acetylcarnitine has been researched along with Brain Ischemia in 16 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-nine cases with acute ischemic stroke with the onset of symptoms less than 24 hours not candidates for reperfusion therapy were randomly assigned to either the ALC group (1000 mg three times per day for three consecutive days) or the matching placebo group." | 3.11 | Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial. ( Abolfathi, P; Mazdeh, M; Mehrpooya, M; Mohammadi, Y; Sabetghadam, M, 2022) |
| " Despite intensive research, the quest for promising neuroprotective drugs has largely failed, not only because of ineffectiveness, but also because of serious side-effects and dosing difficulties." | 1.40 | Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia. ( Farkas, T; Gellért, L; Iwamori, N; Kis, Z; Knapp, L; Kocsis, K; Oláh, G; Ono, E; Takakuwa, H; Toldi, J, 2014) |
| "Carnitine plays important roles in mitochondrial metabolism and in modulating the ratio of coenzyme A (CoA)/acyl-CoA." | 1.38 | Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. ( Cui, D; Niu, J; Wang, T; Xu, S; Zhang, H; Zhang, R; Zhang, Z, 2012) |
| "We used a transient middle cerebral artery occlusion (MCAO) model to evaluate the protective roles of LC and ALC in acute focal cerebral ischemia in vivo and to understand the possible mechanisms using model of PC12 cell cultures in vitro." | 1.38 | Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. ( Cui, D; Niu, J; Wang, T; Xu, S; Zhang, H; Zhang, R; Zhang, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Mazdeh, M | 1 |
| Abolfathi, P | 1 |
| Sabetghadam, M | 1 |
| Mohammadi, Y | 1 |
| Mehrpooya, M | 1 |
| Kocsis, K | 3 |
| Knapp, L | 3 |
| Gellért, L | 1 |
| Oláh, G | 1 |
| Kis, Z | 3 |
| Takakuwa, H | 1 |
| Iwamori, N | 1 |
| Ono, E | 1 |
| Toldi, J | 3 |
| Farkas, T | 3 |
| Mészáros, J | 1 |
| Vécsei, L | 2 |
| Frank, R | 1 |
| Szabó, J | 1 |
| Demarest, TG | 1 |
| Schuh, RA | 1 |
| Waite, EL | 1 |
| Waddell, J | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 4 |
| Jalal, FY | 1 |
| Böhlke, M | 1 |
| Maher, TJ | 1 |
| Goo, MJ | 1 |
| Choi, SM | 1 |
| Kim, SH | 1 |
| Ahn, BO | 1 |
| Zhang, R | 1 |
| Zhang, H | 1 |
| Zhang, Z | 1 |
| Wang, T | 1 |
| Niu, J | 1 |
| Cui, D | 1 |
| Xu, S | 1 |
| Rosenthal, RE | 3 |
| Bogaert, YE | 2 |
| Zanelli, SA | 1 |
| Solenski, NJ | 1 |
| Famularo, G | 1 |
| Sarazani, S | 1 |
| Polchi, S | 1 |
| Panegrossi, A | 1 |
| Calvani, M | 1 |
| Arrigoni-Martelli, E | 1 |
| Williams, R | 1 |
| Getson, PR | 1 |
| Rosadini, G | 1 |
| Marenco, S | 1 |
| Nobili, F | 1 |
| Novellone, G | 1 |
| Rodriguez, G | 1 |
| Vecchi, GP | 1 |
| Neri, M | 1 |
| Cortelloni, C | 1 |
| De Vreese, L | 1 |
| Sirotti, C | 1 |
| Cipolli, C | 1 |
| Fabbri, L | 1 |
| Zerbini, O | 1 |
| Sinforiani, E | 1 |
| Iannuccelli, M | 1 |
| Mauri, M | 1 |
| Costa, A | 1 |
| Merlo, P | 1 |
| Bono, G | 1 |
| Nappi, G | 1 |
3 reviews available for acetylcarnitine and Brain Ischemia
| Article | Year |
|---|---|
Mechanisms of ischemic neuroprotection by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Brain Chemistry; Brain Ischemia; Energy Metabolism; Humans; Neuroprotectiv | 2005 |
[Ischemic stroke. What approach in the Emergency Department?].
Topics: Acetylcarnitine; Acute Disease; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulatio | 1997 |
Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.
Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Carnitine; Dogs; Oxidation-Reduction; Rats; Reperfu | 1999 |
2 trials available for acetylcarnitine and Brain Ischemia
| Article | Year |
|---|---|
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial.
Topics: Acetylcarnitine; Antioxidants; Biomarkers; Brain Ischemia; Humans; Iran; Ischemic Stroke; Stroke; Tr | 2022 |
Methodology of a controlled clinical study for cerebral aging evaluation.
Topics: Acetylcarnitine; Aging; Brain Ischemia; Clinical Trials as Topic; Humans; Multicenter Studies as Top | 1990 |
11 other studies available for acetylcarnitine and Brain Ischemia
| Article | Year |
|---|---|
Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia.
Topics: Acetylcarnitine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carotid Artery Diseases; Dendriti | 2014 |
Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study.
Topics: Acetylcarnitine; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen-glucose deprivation.
Topics: Acetylcarnitine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Chromones; Dose-Response Relation | 2016 |
Sex dependent alterations in mitochondrial electron transport chain proteins following neonatal rat cerebral hypoxic-ischemia.
Topics: Acetylcarnitine; Animals; Animals, Newborn; Brain Ischemia; Electron Transport Chain Complex Protein | 2016 |
Acetyl-L-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats.
Topics: Acetylcarnitine; Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Male; Microdialysis; N | 2010 |
Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Brain Ischemia; Male; Memory Disorders; Neuropr | 2012 |
Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro.
Topics: Acetylcarnitine; Animals; Apoptosis; Brain Ischemia; Carnitine; Infarction, Middle Cerebral Artery; | 2012 |
Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs.
Topics: Acetylcarnitine; Analysis of Variance; Animals; Brain Ischemia; Disease Models, Animal; Dogs; Heart | 2005 |
Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Dogs; Energy Metabolism; Female; Heart Arrest; Lact | 1992 |
Acute effects of acetyl-L-carnitine on regional cerebral blood flow in patients with brain ischaemia.
Topics: Acetylcarnitine; Aged; Brain; Brain Ischemia; Carbon Dioxide; Carnitine; Cerebrovascular Circulation | 1990 |
Neuropsychological changes in demented patients treated with acetyl-L-carnitine.
Topics: Acetylcarnitine; Aged; Brain Ischemia; Carnitine; Dementia; Female; Humans; Male; Middle Aged; Pirac | 1990 |