acetovanillone has been researched along with Parkinson Disease in 7 studies
apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral administration of Mito-apocynin (10 mg/kg, thrice a week) showed excellent central nervous system bioavailability and significantly improved locomotor activity and coordination in MitoPark mice." | 1.46 | Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. ( Anantharam, V; Ay, M; Bennett, B; Brenza, T; Charli, A; Ghaisas, S; Ghosh, A; Jin, H; Kalyanaraman, B; Kanthasamy, A; Kanthasamy, AG; Kim, D; Langley, M; Luo, J; Narasimhan, B; Sarkar, S; Schlichtmann, B; Zielonka, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Nascimento, ALF | 1 |
| Medeiros, POS | 1 |
| Pedrão, LFAT | 1 |
| Queiroz, VC | 1 |
| Oliveira, LM | 1 |
| Novaes, LS | 1 |
| Caetano, AL | 1 |
| Munhoz, CD | 1 |
| Takakura, AC | 1 |
| Falquetto, B | 1 |
| Langley, M | 1 |
| Ghosh, A | 1 |
| Charli, A | 1 |
| Sarkar, S | 1 |
| Ay, M | 1 |
| Luo, J | 1 |
| Zielonka, J | 2 |
| Brenza, T | 1 |
| Bennett, B | 1 |
| Jin, H | 1 |
| Ghaisas, S | 1 |
| Schlichtmann, B | 1 |
| Kim, D | 1 |
| Anantharam, V | 1 |
| Kanthasamy, A | 1 |
| Narasimhan, B | 1 |
| Kalyanaraman, B | 2 |
| Kanthasamy, AG | 2 |
| Hou, L | 2 |
| Sun, F | 2 |
| Huang, R | 1 |
| Sun, W | 1 |
| Zhang, D | 1 |
| Wang, Q | 2 |
| Dranka, BP | 1 |
| Gifford, A | 1 |
| McAllister, D | 1 |
| Joseph, J | 1 |
| O'Hara, CL | 1 |
| Stucky, CL | 1 |
| Sharma, N | 1 |
| Nehru, B | 1 |
| Zhang, C | 1 |
| Wang, K | 1 |
| Liu, X | 1 |
| Wang, H | 1 |
| Che, Y | 1 |
| Zhou, X | 1 |
| Zhao, X | 1 |
| Gao, HM | 1 |
| Liu, B | 1 |
| Hong, JS | 1 |
7 other studies available for acetovanillone and Parkinson Disease
| Article | Year |
|---|---|
Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drinking Water; NADPH Oxidases; Oxidative Str | 2022 |
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.
Topics: Acetophenones; Administration, Oral; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; | 2017 |
Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model.
Topics: Acetophenones; Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dopaminergic Neur | 2019 |
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Topics: Acetophenones; Animals; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice, Transgenic; Mit | 2014 |
Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Cytokines; Disease Models, Animal; Dopaminer | 2016 |
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation.
Topics: Acetophenones; Adrenergic Neurons; Animals; Disease Models, Animal; Enzyme Inhibitors; Locus Coerule | 2017 |
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
Topics: Acetophenones; Animals; Cells, Cultured; Coculture Techniques; Dopamine; Drug Resistance; Enzyme Inh | 2003 |