzani, AD2
Criscuolo, M2
Ficarra, G2
Gallinelli, A2
Trentini, GP2
Genazzani, AR2
Michalak, A1
Qureshi, IA1
Biagiotti, G1
Cavallini, G1
Postiglione, A2
Soricelli, A2
Cicerano, U2
Mansi, L1
De Chiara, S2
Gallotta, G2
Schettini, G1
Salvatore, M2
Mancini, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome; a Randomized Control Trial.[NCT02141035]Phase 2/Phase 320 participants (Actual)Interventional2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for acetylcarnitine and Chronic Disease

ArticleYear
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2021, Volume: 121, Issue:5

    Topics: Acetylcarnitine; Aged; Cardiovascular Diseases; Carnitine; Cerebrovascular Disorders; Chronic Diseas

2021
Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report.
    BJU international, 2001, Volume: 88, Issue:1

    Topics: Acetylcarnitine; Acute Disease; Administration, Oral; Adult; Aged; Chronic Disease; Humans; Male; Mi

2001
Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct.
    Pharmacological research, 1991, Volume: 23, Issue:3

    Topics: Acetylcarnitine; Aged; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascular Disorders;

1991

Other Studies

9 other studies available for acetylcarnitine and Chronic Disease

ArticleYear
Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium.
    American heart journal, 2022, Volume: 248

    Topics: Acetylcarnitine; Biomarkers; Carnitine; Choline; Chronic Disease; Heart Failure; Humans

2022
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
    Molecular pain, 2017, Volume: 13

    Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen

2017
Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia.
    Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:8

    Topics: Acetylcarnitine; Age Factors; Animals; Antioxidants; Carnitine; Catalase; Cell Membrane; Chronic Dis

2008
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain.
    Trends in pharmacological sciences, 2010, Volume: 31, Issue:4

    Topics: Acetylcarnitine; Animals; Chronic Disease; Epigenesis, Genetic; Humans; Pain; Pain Management; Recep

2010
Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and placebo-control trials.
    Turkish neurosurgery, 2007, Volume: 17, Issue:2

    Topics: Acetylcarnitine; Animals; Axons; Chronic Disease; Decompression, Surgical; Disease Models, Animal; F

2007
Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats.
    Neuroendocrinology, 1993, Volume: 57, Issue:6

    Topics: Acetylcarnitine; Animals; beta-Endorphin; Chronic Disease; Ether; Gonadotropin-Releasing Hormone; Hy

1993
Acetyl-L-carnitine effect on pituitary and plasma beta-endorphin responsiveness to different chronic intermittent stressors.
    Journal of neuroendocrinology, 1993, Volume: 5, Issue:2

    Topics: Acetylcarnitine; Animals; beta-Endorphin; Chronic Disease; Cold Temperature; Ether; Male; Pituitary

1993
Tissue acylcarnitine and acyl-coenzyme A profiles in chronically hyperammonemic mice treated with sodium benzoate and supplementary L-carnitine.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1995, Volume: 49, Issue:7-8

    Topics: Acetylcarnitine; Acyl Coenzyme A; Ammonia; Animals; Benzoates; Benzoic Acid; Carnitine; Chronic Dise

1995
Cerebral blood flow in patients with chronic cerebrovascular disease: effect of acetyl L-carnitine.
    International journal of clinical pharmacology research, 1990, Volume: 10, Issue:1-2

    Topics: Acetylcarnitine; Aged; Arteriosclerosis; Carnitine; Cerebrovascular Circulation; Cerebrovascular Dis

1990