acetone has been researched along with Seizures in 26 studies
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 7.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "gummosa protected mice against tonic convulsions induced by maximal electroshock (the median effective dose [ED(50)]=198." | 5.31 | Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. ( Kamalinejad, M; Mandgary, A; Sayyah, M, 2002) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 3.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "Solvent blood concentrations and subnarcotic effects (inhibition of electrically evoked seizures) were measured in rats exposed to constant or fluctuating air concentrations of toluene or acetone." | 3.69 | Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats. ( Frantík, E; Hornychová, M; Nosek, M; Vodicková, L, 1996) |
| "Ketosis is believed to be necessary to the anticonvulsant mechanism of the ketogenic diet; however, the relationship between ketosis and seizure control has not been established." | 2.42 | Non-invasive detection of ketosis and its application in refractory epilepsy. ( Musa-Veloso, K, 2004) |
| "Onset of convulsions and death were observed in rats with increased CYP2E1 activity, whereas convulsions and death did not appear in rats within 1 h after treatment with AN alone." | 1.36 | Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence. ( Aschner, M; Fangan, H; Guangwei, X; Rongzhu, L; Shizhong, W; Suhua, W; Wenrong, X; Xiaowu, Z; Ye, Z, 2010) |
| "Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)." | 1.33 | A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats. ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| "gummosa protected mice against tonic convulsions induced by maximal electroshock (the median effective dose [ED(50)]=198." | 1.31 | Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. ( Kamalinejad, M; Mandgary, A; Sayyah, M, 2002) |
| " Results of oral dose-response studies utilizing a 1:1 (w/w) mixture of acetonitrile and acetone, or varying doses of acetonitrile administered together with a constant dose of acetone, indicated that acetone potentiated acute acetonitrile toxicity three- to fourfold in rats." | 1.27 | Acetone potentiation of acute acetonitrile toxicity in rats. ( Freeman, JJ; Hayes, EP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Likhodii, S | 1 |
| Nylen, K | 2 |
| Burnham, WM | 3 |
| Suhua, W | 1 |
| Rongzhu, L | 1 |
| Wenrong, X | 1 |
| Guangwei, X | 1 |
| Xiaowu, Z | 1 |
| Shizhong, W | 1 |
| Ye, Z | 1 |
| Fangan, H | 1 |
| Aschner, M | 1 |
| Raza, ML | 1 |
| Zeeshan, M | 1 |
| Ahmad, M | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Hasebe, N | 1 |
| Abe, K | 1 |
| Sugiyama, E | 1 |
| Hosoi, R | 1 |
| Inoue, O | 1 |
| Likhodii, SS | 3 |
| Sayyah, M | 1 |
| Mandgary, A | 1 |
| Kamalinejad, M | 1 |
| DAVANZO, JP | 1 |
| MATTHEWS, RJ | 1 |
| STAFFORD, JE | 1 |
| Musa-Veloso, K | 2 |
| Volk, H | 1 |
| Potschka, H | 1 |
| Löscher, W | 1 |
| Hum, KM | 1 |
| Kalapos, MP | 2 |
| Gasior, M | 2 |
| French, A | 1 |
| Joy, MT | 1 |
| Tang, RS | 1 |
| Hartman, AL | 2 |
| Rogawski, MA | 2 |
| Kreindler, A | 1 |
| Cardaş, M | 1 |
| Macovei, M | 1 |
| Frantík, E | 1 |
| Vodicková, L | 1 |
| Hornychová, M | 1 |
| Nosek, M | 1 |
| Cunnane, SC | 1 |
| Wason, S | 1 |
| Gibler, WB | 1 |
| Hassan, M | 1 |
| Freeman, JJ | 1 |
| Hayes, EP | 1 |
| Roe, TF | 1 |
| Kogut, MD | 1 |
| King, LJ | 1 |
| Carl, JL | 1 |
| Lao, L | 1 |
| Boongird, P | 1 |
| Smith, BH | 1 |
| Postolache, V | 1 |
| Safta, L | 1 |
| Cuparencu, B | 1 |
| Steiner, L | 1 |
| Ambs, E | 1 |
| Brunnberg, J | 1 |
| Gekle, D | 1 |
| Labram, C | 1 |
| Jacques, G | 1 |
| Prasad, S | 1 |
| Malhotra, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetone and Seizures
| Article | Year |
|---|---|
Acetone as an anticonvulsant.
Topics: Acetone; Animals; Anticonvulsants; Diet, Ketogenic; Humans; Ketone Bodies; Seizures | 2008 |
Non-invasive detection of ketosis and its application in refractory epilepsy.
Topics: Acetone; Animals; Epilepsy; Humans; Ketones; Ketosis; Seizures | 2004 |
24 other studies available for acetone and Seizures
| Article | Year |
|---|---|
Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence.
Topics: Acetone; Acrylonitrile; Animals; Brain; Carcinogens; Cyanides; Cytochrome P-450 CYP2E1; Cytochrome P | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kain | 2010 |
Ketogenic diet: does acetone stop seizures?
Topics: Acetone; Animals; Anticonvulsants; Cerebrospinal Fluid; Convulsants; Diet; Epilepsy; Fasting; Humans | 2002 |
Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Acetone; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; E | 2002 |
STUDIES ON THE MECHANISM OF ACTION OF AMINOOXYACETIC ACID. I. REVERSAL OF AMINOOXYACETIC ACID-INDUCED CONVULSIONS BY VARIOUS AGENTS.
Topics: Acetates; Acetone; Aldehydes; Aminooxyacetic Acid; Antidotes; Cats; Electroencephalography; Glycine; | 1964 |
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables.
Topics: Acetone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Fixatives; Formald | 2005 |
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Antic | 2006 |
Possible mechanism for the effect of ketogenic diet in cases of uncontrolled seizures. The reconsideration of acetone theory.
Topics: Acetone; Child; Diet; Humans; Ketone Bodies; Models, Biological; Seizures | 2007 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
What is the antiseizure activity of acetone due to?
Topics: Acetone; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Drug Contaminati | 2007 |
The anticonvulsant activity of acetone does not depend upon its metabolites.
Topics: Acetone; Animals; Anticonvulsants; Blood-Brain Barrier; Disease Models, Animal; Humans; Injections, | 2008 |
[Convulsions during a coma caused by hyperglycemia and hyperosmolarity, without acetonemia].
Topics: Acetone; Adult; Diabetic Coma; Humans; Insulin; Male; Seizures | 1967 |
Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats.
Topics: Acetone; Administration, Inhalation; Animals; Body Burden; Dose-Response Relationship, Drug; Male; M | 1996 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |
Ventricular tachycardia associated with non-freon aerosol propellants.
Topics: Acetone; Aerosol Propellants; Aerosols; Alkenes; Butanes; Child, Preschool; Female; Fluorocarbons; H | 1986 |
Acetone potentiation of acute acetonitrile toxicity in rats.
Topics: Acetone; Acetonitriles; Animals; Cyanides; Dose-Response Relationship, Drug; Drug Synergism; Female; | 1985 |
Hypopituitarism and ketotic hypoglycemia.
Topics: Acetone; Acidosis; Arginine; Body Height; Body Weight; Child; Fatty Acids, Nonesterified; Female; Gl | 1971 |
Carbohydrate metabolism in brain during convulsions and its modification by phenobarbitone.
Topics: Acetone; Animals; Brain; Carbohydrate Metabolism; Citrates; Electric Stimulation; Fumarates; Ketoglu | 1973 |
Focal seizures as a manifestation of hyperglycemia without ketoacidosis. A case report.
Topics: Acetone; Blood Glucose; Humans; Hyperglycemia; Insulin; Male; Middle Aged; Seizures | 1971 |
[Effect of acetone upon pentamethylenetetrazole convulsions].
Topics: Acetone; Animals; Central Nervous System; Female; Male; Mice; Pentylenetetrazole; Reserpine; Seizure | 1970 |
[Cerebral convulsion as symptom in spontaneous hypoglycemia in childhood].
Topics: Acetone; Adrenal Cortex Hormones; Blood Glucose; Child, Preschool; Diagnosis, Differential; Diet The | 1971 |
[Critical studies on hyperglycemic syndrome with hyperosmolarity and without acidoketosis. Apropos of 5 cases].
Topics: Acetone; Aged; Blood Urea Nitrogen; Dehydration; Diabetic Coma; Diuresis; Female; Humans; Hydrogen-I | 1968 |
Studies on Withania ashwagandha Kaul. VI. The effect of the alkaloidal fractions (acetone, alcohol and water soluble) on the central nervous system.
Topics: Acetone; Alkaloids; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Drug Synerg | 1968 |