acetovanillone and Disease Models, Animal studies

acetovanillone and Disease Models, Animal

apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
" The present study aimed to evaluate the chemopreventive effects of resveratrol (RV) and apocynin (AC) in N-Nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamster."	7.81	Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2. ( Hayashi, K; Hori, Y; Joh, T; Kato, A; Kato, H; Kondo, H; Kuno, T; Miyabe, K; Mori, T; Naiki-Ito, A; Naitoh, I; Nakazawa, T; Nishi, Y; Ohara, H; Shimizu, S; Suzuki, S; Takahashi, S; Tsutsumi, M; Umemura, S; Yoshida, M, 2015)
"The present study aimed to investigate the possible mechanism(s) through which lycopene inhibits neointimal hyperplasia in restenosis models."	7.80	Lycopene inhibits neointimal hyperplasia through regulating lipid metabolism and suppressing oxidative stress. ( He, R; Lei, H; Liu, Q; Mao, M; Zhang, N; Zhou, C; Zuo, Z, 2014)
"Moderate (approximately 2-fold) increases in plasma unconjugated bilirubin levels are able to attenuate the development of angiotensin II (Ang II)-dependent hypertension."	7.79	Antihypertensive actions of moderate hyperbilirubinemia: role of superoxide inhibition. ( Gousset, MU; Pruett, BE; Stec, DE; Storm, MV, 2013)
"Enalapril prevented the increase in heart weight index (HWI), carotid cross-sectional area (CSA) and albuminuria induced by Ang II."	5.33	Prevention and reversal by enalapril of target organ damage in angiotensin II hypertension. ( Cordaillat, M; Jover, B; Mimran, A; Rugale, C, 2005)
"In the histological examination, on the 3rd, 7th and 21st days, inflammation was found to be reduced in the groups given taurine and apocynin on the 3rd day."	4.12	Effects of taurine and apocynin on the zone of stasis. ( Abbas Ali Noma, S; Fırat, C; Öcük, Ö; Özhan, O; Parlakpınar, H; Ulu, A; Vardı, N; Yıldız, A, 2022)
" The strong inhibitory activity of compound 55 against an in vivo colitis model was confirmed by its dose-dependent inhibitory activity in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, demonstrating compound 55 as a new potential candidate for the development of therapeutics against IBD."	3.85	Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. ( Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB, 2017)
"We determined effects of the NADPH oxidase (NOX) inhibitor apocynin (APO) or the antioxidant enzymatically modified isoquercitrin (EMIQ) on an early stage of hepatocarcinogenesis in the liver with steatosis."	3.85	Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats. ( Abe, H; Hayashi, SM; Kangawa, Y; Kawashima, M; Kimura, M; Mizukami, S; Murayama, H; Nagahara, R; Shibutani, M; Yoshida, T, 2017)
" The present study aimed to evaluate the chemopreventive effects of resveratrol (RV) and apocynin (AC) in N-Nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamster."	3.81	Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2. ( Hayashi, K; Hori, Y; Joh, T; Kato, A; Kato, H; Kondo, H; Kuno, T; Miyabe, K; Mori, T; Naiki-Ito, A; Naitoh, I; Nakazawa, T; Nishi, Y; Ohara, H; Shimizu, S; Suzuki, S; Takahashi, S; Tsutsumi, M; Umemura, S; Yoshida, M, 2015)
"Sepsis resulted in cognitive impairments, which was accompanied by selective phenotype loss of PV interneurons and increased gp91(phox), 4-hydroxynonenal, malondialdehyde, IL-1β, and IL-6 expressions."	3.81	Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice. ( Ji, MH; Jia, M; Ju, LS; Qiu, LL; Shen, JC; Sun, XR; Tang, H; Yang, JJ; Zhang, H; Zuo, ZY, 2015)
"The present study aimed to investigate the possible mechanism(s) through which lycopene inhibits neointimal hyperplasia in restenosis models."	3.80	Lycopene inhibits neointimal hyperplasia through regulating lipid metabolism and suppressing oxidative stress. ( He, R; Lei, H; Liu, Q; Mao, M; Zhang, N; Zhou, C; Zuo, Z, 2014)
"Moderate (approximately 2-fold) increases in plasma unconjugated bilirubin levels are able to attenuate the development of angiotensin II (Ang II)-dependent hypertension."	3.79	Antihypertensive actions of moderate hyperbilirubinemia: role of superoxide inhibition. ( Gousset, MU; Pruett, BE; Stec, DE; Storm, MV, 2013)
"67 Mb heterozygous deletion including the Eln gene, presented with a generalized arteriopathy, hypertension, and cardiac hypertrophy, associated with elevated angiotensin II (angII), oxidative stress parameters, and Ncf1 expression."	3.78	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome. ( Bustelo, XR; Campuzano, V; Coustets, M; Francke, U; Menacho-Márquez, M; Nevado, J; Pérez-Jurado, LA; Sánchez-Rodríguez, C; Segura-Puimedon, M; Terrado, V, 2012)
"To examine the hypothesis that NAD(P)H oxidase (Nox)-derived superoxide generation is involved in the development of angiotensin II (ANG II)-induced hypertension, we evaluated the responses to ANG II infusion (65 ng/min; osmotic mini-pump) for 2 weeks in rats treated with or without apocynin (APO) (inhibitor of Nox subunits assembly) in drinking water (12 mmol/L)."	3.73	Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. ( Majid, DS; Pech, V; Sikka, SC; Sindhu, RK; Vaziri, ND, 2006)
"We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension."	3.72	Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. ( Chen, AF; Fink, GD; Hesslinger, C; Kapatos, G; Kovesdi, I; Lookingland, KJ; Yang, XQ; Zheng, JS, 2003)
"Liver fibrosis is the reversible deposition of extracellular matrix (ECM) and scar formation after liver damage by various stimuli."	1.56	Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. ( Huang, C; Liu, C; Luo, F; Luo, Q; Wan, S; Zhu, X, 2020)
"Oral administration of Mito-apocynin (10 mg/kg, thrice a week) showed excellent central nervous system bioavailability and significantly improved locomotor activity and coordination in MitoPark mice."	1.46	Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. ( Anantharam, V; Ay, M; Bennett, B; Brenza, T; Charli, A; Ghaisas, S; Ghosh, A; Jin, H; Kalyanaraman, B; Kanthasamy, A; Kanthasamy, AG; Kim, D; Langley, M; Luo, J; Narasimhan, B; Sarkar, S; Schlichtmann, B; Zielonka, J, 2017)
"Stroke is a universal cause of death and permanent disability."	1.46	Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. ( Bai, H; Feng, D; Gao, L; Guo, H; Jiang, H; Li, X; Liu, H; Qu, Y; Wang, B; Yue, L; Zhao, L, 2017)
"Oxidative stress is increased in COPD, IAV-induced lung inflammation and AECOPD."	1.43	Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice. ( Bozinovski, S; Gunasinghe, P; Oostwoud, LC; Selemidis, S; Seow, HJ; Vlahos, R; Ye, JM, 2016)
"Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression."	1.43	Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. ( César-Gomes, CJ; Da Fonseca, LJ; Guedes, Gda S; Nunes-Souza, V; Rabelo, LA; Smaniotto, S, 2016)
"Post-traumatic stress disorder (PTSD) is a common psychiatric disease following exposure to a severe traumatic event or physiological stress, yet the precise mechanisms underlying PTSD remains largely to be determined."	1.43	NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder. ( Ji, MH; Liu, FF; Pan, W; Sun, XR; Wang, XM; Yang, JJ; Yang, LD; Yuan, HM; Zhang, H, 2016)
"Hyperoxaluria was induced in male Wistar rats by administering 0."	1.43	Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin. ( Kaur, T; Sharma, M; Singla, SK, 2016)
" Mito-Apo showed excellent brain bioavailability and also markedly attenuated MPTP-induced oxidative markers in the substantia nigra (SN)."	1.43	Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. ( Anantharam, V; Brenza, T; Ghosh, A; Harischandra, DS; Jin, H; Joseph, J; Kalyanaraman, B; Kanthasamy, A; Kanthasamy, AG; Langley, MR; Narasimhan, B; Neal, ML, 2016)
"Obesity is a risk factor for colorectal cancer."	1.42	Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice. ( Fujii, G; Fujimoto, K; Ishigamori, R; Ishino, K; Komiya, M; Miyamoto, S; Mutoh, M; Onuma, W; Takahashi, M; Totsuka, Y, 2015)
"Type 4 cardiorenal syndrome (CRS) refers to the cardiac injury induced by chronic kidney disease."	1.42	Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition. ( Chen, J; Huang, F; Huang, H; Liu, X; Liu, Y; Tang, W; Wang, JF; Zhang, K, 2015)
"Sepsis was induced in WT and gp91(phox) knockout mice (gp91(phox-/-)) by cecal ligation and puncture (CLP) to induce fecal peritonitis."	1.40	The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. ( Bozza, FA; Britto, LR; Castro-Faria-Neto, HC; Cunha, FQ; D'Avila, JC; Hernandes, MS; Kinjo, ER; Lopes, LR; Reis, PA; Trevelin, SC, 2014)
"Preeclampsia is associated with oxidative stress, which is suspected to play a role in hypertension, placental ischemia, and fetal demise associated with the disease."	1.40	CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia. ( Chatman, K; Cornelius, DC; Heath, J; LaMarca, B; Moseley, J; Scott, J; Wallace, K, 2014)
"Chronic neuropathic pain is a common consequence of spinal cord injury (SCI), develops over time and negatively impacts quality of life, often leading to substance abuse and suicide."	1.40	Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. ( Hassler, SN; Hulsebosch, CE; Johnson, KM, 2014)
"Kidney fibrosis is a typical feature of chronic kidney disease and is characterized as an expansion of the interstitium due to increases in extracellular matrix molecules and interstitial cells caused by accumulations of extrarenal cells and by the proliferation or differentiation of intrarenal cells."	1.40	Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis. ( Han, SJ; Jang, HS; Kim, JI; Park, KM, 2014)
"Treatment with MitoTEMPO reduced sudden cardiac death in ACE8/8 mice (from 74% to 18%; P<0."	1.39	Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. ( Arasu, D; Bonini, MG; Dolmatova, E; Dudley, SC; Duffy, HS; Gu, L; Jeong, EM; Liu, H; Rutledge, CA; Sovari, AA; Vahdani, N; Xiao, L; Zandieh, S, 2013)
"Pilocarpine-induced seizure increased p47 immunofluorescence in the plasma membrane of hippocampal neurons at 12h post-insult and apocynin treatment prevented this increase."	1.39	Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death. ( Choi, BY; Choi, HC; Chung, TN; Jang, BG; Kim, HS; Kim, JH; Sohn, M; Song, HK; Suh, SW, 2013)
"Treatment with diapocynin also significantly improved locomotor activity, restored dopamine and its metabolites, and protected dopaminergic neurons and their nerve terminals in this pre-clinical model of PD."	1.38	Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. ( Anantharam, V; Dranka, BP; Ghosh, A; Joseph, J; Kalyanaraman, B; Kanthasamy, A; Kanthasamy, AG; Srivastava, P, 2012)
"The development of S1P-induced hyperalgesia was blocked by apocynin, a NADPH oxidase inhibitor; N(G)-nitro-l-arginine methyl ester, a nonselective NOS inhibitor; and by the potent PN decomposition catalysts (FeTM-4-PyP(5+) and MnTE-2-PyP(5+))."	1.37	Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. ( Chen, Z; Doyle, T; Finley, A; Salvemini, D, 2011)
" This was associated with improved nitric oxide (NO) bioavailability and protection against oxLDL-induced inhibition of angiogenic activities."	1.37	Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells. ( Dussault, S; Groleau, J; Haddad, P; Maingrette, F; Rivard, A; Turgeon, J, 2011)
"Diabetic EPCs demonstrate reduced eNOS expression and decreased NO bioavailability and migration in response to SDF-1α."	1.37	Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. ( Caballero, S; Grant, MB; Jarajapu, YP; Li, Q; Lo, MC; Nakagawa, T; Verma, A, 2011)
"Risk of intracerebral hemorrhage is the primary factor limiting use of tissue plasminogen activator (tPA) for stroke."	1.37	Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production. ( Suh, SW; Swanson, RA; Tang, XN; Won, SJ; Yenari, MA, 2011)
" Moreover, the administration of MK-801 to rats as a pretreatment resulted in a complete prevention of the QUIN-induced NAD(P)H activation, suggesting that this toxic event is completely dependent on N-methyl-D-aspartate receptor overactivation."	1.36	NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: protective role of apocynin. ( Galván-Arzate, S; Maldonado, PD; Molina-Jijón, E; Pedraza-Chaverrí, J; Santamaría, A; Villeda-Hernández, J, 2010)
"Enalapril prevented the increase in heart weight index (HWI), carotid cross-sectional area (CSA) and albuminuria induced by Ang II."	1.33	Prevention and reversal by enalapril of target organ damage in angiotensin II hypertension. ( Cordaillat, M; Jover, B; Mimran, A; Rugale, C, 2005)
"Global cerebral ischemia was induced in gerbils by a 5-min occlusion of bilateral common carotid arteries (CCA)."	1.33	Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. ( Korthuis, RJ; Simonyi, A; Sun, AY; Sun, GY; Tompkins, KD; Wang, Q, 2006)

Research

Studies (144)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.69)	18.2507
2000's	32 (22.22)	29.6817
2010's	93 (64.58)	24.3611
2020's	18 (12.50)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (0.69)

18.2507

2000's

32 (22.22)

29.6817

2010's

93 (64.58)

24.3611

2020's

18 (12.50)

2.80

Authors

Authors	Studies
Kadayat, TM	1
Banskota, S	1
Gurung, P	1
Bist, G	1
Thapa Magar, TB	1
Shrestha, A	1
Kim, JA	1
Lee, ES	1
Ozdemir, R	1
Gokce, IK	1
Tekin, S	1
Cetin Taslidere, A	1
Turgut, H	1
Tanbek, K	1
Gul, CC	1
Deveci, MF	1
Aslan, M	1
Öcük, Ö	1
Fırat, C	1
Yıldız, A	1
Vardı, N	3
Ulu, A	1
Abbas Ali Noma, S	1
Parlakpınar, H	3
Özhan, O	1
Nascimento, ALF	1
Medeiros, POS	1
Pedrão, LFAT	1
Queiroz, VC	1
Oliveira, LM	1
Novaes, LS	1
Caetano, AL	1
Munhoz, CD	1
Takakura, AC	1
Falquetto, B	1
Yang, Q	1
Chen, HY	1
Wang, JN	1
Han, HQ	1
Jiang, L	1
Wu, WF	1
Wei, B	1
Gao, L	2
Ma, QY	1
Liu, XQ	1
Chen, Q	2
Wen, JG	1
Jin, J	1
Huang, Y	1
Ni, WJ	1
Ma, TT	1
Li, J	1
Meng, XM	1
Yang, X	1
An, N	1
Zhong, C	1
Guan, M	1
Jiang, Y	1
Li, X	2
Zhang, H	6
Wang, L	2
Ruan, Y	1
Gao, Y	1
Liu, N	1
Shang, H	1
Xing, Y	1
Peng, X	1
Yang, Y	1
Tang, L	1
Wan, J	1
Dai, J	1
Li, L	1
Huang, J	1
Shen, Y	2
Lin, L	2
Gong, X	1
Zhang, L	1
Rana, P	1
Rama Rao, KV	1
Ravula, A	1
Trivedi, R	1
D'Souza, M	1
Singh, AK	1
Gupta, RK	1
Chandra, N	1
Wan, S	1
Luo, F	1
Huang, C	1
Liu, C	1
Luo, Q	1
Zhu, X	1
Liu, F	1
Fan, LM	1
Michael, N	1
Li, JM	1
Suzuki, S	2
Cohen, SM	1
Arnold, LL	1
Pennington, KL	1
Gi, M	1
Kato, H	2
Naiki, T	1
Naiki-Ito, A	2
Wanibuchi, H	1
Takahashi, S	2
Chia, TY	2
Murugaiyah, V	2
Sattar, MA	2
Khan, NAK	1
Ahmad, A	2
Abdulla, MH	2
Johns, EJ	2
Mei, HY	2
Akhtar, S	2
Ahmad, FU	2
Keskin, ER	1
Çakan, D	3
Khan, NA	1
Hassan, Z	1
Kaur, G	1
Dong, X	1
Jin, X	1
Chen, Y	3
Li, F	1
Wang, Y	2
Yu, X	1
Gu, J	1
Zhang, X	2
Zhou, B	1
Sun, Y	2
Xu, C	1
Qian, S	1
Langley, M	1
Ghosh, A	3
Charli, A	1
Sarkar, S	1
Ay, M	1
Luo, J	1
Zielonka, J	1
Brenza, T	2
Bennett, B	1
Jin, H	2
Ghaisas, S	1
Schlichtmann, B	1
Kim, D	1
Anantharam, V	3
Kanthasamy, A	3
Narasimhan, B	2
Kalyanaraman, B	3
Kanthasamy, AG	3
Yeh, TY	1
Tseng, GF	1
Tseng, CY	1
Huang, YH	1
Liu, PH	1
Nadeem, A	1
Siddiqui, N	1
Al-Harbi, NO	1
Attia, SM	1
AlSharari, SD	1
Ahmad, SF	1
Feng, Y	1
Cui, C	1
Liu, X	4
Wu, Q	1
Hu, F	1
Ma, Z	2
Guo, H	1
Zhao, L	1
Wang, B	1
Liu, H	3
Yue, L	1
Bai, H	1
Jiang, H	1
Feng, D	1
Qu, Y	1
Aras-López, R	1
Almeida, L	1
Andreu-Fernández, V	1
Tovar, J	1
Martínez, L	1
Feng, W	1
Zhang, K	3
Liu, Y	4
Chen, J	4
Cai, Q	2
He, W	1
Zhang, Y	2
Wang, MH	1
Wang, J	4
Huang, H	3
Montes-Rivera, JO	1
Tamay-Cach, F	1
Quintana-Pérez, JC	1
Guevara-Salazar, JA	1
Trujillo-Ferrara, JG	1
Del Valle-Mondragón, L	1
Arellano-Mendoza, MG	1
Starke, RM	1
Thompson, JW	1
Ali, MS	1
Pascale, CL	1
Martinez Lege, A	1
Ding, D	1
Chalouhi, N	1
Hasan, DM	1
Jabbour, P	1
Owens, GK	1
Toborek, M	1
Hare, JM	1
Dumont, AS	1
Cheng, L	1
Chen, L	1
Wei, X	1
Ren, Z	1
Zeng, S	1
Wen, H	1
Gao, C	1
Zhang, B	1
Bailey, WM	1
McVicar, AL	1
Stewart, AN	1
Veldhorst, AK	1
Gensel, JC	1
Köroğlu, KM	1
Çevik, Ö	1
Şener, G	1
Ercan, F	1
Hou, L	2
Sun, F	2
Huang, R	1
Sun, W	2
Zhang, D	1
Wang, Q	3
Reckelhoff, JF	1
Romero, DG	1
Yanes Cardozo, LL	1
Hwang, YJ	1
Nam, SJ	1
Chun, W	1
Kim, SI	1
Park, SC	1
Kang, CD	1
Lee, SJ	1
Oliveira, LB	1
Celes, FS	1
Paiva, CN	1
de Oliveira, CI	1
Stec, DE	1
Storm, MV	1
Pruett, BE	1
Gousset, MU	1
Sovari, AA	1
Rutledge, CA	1
Jeong, EM	1
Dolmatova, E	1
Arasu, D	1
Vahdani, N	1
Gu, L	1
Zandieh, S	1
Xiao, L	1
Bonini, MG	1
Duffy, HS	1
Dudley, SC	1
La Favor, JD	1
Anderson, EJ	1
Dawkins, JT	1
Hickner, RC	1
Wingard, CJ	1
Khanicheh, E	1
Qi, Y	1
Xie, A	1
Mitterhuber, M	1
Xu, L	1
Mochizuki, M	1
Daali, Y	1
Jaquet, V	2
Krause, KH	2
Ruggeri, ZM	1
Kuster, GM	1
Lindner, JR	1
Kaufmann, BA	1
Marín, M	1
Giner, RM	1
Ríos, JL	1
Recio, Mdel C	1
Schulz, R	1
Murzabekova, G	1
Egemnazarov, B	1
Kraut, S	1
Eisele, HJ	1
Dumitrascu, R	1
Heitmann, J	1
Seimetz, M	1
Witzenrath, M	1
Ghofrani, HA	1
Schermuly, RT	1
Grimminger, F	1
Seeger, W	1
Weissmann, N	1
Choi, DH	1
Lee, KH	1
Kim, JH	4
Seo, JH	1
Kim, HY	1
Shin, CY	1
Han, JS	1
Han, SH	1
Kim, YS	1
Lee, J	1
Hernandes, MS	1
D'Avila, JC	1
Trevelin, SC	1
Reis, PA	1
Kinjo, ER	1
Lopes, LR	1
Castro-Faria-Neto, HC	1
Cunha, FQ	1
Britto, LR	1
Bozza, FA	1
Lu, XY	1
Wang, HD	1
Xu, JG	1
Ding, K	1
Li, T	1
Khan, SR	1
Joshi, S	1
Wang, W	1
Peck, AB	1
Jang, HS	1
Kim, JI	1
Han, SJ	1
Park, KM	1
Mao, M	1
Lei, H	1
Liu, Q	1
He, R	1
Zuo, Z	1
Zhang, N	1
Zhou, C	1
Hassler, SN	1
Johnson, KM	1
Hulsebosch, CE	1
Feillet-Coudray, C	1
Fouret, G	1
Ebabe Elle, R	1
Rieusset, J	1
Bonafos, B	1
Chabi, B	1
Crouzier, D	1
Zarkovic, K	1
Zarkovic, N	1
Ramos, J	1
Badia, E	1
Murphy, MP	1
Cristol, JP	1
Coudray, C	1
Ramonaite, R	1
Skieceviciene, J	1
Juzenas, S	1
Salteniene, V	1
Kupcinskas, J	1
Matusevicius, P	1
Borutaite, V	1
Kupcinskas, L	1
Wallace, K	1
Cornelius, DC	1
Scott, J	1
Heath, J	1
Moseley, J	1
Chatman, K	1
LaMarca, B	1
Martins, JB	1
Chaudhary, AK	1
Jiang, S	1
Kwofie, M	1
Mackie, P	1
Miller, FJ	1
Kilic, T	1
Taslidere, E	1
Yildiz, S	1
Polat, A	1
Colak, C	1
Ermis, H	1
Yin, X	1
Li, B	1
Zhao, Y	1
Zheng, Y	1
Choi, BY	3
Kho, AR	1
Kim, IY	1
Lee, SH	1
Lee, BE	2
Choi, E	1
Sohn, M	3
Stevenson, M	1
Chung, TN	2
Kauppinen, TM	1
Suh, SW	4
Sharma, N	2
Nehru, B	2
Huang, F	1
Wang, JF	1
Tang, W	1
Nichols, NL	1
Satriotomo, I	1
Harrigan, DJ	1
Mitchell, GS	1
Komiya, M	1
Fujii, G	1
Miyamoto, S	1
Takahashi, M	2
Ishigamori, R	1
Onuma, W	1
Ishino, K	1
Totsuka, Y	1
Fujimoto, K	1
Mutoh, M	1
Kapoor, M	1
Ji, MH	3
Qiu, LL	1
Tang, H	1
Ju, LS	1
Sun, XR	3
Jia, M	1
Zuo, ZY	1
Shen, JC	1
Yang, JJ	3
Kato, A	1
Nakazawa, T	1
Hayashi, K	1
Naitoh, I	1
Miyabe, K	1
Shimizu, S	1
Kondo, H	1
Nishi, Y	1
Yoshida, M	1
Umemura, S	1
Hori, Y	1
Mori, T	1
Tsutsumi, M	1
Kuno, T	1
Ohara, H	1
Joh, T	1
Liu, FF	1
Yang, LD	1
Pan, W	1
Wang, XM	1
Yuan, HM	1
Sharma, M	1
Kaur, T	1
Singla, SK	1
Langley, MR	1
Harischandra, DS	1
Neal, ML	1
Joseph, J	2
Oostwoud, LC	1
Gunasinghe, P	1
Seow, HJ	1
Ye, JM	1
Selemidis, S	1
Bozinovski, S	1
Vlahos, R	1
Capogrosso, RF	1
Cozzoli, A	1
Mantuano, P	1
Camerino, GM	1
Massari, AM	1
Sblendorio, VT	1
De Bellis, M	1
Tamma, R	1
Giustino, A	1
Nico, B	1
Montagnani, M	1
De Luca, A	1
Nunes-Souza, V	1
César-Gomes, CJ	1
Da Fonseca, LJ	1
Guedes, Gda S	1
Smaniotto, S	1
Rabelo, LA	1
Zhang, ZZ	1
Zhao, HT	1
Li, HH	1
Li, KY	1
Ozer, MA	1
Polat, N	1
Ozen, S	1
Ogurel, T	1
Yoshida, T	1
Murayama, H	1
Kawashima, M	1
Nagahara, R	1
Kangawa, Y	1
Mizukami, S	1
Kimura, M	1
Abe, H	1
Hayashi, SM	1
Shibutani, M	1
Choi, SH	1

Studies

Kadayat, TM

Banskota, S

Gurung, P

Bist, G

Thapa Magar, TB

Shrestha, A

Kim, JA

Lee, ES

Ozdemir, R

Gokce, IK

Tekin, S

Cetin Taslidere, A

Turgut, H

Tanbek, K

Gul, CC

Deveci, MF

Aslan, M

Öcük, Ö

Fırat, C

Yıldız, A

Vardı, N

Ulu, A

Abbas Ali Noma, S

Parlakpınar, H

Özhan, O

Nascimento, ALF

Medeiros, POS

Pedrão, LFAT

Queiroz, VC

Oliveira, LM

Novaes, LS

Caetano, AL

Munhoz, CD

Takakura, AC

Falquetto, B

Yang, Q

Chen, HY

Wang, JN

Han, HQ

Jiang, L

Wu, WF

Wei, B

Gao, L

Ma, QY

Liu, XQ

Chen, Q

Wen, JG

Jin, J

Huang, Y

Ni, WJ

Ma, TT

Li, J

Meng, XM

Yang, X

An, N

Zhong, C

Guan, M

Jiang, Y

Li, X

Zhang, H

Wang, L

Ruan, Y

Gao, Y

Liu, N

Shang, H

Xing, Y

Peng, X

Yang, Y

Tang, L

Wan, J

Dai, J

Li, L

Huang, J

Shen, Y

Lin, L

Gong, X

Zhang, L

Rana, P

Rama Rao, KV

Ravula, A

Trivedi, R

D'Souza, M

Singh, AK

Gupta, RK

Chandra, N

Wan, S

Luo, F

Huang, C

Liu, C

Luo, Q

Zhu, X

Liu, F

Fan, LM

Michael, N

Li, JM

Suzuki, S

Cohen, SM

Arnold, LL

Pennington, KL

Gi, M

Kato, H

Naiki, T

Naiki-Ito, A

Wanibuchi, H

Takahashi, S

Chia, TY

Murugaiyah, V

Sattar, MA

Khan, NAK

Ahmad, A

Abdulla, MH

Johns, EJ

Mei, HY

Akhtar, S

Ahmad, FU

Keskin, ER

Çakan, D

Khan, NA

Hassan, Z

Kaur, G

Dong, X

Jin, X

Chen, Y

Li, F

Wang, Y

Yu, X

Gu, J

Zhang, X

Zhou, B

Sun, Y

Xu, C

Qian, S

Langley, M

Ghosh, A

Charli, A

Sarkar, S

Ay, M

Luo, J

Zielonka, J

Brenza, T

Bennett, B

Jin, H

Ghaisas, S

Schlichtmann, B

Kim, D

Anantharam, V

Kanthasamy, A

Narasimhan, B

Kalyanaraman, B

Kanthasamy, AG

Yeh, TY

Tseng, GF

Tseng, CY

Huang, YH

Liu, PH

Nadeem, A

Siddiqui, N

Al-Harbi, NO

Attia, SM

AlSharari, SD

Ahmad, SF

Feng, Y

Cui, C

Liu, X

Wu, Q

Hu, F

Ma, Z

Guo, H

Zhao, L

Wang, B

Liu, H

Yue, L

Bai, H

Jiang, H

Feng, D

Qu, Y

Aras-López, R

Almeida, L

Andreu-Fernández, V

Tovar, J

Martínez, L

Feng, W

Zhang, K

Liu, Y

Chen, J

Cai, Q

He, W

Zhang, Y

Wang, MH

Wang, J

Huang, H

Montes-Rivera, JO

Tamay-Cach, F

Quintana-Pérez, JC

Guevara-Salazar, JA

Trujillo-Ferrara, JG

Del Valle-Mondragón, L

Arellano-Mendoza, MG

Starke, RM

Thompson, JW

Ali, MS

Pascale, CL

Martinez Lege, A

Ding, D

Chalouhi, N

Hasan, DM

Jabbour, P

Owens, GK

Toborek, M

Hare, JM

Dumont, AS

Cheng, L

Chen, L

Wei, X

Ren, Z

Zeng, S

Wen, H

Gao, C

Zhang, B

Bailey, WM

McVicar, AL

Stewart, AN

Veldhorst, AK

Gensel, JC

Köroğlu, KM

Çevik, Ö

Şener, G

Ercan, F

Hou, L

Sun, F

Huang, R

Sun, W

Zhang, D

Wang, Q

Reckelhoff, JF

Romero, DG

Yanes Cardozo, LL

Hwang, YJ

Nam, SJ

Chun, W

Kim, SI

Park, SC

Kang, CD

Lee, SJ

Oliveira, LB

Celes, FS

Paiva, CN

de Oliveira, CI

Stec, DE

Storm, MV

Pruett, BE

Gousset, MU

Sovari, AA

Rutledge, CA

Jeong, EM

Dolmatova, E

Arasu, D

Vahdani, N

Gu, L

Zandieh, S

Xiao, L

Bonini, MG

Duffy, HS

Dudley, SC

La Favor, JD

Anderson, EJ

Dawkins, JT

Hickner, RC

Wingard, CJ

Khanicheh, E

Qi, Y

Xie, A

Mitterhuber, M

Xu, L

Mochizuki, M

Daali, Y

Jaquet, V

Krause, KH

Ruggeri, ZM

Kuster, GM

Lindner, JR

Kaufmann, BA

Marín, M

Giner, RM

Ríos, JL

Recio, Mdel C

Schulz, R

Murzabekova, G

Egemnazarov, B

Kraut, S

Eisele, HJ

Dumitrascu, R

Heitmann, J

Seimetz, M

Witzenrath, M

Ghofrani, HA

Schermuly, RT

Grimminger, F

Seeger, W

Weissmann, N

Choi, DH

Lee, KH

Kim, JH

Seo, JH

Kim, HY

Shin, CY

Han, JS

Han, SH

Kim, YS

Lee, J

Hernandes, MS

D'Avila, JC

Trevelin, SC

Reis, PA

Kinjo, ER

Lopes, LR

Castro-Faria-Neto, HC

Cunha, FQ

Britto, LR

Bozza, FA

Lu, XY

Wang, HD

Xu, JG

Ding, K

Li, T

Khan, SR

Joshi, S

Wang, W

Peck, AB

Jang, HS

Kim, JI

Han, SJ

Park, KM

Mao, M

Lei, H

Liu, Q

He, R

Zuo, Z

Zhang, N

Zhou, C

Hassler, SN

Johnson, KM

Hulsebosch, CE

Feillet-Coudray, C

Fouret, G

Ebabe Elle, R

Rieusset, J

Bonafos, B

Chabi, B

Crouzier, D

Zarkovic, K

Zarkovic, N

Ramos, J

Badia, E

Murphy, MP

Cristol, JP

Coudray, C

Ramonaite, R

Skieceviciene, J

Juzenas, S

Salteniene, V

Kupcinskas, J

Matusevicius, P

Borutaite, V

Kupcinskas, L

Wallace, K

Cornelius, DC

Scott, J

Heath, J

Moseley, J

Chatman, K

LaMarca, B

Martins, JB

Chaudhary, AK

Jiang, S

Kwofie, M

Mackie, P

Miller, FJ

Kilic, T

Taslidere, E

Yildiz, S

Polat, A

Colak, C

Ermis, H

Yin, X

Li, B

Zhao, Y

Zheng, Y

Choi, BY

Kho, AR

Kim, IY

Lee, SH

Lee, BE

Choi, E

Sohn, M

Stevenson, M

Chung, TN

Kauppinen, TM

Suh, SW

Sharma, N

Nehru, B

Huang, F

Wang, JF

Tang, W

Nichols, NL

Satriotomo, I

Harrigan, DJ

Mitchell, GS

Komiya, M

Fujii, G

Miyamoto, S

Takahashi, M

Ishigamori, R

Onuma, W

Ishino, K

Totsuka, Y

Fujimoto, K

Mutoh, M

Kapoor, M

Ji, MH

Qiu, LL

Tang, H

Ju, LS

Sun, XR

Jia, M

Zuo, ZY

Shen, JC

Yang, JJ

Kato, A

Nakazawa, T

Hayashi, K

Naitoh, I

Miyabe, K

Shimizu, S

Kondo, H

Nishi, Y

Yoshida, M

Umemura, S

Hori, Y

Mori, T

Tsutsumi, M

Kuno, T

Ohara, H

Joh, T

Liu, FF

Yang, LD

Pan, W

Wang, XM

Yuan, HM

Sharma, M

Kaur, T

Singla, SK

Langley, MR

Harischandra, DS

Neal, ML

Joseph, J

Oostwoud, LC

Gunasinghe, P

Seow, HJ

Ye, JM

Selemidis, S

Bozinovski, S

Vlahos, R

Capogrosso, RF

Cozzoli, A

Mantuano, P

Camerino, GM

Massari, AM

Sblendorio, VT

De Bellis, M

Tamma, R

Giustino, A

Nico, B

Montagnani, M

De Luca, A

Nunes-Souza, V

César-Gomes, CJ

Da Fonseca, LJ

Guedes, Gda S

Smaniotto, S

Rabelo, LA

Zhang, ZZ

Zhao, HT

Li, HH

Li, KY

Ozer, MA

Polat, N

Ozen, S

Ogurel, T

Yoshida, T

Murayama, H

Kawashima, M

Nagahara, R

Kangawa, Y

Mizukami, S

Kimura, M

Abe, H

Hayashi, SM

Shibutani, M

Choi, SH

Suh, GJ

Kwon, WY

Kim, KS

Park, MJ

Kim, T

Ko, JI

Qin, YY

Li, M

Feng, X

Cao, L

Shen, XK

Sun, M

Sheng, R

Han, F

Qin, ZH

Zhang, C

Wang, K

Wang, H

Che, Y

Zhou, X

Zhao, X

Dominah, GA

McMinimy, RA

Kallon, S

Kwakye, GF

LaSpina, M

Tripathi, S

Gatto, LA

Bruch, D

Maier, KG

Kittur, DS

Schlüter, T

Steinbach, AC

Steffen, A

Rettig, R

Grisk, O

Fabian, RH

Perez-Polo, JR

Kent, TA

Liu, W

Sood, R

Sakoglu, U

Hendren, J

Cetin, O

Miyake, M

Liu, KJ

Tian, N

Moore, RS

Phillips, WE

Braddy, S

Pryor, JS

Stockstill, RL

Hughson, MD

Manning, RD

Carlström, M

Lai, EY

Patzak, A

Brown, RD

Persson, AE

Zhu, C

Bilali, A

Georgieva, GS

Kurata, S

Mitaka, C

Imai, T

Zhang, P

Hou, M

Li, Y

Xu, X

Barsoum, M

Bache, RJ

Zhang, W

Rojas, M

Lilly, B

Tsai, NT

Lemtalsi, T

Liou, GI

Caldwell, RW

Caldwell, RB

Li, CY

Deng, YL

Sun, BH

Byfield, G

Budd, S

Hartnett, ME

Pandey, A

Kour, K

Bani, S

Suri, KA

Satti, NK

Sharma, P

Qazi, GN

Saitoh, S

Matsumoto, K

Kamioka, M

Ohkawara, H

Kaneshiro, T

Ishibashi, T

Maruyama, Y

Miller, SJ

Coppinger, BJ

Unthank, JL

Maldonado, PD

Molina-Jijón, E

Villeda-Hernández, J

Galván-Arzate, S

Santamaría, A

Pedraza-Chaverrí, J

Kim, GS

Jung, JE

Niizuma, K

Chan, PH

Awad, AE

Kandalam, V

Chakrabarti, S

Wang, X

Penninger, JM

Davidge, ST

Oudit, GY

Kassiri, Z

Mazor, R

Itzhaki, O

Sela, S

Yagil, Y

Cohen-Mazor, M

Yagil, C

Kristal, B

Buday, A

Orsy, P

Godó, M

Mózes, M

Kökény, G

Lacza, Z

Koller, A

Ungvári, Z

Gross, ML

Benyó, Z

Hamar, P

Palm, F

Nangaku, M

Fasching, A

Tanaka, T

Nordquist, L

Hansell, P

Kawakami, T

Nishijima, F

Fujita, T

Kopkan, L

Hess, A

Husková, Z

Cervenka, L

Navar, LG

Majid, DS

Musicki, B

Liu, T

Lagoda, GA

Strong, TD

Sezen, SF

Johnson, JM

Burnett, AL

Dendooven, A

Ishola, DA

Nguyen, TQ

Van der Giezen, DM

Kok, RJ

Goldschmeding, R

Joles, JA

Viačková, D

Pekarová, M

Crhák, T

Búcsaiová, M

Matiašovic, J

Lojek, A

Kubala, L

Genovese, T

Mazzon, E

Paterniti, I

Esposito, E

Bramanti, P

Cuzzocrea, S

Doyle, T

Finley, A

Chen, Z

Salvemini, D

Dumont, M

Stack, C

Elipenhali, C

Calingasan, NY

Wille, E

Beal, MF

Meng, R

Zhu, DL

Bi, Y

Yang, DH

Wang, YP

Haddad, P

Dussault, S

Groleau, J

Turgeon, J

Maingrette, F

Rivard, A

Chiang, CH

Chuang, CH

Liu, SL

Lee, TS

Kou, YR

Jarajapu, YP

Caballero, S

Verma, A

Nakagawa, T

Lo, MC

Li, Q

Grant, MB

Kinugasa, S

Tojo, A

Sakai, T

Tsumura, H

Hirata, Y

Won, SJ

Tang, XN

Yenari, MA

Swanson, RA

Fan, R

Shan, X

Qian, H

Song, C

Wu, G

Miao, Y

Cha, W

Connell, BJ

Saleh, MC

Khan, BV

Rajagopal, D

Saleh, TM

Mathis, KW

Venegas-Pont, M

Masterson, CW

Stewart, NJ

Wasson, KL

Ryan, MJ

Campuzano, V

Segura-Puimedon, M

Terrado, V

Sánchez-Rodríguez, C

Coustets, M

Menacho-Márquez, M

Nevado, J

Bustelo, XR

Francke, U

Pérez-Jurado, LA

Dowling, JJ

Arbogast, S

Hur, J

Nelson, DD

McEvoy, A

Waugh, T

Marty, I

Lunardi, J

Brooks, SV

Kuwada, JY

Ferreiro, A

Seo, JS

Park, JY

Choi, J

Kim, TK

Shin, JH

Lee, JK

Han, PL

Schiavone, S

Sorce, S

Dubois-Dauphin, M

Hultqvist, M

Bäckdahl, L

Holmdahl, R

Colaianna, M

Cuomo, V

Trabace, L

Jang, BG

Song, HK

Srivastava, P

Dranka, BP

Song, SX

Gao, JL

Wang, KJ

Li, R

Tian, YX

Wei, JQ

Cui, JZ

Zhang, GL

Dai, DZ

Dai, Y

Kim, HS

Choi, HC

Jiang, Z

Rompala, GR

Zhang, S

Cowell, RM

Nakazawa, K

Zheng, JS

Yang, XQ

Lookingland, KJ

Fink, GD

Hesslinger, C

Kapatos, G

Kovesdi, I

Chen, AF

Kase, H

Hashikabe, Y

Uchida, K

Nakanishi, N

Hattori, Y

Rugale, C

Cordaillat, M

Mimran, A

Jover, B

Pech, V

Sikka, SC

Sindhu, RK

Vaziri, ND

Tompkins, KD

Simonyi, A

Korthuis, RJ

Sun, AY

Sun, GY

Matsumoto, T

Kobayashi, T

Wachi, H

Seyama, Y

Kamata, K

Yusof, M

Kamada, K

Gaskin, FS

Rocic, P

Kolz, C

Reed, R

Potter, B

Chilian, WM

Qin, F

Simeone, M

Patel, R

Saito, Y

Geisen, P

Uppal, A

Titova, E

Ostrowski, RP

Sowers, LC

Zhang, JH

Tang, J

Yamamoto, E

Kataoka, K

Shintaku, H

Yamashita, T

Tokutomi, Y

Dong, YF

Matsuba, S

Ichijo, H

Ogawa, H

Kim-Mitsuyama, S

Masamune, A

Watanabe, T

Kikuta, K

Satoh, K

Shimosegawa, T

Harraz, MM

Marden, JJ

Zhou, W

Williams, A

Sharov, VS

Nelson, K

Luo, M

Paulson, H

Schöneich, C

Engelhardt, JF

Xiong, W

Mactaggart, J

Knispel, R

Worth, J

Zhu, Z

Baxter, BT

Johanning, J

Rachmilewitz, D

Okon, E

Karmeli, F

Ben-Shaul, V

Lomnitski, L

Nyska, A

Carbonatto, M

Peano, S

Zurovsky, Y

Bergman, M

Eldridge, SR

Grossman, S

Muijsers, RB

van Ark, I

Folkerts, G

Koster, AS

van Oosterhout, AJ

Postma, DS

Nijkamp, FP

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Pomegranate Juice on Oxidative Stress Biomarkers During Treatment With IV Iron During One Dialysis Session[NCT02107053]		25 participants (Actual)	Interventional	2014-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

The Effect of Pomegranate Juice on Oxidative Stress Biomarkers During Treatment With IV Iron During One Dialysis Session[NCT02107053]

25 participants (Actual)

Interventional

2014-04-30

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for acetovanillone and Disease Models, Animal

Article	Year
Sex, Oxidative Stress, and Hypertension: Insights From Animal Models. Physiology (Bethesda, Md.), 2019, 05-01, Volume: 34, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Female; Humans; Hyper	2019
The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model. Documenta ophthalmologica. Advances in ophthalmology, 2010, Volume: 120, Issue:1 Topics: Acetophenones; Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Infant, Newborn; NADPH Ox	2010
Oxidative stress in obstructive nephropathy. International journal of experimental pathology, 2011, Volume: 92, Issue:3 Topics: Acetophenones; Animals; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Kidney; Mice; NADPH Oxi	2011

Article

Year

Sex, Oxidative Stress, and Hypertension: Insights From Animal Models.

Physiology (Bethesda, Md.), 2019, 05-01, Volume: 34, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Female; Humans; Hyper

2019

The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model.

Documenta ophthalmologica. Advances in ophthalmology, 2010, Volume: 120, Issue:1

Topics: Acetophenones; Animals; Disease Models, Animal; Enzyme Inhibitors; Humans; Infant, Newborn; NADPH Ox

2010

Oxidative stress in obstructive nephropathy.

International journal of experimental pathology, 2011, Volume: 92, Issue:3

Topics: Acetophenones; Animals; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Kidney; Mice; NADPH Oxi

2011

Other Studies

141 other studies available for acetovanillone and Disease Models, Animal

Article	Year
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. European journal of medicinal chemistry, 2017, Sep-08, Volume: 137 Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discov	2017
The protective effects of apocynin in hyperoxic lung injury in neonatal rats. Pediatric pulmonology, 2022, Volume: 57, Issue:1 Topics: Acetophenones; Animals; Animals, Newborn; Disease Models, Animal; Hyperoxia; Lung; Lung Injury; Oxid	2022
Effects of taurine and apocynin on the zone of stasis. Burns : journal of the International Society for Burn Injuries, 2022, Volume: 48, Issue:8 Topics: Animals; Antioxidants; Burns; Disease Models, Animal; Inflammation; Rats; Rats, Sprague-Dawley; Taur	2022
Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease. Neuroscience, 2022, 10-15, Volume: 502 Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drinking Water; NADPH Oxidases; Oxidative Str	2022
Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clinical science (London, England : 1979), 2020, 01-31, Volume: 134, Issue:2 Topics: Acetophenones; Animals; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DN	2020
Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation. Redox biology, 2020, Volume: 30 Topics: Acetophenones; Adenine; Animals; Atrial Fibrillation; Calcium; Calcium-Calmodulin-Dependent Protein	2020
Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125 Topics: Acetophenones; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti	2020
Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics : Official journal of the Metabolomic Society, 2020, 03-12, Volume: 16, Issue:3 Topics: Acetophenones; Animals; Blast Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Male; Met	2020
Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. Aging, 2020, 06-03, Volume: 12, Issue:11 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Carbon Tetrachloride; Disease	2020
In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study. Pharmacology research & perspectives, 2020, Volume: 8, Issue:4 Topics: Acetophenones; Aging; Animals; Antioxidants; Blood-Brain Barrier; Computer Simulation; Diet, High-Fa	2020
Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Toxicology letters, 2021, Jan-01, Volume: 336 Topics: Acetophenones; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Enz	2021
The restorative effect of apocynin and catalase in l-arginine induced hypotension on normotensive subjects - the role of oxidative stress. Physiological research, 2020, 12-22, Volume: 69, Issue:6 Topics: Acetophenones; Animals; Antioxidants; Arginine; Blood Pressure; Catalase; Disease Models, Animal; Hy	2020
The Effect of Apocynin on Fat Graft Survival. Aesthetic plastic surgery, 2021, Volume: 45, Issue:4 Topics: Acetophenones; Adipose Tissue; Animals; Disease Models, Animal; Graft Survival; Rats; Rats, Wistar	2021
Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression. Physiological research, 2021, 03-17, Volume: 70, Issue:1 Topics: Acetophenones; Animals; Antioxidants; Catalase; Disease Models, Animal; Drug Therapy, Combination; E	2021
The Effect of Apocynin on Fat Graft Survival. Aesthetic plastic surgery, 2021, Volume: 45, Issue:6 Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans	2021
The Effect of Apocynin on Fat Graft Survival. Aesthetic plastic surgery, 2021, Volume: 45, Issue:6 Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans	2021
Invited Response on: The Effect of Apocynin on Fat Graft Survival. Aesthetic plastic surgery, 2021, Volume: 45, Issue:6 Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans	2021
The Effect of Apocynin on Fat Graft Survival. Aesthetic plastic surgery, 2021, Volume: 45, Issue:6 Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans	2021
Role of NADPH Oxidase-Induced Hypoxia-Induced Factor-1 Neural plasticity, 2021, Volume: 2021 Topics: Acetophenones; Animals; Blood-Brain Barrier; Disease Models, Animal; Enzyme Inhibitors; Hypoxia-Indu	2021
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling, 2017, Nov-10, Volume: 27, Issue:14 Topics: Acetophenones; Administration, Oral; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal;	2017
Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex. Acta neurobiologiae experimentalis, 2017, Volume: 77, Issue:1 Topics: Acetophenones; Afferent Pathways; Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biotin; Brain Inj	2017
Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model. International immunopharmacology, 2017, Volume: 47 Topics: Acetophenones; Acute Lung Injury; Animals; Behavior Rating Scale; Cells, Cultured; Depression; Disea	2017
Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury. Neurochemical research, 2017, Volume: 42, Issue:11 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Brain Injuries, Traumati	2017
Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:12 Topics: Acetophenones; Adiponectin; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; DNA Nucleoti	2017
Anti-oxidants correct disturbance of redox enzymes in the hearts of rat fetuses with congenital diaphragmatic hernia. Pediatric surgery international, 2018, Volume: 34, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Catalase; Catechin; Disease Models, Animal; Female; Glutathion	2018
Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease. American journal of physiology. Heart and circulatory physiology, 2018, 03-01, Volume: 314, Issue:3 Topics: Acetophenones; Advanced Oxidation Protein Products; Animals; Antioxidants; Apoptosis; Cell Line; Dis	2018
Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease. Renal failure, 2018, Volume: 40, Issue:1 Topics: Acetophenones; Adjuvants, Pharmaceutic; Animals; Antihypertensive Agents; Antioxidants; Blood Pressu	2018
Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:3 Topics: Acetophenones; Aneurysm, Ruptured; Animals; Antioxidants; Cells, Cultured; Cerebral Arteries; Cigare	2018
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of neuroinflammation, 2018, Aug-29, Volume: 15, Issue:1 Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal	2018
Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury. Brain, behavior, and immunity, 2019, Volume: 76 Topics: Acetophenones; Age Factors; Animals; Disease Models, Animal; Female; Inflammation; Macrophage Activa	2019
Apocynin alleviates cisplatin-induced testicular cytotoxicity by regulating oxidative stress and apoptosis in rats. Andrologia, 2019, Volume: 51, Issue:4 Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Cisplatin; Disease Models, Animal; Male; Oxidative	2019
Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model. Redox biology, 2019, Volume: 22 Topics: Acetophenones; Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dopaminergic Neur	2019
Anti-inflammatory effects of apocynin on dextran sulfate sodium-induced mouse colitis model. PloS one, 2019, Volume: 14, Issue:5 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Dextran Sulfate; Diseas	2019
The Paradoxical Leishmanicidal Effects of Superoxide Dismutase (SOD)-Mimetic Tempol in Frontiers in cellular and infection microbiology, 2019, Volume: 9 Topics: Acetophenones; Animals; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Ditiocarb; Drug Thera	2019
Antihypertensive actions of moderate hyperbilirubinemia: role of superoxide inhibition. American journal of hypertension, 2013, Volume: 26, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Bilirubin; Blood Pressure; Disease Models, Animal; Drug Impl	2013
Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. Circulation. Arrhythmia and electrophysiology, 2013, Volume: 6, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Connexin 43; Cyclic N-Oxides; Death, Sudden, Cardiac; Disease	2013
Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment. American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-15, Volume: 305, Issue:4 Topics: Acetophenones; Animals; Biopterins; Coronary Artery Disease; Coronary Vessels; Diet, High-Fat; Disea	2013
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:9 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Antioxidants; Aortic Diseases; APOBEC-1 Deaminase;	2013
Protective effect of apocynin in a mouse model of chemically-induced colitis. Planta medica, 2013, Volume: 79, Issue:15 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2	2013
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2. Journal of hypertension, 2014, Volume: 32, Issue:2 Topics: Acetophenones; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Mal	2014
NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia. Antioxidants & redox signaling, 2014, Aug-01, Volume: 21, Issue:4 Topics: Acetophenones; Animals; Cell Death; Dementia, Vascular; Disease Models, Animal; DNA Damage; Gene Exp	2014
The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. Journal of neuroinflammation, 2014, Feb-27, Volume: 11 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Avoidance Learning; Bacterial Prote	2014
NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury. Neurochemistry international, 2014, Volume: 69 Topics: Acetophenones; Animals; Antioxidants; Blood-Brain Barrier; Brain Injuries; Disease Models, Animal; M	2014
Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria. American journal of physiology. Renal physiology, 2014, Jun-01, Volume: 306, Issue:11 Topics: Acetophenones; Animals; Disease Models, Animal; Gene Expression Profiling; Hydroxyproline; Hyperoxal	2014
Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis. American journal of physiology. Renal physiology, 2014, Jun-15, Volume: 306, Issue:12 Topics: Acetophenones; Acute Kidney Injury; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Pr	2014
Lycopene inhibits neointimal hyperplasia through regulating lipid metabolism and suppressing oxidative stress. Molecular medicine reports, 2014, Volume: 10, Issue:1 Topics: Acetophenones; Animals; Antioxidants; ATP Binding Cassette Transporter 1; Carotenoids; Cell Prolifer	2014
Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Journal of neurochemistry, 2014, Volume: 131, Issue:4 Topics: Acetophenones; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids; Hyper	2014
The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol. Free radical research, 2014, Volume: 48, Issue:10 Topics: Acetophenones; Allopurinol; Animals; Antioxidants; Blotting, Western; Diet, High-Fat; Disease Models	2014
Protective action of NADPH oxidase inhibitors and role of NADPH oxidase in pathogenesis of colon inflammation in mice. World journal of gastroenterology, 2014, Sep-21, Volume: 20, Issue:35 Topics: Acetophenones; Acute Disease; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chronic Disease; C	2014
CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:5 Topics: Acetophenones; Adolescent; Adult; Animals; Antioxidants; CD4-Positive T-Lymphocytes; Cells, Cultured	2014
Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia. International journal of molecular sciences, 2014, Nov-04, Volume: 15, Issue:11 Topics: Acetophenones; Action Potentials; Animals; Blotting, Western; Disease Models, Animal; Dogs; Female;	2014
Protective and therapeutic effect of apocynin on bleomycin-induced lung fibrosis in rats. Inflammation, 2015, Volume: 38, Issue:3 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Bleomycin	2015
[Protective effects of antioxidants on chronic intermittent hypoxia-induced cardiac remodeling in mice]. Zhonghua xin xue guan bing za zhi, 2014, Volume: 42, Issue:11 Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Heart; Hypoxia; Mice; Mice,	2014
Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice. Journal of neuroinflammation, 2015, May-28, Volume: 12 Topics: Acetophenones; Animals; Animals, Newborn; Blood-Testis Barrier; Brain; Cells, Cultured; Cytokines; D	2015
Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology, 2016, Volume: 53, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Cytokines; Disease Models, Animal; Dopaminer	2016
Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition. Journal of the American Heart Association, 2015, Jun-24, Volume: 4, Issue:7 Topics: Acetophenones; Aged; Aged, 80 and over; Animals; Antioxidants; Cardio-Renal Syndrome; Cardiomegaly;	2015
Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS. Experimental neurology, 2015, Volume: 273 Topics: Acetophenones; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Anti-Inflammatory Agents, Non-St	2015
Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice. Cancer science, 2015, Volume: 106, Issue:11 Topics: Acetophenones; Animals; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Chromatography, Liq	2015
Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids. Oncotarget, 2015, Sep-22, Volume: 6, Issue:28 Topics: 8,11,14-Eicosatrienoic Acid; Acetophenones; Aged; Angiotensin II; Animals; Cardio-Renal Syndrome; Ca	2015
Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations. Behavioural brain research, 2016, Jan-01, Volume: 296 Topics: Acetophenones; alpha-Synuclein; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Dopami	2016
Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice. Journal of neuroinflammation, 2015, Sep-29, Volume: 12 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cognition Disorder	2015
Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2. Oncotarget, 2015, Dec-15, Volume: 6, Issue:40 Topics: Acetophenones; Adenocarcinoma; Animals; Anticarcinogenic Agents; Antioxidants; Blotting, Western; Ca	2015
NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder. Molecular neurobiology, 2016, Volume: 53, Issue:10 Topics: Acetophenones; Aldehydes; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Fear; Hippocam	2016
Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin. Mitochondrion, 2016, Volume: 27 Topics: Acetophenones; Acetylcysteine; Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combinat	2016
Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016, Volume: 11, Issue:2 Topics: Acetophenones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cel	2016
Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice. Scientific reports, 2016, Feb-15, Volume: 6 Topics: Acetophenones; Animals; Azoles; Disease Models, Animal; Humans; Influenza A virus; Isoindoles; Male;	2016
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone. Pharmacological research, 2016, Volume: 106 Topics: Acetophenones; Animals; Antioxidants; Disease Models, Animal; Male; Methylprednisolone; Mice; Mice,	2016
Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative medicine and cellular longevity, 2016, Volume: 2016 Topics: Acetophenones; Aging; Animals; Antioxidants; Blood Glucose; Catalase; Cyclic N-Oxides; Diet, High-Fa	2016
Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures. Neurotoxicity research, 2016, Volume: 30, Issue:4 Topics: Acetophenones; Animals; Anxiety; Brain; Cognitive Dysfunction; Cohort Studies; Disease Models, Anima	2016
Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes. International ophthalmology, 2017, Volume: 37, Issue:3 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Male; Ophth	2017
Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2017, Volume: 69, Issue:1 Topics: Acetophenones; Animals; Carcinogenesis; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Immu	2017
Apocynin suppressed the nuclear factor-κB pathway and attenuated lung injury in a rat hemorrhagic shock model. The journal of trauma and acute care surgery, 2017, Volume: 82, Issue:3 Topics: Acetophenones; Acute Lung Injury; Animals; Biomarkers; Disease Models, Animal; Lipid Peroxidation; M	2017
Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free radical biology & medicine, 2017, Volume: 104 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models,	2017
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation. Toxicology, 2017, 04-01, Volume: 380 Topics: Acetophenones; Adrenergic Neurons; Animals; Disease Models, Animal; Enzyme Inhibitors; Locus Coerule	2017
Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington's disease. Neurotoxicology, 2017, Volume: 60 Topics: Acetophenones; Animals; Antioxidants; Cells, Cultured; Chlorpyrifos; Corpus Striatum; Curcumin; Dise	2017
An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice. The Journal of surgical research, 2008, Volume: 148, Issue:2 Topics: Acetophenones; Animals; Antibodies, Monoclonal; Cyclosporine; Diet, Sodium-Restricted; Disease Model	2008
Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition. Cardiovascular research, 2008, Nov-01, Volume: 80, Issue:2 Topics: Acetophenones; Age Factors; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relations	2008
Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4 Topics: Acetophenones; Animals; Animals, Newborn; Biopterins; Carbon Dioxide; Cerebral Cortex; Cerebrovascul	2008
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke. Journal of neurochemistry, 2008, Volume: 107, Issue:5 Topics: Acetophenones; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cla	2008
NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:6 Topics: Acetophenones; Allopurinol; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Gene	2008
Role of NOX2 in the regulation of afferent arteriole responsiveness. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:1 Topics: Acetophenones; Adenosine; Angiotensin II; Animals; Arterioles; Blood Pressure; Disease Models, Anima	2009
Salvage of nonischemic control lung from injury by unilateral ischemic lung with apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, in isolated perfused rat lung. Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:6 Topics: Acetophenones; ADAM Proteins; ADAM17 Protein; Animals; Bronchoalveolar Lavage Fluid; Cell Membrane P	2008
NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:3 Topics: Acetophenones; Acetylcholine; Aldehydes; Animals; Antioxidants; Cardiac Pacing, Artificial; Coronary	2009
NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:6 Topics: Acetophenones; Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Diabetes Mellitus, Exper	2009
Effects of apocynin and losartan treatment on renal oxidative stress in a rat model of calcium oxalate nephrolithiasis. International urology and nephrology, 2009, Volume: 41, Issue:4 Topics: Acetophenones; Analysis of Variance; Angiotensin II; Animals; Antioxidants; Biopsy, Needle; Blotting	2009
The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7 Topics: Acetophenones; Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Enzyme Inhibito	2009
Amelioration of adjuvant induced arthritis by apocynin. Phytotherapy research : PTR, 2009, Volume: 23, Issue:10 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Apocynum; Arthritis, Experimental; Capillary Perme	2009
Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. Coronary artery disease, 2009, Volume: 20, Issue:6 Topics: Acetophenones; Angina Pectoris, Variant; Animals; Aspartic Acid Endopeptidases; Coronary Angiography	2009
Antioxidants reverse age-related collateral growth impairment. Journal of vascular research, 2010, Volume: 47, Issue:2 Topics: Acetophenones; Age Factors; Aging; Animals; Antioxidants; Collateral Circulation; Cyclic N-Oxides; D	2010
NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: protective role of apocynin. Journal of neuroscience research, 2010, Feb-15, Volume: 88, Issue:3 Topics: Acetophenones; Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Lipid Peroxidat	2010
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Nov-25, Volume: 29, Issue:47 Topics: Acetophenones; Animals; Brain; Brain Ischemia; Casein Kinase II; Cytoprotection; Disease Models, Ani	2009
Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:3 Topics: Acetophenones; Animals; Animals, Newborn; Cardiomyopathies; Cells, Cultured; Class Ib Phosphatidylin	2010
Tumor necrosis factor-alpha: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension. Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:2 Topics: Acetophenones; Analysis of Variance; Animals; Blood Pressure Determination; Cytokines; Disease Model	2010
Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:2 Topics: Acetophenones; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Body Weight; Card	2010
Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:2 Topics: Acetophenones; Animals; Carbon; Cell Hypoxia; Disease Models, Animal; Disease Progression; Enzyme In	2010
High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Dinoprost; Disease Models, An	2010
Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. The journal of sexual medicine, 2010, Volume: 7, Issue:9 Topics: Acetophenones; Aldehydes; Animals; Cell Adhesion Molecules; Cholesterol, Dietary; Disease Models, An	2010
Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin. Immunobiology, 2011, Volume: 216, Issue:4 Topics: Acetophenones; Adjuvants, Immunologic; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cell Lin	2011
Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats. Brain research, 2011, Feb-04, Volume: 1372 Topics: Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cytochromes c; Disease Models,	2011
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. Pain, 2011, Volume: 152, Issue:3 Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Int	2011
Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease. Neuroscience letters, 2011, Apr-04, Volume: 492, Issue:3 Topics: Acetophenones; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Di	2011
Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice. Mediators of inflammation, 2010, Volume: 2010 Topics: Acetophenones; Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base	2010
Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells. Atherosclerosis, 2011, Volume: 217, Issue:2 Topics: Acetophenones; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitor	2011
Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive care medicine, 2011, Volume: 37, Issue:8 Topics: Acetophenones; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants;	2011
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. Investigative ophthalmology & visual science, 2011, Jul-07, Volume: 52, Issue:8 Topics: Acetophenones; Adult; Animals; Antigens, CD34; Benzodioxoles; Chemokine CXCL12; Cyclic GMP; Diabetic	2011
Apocynin attenuates ischemia-reperfusion lung injury in an isolated and perfused rat lung model. Translational research : the journal of laboratory and clinical medicine, 2011, Volume: 158, Issue:1 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models,	2011
Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase. Kidney international, 2011, Volume: 80, Issue:12 Topics: Acetophenones; Albuminuria; Animals; Biological Transport; Disease Models, Animal; Endocytosis; Enzy	2011
Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production. Annals of neurology, 2011, Volume: 70, Issue:4 Topics: Acetophenones; Animals; Antioxidants; Blood Glucose; Blood-Brain Barrier; Cerebral Hemorrhage; Disea	2011
Anti-oxidative effect of apocynin on insulin resistance in high-fat diet mice. Annals of clinical and laboratory science, 2011,Summer, Volume: 41, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Biomarkers; Catalase; Dietary Fats; Disease Models, Animal; Gl	2011
Protective effect of apocynin in an established alcoholic steatohepatitis rat model. Immunopharmacology and immunotoxicology, 2012, Volume: 34, Issue:4 Topics: Acetophenones; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models	2012
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion. American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Volume: 302, Issue:7 Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl	2012
Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:3 Topics: Acetophenones; Albuminuria; Animals; Antioxidants; Autoimmunity; Blood Pressure; Cyclic N-Oxides; Di	2012
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome. PLoS genetics, 2012, Volume: 8, Issue:2 Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pre	2012
Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 4 Topics: Acetophenones; Acetylcysteine; Animals; Animals, Genetically Modified; Antioxidants; Behavior, Anima	2012
NADPH oxidase mediates depressive behavior induced by chronic stress in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jul-11, Volume: 32, Issue:28 Topics: Acetophenones; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Ascorb	2012
NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology. Translational psychiatry, 2012, May-08, Volume: 2 Topics: Acetophenones; Alleles; Animals; Antioxidants; Brain; Disease Models, Animal; DNA Mutational Analysi	2012
Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation. Brain research, 2012, Oct-24, Volume: 1481 Topics: Acetophenones; Animals; Blood-Brain Barrier; Brain Injuries; CA3 Region, Hippocampal; Cell Death; Di	2012
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. Journal of neuroinflammation, 2012, Oct-23, Volume: 9 Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chromatography, High Pressure	2012
Attenuation of brain edema and spatial learning deﬁcits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats. Molecular medicine reports, 2013, Volume: 7, Issue:1 Topics: Acetophenones; Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Enzyme Activation; Lear	2013
Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes. Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 36 Topics: 3-Hydroxysteroid Dehydrogenases; Acetophenones; Animals; Berberine; Biomarkers; Calcium Channel Bloc	2013
Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death. Brain research, 2013, Mar-07, Volume: 1499 Topics: Acetophenones; Animals; Cell Death; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocam	2013
Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons. Biological psychiatry, 2013, May-15, Volume: 73, Issue:10 Topics: Acetophenones; Animals; Antioxidants; Cerebral Cortex; Disease Models, Animal; Humans; Interneurons;	2013
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation, 2003, Sep-09, Volume: 108, Issue:10 Topics: Acetophenones; Animals; Antioxidants; Atrasentan; Biopterins; Carotid Arteries; Cyclic N-Oxides; Des	2003
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. Journal of hypertension, 2005, Volume: 23, Issue:7 Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis	2005
Prevention and reversal by enalapril of target organ damage in angiotensin II hypertension. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2005, Volume: 6, Issue:3 Topics: Acetophenones; Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-	2005
Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets. American journal of hypertension, 2006, Volume: 19, Issue:5 Topics: Acetophenones; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Diet, Sodium-Restricted;	2006
Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain research, 2006, May-23, Volume: 1090, Issue:1 Topics: Acetophenones; Aldehydes; Animals; Antioxidants; Biomarkers; Brain Ischemia; Cell Death; Cerebral In	2006
Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Atherosclerosis, 2007, Volume: 192, Issue:1 Topics: Acetophenones; Acetylcholine; Animals; Antioxidants; Basilar Artery; Diabetes Mellitus, Type 2; Dise	2007
Angiotensin II mediates postischemic leukocyte-endothelial interactions: role of calcitonin gene-related peptide. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6 Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Recept	2007
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6 Topics: Acetophenones; Animals; Blood Flow Velocity; Cells, Cultured; Collateral Circulation; Coronary Circu	2007
Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free radical biology & medicine, 2007, Jul-15, Volume: 43, Issue:2 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blood Pressure; Disease	2007
Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity. Molecular vision, 2007, Jun-12, Volume: 13 Topics: Acetophenones; Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cryoultramicrotomy;	2007
Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:9 Topics: Acetophenones; Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; C	2007
The polymorphonuclear leukocyte contributes to the development of hypertension in the Sabra rat. Journal of hypertension, 2007, Volume: 25, Issue:11 Topics: Acetophenones; Animals; Blood Pressure; CD11b Antigen; Disease Models, Animal; Hypertension; Leukocy	2007
Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure. Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12 Topics: Acetophenones; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihyp	2007
NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:1 Topics: Acetophenones; Actins; Angiotensin II; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; C	2008
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. The Journal of clinical investigation, 2008, Volume: 118, Issue:2 Topics: Acetophenones; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Inhibitors; Hy	2008
Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model. Atherosclerosis, 2009, Volume: 202, Issue:1 Topics: Acetophenones; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Extracellular Matrix; Ma	2009
Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn's disease. Gut, 1997, Volume: 41, Issue:3 Topics: Acetophenones; Animals; Antioxidants; Crohn Disease; Cyclic N-Oxides; Disease Models, Animal; Enteri	1997
Effect of natural antioxidants and apocynin on LPS-induced endotoxemia in rabbit. Human & experimental toxicology, 2000, Volume: 19, Issue:11 Topics: Acetophenones; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal	2000
Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalve	2001

Article

Year

Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.

European journal of medicinal chemistry, 2017, Sep-08, Volume: 137

Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discov

2017

The protective effects of apocynin in hyperoxic lung injury in neonatal rats.

Pediatric pulmonology, 2022, Volume: 57, Issue:1

Topics: Acetophenones; Animals; Animals, Newborn; Disease Models, Animal; Hyperoxia; Lung; Lung Injury; Oxid

2022

Effects of taurine and apocynin on the zone of stasis.

Burns : journal of the International Society for Burn Injuries, 2022, Volume: 48, Issue:8

Topics: Animals; Antioxidants; Burns; Disease Models, Animal; Inflammation; Rats; Rats, Sprague-Dawley; Taur

2022

Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease.

Neuroscience, 2022, 10-15, Volume: 502

Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Drinking Water; NADPH Oxidases; Oxidative Str

2022

Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7.

Clinical science (London, England : 1979), 2020, 01-31, Volume: 134, Issue:2

Topics: Acetophenones; Animals; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DN

2020

Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation.

Redox biology, 2020, Volume: 30

Topics: Acetophenones; Adenine; Animals; Atrial Fibrillation; Calcium; Calcium-Calmodulin-Dependent Protein

2020

Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125

Topics: Acetophenones; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti

2020

Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury.

Metabolomics : Official journal of the Metabolomic Society, 2020, 03-12, Volume: 16, Issue:3

Topics: Acetophenones; Animals; Blast Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Male; Met

2020

Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.

Aging, 2020, 06-03, Volume: 12, Issue:11

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Carbon Tetrachloride; Disease

2020

In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study.

Pharmacology research & perspectives, 2020, Volume: 8, Issue:4

Topics: Acetophenones; Aging; Animals; Antioxidants; Blood-Brain Barrier; Computer Simulation; Diet, High-Fa

2020

Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin.

Toxicology letters, 2021, Jan-01, Volume: 336

Topics: Acetophenones; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Enz

2021

The restorative effect of apocynin and catalase in l-arginine induced hypotension on normotensive subjects - the role of oxidative stress.

Physiological research, 2020, 12-22, Volume: 69, Issue:6

Topics: Acetophenones; Animals; Antioxidants; Arginine; Blood Pressure; Catalase; Disease Models, Animal; Hy

2020

The Effect of Apocynin on Fat Graft Survival.

Aesthetic plastic surgery, 2021, Volume: 45, Issue:4

Topics: Acetophenones; Adipose Tissue; Animals; Disease Models, Animal; Graft Survival; Rats; Rats, Wistar

2021

Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression.

Physiological research, 2021, 03-17, Volume: 70, Issue:1

Topics: Acetophenones; Animals; Antioxidants; Catalase; Disease Models, Animal; Drug Therapy, Combination; E

2021

The Effect of Apocynin on Fat Graft Survival.

Aesthetic plastic surgery, 2021, Volume: 45, Issue:6

Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans

2021

The Effect of Apocynin on Fat Graft Survival.

Aesthetic plastic surgery, 2021, Volume: 45, Issue:6

Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans

2021

Invited Response on: The Effect of Apocynin on Fat Graft Survival.

Aesthetic plastic surgery, 2021, Volume: 45, Issue:6

Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans

2021

The Effect of Apocynin on Fat Graft Survival.

Aesthetic plastic surgery, 2021, Volume: 45, Issue:6

Topics: Acetophenones; Animals; Disease Models, Animal; Graft Survival; Humans

2021

Role of NADPH Oxidase-Induced Hypoxia-Induced Factor-1

Neural plasticity, 2021, Volume: 2021

Topics: Acetophenones; Animals; Blood-Brain Barrier; Disease Models, Animal; Enzyme Inhibitors; Hypoxia-Indu

2021

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.

Antioxidants & redox signaling, 2017, Nov-10, Volume: 27, Issue:14

Topics: Acetophenones; Administration, Oral; Animals; Antioxidants; Cells, Cultured; Disease Models, Animal;

2017

Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex.

Acta neurobiologiae experimentalis, 2017, Volume: 77, Issue:1

Topics: Acetophenones; Afferent Pathways; Aldehydes; Animals; Antioxidants; Ascorbic Acid; Biotin; Brain Inj

2017

Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model.

International immunopharmacology, 2017, Volume: 47

Topics: Acetophenones; Acute Lung Injury; Animals; Behavior Rating Scale; Cells, Cultured; Depression; Disea

2017

Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury.

Neurochemical research, 2017, Volume: 42, Issue:11

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Brain Injuries, Traumati

2017

Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury.

Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:12

Topics: Acetophenones; Adiponectin; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; DNA Nucleoti

2017

Anti-oxidants correct disturbance of redox enzymes in the hearts of rat fetuses with congenital diaphragmatic hernia.

Pediatric surgery international, 2018, Volume: 34, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Catalase; Catechin; Disease Models, Animal; Female; Glutathion

2018

Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease.

American journal of physiology. Heart and circulatory physiology, 2018, 03-01, Volume: 314, Issue:3

Topics: Acetophenones; Advanced Oxidation Protein Products; Animals; Antioxidants; Apoptosis; Cell Line; Dis

2018

Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease.

Renal failure, 2018, Volume: 40, Issue:1

Topics: Acetophenones; Adjuvants, Pharmaceutic; Animals; Antihypertensive Agents; Antioxidants; Blood Pressu

2018

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:3

Topics: Acetophenones; Aneurysm, Ruptured; Animals; Antioxidants; Cells, Cultured; Cerebral Arteries; Cigare

2018

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.

Journal of neuroinflammation, 2018, Aug-29, Volume: 15, Issue:1

Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal

2018

Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury.

Brain, behavior, and immunity, 2019, Volume: 76

Topics: Acetophenones; Age Factors; Animals; Disease Models, Animal; Female; Inflammation; Macrophage Activa

2019

Apocynin alleviates cisplatin-induced testicular cytotoxicity by regulating oxidative stress and apoptosis in rats.

Andrologia, 2019, Volume: 51, Issue:4

Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Cisplatin; Disease Models, Animal; Male; Oxidative

2019

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model.

Redox biology, 2019, Volume: 22

Topics: Acetophenones; Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dopaminergic Neur

2019

Anti-inflammatory effects of apocynin on dextran sulfate sodium-induced mouse colitis model.

PloS one, 2019, Volume: 14, Issue:5

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Dextran Sulfate; Diseas

2019

The Paradoxical Leishmanicidal Effects of Superoxide Dismutase (SOD)-Mimetic Tempol in

Frontiers in cellular and infection microbiology, 2019, Volume: 9

Topics: Acetophenones; Animals; Antioxidants; Cyclic N-Oxides; Disease Models, Animal; Ditiocarb; Drug Thera

2019

Antihypertensive actions of moderate hyperbilirubinemia: role of superoxide inhibition.

American journal of hypertension, 2013, Volume: 26, Issue:7

Topics: Acetophenones; Angiotensin II; Animals; Bilirubin; Blood Pressure; Disease Models, Animal; Drug Impl

2013

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.

Circulation. Arrhythmia and electrophysiology, 2013, Volume: 6, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Connexin 43; Cyclic N-Oxides; Death, Sudden, Cardiac; Disease

2013

Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment.

American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-15, Volume: 305, Issue:4

Topics: Acetophenones; Animals; Biopterins; Coronary Artery Disease; Coronary Vessels; Diet, High-Fat; Disea

2013

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.

Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:9

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Antioxidants; Aortic Diseases; APOBEC-1 Deaminase;

2013

Protective effect of apocynin in a mouse model of chemically-induced colitis.

Planta medica, 2013, Volume: 79, Issue:15

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2

2013

Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.

Journal of hypertension, 2014, Volume: 32, Issue:2

Topics: Acetophenones; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Mal

2014

NADPH oxidase 1, a novel molecular source of ROS in hippocampal neuronal death in vascular dementia.

Antioxidants & redox signaling, 2014, Aug-01, Volume: 21, Issue:4

Topics: Acetophenones; Animals; Cell Death; Dementia, Vascular; Disease Models, Animal; DNA Damage; Gene Exp

2014

The role of Nox2-derived ROS in the development of cognitive impairment after sepsis.

Journal of neuroinflammation, 2014, Feb-27, Volume: 11

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Avoidance Learning; Bacterial Prote

2014

NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury.

Neurochemistry international, 2014, Volume: 69

Topics: Acetophenones; Animals; Antioxidants; Blood-Brain Barrier; Brain Injuries; Disease Models, Animal; M

2014

Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.

American journal of physiology. Renal physiology, 2014, Jun-01, Volume: 306, Issue:11

Topics: Acetophenones; Animals; Disease Models, Animal; Gene Expression Profiling; Hydroxyproline; Hyperoxal

2014

Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis.

American journal of physiology. Renal physiology, 2014, Jun-15, Volume: 306, Issue:12

Topics: Acetophenones; Acute Kidney Injury; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Pr

2014

Lycopene inhibits neointimal hyperplasia through regulating lipid metabolism and suppressing oxidative stress.

Molecular medicine reports, 2014, Volume: 10, Issue:1

Topics: Acetophenones; Animals; Antioxidants; ATP Binding Cassette Transporter 1; Carotenoids; Cell Prolifer

2014

Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats.

Journal of neurochemistry, 2014, Volume: 131, Issue:4

Topics: Acetophenones; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids; Hyper

2014

The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.

Free radical research, 2014, Volume: 48, Issue:10

Topics: Acetophenones; Allopurinol; Animals; Antioxidants; Blotting, Western; Diet, High-Fat; Disease Models

2014

Protective action of NADPH oxidase inhibitors and role of NADPH oxidase in pathogenesis of colon inflammation in mice.

World journal of gastroenterology, 2014, Sep-21, Volume: 20, Issue:35

Topics: Acetophenones; Acute Disease; Animals; Anti-Inflammatory Agents; Cells, Cultured; Chronic Disease; C

2014

CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia.

Hypertension (Dallas, Tex. : 1979), 2014, Volume: 64, Issue:5

Topics: Acetophenones; Adolescent; Adult; Animals; Antioxidants; CD4-Positive T-Lymphocytes; Cells, Cultured

2014

Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia.

International journal of molecular sciences, 2014, Nov-04, Volume: 15, Issue:11

Topics: Acetophenones; Action Potentials; Animals; Blotting, Western; Disease Models, Animal; Dogs; Female;

2014

Protective and therapeutic effect of apocynin on bleomycin-induced lung fibrosis in rats.

Inflammation, 2015, Volume: 38, Issue:3

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Bleomycin

2015

[Protective effects of antioxidants on chronic intermittent hypoxia-induced cardiac remodeling in mice].

Zhonghua xin xue guan bing za zhi, 2014, Volume: 42, Issue:11

Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Heart; Hypoxia; Mice; Mice,

2014

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice.

Journal of neuroinflammation, 2015, May-28, Volume: 12

Topics: Acetophenones; Animals; Animals, Newborn; Blood-Testis Barrier; Brain; Cells, Cultured; Cytokines; D

2015

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model.

Molecular neurobiology, 2016, Volume: 53, Issue:5

Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Cytokines; Disease Models, Animal; Dopaminer

2016

Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition.

Journal of the American Heart Association, 2015, Jun-24, Volume: 4, Issue:7

Topics: Acetophenones; Aged; Aged, 80 and over; Animals; Antioxidants; Cardio-Renal Syndrome; Cardiomegaly;

2015

Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS.

Experimental neurology, 2015, Volume: 273

Topics: Acetophenones; Age Factors; Amyotrophic Lateral Sclerosis; Animals; Anti-Inflammatory Agents, Non-St

2015

Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice.

Cancer science, 2015, Volume: 106, Issue:11

Topics: Acetophenones; Animals; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Chromatography, Liq

2015

Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids.

Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

Topics: 8,11,14-Eicosatrienoic Acid; Acetophenones; Aged; Angiotensin II; Animals; Cardio-Renal Syndrome; Ca

2015

Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations.

Behavioural brain research, 2016, Jan-01, Volume: 296

Topics: Acetophenones; alpha-Synuclein; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Dopami

2016

Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice.

Journal of neuroinflammation, 2015, Sep-29, Volume: 12

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cognition Disorder

2015

Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2.

Oncotarget, 2015, Dec-15, Volume: 6, Issue:40

Topics: Acetophenones; Adenocarcinoma; Animals; Anticarcinogenic Agents; Antioxidants; Blotting, Western; Ca

2015

NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder.

Molecular neurobiology, 2016, Volume: 53, Issue:10

Topics: Acetophenones; Aldehydes; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Fear; Hippocam

2016

Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin.

Mitochondrion, 2016, Volume: 27

Topics: Acetophenones; Acetylcysteine; Animals; Antioxidants; Disease Models, Animal; Drug Therapy, Combinat

2016

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016, Volume: 11, Issue:2

Topics: Acetophenones; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cel

2016

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice.

Scientific reports, 2016, Feb-15, Volume: 6

Topics: Acetophenones; Animals; Azoles; Disease Models, Animal; Humans; Influenza A virus; Isoindoles; Male;

2016

Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone.

Pharmacological research, 2016, Volume: 106

Topics: Acetophenones; Animals; Antioxidants; Disease Models, Animal; Male; Methylprednisolone; Mice; Mice,

2016

Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy.

Oxidative medicine and cellular longevity, 2016, Volume: 2016

Topics: Acetophenones; Aging; Animals; Antioxidants; Blood Glucose; Catalase; Cyclic N-Oxides; Diet, High-Fa

2016

Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures.

Neurotoxicity research, 2016, Volume: 30, Issue:4

Topics: Acetophenones; Animals; Anxiety; Brain; Cognitive Dysfunction; Cohort Studies; Disease Models, Anima

2016

Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes.

International ophthalmology, 2017, Volume: 37, Issue:3

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Male; Ophth

2017

Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2017, Volume: 69, Issue:1

Topics: Acetophenones; Animals; Carcinogenesis; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Immu

2017

Apocynin suppressed the nuclear factor-κB pathway and attenuated lung injury in a rat hemorrhagic shock model.

The journal of trauma and acute care surgery, 2017, Volume: 82, Issue:3

Topics: Acetophenones; Acute Lung Injury; Animals; Biomarkers; Disease Models, Animal; Lipid Peroxidation; M

2017

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke.

Free radical biology & medicine, 2017, Volume: 104

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models,

2017

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation.

Toxicology, 2017, 04-01, Volume: 380

Topics: Acetophenones; Adrenergic Neurons; Animals; Disease Models, Animal; Enzyme Inhibitors; Locus Coerule

2017

Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington's disease.

Neurotoxicology, 2017, Volume: 60

Topics: Acetophenones; Animals; Antioxidants; Cells, Cultured; Chlorpyrifos; Corpus Striatum; Curcumin; Dise

2017

An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice.

The Journal of surgical research, 2008, Volume: 148, Issue:2

Topics: Acetophenones; Animals; Antibodies, Monoclonal; Cyclosporine; Diet, Sodium-Restricted; Disease Model

2008

Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition.

Cardiovascular research, 2008, Nov-01, Volume: 80, Issue:2

Topics: Acetophenones; Age Factors; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relations

2008

Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia.

American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

Topics: Acetophenones; Animals; Animals, Newborn; Biopterins; Carbon Dioxide; Cerebral Cortex; Cerebrovascul

2008

Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke.

Journal of neurochemistry, 2008, Volume: 107, Issue:5

Topics: Acetophenones; Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cla

2008

NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension.

American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:6

Topics: Acetophenones; Allopurinol; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Gene

2008

Role of NOX2 in the regulation of afferent arteriole responsiveness.

American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:1

Topics: Acetophenones; Adenosine; Angiotensin II; Animals; Arterioles; Blood Pressure; Disease Models, Anima

2009

Salvage of nonischemic control lung from injury by unilateral ischemic lung with apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, in isolated perfused rat lung.

Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:6

Topics: Acetophenones; ADAM Proteins; ADAM17 Protein; Animals; Bronchoalveolar Lavage Fluid; Cell Membrane P

2008

NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart.

American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:3

Topics: Acetophenones; Acetylcholine; Aldehydes; Animals; Antioxidants; Cardiac Pacing, Artificial; Coronary

2009

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation.

Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:6

Topics: Acetophenones; Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Diabetes Mellitus, Exper

2009

Effects of apocynin and losartan treatment on renal oxidative stress in a rat model of calcium oxalate nephrolithiasis.

International urology and nephrology, 2009, Volume: 41, Issue:4

Topics: Acetophenones; Analysis of Variance; Angiotensin II; Animals; Antioxidants; Biopsy, Needle; Blotting

2009

The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7

Topics: Acetophenones; Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Enzyme Inhibito

2009

Amelioration of adjuvant induced arthritis by apocynin.

Phytotherapy research : PTR, 2009, Volume: 23, Issue:10

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Apocynum; Arthritis, Experimental; Capillary Perme

2009

Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction.

Coronary artery disease, 2009, Volume: 20, Issue:6

Topics: Acetophenones; Angina Pectoris, Variant; Animals; Aspartic Acid Endopeptidases; Coronary Angiography

2009

Antioxidants reverse age-related collateral growth impairment.

Journal of vascular research, 2010, Volume: 47, Issue:2

Topics: Acetophenones; Age Factors; Aging; Animals; Antioxidants; Collateral Circulation; Cyclic N-Oxides; D

2010

NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: protective role of apocynin.

Journal of neuroscience research, 2010, Feb-15, Volume: 88, Issue:3

Topics: Acetophenones; Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Lipid Peroxidat

2010

CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Nov-25, Volume: 29, Issue:47

Topics: Acetophenones; Animals; Brain; Brain Ischemia; Casein Kinase II; Cytoprotection; Disease Models, Ani

2009

Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner.

American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:3

Topics: Acetophenones; Animals; Animals, Newborn; Cardiomyopathies; Cells, Cultured; Class Ib Phosphatidylin

2010

Tumor necrosis factor-alpha: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension.

Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:2

Topics: Acetophenones; Analysis of Variance; Animals; Blood Pressure Determination; Cytokines; Disease Model

2010

Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.

American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:2

Topics: Acetophenones; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Body Weight; Card

2010

Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.

American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:2

Topics: Acetophenones; Animals; Carbon; Cell Hypoxia; Disease Models, Animal; Disease Progression; Enzyme In

2010

High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity.

American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Dinoprost; Disease Models, An

2010

Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase.

The journal of sexual medicine, 2010, Volume: 7, Issue:9

Topics: Acetophenones; Aldehydes; Animals; Cell Adhesion Molecules; Cholesterol, Dietary; Disease Models, An

2010

Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin.

Immunobiology, 2011, Volume: 216, Issue:4

Topics: Acetophenones; Adjuvants, Immunologic; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cell Lin

2011

Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats.

Brain research, 2011, Feb-04, Volume: 1372

Topics: Acetophenones; Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Cytochromes c; Disease Models,

2011

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.

Pain, 2011, Volume: 152, Issue:3

Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Int

2011

Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease.

Neuroscience letters, 2011, Apr-04, Volume: 492, Issue:3

Topics: Acetophenones; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Di

2011

Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice.

Mediators of inflammation, 2010, Volume: 2010

Topics: Acetophenones; Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base

2010

Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells.

Atherosclerosis, 2011, Volume: 217, Issue:2

Topics: Acetophenones; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitor

2011

Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model.

Intensive care medicine, 2011, Volume: 37, Issue:8

Topics: Acetophenones; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants;

2011

Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells.

Investigative ophthalmology & visual science, 2011, Jul-07, Volume: 52, Issue:8

Topics: Acetophenones; Adult; Animals; Antigens, CD34; Benzodioxoles; Chemokine CXCL12; Cyclic GMP; Diabetic

2011

Apocynin attenuates ischemia-reperfusion lung injury in an isolated and perfused rat lung model.

Translational research : the journal of laboratory and clinical medicine, 2011, Volume: 158, Issue:1

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models,

2011

Selective albuminuria via podocyte albumin transport in puromycin nephrotic rats is attenuated by an inhibitor of NADPH oxidase.

Kidney international, 2011, Volume: 80, Issue:12

Topics: Acetophenones; Albuminuria; Animals; Biological Transport; Disease Models, Animal; Endocytosis; Enzy

2011

Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.

Annals of neurology, 2011, Volume: 70, Issue:4

Topics: Acetophenones; Animals; Antioxidants; Blood Glucose; Blood-Brain Barrier; Cerebral Hemorrhage; Disea

2011

Anti-oxidative effect of apocynin on insulin resistance in high-fat diet mice.

Annals of clinical and laboratory science, 2011,Summer, Volume: 41, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Biomarkers; Catalase; Dietary Fats; Disease Models, Animal; Gl

2011

Protective effect of apocynin in an established alcoholic steatohepatitis rat model.

Immunopharmacology and immunotoxicology, 2012, Volume: 34, Issue:4

Topics: Acetophenones; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models

2012

UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.

American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Volume: 302, Issue:7

Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl

2012

Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus.

Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:3

Topics: Acetophenones; Albuminuria; Animals; Antioxidants; Autoimmunity; Blood Pressure; Cyclic N-Oxides; Di

2012

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

PLoS genetics, 2012, Volume: 8, Issue:2

Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pre

2012

Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy.

Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 4

Topics: Acetophenones; Acetylcysteine; Animals; Animals, Genetically Modified; Antioxidants; Behavior, Anima

2012

NADPH oxidase mediates depressive behavior induced by chronic stress in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jul-11, Volume: 32, Issue:28

Topics: Acetophenones; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Ascorb

2012

NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology.

Translational psychiatry, 2012, May-08, Volume: 2

Topics: Acetophenones; Alleles; Animals; Antioxidants; Brain; Disease Models, Animal; DNA Mutational Analysi

2012

Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation.

Brain research, 2012, Oct-24, Volume: 1481

Topics: Acetophenones; Animals; Blood-Brain Barrier; Brain Injuries; CA3 Region, Hippocampal; Cell Death; Di

2012

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.

Journal of neuroinflammation, 2012, Oct-23, Volume: 9

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Chromatography, High Pressure

2012

Attenuation of brain edema and spatial learning deﬁcits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats.

Molecular medicine reports, 2013, Volume: 7, Issue:1

Topics: Acetophenones; Animals; Brain Edema; Brain Injuries; Disease Models, Animal; Enzyme Activation; Lear

2013

Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.

Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 36

Topics: 3-Hydroxysteroid Dehydrogenases; Acetophenones; Animals; Berberine; Biomarkers; Calcium Channel Bloc

2013

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death.

Brain research, 2013, Mar-07, Volume: 1499

Topics: Acetophenones; Animals; Cell Death; Convulsants; Disease Models, Animal; Enzyme Inhibitors; Hippocam

2013

Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

Biological psychiatry, 2013, May-15, Volume: 73, Issue:10

Topics: Acetophenones; Animals; Antioxidants; Cerebral Cortex; Disease Models, Animal; Humans; Interneurons;

2013

Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.

Circulation, 2003, Sep-09, Volume: 108, Issue:10

Topics: Acetophenones; Animals; Antioxidants; Atrasentan; Biopterins; Carotid Arteries; Cyclic N-Oxides; Des

2003

Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.

Journal of hypertension, 2005, Volume: 23, Issue:7

Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis

2005

Prevention and reversal by enalapril of target organ damage in angiotensin II hypertension.

Journal of the renin-angiotensin-aldosterone system : JRAAS, 2005, Volume: 6, Issue:3

Topics: Acetophenones; Albuminuria; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-

2005

Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets.

American journal of hypertension, 2006, Volume: 19, Issue:5

Topics: Acetophenones; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Diet, Sodium-Restricted;

2006

Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus.

Brain research, 2006, May-23, Volume: 1090, Issue:1

Topics: Acetophenones; Aldehydes; Animals; Antioxidants; Biomarkers; Brain Ischemia; Cell Death; Cerebral In

2006

Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

Atherosclerosis, 2007, Volume: 192, Issue:1

Topics: Acetophenones; Acetylcholine; Animals; Antioxidants; Basilar Artery; Diabetes Mellitus, Type 2; Dise

2007

Angiotensin II mediates postischemic leukocyte-endothelial interactions: role of calcitonin gene-related peptide.

American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Recept

2007

Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.

American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

Topics: Acetophenones; Animals; Blood Flow Velocity; Cells, Cultured; Collateral Circulation; Coronary Circu

2007

Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction.

Free radical biology & medicine, 2007, Jul-15, Volume: 43, Issue:2

Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blood Pressure; Disease

2007

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.

Molecular vision, 2007, Jun-12, Volume: 13

Topics: Acetophenones; Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cryoultramicrotomy;

2007

Effects of apocynin and ethanol on intracerebral haemorrhage-induced brain injury in rats.

Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:9

Topics: Acetophenones; Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Cerebral Hemorrhage; C

2007

The polymorphonuclear leukocyte contributes to the development of hypertension in the Sabra rat.

Journal of hypertension, 2007, Volume: 25, Issue:11

Topics: Acetophenones; Animals; Blood Pressure; CD11b Antigen; Disease Models, Animal; Hypertension; Leukocy

2007

Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure.

Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12

Topics: Acetophenones; Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihyp

2007

NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells.

American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:1

Topics: Acetophenones; Actins; Angiotensin II; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; C

2008

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.

The Journal of clinical investigation, 2008, Volume: 118, Issue:2

Topics: Acetophenones; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Inhibitors; Hy

2008

Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model.

Atherosclerosis, 2009, Volume: 202, Issue:1

Topics: Acetophenones; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Extracellular Matrix; Ma

2009

Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn's disease.

Gut, 1997, Volume: 41, Issue:3

Topics: Acetophenones; Animals; Antioxidants; Crohn Disease; Cyclic N-Oxides; Disease Models, Animal; Enteri

1997

Effect of natural antioxidants and apocynin on LPS-induced endotoxemia in rabbit.

Human & experimental toxicology, 2000, Volume: 19, Issue:11

Topics: Acetophenones; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal

2000

Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice.

British journal of pharmacology, 2001, Volume: 134, Issue:2

Topics: Acetophenones; Amidines; Animals; Antioxidants; Benzylamines; Bronchial Hyperreactivity; Bronchoalve

2001