Page last updated: 2024-10-22

acetovanillone and Cerebral Ischemia

acetovanillone has been researched along with Cerebral Ischemia in 14 studies

apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.

Research Excerpts

ExcerptRelevanceReference
"Stroke is a universal cause of death and permanent disability."1.46Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. ( Bai, H; Feng, D; Gao, L; Guo, H; Jiang, H; Li, X; Liu, H; Qu, Y; Wang, B; Yue, L; Zhao, L, 2017)
"Two hours after the end of EA pretreatment, focal cerebral ischemia was induced following 24h reperfusion."1.40Electroacupuncture pretreatment inhibits NADPH oxidase-mediated oxidative stress in diabetic mice with cerebral ischemia. ( Guo, F; Jiang, T; Liu, L; Song, W; Wang, F; Wang, Q; Xiong, L; Yin, H; Zhong, H, 2014)
"The present study was designed to determine a dose-response relationship between apocynin and infarct volume as well as to provide a possible molecular mechanism mediating this effect."1.37Apocynin may limit total cell death following cerebral ischemia and reperfusion by enhancing apoptosis. ( Connell, BJ; Khan, BV; Saleh, MC; Saleh, TM, 2011)
"Global cerebral ischemia was induced in gerbils by a 5-min occlusion of bilateral common carotid arteries (CCA)."1.33Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. ( Korthuis, RJ; Simonyi, A; Sun, AY; Sun, GY; Tompkins, KD; Wang, Q, 2006)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (28.57)29.6817
2010's10 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, X1
Guo, H1
Zhao, L1
Wang, B1
Liu, H1
Yue, L1
Bai, H1
Jiang, H1
Gao, L1
Feng, D1
Qu, Y1
Kapoor, M1
Sharma, N1
Sandhir, R1
Nehru, B1
Tang, X1
Zhong, W1
Tu, Q1
Ding, B1
Guo, F1
Song, W1
Jiang, T1
Liu, L1
Wang, F1
Zhong, H1
Yin, H1
Wang, Q2
Xiong, L1
Qin, YY1
Li, M1
Feng, X1
Wang, J1
Cao, L1
Shen, XK1
Chen, J1
Sun, M1
Sheng, R1
Han, F1
Qin, ZH1
Chen, H1
Song, YS1
Chan, PH2
Kim, GS1
Jung, JE1
Niizuma, K1
Zhao, H1
Mayhan, WG1
Arrick, DM1
Xiong, W1
Sun, H1
Woodfin, A1
Hu, DE1
Sarker, M1
Kurokawa, T1
Fraser, P1
Connell, BJ2
Saleh, MC1
Khan, BV1
Saleh, TM2
Tang, XN2
Zheng, Z1
Giffard, RG2
Yenari, MA2
Xu, L1
Qiao, Y1
Tompkins, KD1
Simonyi, A1
Korthuis, RJ1
Sun, AY1
Sun, GY1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Minocycline on Patients With Acute Anterior Circulation Ischemic Stroke Undergoing Intravenous Thrombectomy[NCT05487417]Phase 4180 participants (Anticipated)Interventional2022-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for acetovanillone and Cerebral Ischemia

ArticleYear
Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:12

    Topics: Acetophenones; Adiponectin; Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; DNA Nucleoti

2017
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Acetophenones; Animals; Brain Ischemia; Enzyme Inhibitors; Hippocampus; Male; Maze Learning; NADPH O

2018
NADPH oxidase mediates the expression of MMP-9 in cerebral tissue after ischemia-reperfusion damage.
    Neurological research, 2014, Volume: 36, Issue:2

    Topics: Acetophenones; Animals; Blotting, Western; Brain; Brain Ischemia; Enzyme Inhibitors; Infarction, Mid

2014
Electroacupuncture pretreatment inhibits NADPH oxidase-mediated oxidative stress in diabetic mice with cerebral ischemia.
    Brain research, 2014, Jul-21, Volume: 1573

    Topics: Acetophenones; Animals; Brain; Brain Ischemia; Cinnamates; Diabetes Mellitus, Experimental; Electroa

2014
Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke.
    Free radical biology & medicine, 2017, Volume: 104

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models,

2017
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009, Volume: 29, Issue:7

    Topics: Acetophenones; Animals; Antioxidants; Brain Chemistry; Brain Infarction; Brain Ischemia; Inflammatio

2009
CK2 is a novel negative regulator of NADPH oxidase and a neuroprotectant in mice after cerebral ischemia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Nov-25, Volume: 29, Issue:47

    Topics: Acetophenones; Animals; Brain; Brain Ischemia; Casein Kinase II; Cytoprotection; Disease Models, Ani

2009
Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase.
    Alcoholism, clinical and experimental research, 2010, Volume: 34, Issue:11

    Topics: Acetophenones; Animals; Blotting, Western; Brain Ischemia; Central Nervous System Depressants; Ethan

2010
Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion.
    Free radical biology & medicine, 2011, Feb-15, Volume: 50, Issue:4

    Topics: Acetophenones; Animals; Bradykinin; Bradykinin Receptor Antagonists; Brain; Brain Ischemia; Capillar

2011
Apocynin may limit total cell death following cerebral ischemia and reperfusion by enhancing apoptosis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:12

    Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Brain Ischemia; DNA Fragmentation; Dose-Response Re

2011
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
    Annals of neurology, 2011, Volume: 70, Issue:4

    Topics: Acetophenones; Animals; Bone Marrow Cells; Brain; Brain Ischemia; Enzyme Inhibitors; Male; Membrane

2011
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
    Neuroscience letters, 2012, Jan-17, Volume: 507, Issue:1

    Topics: Acetophenones; Animals; Brain; Brain Ischemia; Drug Combinations; Humans; Male; Neuroprotective Agen

2012
Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro.
    Stroke, 2006, Volume: 37, Issue:4

    Topics: Acetophenones; Animals; Antioxidants; Astrocytes; Blood-Brain Barrier; Brain; Brain Ischemia; Cell D

2006
Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus.
    Brain research, 2006, May-23, Volume: 1090, Issue:1

    Topics: Acetophenones; Aldehydes; Animals; Antioxidants; Biomarkers; Brain Ischemia; Cell Death; Cerebral In

2006