Compounds > acetone
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acetone and Acute Liver Injury, Drug-Induced

acetone has been researched along with Acute Liver Injury, Drug-Induced in 29 studies

methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).

Research Excerpts

ExcerptRelevanceReference
"Diclofenac sodium was used as the toxicant in hepatoprotective studies, in which various serum biochemical parameters and liver glycogen were assessed."1.35Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats. ( Chanda, S; Nair, R; Tanna, A, 2009)
"Obesity is a growing health problem in the United States."1.34Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. ( Cederbaum, AI; Dey, A, 2007)
" Serum enzyme activities, measured 24 h post dosing as indices of acute liver injury, exhibited distinct maxima in both fed and fasted animals dosed with CCl(4) near the beginning of their dark/active cycle."1.31Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity. ( Bruckner, JV; Lee, KM; Muralidhara, S; Ramanathan, R, 2002)
"Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice."1.29Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993)
"Acetone pretreatment reduced the inhibition of protein synthesis caused by hydrazine compared to the control."1.29Role of cytochrome P450 in hydrazine toxicity in isolated hepatocytes in vitro. ( Delaney, J; Timbrell, JA, 1995)
"Acetone pretreatment of rats also produced an exacerbation of liver damage induced by acute administration of TB (150 mg/kg), as judged by the extent of liver necrosis and serum alanine-amino transferase (ALAT) activities."1.28Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide. ( Chieli, E; Gervasi, PG; Longo, V; Puccini, P; Saviozzi, M, 1990)
"Administration of acetone to rats in amounts larger than or equal to a minimal effective dosage (MED) is known to potentiate the severity of the liver damage produced by CCl4 alone."1.27Assessment of the minimal effective dose of acetone for potentiation of the hepatotoxicity induced by trichloroethylene-carbon tetrachloride mixtures. ( Brodeur, J; Charbonneau, M; Greselin, E; Perreault, F; Plaa, GL, 1988)
"Pretreatment with acetone or isopropanol (2."1.27Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol. ( Chung, HR; Lorr, NA; Miller, KW; Yang, CS, 1984)
" The potentiated response observed with acetone plus BrCHCl2 or Br2CHCl was equal to or greater than that observed with acetone plus an approximately equimolar dosage of CHCl3."1.27Acetone-induced potentiation of trihalomethane toxicity in male rats. ( Brown, EM; Hewitt, WR; Plaa, GL, 1983)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199016 (55.17)18.7374
1990's4 (13.79)18.2507
2000's6 (20.69)29.6817
2010's2 (6.90)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Phipps, KR1
Lozon, D1
Baldwin, N1
El-Gengaihi, SE1
Hassan, EE1
Hamed, MA1
Zahran, HG1
Mohammed, MA1
Tanna, A1
Nair, R1
Chanda, S1
Nakamura, S1
Okazaki, Y1
Ninomiya, K1
Morikawa, T1
Matsuda, H1
Yoshikawa, M1
Coballase-Urrutia, E1
Pedraza-Chaverri, J1
Cárdenas-Rodríguez, N1
Huerta-Gertrudis, B1
García-Cruz, ME1
Ramírez-Morales, A1
Sánchez-González, DJ1
Martínez-Martínez, CM1
Camacho-Carranza, R1
Espinosa-Aguirre, JJ1
HIEMCKE, T1
Lu, Y1
Cederbaum, AI2
DiSilvestro, RA1
Zhang, W1
DiSilvestro, DJ1
Dey, A1
Plaa, GL7
Hewitt, WR3
du Souich, P1
Caillé, G1
Lock, S1
Lorr, NA1
Miller, KW1
Chung, HR1
Yang, CS1
Dawson, JR1
Norbeck, K1
Anundi, I1
Moldéus, P1
Brown, EM1
MacDonald, JR1
Gandolfi, AJ1
Sipes, IG1
Laham, S1
Potvin, M1
Schrader, K1
Marino, I1
Jaw, S1
Jeffery, EH1
Delaney, J1
Timbrell, JA1
Tomei, F1
Giuntoli, P1
Biagi, M1
Baccolo, TP1
Tomao, E1
Rosati, MV1
Bruckner, JV1
Ramanathan, R1
Lee, KM1
Muralidhara, S1
Chieli, E1
Saviozzi, M1
Puccini, P1
Longo, V1
Gervasi, PG1
Charbonneau, M1
Perreault, F1
Greselin, E1
Brodeur, J1
Hewitt, LA1
Valiquette, C1
Saprin, AN1
Shuliakovskaia, TS1
Traiger, GJ2
King, ME1
Shefner, AM1
Bates, RR1
Kuznetsova, EE1
Frolova, AD1

Other Studies

29 other studies available for acetone and Acute Liver Injury, Drug-Induced

ArticleYear
Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary.
    Regulatory toxicology and pharmacology : RTP, 2021, Volume: 119

    Topics: Acetone; Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Diet; Female; Liver; Male;

2021
Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent.
    Journal of dietary supplements, 2013, Volume: 10, Issue:1

    Topics: Acetone; Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis

2013
Assessment of anti-inflammatory and hepatoprotective potency of Polyalthia longifolia var. pendula leaf in Wistar albino rats.
    Journal of natural medicines, 2009, Volume: 63, Issue:1

    Topics: Acetone; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemi

2009
Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.
    Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:12

    Topics: Acetone; Animals; beta-Glucosidase; Cell Survival; Chemical and Drug Induced Liver Injury; Diterpene

2008
Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl(4)-induced toxicity in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2011, Volume: 63, Issue:4

    Topics: Acetone; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Asteraceae; Carbo

2011
[METABOLIC ACIDOSIS DUE TO PARALDEHYDE].
    Nederlands tijdschrift voor geneeskunde, 1964, Nov-07, Volume: 108

    Topics: Acetone; Acidosis; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis; Hepat

1964
Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 89, Issue:2

    Topics: Acetone; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced

2006
Kava feeding in rats does not cause liver injury nor enhance galactosamine-induced hepatitis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:7

    Topics: Acetone; Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Diet; Do

2007
Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Acetone; Animals; Apoptosis; Caspase 3; Catalysis; Chemical and Drug Induced Liver Injury; Cytochrom

2007
Isopropanol and acetone potentiation of carbon tetrachloride-induced hepatotoxicity: single versus repetitive pretreatments in rats.
    Journal of toxicology and environmental health, 1982, Volume: 9, Issue:2

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Dru

1982
Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol.
    Toxicology and applied pharmacology, 1984, Volume: 73, Issue:3

    Topics: 1-Propanol; Acetone; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytoc

1984
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
    Archives of toxicology, 1984, Volume: 55, Issue:1

    Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Ch

1984
Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.
    Toxicology letters, 1983, Volume: 16, Issue:1-2

    Topics: Acetone; Alanine Transaminase; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury;

1983
Acetone-induced potentiation of trihalomethane toxicity in male rats.
    Toxicology letters, 1983, Volume: 16, Issue:3-4

    Topics: Acetone; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relati

1983
Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.
    Toxicology letters, 1982, Volume: 13, Issue:1-2

    Topics: Acetone; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Glut

1982
Studies on inhalation toxicity of 2-propanol.
    Drug and chemical toxicology, 1980, Volume: 3, Issue:4

    Topics: 1-Propanol; Acetone; Animals; Biotransformation; Body Temperature; Chemical and Drug Induced Liver I

1980
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav

1993
Role of cytochrome P450 in hydrazine toxicity in isolated hepatocytes in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:12

    Topics: Acetone; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1;

1995
Liver damage among shoe repairers.
    American journal of industrial medicine, 1999, Volume: 36, Issue:5

    Topics: Acetates; Acetone; Adhesives; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotran

1999
Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Acetone; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Circadian

2002
Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide.
    Archives of toxicology, 1990, Volume: 64, Issue:2

    Topics: Acetone; Alanine Transaminase; Amides; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P

1990
Assessment of the minimal effective dose of acetone for potentiation of the hepatotoxicity induced by trichloroethylene-carbon tetrachloride mixtures.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1988, Volume: 10, Issue:3

    Topics: Acetone; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Chemical and Drug In

1988
The role of biotransformation-detoxication in acetone-, 2-butanone-, and 2-hexanone-potentiated chloroform-induced hepatotoxicity.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:11

    Topics: Acetone; Animals; Biotransformation; Butanones; Chemical and Drug Induced Liver Injury; Chloroform;

1987
[New type of ESR signal arising in animal tissues treated with a series of chemical agents and during necroses].
    Doklady Akademii nauk SSSR, 1969, Dec-01, Volume: 189, Issue:4

    Topics: Acetone; Animals; Chemical and Drug Induced Liver Injury; Electron Spin Resonance Spectroscopy; Etha

1969
A patient with diabetes.
    British medical journal, 1974, Oct-19, Volume: 4, Issue:5937

    Topics: Acetone; Adult; Autopsy; Bacteriuria; Brain; Chemical and Drug Induced Liver Injury; Cystoscopy; Dia

1974
Effect of aminotriazole on isopropanol- and acetone-induced potentiation of CCl 4 hepatotoxicity.
    Canadian journal of physiology and pharmacology, 1973, Volume: 51, Issue:4

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Amitrole; Aniline Compounds; Animals; Carbon Tetrachlorid

1973
Carcinogenesis bioassay of chlorinated dibenzodioxins and related chemicals.
    Environmental health perspectives, 1973, Volume: 5

    Topics: Acetone; Administration, Oral; Animals; Benz(a)Anthracenes; Body Weight; Carcinoma, Squamous Cell; C

1973
Chlorinated hydrocarbon toxicity. Potentiation by isopropyl alcohol and acetone.
    Archives of environmental health, 1974, Volume: 28, Issue:5

    Topics: 1-Propanol; Acetone; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofo

1974
[Pathogenesis of the toxic action of perfluoroacetone dihydrate].
    Gigiena truda i professional'nye zabolevaniia, 1971, Volume: 15, Issue:2

    Topics: Acetone; Animals; Chemical and Drug Induced Liver Injury; Chemical Industry; Environmental Exposure;

1971