acetylcarnitine has been researched along with Aging in 98 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study is to verify whether LAC can have an antidepressant action in a population of elderly patients with dysthymic disorder in comparison with a traditional antidepressant such as fluoxetine." | 9.17 | L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine. ( Bersani, FS; Bersani, G; Colletti, C; Denaro, A; Koverech, A; Liberati, D; Meco, G; Nicolai, R, 2013) |
| "The effect of aging and treatment with acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes was studied." | 7.68 | Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. ( Cafagna, F; Gadaleta, MN; Quagliariello, E; Ruggiero, FM, 1990) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 7.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "L-carnitine has also demonstrated antioxidant properties in animal models of oxidative damage." | 6.44 | The aging eye and the role of L-carnitine and its derivatives. ( Imperatrice, B; Karavitis, P; Pescosolido, N, 2008) |
| " The aim of the study is to verify whether LAC can have an antidepressant action in a population of elderly patients with dysthymic disorder in comparison with a traditional antidepressant such as fluoxetine." | 5.17 | L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine. ( Bersani, FS; Bersani, G; Colletti, C; Denaro, A; Koverech, A; Liberati, D; Meco, G; Nicolai, R, 2013) |
| "The effect of aging and treatment with acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes was studied." | 3.68 | Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. ( Cafagna, F; Gadaleta, MN; Quagliariello, E; Ruggiero, FM, 1990) |
| "Acetyl-l-carnitine (ALCAR) exerts antiaging effects with study we evaluated the effect of a chronic treatment with ALCAR (6 weeks, 50 mg/kg/day) on the open field behavior of 5-month-old and 26-month-old male Wistar rats." | 3.68 | Differential effect of acetyl-l-carnitine on open field behavior in young and old rats. ( Blokland, A; Jolles, J; Raaijmakers, W; van der Staay, FJ, 1990) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 3.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people." | 3.67 | Age-dependent decrease of carnitine content in muscle of mice and humans. ( Costell, M; Grisolía, S; O'Connor, JE, 1989) |
| "Brain autoradiography in adrenalectomized rats injected with 3H-corticosterone 2 hr before sacrifice was used to study the effect of aging and long-term acetyl-l-carnitine treatment on the hippocampal glucocorticoid receptor." | 3.67 | Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study. ( Amenta, F; Angelucci, L; Maccari, S; Patacchioli, FR; Ramacci, MT; Taglialatela, G, 1989) |
| "L-carnitine (LC) plays an important role in energy production from long-chain fatty acids in mitochondria, and its serum level is lower in prefrail and frail subjects." | 3.11 | Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial. ( Bertino, G; Bonfiglio, C; Castorina, M; Catania, VE; Cauli, O; Chisari, LM; Malaguarnera, G; Malaguarnera, M, 2022) |
| "Prefrailty is the intermediate stage between frailty and robust condition." | 3.11 | Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial. ( Bertino, G; Bonfiglio, C; Castorina, M; Catania, VE; Cauli, O; Chisari, LM; Malaguarnera, G; Malaguarnera, M, 2022) |
| "The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism." | 2.50 | Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014) |
| "L-carnitine has also demonstrated antioxidant properties in animal models of oxidative damage." | 2.44 | The aging eye and the role of L-carnitine and its derivatives. ( Imperatrice, B; Karavitis, P; Pescosolido, N, 2008) |
| "Treatment with acetylcarnitine (AcCN) increases the activity of cytochrome oxidase in the aged heart." | 1.33 | Reversal of mitochondrial defects before ischemia protects the aged heart. ( He, D; Hoppel, CL; Lesnefsky, EJ; Moghaddas, S, 2006) |
| " This study indicates that chronic administration of ALCAR increases cholinergic synaptic transmission and consequently enhances learning capacity as a cognitive function in aging rats." | 1.31 | Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. ( Ando, S; Fukui, F; Kawabata, T; Kobayashi, S; Ohashi, Y; Tadenuma, T; Tanaka, Y, 2001) |
| " This reduction is attenuated after long-term administration with L-acetylcarnitine (10 mg/Kg i." | 1.28 | L-acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus. ( Fiore, L; Rampello, L, 1989) |
| "The effects of long-term dosing with acetyl-L-carnitine (ALC) were examined in aged rats, and they were compared with those in young rats." | 1.27 | Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats. ( Anami, K; Fujii, T; Kohjimoto, Y; Kuwaki, T; Matsumoto, M; Ogawa, T; Ono, T; Satoh, H; Shirakawa, K; Yasuda, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (16.33) | 18.7374 |
| 1990's | 41 (41.84) | 18.2507 |
| 2000's | 26 (26.53) | 29.6817 |
| 2010's | 14 (14.29) | 24.3611 |
| 2020's | 1 (1.02) | 2.80 |
| Authors | Studies |
|---|---|
| Malaguarnera, G | 1 |
| Catania, VE | 1 |
| Bertino, G | 1 |
| Chisari, LM | 1 |
| Castorina, M | 3 |
| Bonfiglio, C | 1 |
| Cauli, O | 1 |
| Malaguarnera, M | 1 |
| Nicassio, L | 2 |
| Fracasso, F | 4 |
| Sirago, G | 1 |
| Musicco, C | 4 |
| Picca, A | 1 |
| Marzetti, E | 1 |
| Calvani, R | 1 |
| Cantatore, P | 7 |
| Gadaleta, MN | 13 |
| Pesce, V | 5 |
| Singh, M | 1 |
| Miura, P | 1 |
| Renden, R | 1 |
| Li, R | 1 |
| Liu, Y | 1 |
| Xie, J | 1 |
| Huang, X | 1 |
| Zhang, L | 1 |
| Liu, H | 1 |
| Li, L | 1 |
| Bersani, G | 1 |
| Meco, G | 1 |
| Denaro, A | 1 |
| Liberati, D | 1 |
| Colletti, C | 1 |
| Nicolai, R | 1 |
| Bersani, FS | 1 |
| Koverech, A | 2 |
| Phillipson, OT | 1 |
| Kerner, J | 1 |
| Yohannes, E | 1 |
| Lee, K | 1 |
| Virmani, A | 1 |
| Cavazza, C | 1 |
| Chance, MR | 1 |
| Hoppel, C | 1 |
| Snigdha, S | 1 |
| de Rivera, C | 2 |
| Milgram, NW | 2 |
| Cotman, CW | 3 |
| Traina, G | 1 |
| Bielefeld, EC | 1 |
| Coling, D | 1 |
| Chen, GD | 1 |
| Henderson, D | 1 |
| Long, J | 1 |
| Gao, F | 1 |
| Tong, L | 1 |
| Ames, BN | 8 |
| Liu, J | 5 |
| Pescosolido, N | 1 |
| Imperatrice, B | 1 |
| Karavitis, P | 1 |
| Freo, U | 1 |
| Dam, M | 1 |
| Ori, C | 1 |
| Capelli, V | 2 |
| Timperio, AM | 2 |
| Calvani, M | 5 |
| Mosconi, L | 2 |
| Zolla, L | 1 |
| Shenk, JC | 2 |
| Fischbach, K | 2 |
| Xu, K | 1 |
| Puchowicz, M | 1 |
| Obrenovich, ME | 2 |
| Gasimov, E | 2 |
| Alvarez, LM | 1 |
| Lamanna, JC | 1 |
| Aliev, G | 2 |
| Christie, LA | 1 |
| Opii, WO | 1 |
| Head, E | 1 |
| Araujo, JA | 1 |
| Calabrese, V | 2 |
| Cornelius, C | 1 |
| Mancuso, C | 1 |
| Lentile, R | 1 |
| Stella, AM | 1 |
| Butterfield, DA | 2 |
| Glade, MJ | 1 |
| Kobayashi, S | 2 |
| Iwamoto, M | 1 |
| Kon, K | 1 |
| Waki, H | 2 |
| Ando, S | 3 |
| Tanaka, Y | 3 |
| Goo, MJ | 1 |
| Choi, SM | 1 |
| Kim, SH | 1 |
| Ahn, BO | 1 |
| Sharman, EH | 1 |
| Vaziri, ND | 1 |
| Ni, Z | 1 |
| Sharman, KG | 1 |
| Bondy, SC | 1 |
| Yasui, F | 1 |
| Matsugo, S | 1 |
| Ishibashi, M | 1 |
| Kajita, T | 1 |
| Ezashi, Y | 1 |
| Oomura, Y | 1 |
| Kojo, S | 1 |
| Sasaki, K | 1 |
| Sasaki, R | 1 |
| Fukui, F | 2 |
| Kawabata, T | 2 |
| Okazaki, M | 1 |
| Hasegawa, K | 1 |
| Bastianetto, S | 1 |
| Quirion, R | 1 |
| Giuffrida Stella, AM | 2 |
| Marini, G | 1 |
| Ceccarelli, P | 1 |
| Mancia, M | 3 |
| Lesnefsky, EJ | 1 |
| He, D | 1 |
| Moghaddas, S | 1 |
| Hoppel, CL | 1 |
| Pacheco, GJ | 1 |
| Chen, SG | 1 |
| Ward, WF | 1 |
| Richardson, AG | 1 |
| Smith, MA | 1 |
| Perry, G | 1 |
| Marotta, F | 1 |
| Chui, de H | 1 |
| Lorenzetti, A | 1 |
| Fayet, F | 1 |
| Liu, T | 1 |
| Marandola, P | 1 |
| Petruzzella, V | 2 |
| Daddabbo, L | 1 |
| Olivieri, C | 1 |
| Loguercio Polosa, P | 1 |
| Caprioli, A | 4 |
| Markowska, AL | 1 |
| Olton, DS | 1 |
| Bertoni-Freddari, C | 1 |
| Fattoretti, P | 1 |
| Casoli, T | 1 |
| Spagna, C | 1 |
| Casell, U | 1 |
| Esposti, D | 1 |
| Mariani, M | 1 |
| Demartini, G | 1 |
| Lucini, V | 1 |
| Fraschini, F | 1 |
| Ambrosini, AM | 1 |
| Pacific, L | 1 |
| Ramacci, MT | 20 |
| Angelucci, L | 16 |
| Paradies, G | 5 |
| Ruggiero, FM | 6 |
| Petrosillo, G | 4 |
| Quagliariello, E | 5 |
| De Angelis, C | 3 |
| Scarfò, C | 3 |
| Falcinelli, M | 3 |
| Perna, E | 2 |
| Reda, E | 2 |
| Piovesan, P | 1 |
| Pacifici, L | 2 |
| Taglialatela, G | 4 |
| Ferraris, L | 1 |
| Carta, A | 1 |
| Bravi, D | 1 |
| Bhuachalla, SN | 1 |
| Florio, T | 1 |
| Meucci, O | 1 |
| Grimaldi, M | 1 |
| Ventra, C | 1 |
| Cocozza, E | 1 |
| Avallone, A | 1 |
| Postiglione, A | 1 |
| Marino, A | 1 |
| Schettini, G | 1 |
| Hsueh, CM | 1 |
| Chen, SF | 1 |
| Ghanta, VK | 1 |
| Hiramoto, RN | 1 |
| Hagen, TM | 3 |
| Ingersoll, RT | 1 |
| Wehr, CM | 2 |
| Lykkesfeldt, J | 1 |
| Vinarsky, V | 1 |
| Bartholomew, JC | 1 |
| Song, MH | 1 |
| Cormio, A | 1 |
| Lezza, AM | 1 |
| Rao, KV | 1 |
| Qureshi, IA | 1 |
| Seidman, MD | 1 |
| Khan, MJ | 1 |
| Bai, U | 1 |
| Shirwany, N | 1 |
| Quirk, WS | 1 |
| Aureli, T | 3 |
| Di Cocco, ME | 2 |
| Capuani, G | 2 |
| Ricciolini, R | 2 |
| Manetti, C | 1 |
| Miccheli, A | 3 |
| Conti, F | 3 |
| Kaur, J | 1 |
| Sharma, D | 1 |
| Singh, R | 1 |
| Mollica, MP | 2 |
| Iossa, S | 2 |
| Soboll, S | 1 |
| Liverini, G | 2 |
| Tadenuma, T | 1 |
| Ohashi, Y | 1 |
| Killilea, DW | 1 |
| Lionetti, L | 1 |
| Crescenzo, R | 1 |
| Botta, M | 1 |
| Barletta, A | 1 |
| Moreau, R | 1 |
| Suh, JH | 1 |
| Visioli, F | 1 |
| Hansford, RG | 1 |
| Bellucci, A | 1 |
| Werrbach-Perez, K | 2 |
| Jackson, GR | 1 |
| Perez-Polo, JR | 1 |
| Manfridi, A | 1 |
| Forloni, GL | 1 |
| Arrigoni-Martelli, E | 1 |
| Algeri, S | 1 |
| Ghirardi, O | 8 |
| Milano, S | 3 |
| Giuliani, A | 3 |
| Villa, RF | 3 |
| Gorini, A | 2 |
| Ramacc, MT | 1 |
| Sershen, H | 1 |
| Harsing, LG | 1 |
| Banay-Schwartz, M | 1 |
| Hashim, A | 1 |
| Lajtha, A | 1 |
| De Simone, R | 1 |
| Aloe, L | 1 |
| Scaccianoce, S | 1 |
| Alemà, S | 1 |
| Cigliana, G | 1 |
| Navarra, D | 1 |
| Imperato, A | 1 |
| Scrocco, MG | 1 |
| Renis, M | 1 |
| Vecchi, GP | 1 |
| Neri, M | 1 |
| Cortelloni, C | 1 |
| De Vreese, L | 1 |
| Sirotti, C | 1 |
| Cipolli, C | 1 |
| Fabbri, L | 1 |
| Zerbini, O | 1 |
| de Sousa, C | 1 |
| English, NR | 1 |
| Stacey, TE | 1 |
| Chalmers, RA | 1 |
| Cafagna, F | 1 |
| Blokland, A | 1 |
| Raaijmakers, W | 1 |
| van der Staay, FJ | 1 |
| Jolles, J | 1 |
| Franceschi, C | 1 |
| Cossarizza, A | 1 |
| Troiano, L | 1 |
| Salati, R | 1 |
| Monti, D | 1 |
| Curti, D | 1 |
| Dagani, F | 1 |
| Galmozzi, MR | 1 |
| Marzatico, F | 1 |
| Fiore, L | 1 |
| Rampello, L | 1 |
| Ricci, A | 1 |
| Amenta, F | 3 |
| Costell, M | 1 |
| O'Connor, JE | 1 |
| Grisolía, S | 1 |
| Patacchioli, FR | 1 |
| Maccari, S | 1 |
| Hulsebosch, C | 1 |
| Morgan, B | 1 |
| Perez-Polo, R | 1 |
| Turpeenoja, L | 1 |
| Benzi, G | 2 |
| Kohjimoto, Y | 1 |
| Ogawa, T | 1 |
| Matsumoto, M | 1 |
| Shirakawa, K | 1 |
| Kuwaki, T | 1 |
| Yasuda, H | 1 |
| Anami, K | 1 |
| Fujii, T | 1 |
| Satoh, H | 1 |
| Ono, T | 1 |
| De Rossi, M | 1 |
| Lucreziotti, MR | 1 |
| Mione, MC | 1 |
| Guarnaschelli, C | 1 |
| Fugazza, G | 1 |
| Pistarini, C | 1 |
| Badiali De Giorgi, L | 2 |
| Bonvicini, F | 2 |
| Bianchi, D | 2 |
| Bossoni, G | 2 |
| Laschi, R | 2 |
| Zanada, F | 1 |
13 reviews available for acetylcarnitine and Aging
| Article | Year |
|---|---|
Management of the aging risk factor for Parkinson's disease.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb | 2014 |
The neurobiology of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Apoptosis; Brain; Dietary Supplements; Energy Metabolism; Epigenesi | 2016 |
The aging eye and the role of L-carnitine and its derivatives.
Topics: Acetylcarnitine; Aged; Aging; Animals; Antioxidants; Carnitine; Eye; Eye Diseases; Humans; Vitamin B | 2008 |
Oxidative stress and cognitive longevity.
Topics: Acetylcarnitine; Aging; Animals; Central Nervous System; Cognition; Cognition Disorders; Humans; Lon | 2010 |
Delaying the mitochondrial decay of aging.
Topics: Acetylcarnitine; Aging; Animals; Biotin; Brain; Copper; Heme; Humans; Kinetics; Mitochondria; Pantot | 2004 |
Natural antioxidants and neurodegenerative diseases.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Brain; Food; Ginkgo biloba; Humans; Neurodegenerative | 2004 |
Delaying the mitochondrial decay of aging with acetylcarnitine.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Brain; Carnitine; Dose-Response Relationship, Dr | 2004 |
Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes.
Topics: Acetylcarnitine; Aging; Animals; Caloric Restriction; Carnitine; Carnitine Acyltransferases; Cell Ph | 2006 |
Acetyl-L-carnitine affects aged brain receptorial system in rodents.
Topics: Acetylcarnitine; Aging; Animals; Brain; Calcium Channels; Male; Mice; Mice, Inbred BALB C; Rats; Rat | 1994 |
Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Brain; Carnitine O-Acetyltransferase; Humans; Mi | 1993 |
Aging and mitochondria.
Topics: Acetylcarnitine; Aged; Aging; Animals; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Mi | 1998 |
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Dietary Supplements; Heart; | 2002 |
Potential strategies against age-related brain deterioration. Dietary and pharmacological approaches.
Topics: Acetylcarnitine; Acetylcholine; Adrenal Medulla; Aging; Animals; Brain; Catecholamines; Cognition; D | 1992 |
3 trials available for acetylcarnitine and Aging
| Article | Year |
|---|---|
Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
Topics: Acetylcarnitine; Aged; Aging; Carnitine; Double-Blind Method; Frailty; Humans | 2022 |
L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine.
Topics: Acetylcarnitine; Aged; Aged, 80 and over; Aging; Antidepressive Agents; Cognitive Dysfunction; Diagn | 2013 |
Methodology of a controlled clinical study for cerebral aging evaluation.
Topics: Acetylcarnitine; Aging; Brain Ischemia; Clinical Trials as Topic; Humans; Multicenter Studies as Top | 1990 |
82 other studies available for acetylcarnitine and Aging
| Article | Year |
|---|---|
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats.
Topics: Acetylcarnitine; Age Factors; Aging; Animals; Antioxidants; Brain; Dietary Supplements; DNA, Mitocho | 2017 |
Age-related defects in short-term plasticity are reversed by acetyl-L-carnitine at the mouse calyx of Held.
Topics: Acetylcarnitine; Aging; Animals; Anti-Inflammatory Agents; Auditory Pathways; Auditory Perception; F | 2018 |
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Ataxia Telangiectasia Mutated Proteins; Cyclin D1; DN | 2019 |
Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart.
Topics: Acetylation; Acetylcarnitine; Aging; Animals; Mitochondria, Heart; Mitochondrial Proteins; Myocardiu | 2015 |
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes | 2016 |
Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat.
Topics: Acetylcarnitine; Aging; Animals; Auditory Threshold; Dose-Response Relationship, Drug; Evoked Potent | 2008 |
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Brain; Catalase; Electron Transport Chain Complex Proteins; Glutath | 2009 |
Cerebral metabolic effects of acetyl-l-carnitine in rats during aging.
Topics: Acetylcarnitine; Aging; Animals; Autoradiography; Carbon Radioisotopes; Cerebrum; Deoxyglucose; Gluc | 2009 |
Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria.
Topics: Acetylcarnitine; Aging; Animals; Cysteine; Electrophoresis, Gel, Two-Dimensional; Male; Mass Spectro | 2009 |
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov | 2009 |
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.
Topics: Acetylcarnitine; Aging; Amides; Animals; Antioxidants; Cognition; Dietary Supplements; Dogs; Female; | 2009 |
Redox homeostasis and cellular stress response in aging and neurodegeneration.
Topics: Acetylcarnitine; Aging; Animals; Carbon Monoxide; Gene Regulatory Networks; Heme Oxygenase-1; Homeos | 2010 |
Acetyl-L-carnitine improves aged brain function.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Hippocampus; Learning; Male; Maze Learning; Memor | 2010 |
Rat liver mitochondrial proteome: changes associated with aging and acetyl-L-carnitine treatment.
Topics: Acetylcarnitine; Age Factors; Aging; Animals; Electrophoresis, Gel, Two-Dimensional; Male; Metabolic | 2011 |
Protective effects of acetyl-L-carnitine on neurodegenarative changes in chronic cerebral ischemia models and learning-memory impairment in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Brain Ischemia; Male; Memory Disorders; Neuropr | 2012 |
Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver.
Topics: Acetylcarnitine; Aging; Animals; Autophagy; Dietary Supplements; DNA, Mitochondrial; Liver; Male; Mi | 2012 |
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Body Weight; Cerebral Cortex; Down-Regulation; Encephalitis; Explor | 2002 |
Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Brain; Disease Models, Animal; Dose-Response Re | 2002 |
Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats.
Topics: Acetylcarnitine; Age Factors; Aging; Animals; Body Weight; Carnitine; Dietary Supplements; Drinking; | 2004 |
Behavioral and electrophysiological changes induced by acetyl-L-carnitine in aged freely-moving rats.
Topics: Acetylcarnitine; Aging; Animals; Arousal; Attention; Behavior, Animal; Dose-Response Relationship, D | 2006 |
Reversal of mitochondrial defects before ischemia protects the aged heart.
Topics: Acetylcarnitine; Aging; Animals; Disease Models, Animal; Heart; L-Lactate Dehydrogenase; Male; Mitoc | 2006 |
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Topics: Acetylcarnitine; Aging; Animals; Dietary Supplements; Hippocampus; Male; Mitochondria; Neurons; Rand | 2009 |
Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation.
Topics: Acetylcarnitine; Aging; Animals; Blood Gas Analysis; Creatine Kinase; Dietary Supplements; Glycogen; | 2008 |
Mitochondrial DNA transcription and translation in aged rat. Effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; DNA, Mitochondrial; Dose-Response Relationship, Drug; Male; Mitocho | 1994 |
Acetyl-L-Carnitine: chronic treatment improves spatial acquisition in a new environment in aged rats.
Topics: Acetylcarnitine; Aging; Analysis of Variance; Animals; Male; Memory; Rats; Rats, Inbred F344; Space | 1995 |
Dynamic morphology of the synaptic junctional areas during aging: the effect of chronic acetyl-L-carnitine administration.
Topics: Acetylcarnitine; Aging; Animals; Brain; Hippocampus; Male; Nerve Endings; Parasympathetic Nervous Sy | 1994 |
Modulation of melatonin secretion by acetyl-L-carnitine in adult and old rats.
Topics: Acetylcarnitine; Aging; Animals; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Sprague-Dawley | 1994 |
Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Corpus Striatum; Frontal Lobe; Hippocampus; Male; Radioligand Assay | 1994 |
The effect of aging and acetyl-L-carnitine on the function and on the lipid composition of rat heart mitochondria.
Topics: Acetylcarnitine; Aging; Animals; Atractyloside; Electron Transport Complex IV; Kinetics; Male; Membr | 1994 |
Acetyl-L-carnitine prevents age-dependent structural alterations in rat peripheral nerves and promotes regeneration following sciatic nerve injury in young and senescent rats.
Topics: Acetylcarnitine; Aging; Animals; Male; Nerve Crush; Nerve Regeneration; Peripheral Nerves; Rats; Rat | 1994 |
Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria.
Topics: Acetylcarnitine; Adenosine Diphosphate; Aging; Animals; Electron Transport Complex IV; Kinetics; Mal | 1994 |
Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection.
Topics: Acetylcarnitine; Aging; Animals; Autonomic Pathways; Basal Ganglia; Brain Chemistry; Choline O-Acety | 1994 |
Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats.
Topics: Acetylcarnitine; Adenylyl Cyclases; Aging; Animals; Brain; Carbachol; Cerebral Cortex; Dopamine; Mal | 1993 |
Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Cardiolipins; Carnitine Acyltransferases; Fatty Acids; Male; Mitoch | 1995 |
Age- and trauma-dependent modifications of neuromuscular junction and skeletal muscle structure in the rat. Effects of long-term treatment with Acetyl-L-Carnitine.
Topics: Acetylcarnitine; Aging; Animals; Male; Muscle, Skeletal; Neuromuscular Junction; Rats; Rats, Sprague | 1995 |
Involvement of cytokine gene expression in the age-dependent decline of NK cell response.
Topics: Acetylcarnitine; Aging; Animals; Concanavalin A; Cytokines; Female; Gene Expression; Interferons; In | 1996 |
Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.
Topics: Acetylcarnitine; Administration, Oral; Aging; Animals; Male; Mitochondria, Liver; Motor Activity; Ox | 1998 |
Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone.
Topics: Acetylcarnitine; Aging; Animals; Cells, Cultured; Cyclic N-Oxides; Dietary Supplements; Fluoresceins | 1998 |
Reduction in the MK-801 binding sites of the NMDA sub-type of glutamate receptor in a mouse model of congenital hyperammonemia: prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; Amino Acid Metabolism, Inborn Errors; Ammonia; Anima | 1999 |
The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria.
Topics: Acetylcarnitine; Aging; Animals; Male; Mitochondria, Heart; Nootropic Agents; Oxidation-Reduction; P | 1999 |
Biologic activity of mitochondrial metabolites on aging and age-related hearing loss.
Topics: Acetylcarnitine; Aging; Animals; Auditory Threshold; Biological Transport; Cell Membrane; Cochlear N | 2000 |
Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31P NMR spectroscopy.
Topics: Acetylcarnitine; Aging; Animals; Brain; Lipid Metabolism; Lipids; Magnetic Resonance Spectroscopy; M | 2000 |
Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.
Topics: Acetylcarnitine; Aging; Animals; Brain; Glutathione Peroxidase; Glutathione Transferase; Lipid Perox | 2001 |
Acetyl-L-carnitine treatment stimulates oxygen consumption and biosynthetic function in perfused liver of young and old rats.
Topics: Acetyl-CoA C-Acyltransferase; Acetylcarnitine; Aging; Animals; Glucose; Keto Acids; Liver; Male; Mit | 2001 |
Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats.
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Aging; Animals; Cerebral Cortex; Cholinergic Fibe | 2001 |
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.
Topics: Acetylcarnitine; Aging; Aldehydes; Animals; Antioxidants; Brain; Breast; Carnitine O-Acetyltransfera | 2002 |
Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats.
Topics: Acetylcarnitine; Aging; Analysis of Variance; Animals; Basal Metabolism; Body Composition; Energy Me | 2002 |
Lipid oxidation by heart mitochondria from young adult and senescent rats.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Fatty Acids; In Vitro Techniques; Kinetics; Lipid Metabo | 1978 |
Morphological and electrophysiological changes of peripheral nerve-muscle unit in the aged rat prevented by levocarnitine acetyl.
Topics: Acetylcarnitine; Aging; Animals; Male; Nerve Fibers; Neural Conduction; Neuromuscular Junction; Peri | 1992 |
Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Cell Survival; Dose-Response Relationship, Drug; Nerve Growth Facto | 1992 |
Culture of dorsal root ganglion neurons from aged rats: effects of acetyl-L-carnitine and NGF.
Topics: Acetylcarnitine; Aging; Animals; Cells, Cultured; Ganglia, Spinal; Immunohistochemistry; Male; Nerve | 1992 |
Active avoidance learning in old rats chronically treated with levocarnitine acetyl.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Cluster Analysis; Male; Rats; Rats, Inbred Stra | 1992 |
The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria.
Topics: Acetylcarnitine; Aging; Animals; Biological Transport; Carrier Proteins; Kinetics; Male; Membrane Pr | 1992 |
Spatial memory in aged rats: population heterogeneity and effect of levocarnitine acetyl.
Topics: Acetylcarnitine; Aging; Animals; Male; Memory; Rats; Rats, Inbred Strains; Space Perception | 1992 |
Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging.
Topics: Acetylcarnitine; Aging; Animals; Citrate (si)-Synthase; Corpus Striatum; Electron Transport Complex | 1991 |
Multivariate data analysis in biochemistry: a new integrative approach to metabolic control in brain aging.
Topics: Acetylcarnitine; Aging; Animals; Brain; Energy Metabolism; Magnetic Resonance Spectroscopy; Male; Mu | 1991 |
Effect of acetyl-L-carnitine on the dopaminergic system in aging brain.
Topics: Acetylcarnitine; Aging; Amino Acids; Animals; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; | 1991 |
Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats.
Topics: Acetylcarnitine; Aging; Animals; Brain; Choline O-Acetyltransferase; Corpus Striatum; Immunohistoche | 1991 |
Pituitary-adrenocortical and pineal activities in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Adrenal Cortex; Aging; Animals; Male; Melatonin; Pineal Gland; Pituitary-Adrenal Sy | 1991 |
In vivo probing of the brain cholinergic system in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholine; Aging; Analysis of Variance; Animals; Atropine; Hippocampus; Male; P | 1991 |
Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy.
Topics: Acetylcarnitine; Aging; Animals; Brain; Energy Metabolism; Hydrogen; Magnetic Resonance Spectroscopy | 1990 |
Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Blotting, Northern; Brain; Carnitine; DNA; Electron Transport Compl | 1990 |
Measurement of L-carnitine and acylcarnitines in body fluids and tissues in children and in adults.
Topics: Acetylcarnitine; Adult; Aging; Carnitine; Carnitine O-Acetyltransferase; Child; Female; Humans; Live | 1990 |
Age-dependent deficits in radial maze performance in the rat: effect of chronic treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Exploratory Behavior; Learning; Male; Rats; Rats, Inbred | 1990 |
Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Cholesterol; Erythrocytes; Lipids; Phospholipids; Plasma | 1990 |
Differential effect of acetyl-l-carnitine on open field behavior in young and old rats.
Topics: Acetylcarnitine; Aging; Animals; Arousal; Brain; Carnitine; Emotions; Male; Motor Activity; Rats; Ra | 1990 |
Immunological parameters in aging: studies on natural immunomodulatory and immunoprotective substances.
Topics: Acetylcarnitine; Adult; Aged; Aged, 80 and over; Aging; Carnitine; Female; Free Radicals; Hemaggluti | 1990 |
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions.
Topics: Acetylcarnitine; Acetylcholinesterase; Aging; Animals; Brain; Carnitine; Choline; Choline O-Acetyltr | 1989 |
L-acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors | 1989 |
Age-related changes of the mossy fibre system in rat hippocampus: effect of long term acetyl-L-carnitine treatment.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Histocytochemistry; Male; Rats; Rats, Inbre | 1989 |
Age-dependent decrease of carnitine content in muscle of mice and humans.
Topics: Acetylcarnitine; Acylation; Adult; Aged; Aging; Animals; Brain; Carnitine; Carnitine O-Acetyltransfe | 1989 |
Long-term acetyl-L-carnitine preserves spatial learning in the senescent rat.
Topics: Acetylcarnitine; Aging; Animals; Avoidance Learning; Carnitine; Male; Rats; Rats, Inbred Strains; Sw | 1989 |
Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Corticosterone; Female; Hippocampus; Rats; Rats, Inbred | 1989 |
Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Male; Nerve Growth Factors; Rats; Rats, Inbred St | 1988 |
Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Cerebellum; Male; Membrane Proteins; Mitochondria; Rats; | 1988 |
Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Behavior, Animal; Body Weight; Brain; Carnitine; Histocytochemistry | 1988 |
Effect of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain.
Topics: Acetylcarnitine; Aging; Animals; Brain; Carnitine; Cerebellar Cortex; Cerebral Cortex; Female; Hippo | 1988 |
Pathological brain ageing: evaluation of the efficacy of a pharmacological aid.
Topics: Acetylcarnitine; Aged; Aging; Carnitine; Female; Humans; Male; Middle Aged; Neurocognitive Disorders | 1988 |
Effect of acetyl-l-carnitine chronic treatment on discrimination models in aged rats.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Discrimination Learning; Female; Rats; Rats, Inbred Stra | 1988 |
Effects of L-acetylcarnitine treatment and its interruption on dentate gyrus synapses in ageing rat hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Hippocampus; Microscopy, Electron; Rats; Synapses | 1988 |
Ultrastructural aspects of ageing rat hippocampus and effects of L-acetyl-carnitine treatment.
Topics: Acetylcarnitine; Aging; Animals; Axons; Carnitine; Hippocampus; Microscopy, Electron; Rats; Synapses | 1987 |
Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus.
Topics: Acetylcarnitine; Aging; Animals; Carnitine; Female; Hippocampus; In Vitro Techniques; Mitochondria; | 1986 |