acetovanillone has been researched along with Hypoxia in 17 studies
apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor apocynin on the enhanced hypoxia induced factor-1α (HIF-1α) and endothelin-1 (ET-1) expression, elevated systolic blood pressure under chronic intermittent hypoxia (CIH) condition and its action mechanism were investigated." | 7.79 | Effect of NADPH oxidase inhibitor apocynin on the expression of hypoxia-induced factor-1α and endothelin-1 in rat carotid body exposed to chronic intermittent hypoxia. ( Deng, Y; Liu, HG; Liu, K; Liu, X; Shang, J; Xu, YJ; Yang, XH, 2013) |
| "The effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor apocynin on the enhanced hypoxia induced factor-1α (HIF-1α) and endothelin-1 (ET-1) expression, elevated systolic blood pressure under chronic intermittent hypoxia (CIH) condition and its action mechanism were investigated." | 3.79 | Effect of NADPH oxidase inhibitor apocynin on the expression of hypoxia-induced factor-1α and endothelin-1 in rat carotid body exposed to chronic intermittent hypoxia. ( Deng, Y; Liu, HG; Liu, K; Liu, X; Shang, J; Xu, YJ; Yang, XH, 2013) |
| "The PK parameters and concentrations of rhein in the kidney, liver, heart and testes were significantly altered under hypoxia, accompanied with a reduced MnSOD and upregulated NOX compared with the normal." | 3.79 | Hypoxia alters pharmacokinetics of argirein because of mitochondrial dysfunction that is alleviated by apocynin. ( Cong, XD; Dai, DZ; Dai, Y; Gao, J; Yu, F; Zhang, YM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Drummond, SE | 1 |
| Burns, DP | 1 |
| El Maghrani, S | 1 |
| Ziegler, O | 1 |
| Healy, V | 1 |
| O'Halloran, KD | 1 |
| Liu, X | 1 |
| Deng, Y | 1 |
| Shang, J | 1 |
| Yang, XH | 1 |
| Liu, K | 2 |
| Liu, HG | 2 |
| Xu, YJ | 2 |
| Zhang, YM | 1 |
| Yu, F | 1 |
| Dai, DZ | 1 |
| Gao, J | 1 |
| Cong, XD | 1 |
| Dai, Y | 1 |
| Zhang, J | 1 |
| Malik, A | 1 |
| Choi, HB | 1 |
| Ko, RW | 1 |
| Dissing-Olesen, L | 1 |
| MacVicar, BA | 1 |
| Yin, X | 1 |
| Li, B | 1 |
| Zhao, Y | 1 |
| Sun, W | 1 |
| Zheng, Y | 1 |
| Nichols, NL | 1 |
| Satriotomo, I | 1 |
| Harrigan, DJ | 1 |
| Mitchell, GS | 1 |
| Zhang, M | 1 |
| Wu, J | 1 |
| Huo, L | 1 |
| Luo, L | 1 |
| Song, X | 1 |
| Fan, F | 1 |
| Lu, Y | 1 |
| Liang, D | 1 |
| Zhu, X | 1 |
| Gao, Q | 1 |
| Tu, Q | 1 |
| Zhong, Y | 1 |
| Zhu, D | 1 |
| Mao, C | 1 |
| Xu, Z | 1 |
| Morgan, BJ | 1 |
| Bates, ML | 1 |
| Rio, RD | 1 |
| Wang, Z | 1 |
| Dopp, JM | 1 |
| Jun, J | 1 |
| Savransky, V | 1 |
| Nanayakkara, A | 1 |
| Bevans, S | 1 |
| Li, J | 1 |
| Smith, PL | 1 |
| Polotsky, VY | 1 |
| Zhou, YN | 1 |
| Sampath, V | 1 |
| Radish, AC | 1 |
| Eis, AL | 1 |
| Broniowska, K | 1 |
| Hogg, N | 1 |
| Konduri, GG | 1 |
| Hui-guo, L | 1 |
| Kui, L | 1 |
| Yan-ning, Z | 1 |
| Yong-jian, X | 1 |
| Mittal, M | 1 |
| Gu, XQ | 1 |
| Pak, O | 1 |
| Pamenter, ME | 1 |
| Haag, D | 1 |
| Fuchs, DB | 1 |
| Schermuly, RT | 1 |
| Ghofrani, HA | 1 |
| Brandes, RP | 1 |
| Seeger, W | 2 |
| Grimminger, F | 2 |
| Haddad, GG | 1 |
| Weissmann, N | 2 |
| Al-Shabrawey, M | 1 |
| Bartoli, M | 1 |
| El-Remessy, AB | 1 |
| Platt, DH | 1 |
| Matragoon, S | 1 |
| Behzadian, MA | 1 |
| Caldwell, RW | 1 |
| Caldwell, RB | 1 |
| Yenari, MA | 1 |
| Xu, L | 1 |
| Tang, XN | 1 |
| Qiao, Y | 1 |
| Giffard, RG | 1 |
| Spriestersbach, R | 1 |
| Becker, E | 1 |
| Rosseau, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Minocycline on Patients With Acute Anterior Circulation Ischemic Stroke Undergoing Intravenous Thrombectomy[NCT05487417] | Phase 4 | 180 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for acetovanillone and Hypoxia
| Article | Year |
|---|---|
Chronic Intermittent Hypoxia-Induced Diaphragm Muscle Weakness Is NADPH Oxidase-2 Dependent.
Topics: Animals; Diaphragm; Hypoxia; Male; Mice; Mice, Inbred C57BL; Muscle Weakness; NADPH Oxidase 2 | 2023 |
Effect of NADPH oxidase inhibitor apocynin on the expression of hypoxia-induced factor-1α and endothelin-1 in rat carotid body exposed to chronic intermittent hypoxia.
Topics: Acetophenones; Animals; Antioxidants; Carotid Body; Endothelin-1; Hypoxia; Hypoxia-Inducible Factor | 2013 |
Hypoxia alters pharmacokinetics of argirein because of mitochondrial dysfunction that is alleviated by apocynin.
Topics: Acetophenones; Animals; Anthraquinones; Anti-Inflammatory Agents; Arginine; Drug Combinations; Endop | 2013 |
Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.
Topics: Acetophenones; Animals; Animals, Newborn; CD11b Antigen; Enzyme Inhibitors; Excitatory Amino Acid An | 2014 |
[Protective effects of antioxidants on chronic intermittent hypoxia-induced cardiac remodeling in mice].
Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Heart; Hypoxia; Mice; Mice, | 2014 |
Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS.
Topics: Acetophenones; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Anti-Inflammatory Agents, Non-St | 2015 |
Environmental Enrichment Prevent the Juvenile Hypoxia-Induced Developmental Loss of Parvalbumin-Immunoreactive Cells in the Prefrontal Cortex and Neurobehavioral Alterations Through Inhibition of NADPH Oxidase-2-Derived Oxidative Stress.
Topics: Acetophenones; Animals; Anxiety; Behavior, Animal; Environment; Hypoxia; Male; NADPH Oxidases; Oxida | 2016 |
Prenatal hypoxia enhanced angiotensin II-mediated vasoconstriction via increased oxidative signaling in fetal rats.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Body Weight; Cyclic N-Oxides; | 2016 |
Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia.
Topics: Acetophenones; Allopurinol; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antioxidants; Bod | 2016 |
Intermittent hypoxia has organ-specific effects on oxidative stress.
Topics: Acetophenones; Animals; Body Weight; Eating; Enzyme Inhibitors; Erythrocytes; Glutathione; Glutathio | 2008 |
[Effect of NADPH oxidase activity inhibitor apocynin on blood pressure in rats exposed to chronic intermittent hypoxia and the possible mechanisms].
Topics: Acetophenones; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Hypoxia; Male; NADPH Oxidas | 2008 |
Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia.
Topics: Acetophenones; Animals; Apoptosis; Bronchopulmonary Dysplasia; Cell Proliferation; Cells, Cultured; | 2009 |
Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia.
Topics: Acetophenones; Animals; Blotting, Western; Hippocampus; Hypoxia; In Situ Nick-End Labeling; Male; Ma | 2010 |
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.
Topics: Acetophenones; Animals; Cells, Cultured; Hypertension, Pulmonary; Hypoxia; Kv1.5 Potassium Channel; | 2012 |
Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy.
Topics: Acetophenones; Animals; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; | 2005 |
Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro.
Topics: Acetophenones; Animals; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain; Brain Ischemia; Cell D | 2006 |
Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs.
Topics: Acetophenones; Animals; Buffers; Female; Hypoxia; In Vitro Techniques; Lung; Male; NADH, NADPH Oxido | 1995 |