Page last updated: 2024-10-15

acetylcarnitine and Acoustic Trauma

acetylcarnitine has been researched along with Acoustic Trauma in 5 studies

Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.

Acoustic Trauma: Usually refer to hearing loss due to a single noise event such as an explosion or shotgun blast.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rajguru, R1
Du, X1
Chen, K1
Choi, CH1
Li, W1
Cheng, W1
Stewart, C1
Hu, N1
Floyd, RA1
Kopke, RD3
Coleman, JK3
Liu, J3
Campbell, KC1
Riffenburgh, RH1
Kopke, R1
Bielefeld, E1
Zheng, J1
Jackson, R1
Henderson, D1
Ge, X1
Harper, EA1
Jones, GE1
Cater, TL1
Jackson, RL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antioxidation Medication for Noise-induced Hearing Loss[NCT00552786]Phase 253 participants (Actual)Interventional2007-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Temporary Threshold Changes Measurement by Distortion Product Otoacoustic Emissions (DPOAE) (A Total of Four Hearing Assessments Were Completed for Each Formulation Period on the 1st Day Pre- and Post-shift, and the 14th Day Pre- and Post-shift)

Distortion product otoacoustic emissions (DPOAE) is an objective measure to assess the cochlear changes. DPOAE response threshold at high frequency (HF) was defined as the average of response levels (dB SPL) at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by DPOAE were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of DPOAE temporary threshold change was calculated by subtracting the pre-shift DPOAE response threshold from the post-shift DPOAE response threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift

Interventiondecibels (dB SPL) (Mean)
N-acetylcysteine (NAC)-0.85
Placebo-0.89

Temporary Threshold Shift Measurement by Pure Tone Audiometry (A Total of Four Hearing Assessments Were Completed for Each Formulation Period on the 1st Day Pre- and Post-shift, and the 14th Day Pre- and Post-shift)

The hearing threshold level (HL) at high frequency (HF) by pure-tone audiometry (PTA) was defined as the average of HLs at 3k,4k,6kHz for each ear examined. A total of four hearing assessments by PTA were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift. The amount of temporary threshold change was calculated by subtracting the pre-shift hearing threshold from the post-shift hearing threshold at each frequency. (NCT00552786)
Timeframe: A total of four hearing assessments were completed for each formulation period on the 1st day pre- and post-shift, and the 14th day pre- and post-shift

Interventiondecibels (Mean)
N-acetylcysteine (NAC)3.4
Placebo2.7

Reviews

1 review available for acetylcarnitine and Acoustic Trauma

ArticleYear
Military aircrew and noise-induced hearing loss: prevention and management.
    Aviation, space, and environmental medicine, 2013, Volume: 84, Issue:12

    Topics: Acetylcarnitine; Acetylcysteine; Aerospace Medicine; Aircraft; Anti-Inflammatory Agents; Antioxidant

2013

Other Studies

4 other studies available for acetylcarnitine and Acoustic Trauma

ArticleYear
Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment.
    Hearing research, 2012, Volume: 283, Issue:1-2

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Auditory Threshold; Biomarkers; Chinchilla;

2012
Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss.
    The Laryngoscope, 2002, Volume: 112, Issue:9

    Topics: Acetylcarnitine; Analysis of Variance; Animals; Audiometry; Auditory Threshold; Chinchilla; Cochlea;

2002
Prevention of impulse noise-induced hearing loss with antioxidants.
    Acta oto-laryngologica, 2005, Volume: 125, Issue:3

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Chinchilla; Disease Models, Animal; Evoked P

2005
Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine.
    Hearing research, 2007, Volume: 226, Issue:1-2

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Antioxidants; Auditory Threshold; Chinchilla; Female; Hair

2007