Page last updated: 2024-10-22

acetovanillone and Cardiomegaly

acetovanillone has been researched along with Cardiomegaly in 8 studies

apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
" As evident from the HW/BW ratio, HW/TL ratio, echocardiography, and histopathology, hypertrophic responses induced by isoproterenol (Iso; 5 mg/Kg body weight, subcutaneous) were blocked by Apo (10 mg/Kg body weight, intraperitoneal)."7.88Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat. ( Goswami, SK; Prasad, A; Saleem, N, 2018)
"The ability of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor simvastatin to reverse established cardiovascular and renal alterations and oxidative stress was assessed in angiotensin II (AngII) hypertension."7.74Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine. ( Delbosc, S; Jover, B; Mimran, A; Rugale, C, 2007)
" As evident from the HW/BW ratio, HW/TL ratio, echocardiography, and histopathology, hypertrophic responses induced by isoproterenol (Iso; 5 mg/Kg body weight, subcutaneous) were blocked by Apo (10 mg/Kg body weight, intraperitoneal)."3.88Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat. ( Goswami, SK; Prasad, A; Saleem, N, 2018)
"67 Mb heterozygous deletion including the Eln gene, presented with a generalized arteriopathy, hypertension, and cardiac hypertrophy, associated with elevated angiotensin II (angII), oxidative stress parameters, and Ncf1 expression."3.78Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome. ( Bustelo, XR; Campuzano, V; Coustets, M; Francke, U; Menacho-Márquez, M; Nevado, J; Pérez-Jurado, LA; Sánchez-Rodríguez, C; Segura-Puimedon, M; Terrado, V, 2012)
"The ability of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor simvastatin to reverse established cardiovascular and renal alterations and oxidative stress was assessed in angiotensin II (AngII) hypertension."3.74Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine. ( Delbosc, S; Jover, B; Mimran, A; Rugale, C, 2007)
"Type 4 cardiorenal syndrome (CRS) refers to the cardiac injury induced by chronic kidney disease."1.42Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition. ( Chen, J; Huang, F; Huang, H; Liu, X; Liu, Y; Tang, W; Wang, JF; Zhang, K, 2015)
"After abdominal aorta banding to induce cardiac hypertrophy, rats were treated for 8 weeks with apocynin (Apo) or captopril (Cap)."1.36Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species. ( An, W; Lin, Y; Liu, J; Yang, Y; Zang, W; Zhou, J, 2010)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's6 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Saleem, N1
Prasad, A1
Goswami, SK1
Liu, Y2
Liu, X1
Chen, J1
Zhang, K1
Huang, F1
Wang, JF1
Tang, W1
Huang, H1
Buday, A1
Orsy, P1
Godó, M1
Mózes, M1
Kökény, G1
Lacza, Z1
Koller, A1
Ungvári, Z1
Gross, ML1
Benyó, Z1
Hamar, P1
Liu, J1
Zhou, J1
An, W1
Lin, Y1
Yang, Y1
Zang, W1
Campuzano, V1
Segura-Puimedon, M1
Terrado, V1
Sánchez-Rodríguez, C1
Coustets, M1
Menacho-Márquez, M1
Nevado, J1
Bustelo, XR1
Francke, U1
Pérez-Jurado, LA1
Li, YQ1
Li, XB1
Guo, SJ1
Chu, SL1
Gao, PJ1
Zhu, DL1
Niu, WQ1
Jia, N1
Kase, H1
Hashikabe, Y1
Uchida, K1
Nakanishi, N1
Hattori, Y1
Rugale, C1
Delbosc, S1
Mimran, A1
Jover, B1

Other Studies

8 other studies available for acetovanillone and Cardiomegaly

ArticleYear
Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat.
    Molecular and cellular biochemistry, 2018, Volume: 445, Issue:1-2

    Topics: Acetophenones; Adrenergic beta-Agonists; Animals; Biomarkers; Body Weight; Cardiomegaly; Echocardiog

2018
Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition.
    Journal of the American Heart Association, 2015, Jun-24, Volume: 4, Issue:7

    Topics: Acetophenones; Aged; Aged, 80 and over; Animals; Antioxidants; Cardio-Renal Syndrome; Cardiomegaly;

2015
Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:2

    Topics: Acetophenones; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Blood Pressure; Body Weight; Card

2010
Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species.
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:7

    Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Base Sequence; Capt

2010
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.
    PLoS genetics, 2012, Volume: 8, Issue:2

    Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pre

2012
Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:3

    Topics: Acetophenones; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Cardiomegaly; Cardiotonic

2013
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
    Journal of hypertension, 2005, Volume: 23, Issue:7

    Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis

2005
Simvastatin reverses target organ damage and oxidative stress in Angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:3

    Topics: Acetophenones; Albuminuria; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Cardiome

2007
chemdatabank.com