acetone has been researched along with Epilepsy in 13 studies
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 7.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "Although ketosis is an integral aspect of these therapeutic regimens, the direct importance of ketosis to seizure control needs further investigation." | 5.31 | Epilepsy and the ketogenic diet: assessment of ketosis in children using breath acetone. ( Comeau, F; Cunnane, S; Curtis, R; Musa-Veloso, K; Rarama, E, 2002) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy." | 3.75 | Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice. ( Buszewicz, G; Czuczwar, SJ; Gasior, M; Luszczki, JJ; Madro, R; Zarnowska, I; Zarnowski, T, 2009) |
| "A 10 mmol/kg injection of acetone suppressed seizures in 60% of rats (P<0." | 3.71 | Ketogenic diet: does acetone stop seizures? ( Burnham, WM; Likhodii, SS, 2002) |
| "Ketosis is believed to be necessary to the anticonvulsant mechanism of the ketogenic diet; however, the relationship between ketosis and seizure control has not been established." | 2.42 | Non-invasive detection of ketosis and its application in refractory epilepsy. ( Musa-Veloso, K, 2004) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| "Although ketosis is an integral aspect of these therapeutic regimens, the direct importance of ketosis to seizure control needs further investigation." | 1.31 | Epilepsy and the ketogenic diet: assessment of ketosis in children using breath acetone. ( Comeau, F; Cunnane, S; Curtis, R; Musa-Veloso, K; Rarama, E, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zarnowska, I | 1 |
| Luszczki, JJ | 1 |
| Zarnowski, T | 1 |
| Buszewicz, G | 1 |
| Madro, R | 1 |
| Czuczwar, SJ | 1 |
| Gasior, M | 2 |
| Raza, ML | 1 |
| Zeeshan, M | 1 |
| Ahmad, M | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Hu, XL | 1 |
| Cheng, X | 1 |
| Fei, J | 1 |
| Xiong, ZQ | 1 |
| Likhodii, SS | 3 |
| Burnham, WM | 2 |
| Musa-Veloso, K | 3 |
| Rarama, E | 1 |
| Comeau, F | 1 |
| Curtis, R | 1 |
| Cunnane, S | 1 |
| GAYRAL, L | 2 |
| French, A | 1 |
| Joy, MT | 1 |
| Tang, RS | 1 |
| Hartman, AL | 1 |
| Rogawski, MA | 1 |
| Seymour, KJ | 1 |
| Bluml, S | 1 |
| Sutherling, J | 1 |
| Sutherling, W | 1 |
| Ross, BD | 1 |
| Cunnane, SC | 1 |
| DeVivo, DC | 1 |
| Pagliara, AS | 1 |
| Prensky, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetone and Epilepsy
| Article | Year |
|---|---|
Non-invasive detection of ketosis and its application in refractory epilepsy.
Topics: Acetone; Animals; Epilepsy; Humans; Ketones; Ketosis; Seizures | 2004 |
12 other studies available for acetone and Epilepsy
| Article | Year |
|---|---|
Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice.
Topics: Acetone; Animals; Anticonvulsants; Biophysical Phenomena; Disease Models, Animal; Dose-Response Rela | 2009 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet.
Topics: Acetone; Animals; Anticonvulsants; Antimetabolites; Calcium-Calmodulin-Dependent Protein Kinase Kina | 2011 |
Ketogenic diet: does acetone stop seizures?
Topics: Acetone; Animals; Anticonvulsants; Cerebrospinal Fluid; Convulsants; Diet; Epilepsy; Fasting; Humans | 2002 |
Epilepsy and the ketogenic diet: assessment of ketosis in children using breath acetone.
Topics: Acetone; Anticonvulsants; Breath Tests; Child; Diet; Epilepsy; Humans; Ketone Bodies; Ketosis; Time | 2002 |
On the anticonvulsant effect of acetone and the ketogenic diet.
Topics: Acetoacetates; Acetone; Animals; Anticonvulsants; Brain; Combined Modality Therapy; Dose-Response Re | 2002 |
[Two bad girls].
Topics: Acetone; Body Fluids; Child; Epilepsy; Female; Humans; Infant; Psychology, Child | 1956 |
[Two bad girls].
Topics: Acetone; Body Fluids; Child; Epilepsy; Female; Humans; Infant; Psychology, Child | 1956 |
[Two bad girls].
Topics: Acetone; Body Fluids; Child; Epilepsy; Female; Humans; Infant; Psychology, Child | 1956 |
[Two bad girls].
Topics: Acetone; Body Fluids; Child; Epilepsy; Female; Humans; Infant; Psychology, Child | 1956 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma | 2007 |
Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet.
Topics: Acetone; Adolescent; Adult; Brain; Case-Control Studies; Child; Child, Preschool; Dietary Fats; Epil | 1999 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |
A case of anorexia.
Topics: Acetone; Adult; Amenorrhea; Anorexia Nervosa; Autopsy; Blood Pressure; Body Weight; Diet, Reducing; | 1973 |
Ketotic hypoglycemia and the ketogenic diet.
Topics: Acetazolamide; Acetone; Acidosis; Blood Glucose; Child, Preschool; Diet Therapy; Dietary Carbohydrat | 1973 |