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acetylcarnitine and Brain Ischemia

acetylcarnitine has been researched along with Brain Ischemia in 16 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Sixty-nine cases with acute ischemic stroke with the onset of symptoms less than 24 hours not candidates for reperfusion therapy were randomly assigned to either the ALC group (1000 mg three times per day for three consecutive days) or the matching placebo group."3.11Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial. ( Abolfathi, P; Mazdeh, M; Mehrpooya, M; Mohammadi, Y; Sabetghadam, M, 2022)
" Despite intensive research, the quest for promising neuroprotective drugs has largely failed, not only because of ineffectiveness, but also because of serious side-effects and dosing difficulties."1.40Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia. ( Farkas, T; Gellért, L; Iwamori, N; Kis, Z; Knapp, L; Kocsis, K; Oláh, G; Ono, E; Takakuwa, H; Toldi, J, 2014)
"Carnitine plays important roles in mitochondrial metabolism and in modulating the ratio of coenzyme A (CoA)/acyl-CoA."1.38Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. ( Cui, D; Niu, J; Wang, T; Xu, S; Zhang, H; Zhang, R; Zhang, Z, 2012)
"We used a transient middle cerebral artery occlusion (MCAO) model to evaluate the protective roles of LC and ALC in acute focal cerebral ischemia in vivo and to understand the possible mechanisms using model of PC12 cell cultures in vitro."1.38Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. ( Cui, D; Niu, J; Wang, T; Xu, S; Zhang, H; Zhang, R; Zhang, Z, 2012)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (37.50)18.2507
2000's2 (12.50)29.6817
2010's7 (43.75)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Mazdeh, M1
Abolfathi, P1
Sabetghadam, M1
Mohammadi, Y1
Mehrpooya, M1
Kocsis, K3
Knapp, L3
Gellért, L1
Oláh, G1
Kis, Z3
Takakuwa, H1
Iwamori, N1
Ono, E1
Toldi, J3
Farkas, T3
Mészáros, J1
Vécsei, L2
Frank, R1
Szabó, J1
Demarest, TG1
Schuh, RA1
Waite, EL1
Waddell, J1
McKenna, MC1
Fiskum, G4
Jalal, FY1
Böhlke, M1
Maher, TJ1
Goo, MJ1
Choi, SM1
Kim, SH1
Ahn, BO1
Zhang, R1
Zhang, H1
Zhang, Z1
Wang, T1
Niu, J1
Cui, D1
Xu, S1
Rosenthal, RE3
Bogaert, YE2
Zanelli, SA1
Solenski, NJ1
Famularo, G1
Sarazani, S1
Polchi, S1
Panegrossi, A1
Calvani, M1
Arrigoni-Martelli, E1
Williams, R1
Getson, PR1
Rosadini, G1
Marenco, S1
Nobili, F1
Novellone, G1
Rodriguez, G1
Vecchi, GP1
Neri, M1
Cortelloni, C1
De Vreese, L1
Sirotti, C1
Cipolli, C1
Fabbri, L1
Zerbini, O1
Sinforiani, E1
Iannuccelli, M1
Mauri, M1
Costa, A1
Merlo, P1
Bono, G1
Nappi, G1

Reviews

3 reviews available for acetylcarnitine and Brain Ischemia

ArticleYear
Mechanisms of ischemic neuroprotection by acetyl-L-carnitine.
    Annals of the New York Academy of Sciences, 2005, Volume: 1053

    Topics: Acetylcarnitine; Animals; Brain Chemistry; Brain Ischemia; Energy Metabolism; Humans; Neuroprotectiv

2005
[Ischemic stroke. What approach in the Emergency Department?].
    Recenti progressi in medicina, 1997, Volume: 88, Issue:11

    Topics: Acetylcarnitine; Acute Disease; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulatio

1997
Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.
    International journal of tissue reactions, 1999, Volume: 21, Issue:1

    Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Carnitine; Dogs; Oxidation-Reduction; Rats; Reperfu

1999

Trials

2 trials available for acetylcarnitine and Brain Ischemia

ArticleYear
Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Acetylcarnitine; Antioxidants; Biomarkers; Brain Ischemia; Humans; Iran; Ischemic Stroke; Stroke; Tr

2022
Methodology of a controlled clinical study for cerebral aging evaluation.
    International journal of clinical pharmacology research, 1990, Volume: 10, Issue:1-2

    Topics: Acetylcarnitine; Aging; Brain Ischemia; Clinical Trials as Topic; Humans; Multicenter Studies as Top

1990

Other Studies

11 other studies available for acetylcarnitine and Brain Ischemia

ArticleYear
Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia.
    Neuroscience, 2014, Jun-06, Volume: 269

    Topics: Acetylcarnitine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carotid Artery Diseases; Dendriti

2014
Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:6

    Topics: Acetylcarnitine; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug;

2015
Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen-glucose deprivation.
    Neuroscience, 2016, 09-22, Volume: 332

    Topics: Acetylcarnitine; Animals; Brain Ischemia; CA1 Region, Hippocampal; Chromones; Dose-Response Relation

2016
Sex dependent alterations in mitochondrial electron transport chain proteins following neonatal rat cerebral hypoxic-ischemia.
    Journal of bioenergetics and biomembranes, 2016, Volume: 48, Issue:6

    Topics: Acetylcarnitine; Animals; Animals, Newborn; Brain Ischemia; Electron Transport Chain Complex Protein

2016
Acetyl-L-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats.
    Annals of the New York Academy of Sciences, 2010, Volume: 1199

    Topics: Acetylcarnitine; Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Male; Microdialysis; N

2010
Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats.
    Archives of pharmacal research, 2012, Volume: 35, Issue:1

    Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Brain Ischemia; Male; Memory Disorders; Neuropr

2012
Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro.
    International journal of molecular sciences, 2012, Volume: 13, Issue:2

    Topics: Acetylcarnitine; Animals; Apoptosis; Brain Ischemia; Carnitine; Infarction, Middle Cerebral Artery;

2012
Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogs.
    Neuroscience letters, 2005, Apr-18, Volume: 378, Issue:2

    Topics: Acetylcarnitine; Analysis of Variance; Animals; Brain Ischemia; Disease Models, Animal; Dogs; Heart

2005
Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.
    Stroke, 1992, Volume: 23, Issue:9

    Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Dogs; Energy Metabolism; Female; Heart Arrest; Lact

1992
Acute effects of acetyl-L-carnitine on regional cerebral blood flow in patients with brain ischaemia.
    International journal of clinical pharmacology research, 1990, Volume: 10, Issue:1-2

    Topics: Acetylcarnitine; Aged; Brain; Brain Ischemia; Carbon Dioxide; Carnitine; Cerebrovascular Circulation

1990
Neuropsychological changes in demented patients treated with acetyl-L-carnitine.
    International journal of clinical pharmacology research, 1990, Volume: 10, Issue:1-2

    Topics: Acetylcarnitine; Aged; Brain Ischemia; Carnitine; Dementia; Female; Humans; Male; Middle Aged; Pirac

1990