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acetovanillone and Aging

acetovanillone has been researched along with Aging in 27 studies

apocynin : An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression."1.43Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. ( César-Gomes, CJ; Da Fonseca, LJ; Guedes, Gda S; Nunes-Souza, V; Rabelo, LA; Smaniotto, S, 2016)
"However, whether AOPPs are involved in senile osteoporosis is still largely unknown."1.40Advanced oxidation protein products accelerate bone deterioration in aged rats. ( Chen, JT; Huang, ZP; Li, XD; Wu, Q; Wu, XH; Xie, F; Ye, WB; Zeng, JH; Zheng, S; Zhong, ZM; Zhou, J, 2014)
": ED in middle-aged rats is associated with decreased NO bioavailability in erectile tissue due to upregulation of NADPH oxidase subunit gp91(phox) and downregulation of nNOS/p-eNOS."1.39Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats: prevention by antioxidant therapy. ( Antunes, E; Báu, FR; Brugnerotto, AF; Mónica, FZ; Priviero, FB; Silva, FH; Toque, HA, 2013)
" This study examined whether chronic intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents aging-related impairment of vascular function and physical exercise capacity."1.37Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. ( Auger, C; Bronner, C; Dal-Ros, S; Geny, B; Keller, N; Lang, AL; Schini-Kerth, VB; Zoll, J, 2011)
"0%) mediated by reduced nitric oxide (NO) bioavailability (P < 0."1.37Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. ( Calvert, JW; Fleenor, BS; Lefer, DJ; Marshall, KD; Seals, DR; Sindler, AL; Zigler, ML, 2011)
"Habitual aerobic exercise is associated with enhanced endothelium-dependent dilatation (EDD) in older humans, possibly by increasing nitric oxide bioavailability and reducing oxidative stress."1.35Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. ( Connell, ML; Donato, AJ; Durrant, JR; Folian, BJ; Lawson, BR; Lesniewski, LA; Russell, MJ; Seals, DR, 2009)
"This study utilized middle cerebral artery occlusion (MCAO) with tissue plasminogen activator (tPA) to assess inhibition of the NOX2 isoform of NADPH oxidase on brain injury and functional recovery in aged rats."1.35NOX2 inhibition with apocynin worsens stroke outcome in aged rats. ( Huber, JD; Kelly, KA; Li, X; Rosen, CL; Tan, Z; VanGilder, RL, 2009)
" Superoxide anion (O(2)(-)) is a major determinant of nitric oxide (NO) bioavailability and thus endothelial function."1.31Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. ( Brosnan, MJ; Dominiczak, AF; Graham, D; Hamilton, CA; McIntyre, M, 2001)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (29.63)29.6817
2010's17 (62.96)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Liu, F1
Fan, LM1
Michael, N1
Li, JM1
Shibuya, S1
Watanabe, K1
Ozawa, Y1
Shimizu, T1
Du, ZD1
Yu, S1
Qi, Y1
Qu, TF1
He, L1
Wei, W1
Liu, K1
Gong, SS1
Dayal, S1
Wilson, KM1
Motto, DG1
Miller, FJ1
Chauhan, AK1
Lentz, SR1
Zeng, JH1
Zhong, ZM1
Li, XD1
Wu, Q1
Zheng, S1
Zhou, J1
Ye, WB1
Xie, F1
Wu, XH1
Huang, ZP1
Chen, JT1
De Pasquale, R1
Beckhauser, TF1
Hernandes, MS1
Giorgetti Britto, LR1
Han, BH1
Zhou, ML1
Johnson, AW1
Singh, I1
Liao, F1
Vellimana, AK1
Nelson, JW1
Milner, E1
Cirrito, JR1
Basak, J1
Yoo, M1
Dietrich, HH1
Holtzman, DM1
Zipfel, GJ1
Silva, E1
Soares, AI1
Costa, F1
Castro, JP1
Matos, L1
Almeida, H1
Sun, J1
Ming, L1
Shang, F1
Shen, L1
Chen, J1
Jin, Y1
Nunes-Souza, V1
César-Gomes, CJ1
Da Fonseca, LJ1
Guedes, Gda S1
Smaniotto, S1
Rabelo, LA1
Collins, AR1
Lyon, CJ1
Xia, X1
Liu, JZ1
Tangirala, RK1
Yin, F1
Boyadjian, R1
Bikineyeva, A1
Praticò, D1
Harrison, DG1
Hsueh, WA1
Durrant, JR1
Seals, DR2
Connell, ML1
Russell, MJ1
Lawson, BR1
Folian, BJ1
Donato, AJ1
Lesniewski, LA1
Kelly, KA1
Li, X1
Tan, Z1
VanGilder, RL1
Rosen, CL1
Huber, JD1
Denvir, MA1
Gray, GA1
Miller, SJ2
Coppinger, BJ1
Zhou, X2
Unthank, JL2
Bohlen, HG1
Bitar, MS1
Ayed, AK1
Abdel-Halim, SM1
Isenovic, ER1
Al-Mulla, F1
Jeon, SM1
Lee, SJ1
Kwon, TK1
Kim, KJ1
Bae, YS1
Sodero, AO1
Weissmann, C1
Ledesma, MD1
Dotti, CG1
Dal-Ros, S2
Zoll, J1
Lang, AL1
Auger, C2
Keller, N1
Bronner, C2
Geny, B1
Schini-Kerth, VB2
Sindler, AL1
Fleenor, BS1
Calvert, JW1
Marshall, KD1
Zigler, ML1
Lefer, DJ1
Drouin, A1
Farhat, N1
Bolduc, V1
Thorin-Trescases, N1
Gillis, MA1
Villeneuve, L1
Nguyen, A1
Thorin, E1
Silva, FH1
Mónica, FZ1
Báu, FR1
Brugnerotto, AF1
Priviero, FB1
Toque, HA1
Antunes, E1
Adler, A1
Messina, E1
Sherman, B1
Wang, Z1
Huang, H1
Linke, A1
Hintze, TH1
Jacobson, A1
Yan, C1
Gao, Q1
Rincon-Skinner, T1
Rivera, A1
Edwards, J1
Huang, A1
Kaley, G1
Sun, D1
Hamilton, CA1
Brosnan, MJ1
McIntyre, M1
Graham, D1
Dominiczak, AF1

Other Studies

27 other studies available for acetovanillone and Aging

ArticleYear
In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study.
    Pharmacology research & perspectives, 2020, Volume: 8, Issue:4

    Topics: Acetophenones; Aging; Animals; Antioxidants; Blood-Brain Barrier; Computer Simulation; Diet, High-Fa

2020
Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in
    International journal of molecular sciences, 2021, Mar-29, Volume: 22, Issue:7

    Topics: Acetophenones; Aging; Allopurinol; Anemia; Animals; Fatty Liver; Mice, Mutant Strains; Muscular Atro

2021
NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats.
    Neurochemistry international, 2019, Volume: 124

    Topics: Acetophenones; Aging; Animals; Apoptosis; Cochlear Nucleus; Enzyme Inhibitors; Galactose; Male; Maze

2019
Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.
    Circulation, 2013, Mar-26, Volume: 127, Issue:12

    Topics: Acetophenones; Aging; Animals; Blood Platelets; Catalase; Female; Glutathione Peroxidase; Glutathion

2013
Advanced oxidation protein products accelerate bone deterioration in aged rats.
    Experimental gerontology, 2014, Volume: 50

    Topics: Acetophenones; Advanced Oxidation Protein Products; Aging; Animals; Antioxidants; Biomarkers; Biomec

2014
LTP and LTD in the visual cortex require the activation of NOX2.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Sep-17, Volume: 34, Issue:38

    Topics: Acetophenones; Aging; Animals; Antioxidants; Dizocilpine Maleate; Enzyme Activation; Excitatory Amin

2014
Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Feb-24, Volume: 112, Issue:8

    Topics: Acetophenones; Aging; Animals; Apolipoproteins E; Astrocytes; Brain; Cerebral Amyloid Angiopathy; Ce

2015
Antioxidant Supplementation Modulates Age-Related Placental Bed Morphology and Reproductive Outcome in Mice.
    Biology of reproduction, 2015, Volume: 93, Issue:3

    Topics: Acetophenones; Aging; Animals; Antioxidants; Cyclic N-Oxides; Decidua; Female; Fetus; Litter Size; M

2015
Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass.
    Scientific reports, 2015, Dec-21, Volume: 5

    Topics: Acetophenones; Aging; Animals; Bone and Bones; Bone Density; Cell Differentiation; Humans; Mesenchym

2015
Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acetophenones; Aging; Animals; Antioxidants; Blood Glucose; Catalase; Cyclic N-Oxides; Diet, High-Fa

2016
Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes.
    Circulation research, 2009, Mar-27, Volume: 104, Issue:6

    Topics: Acetophenones; Aging; Animals; Antioxidants; Atherosclerosis; Diabetes Mellitus; Diet, Atherogenic;

2009
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.
    The Journal of physiology, 2009, Jul-01, Volume: 587, Issue:Pt 13

    Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascul

2009
NOX2 inhibition with apocynin worsens stroke outcome in aged rats.
    Brain research, 2009, Oct-06, Volume: 1292

    Topics: Acetophenones; Aging; Animals; Antioxidants; Blood-Brain Barrier; Brain; Capillary Permeability; Ede

2009
Run for your life: exercise, oxidative stress and the ageing endothelium.
    The Journal of physiology, 2009, Sep-01, Volume: 587, Issue:Pt 17

    Topics: Acetophenones; Acetylcholine; Aging; Animals; Carotid Arteries; Down-Regulation; Endothelium, Vascul

2009
Antioxidants reverse age-related collateral growth impairment.
    Journal of vascular research, 2010, Volume: 47, Issue:2

    Topics: Acetophenones; Age Factors; Aging; Animals; Antioxidants; Collateral Circulation; Cyclic N-Oxides; D

2010
Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:6

    Topics: Acetophenones; Administration, Topical; Age Factors; Aging; Animals; Antioxidants; Catalase; Enzyme

2009
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
    Life sciences, 2010, Jun-05, Volume: 86, Issue:23-24

    Topics: Acetophenones; Aging; Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; Diabetes Mellitus, Ty

2010
NADPH oxidase is involved in protein kinase CKII down-regulation-mediated senescence through elevation of the level of reactive oxygen species in human colon cancer cells.
    FEBS letters, 2010, Jul-16, Volume: 584, Issue:14

    Topics: Acetophenones; Acetylcysteine; Aging; Antioxidants; Casein Kinase II; Cellular Senescence; Colonic N

2010
Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro.
    Neurobiology of aging, 2011, Volume: 32, Issue:6

    Topics: Acetophenones; Aging; Animals; Apoptosis; Biotinylation; Cell Death; Cholesterol; Cholesterol 24-Hyd

2011
Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.
    Biochemical and biophysical research communications, 2011, Jan-14, Volume: 404, Issue:2

    Topics: Acetophenones; Aging; Angiotensin II; Animals; Antioxidants; Arginase; Endothelium, Vascular; Enzyme

2011
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
    Aging cell, 2011, Volume: 10, Issue:3

    Topics: Acetophenones; Acetylcholine; Administration, Oral; Aging; Animals; Biopterins; Carotid Arteries; Cy

2011
Up-regulation of thromboxane A₂ impairs cerebrovascular eNOS function in aging atherosclerotic mice.
    Pflugers Archiv : European journal of physiology, 2011, Volume: 462, Issue:3

    Topics: Acetophenones; Aging; Animals; Antioxidants; Atherosclerosis; Benzofurans; Catechin; Cerebral Arteri

2011
Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress.
    Biochemical and biophysical research communications, 2012, Mar-09, Volume: 419, Issue:2

    Topics: Acetophenones; Aging; Animals; Antioxidants; Endothelium, Vascular; Mesenteric Arteries; NADPH Oxida

2012
Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats: prevention by antioxidant therapy.
    The journal of sexual medicine, 2013, Volume: 10, Issue:4

    Topics: Acetophenones; Acetylcholine; Aging; Animals; Blood Pressure; Cyclic GMP; Down-Regulation; Electric

2013
NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:3

    Topics: Acetophenones; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Body Weight;

2003
Aging enhances pressure-induced arterial superoxide formation.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Acetophenones; Aging; Animals; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Male; Mesen

2007
Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2

    Topics: Acetophenones; Aging; Animals; Aorta; Blood Pressure; Carotid Arteries; Endothelium, Vascular; Enzym

2001