Page last updated: 2024-10-22

acetovanillone and Asthma

acetovanillone has been researched along with Asthma in 7 studies

apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
" At 36 h before and 16 h after O(3) exposure, methacholine inhalation challenge tests (Mch) were performed, and PC(20) and maximal % fall from baseline (MFEV(1)) were calculated from dose-response curves."6.70Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. ( Hiltermann, JT; Peters, EA; Stolk, J, 2001)
" At 36 h before and 16 h after O(3) exposure, methacholine inhalation challenge tests (Mch) were performed, and PC(20) and maximal % fall from baseline (MFEV(1)) were calculated from dose-response curves."2.70Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. ( Hiltermann, JT; Peters, EA; Stolk, J, 2001)
"Obesity is already responsible for 300,000 deaths per year."1.51The influence of apocynin, lipoic acid and probiotics on antioxidant enzyme levels in the pulmonary tissues of obese asthmatic mice. ( Kleniewska, P; Pawliczak, R, 2019)
"Apocynin also significantly reduced lung inflammation in the tissues."1.38Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation. ( Cho, YS; Chun, E; Jeong, S; Jo, HY; Jung, E; Kim, SY; Lee, KY; Moon, KA; Seon, SH, 2012)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kleniewska, P1
Pawliczak, R3
Chan, TK1
Tan, WSD1
Peh, HY1
Wong, WSF1
Stefanska, J2
Kim, SY1
Moon, KA1
Jo, HY1
Jeong, S1
Seon, SH1
Jung, E1
Cho, YS1
Chun, E1
Lee, KY1
Sarniak, A1
Wlodarczyk, A1
Sokolowska, M1
Pniewska, E1
Doniec, Z1
Nowak, D1
Thomas, M1
Sheran, J1
Smith, N1
Fonseca, S1
Lee, AJ1
Peters, EA1
Hiltermann, JT1
Stolk, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Investigation of the Safety and Efficacy of Oral AKL1 in Patients Diagnosed With Obstructive Lung Disease[NCT00920127]Phase 2/Phase 3164 participants (Anticipated)Interventional2009-06-30Active, not recruiting
Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics[NCT00992667]Phase 110 participants (Actual)Interventional2008-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for acetovanillone and Asthma

ArticleYear
Apocynin: molecular aptitudes.
    Mediators of inflammation, 2008, Volume: 2008

    Topics: Acetophenones; Animals; Arteriosclerosis; Asthma; Cartilage; Cyclooxygenase 2; Free Radical Scavenge

2008

Trials

3 trials available for acetovanillone and Asthma

ArticleYear
Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics.
    Experimental lung research, 2012, Volume: 38, Issue:2

    Topics: Acetophenones; Administration, Inhalation; Adult; Anti-Inflammatory Agents; Antioxidants; Asthma; Br

2012
AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study.
    BMC pulmonary medicine, 2007, Mar-20, Volume: 7

    Topics: Acetophenones; Adolescent; Adult; Aged; Asthma; Cross-Over Studies; Double-Blind Method; Ginkgo bilo

2007
Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics.
    Free radical biology & medicine, 2001, Dec-01, Volume: 31, Issue:11

    Topics: Acetophenones; Administration, Inhalation; Adult; Aerosols; Antioxidants; Asthma; Bronchial Hyperrea

2001

Other Studies

3 other studies available for acetovanillone and Asthma

ArticleYear
The influence of apocynin, lipoic acid and probiotics on antioxidant enzyme levels in the pulmonary tissues of obese asthmatic mice.
    Life sciences, 2019, Oct-01, Volume: 234

    Topics: Acetophenones; Animals; Antioxidants; Asthma; Catalase; Glutathione Peroxidase; Lung; Male; Mice, In

2019
Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 07-01, Volume: 199, Issue:1

    Topics: Acetophenones; Air; Allergens; Animals; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Asthma;

2017
Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation.
    Immunology and cell biology, 2012, Volume: 90, Issue:4

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Humans; Inflammation Mediators;

2012