acetone has been researched along with Absence Seizure in 26 studies
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).
| Excerpt | Reference |
|---|---|
| "Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)." | ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006) |
| Excerpt | Reference |
|---|---|
| "Onset of convulsions and death were observed in rats with increased CYP2E1 activity, whereas convulsions and death did not appear in rats within 1 h after treatment with AN alone." | ( Aschner, M; Fangan, H; Guangwei, X; Rongzhu, L; Shizhong, W; Suhua, W; Wenrong, X; Xiaowu, Z; Ye, Z, 2010) |
| "A pentylenetetrazole seizure test was administered 15 min after the injections." | ( Burnham, WM; Likhodii, SS, 2002) |
| "gummosa protected mice against tonic convulsions induced by maximal electroshock (the median effective dose [ED(50)]=198." | ( Kamalinejad, M; Mandgary, A; Sayyah, M, 2002) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| "As an indicator of ketosis in epilepsy patients consuming a ketogenic diet, breath acetone may be useful for understanding the mechanism of the diet, elucidating the importance of ketosis in seizure protection, and ultimately, enhancing the efficacy of the diet by improving patient monitoring." | ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Likhodii, S | 1 |
| Nylen, K | 2 |
| Burnham, WM | 3 |
| Suhua, W | 1 |
| Rongzhu, L | 1 |
| Wenrong, X | 1 |
| Guangwei, X | 1 |
| Xiaowu, Z | 1 |
| Shizhong, W | 1 |
| Ye, Z | 1 |
| Fangan, H | 1 |
| Aschner, M | 1 |
| Raza, ML | 1 |
| Zeeshan, M | 1 |
| Ahmad, M | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Hasebe, N | 1 |
| Abe, K | 1 |
| Sugiyama, E | 1 |
| Hosoi, R | 1 |
| Inoue, O | 1 |
| Likhodii, SS | 3 |
| Sayyah, M | 1 |
| Mandgary, A | 1 |
| Kamalinejad, M | 1 |
| DAVANZO, JP | 1 |
| MATTHEWS, RJ | 1 |
| STAFFORD, JE | 1 |
| Musa-Veloso, K | 2 |
| Volk, H | 1 |
| Potschka, H | 1 |
| Löscher, W | 1 |
| Hum, KM | 1 |
| Kalapos, MP | 2 |
| Gasior, M | 2 |
| French, A | 1 |
| Joy, MT | 1 |
| Tang, RS | 1 |
| Hartman, AL | 2 |
| Rogawski, MA | 2 |
| Kreindler, A | 1 |
| Cardaş, M | 1 |
| Macovei, M | 1 |
| Frantík, E | 1 |
| Vodicková, L | 1 |
| Hornychová, M | 1 |
| Nosek, M | 1 |
| Cunnane, SC | 1 |
| Wason, S | 1 |
| Gibler, WB | 1 |
| Hassan, M | 1 |
| Freeman, JJ | 1 |
| Hayes, EP | 1 |
| Roe, TF | 1 |
| Kogut, MD | 1 |
| King, LJ | 1 |
| Carl, JL | 1 |
| Lao, L | 1 |
| Boongird, P | 1 |
| Smith, BH | 1 |
| Postolache, V | 1 |
| Safta, L | 1 |
| Cuparencu, B | 1 |
| Steiner, L | 1 |
| Ambs, E | 1 |
| Brunnberg, J | 1 |
| Gekle, D | 1 |
| Labram, C | 1 |
| Jacques, G | 1 |
| Prasad, S | 1 |
| Malhotra, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 review(s) available for acetone and Absence Seizure
| Article | Year |
|---|---|
Acetone as an anticonvulsant.
Topics: Acetone; Animals; Anticonvulsants; Diet, Ketogenic; Humans; Ketone Bodies; Seizures | 2008 |
Non-invasive detection of ketosis and its application in refractory epilepsy.
Topics: Acetone; Animals; Epilepsy; Humans; Ketones; Ketosis; Seizures | 2004 |
24 other study(ies) available for acetone and Absence Seizure
| Article | Year |
|---|---|
Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence.
Topics: Acetone; Acrylonitrile; Animals; Brain; Carcinogens; Cyanides; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dichloroethylenes; Drug Interactions; Electron Transport Complex IV; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Longevity; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbred Strains; Pakistan; Pentylenetetrazole; Phenytoin; Picrotoxin; Ranunculaceae; Seizures; Skin Neoplasms | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kainic Acid; Male; Mice; Motor Activity; Pentanones; Pentylenetetrazole; Seizures | 2010 |
Ketogenic diet: does acetone stop seizures?
Topics: Acetone; Animals; Anticonvulsants; Cerebrospinal Fluid; Convulsants; Diet; Epilepsy; Fasting; Humans; Ketones; Magnetic Resonance Spectroscopy; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2002 |
Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Acetone; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Ferula; Male; Mice; Pentylenetetrazole; Plant Extracts; Seeds; Seizures | 2002 |
STUDIES ON THE MECHANISM OF ACTION OF AMINOOXYACETIC ACID. I. REVERSAL OF AMINOOXYACETIC ACID-INDUCED CONVULSIONS BY VARIOUS AGENTS.
Topics: Acetates; Acetone; Aldehydes; Aminooxyacetic Acid; Antidotes; Cats; Electroencephalography; Glycine; Metabolism; Oximes; Paraldehyde; Pentobarbital; Pharmacology; Pyridoxine; Research; Seizures; Toxicology | 1964 |
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables.
Topics: Acetone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Fixatives; Formaldehyde; Freeze Drying; Frozen Sections; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Polymers; Rats; Rats, Wistar; Seizures; Staining and Labeling; Tissue Fixation | 2005 |
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Dietary Fats; Disease Models, Animal; Electric Stimulation; Ketosis; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Seizures; Sulfides | 2006 |
Possible mechanism for the effect of ketogenic diet in cases of uncontrolled seizures. The reconsideration of acetone theory.
Topics: Acetone; Child; Diet; Humans; Ketone Bodies; Models, Biological; Seizures | 2007 |
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Malondialdehyde; Mice; Pentylenetetrazole; Pyruvaldehyde; Pyruvic Acid; Seizures | 2007 |
What is the antiseizure activity of acetone due to?
Topics: Acetone; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Drug Contamination; Humans; Injections, Intraperitoneal; Mice; Mice, Transgenic; Motor Activity; Papio; Seizures; Tissue Distribution | 2007 |
The anticonvulsant activity of acetone does not depend upon its metabolites.
Topics: Acetone; Animals; Anticonvulsants; Blood-Brain Barrier; Disease Models, Animal; Humans; Injections, Intraperitoneal; Ketosis; Mice; Pyruvaldehyde; Rodentia; Seizures; Treatment Outcome | 2008 |
[Convulsions during a coma caused by hyperglycemia and hyperosmolarity, without acetonemia].
Topics: Acetone; Adult; Diabetic Coma; Humans; Insulin; Male; Seizures | 1967 |
Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats.
Topics: Acetone; Administration, Inhalation; Animals; Body Burden; Dose-Response Relationship, Drug; Male; Models, Biological; Rats; Rats, Wistar; Seizures; Solvents; Time Factors; Toluene | 1996 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fasting; Female; Humans; Ketone Bodies; Ketosis; Kinetics; Male; Seizures | 2002 |
Ventricular tachycardia associated with non-freon aerosol propellants.
Topics: Acetone; Aerosol Propellants; Aerosols; Alkenes; Butanes; Child, Preschool; Female; Fluorocarbons; Heart Ventricles; Humans; Propane; Seizures; Tachycardia | 1986 |
Acetone potentiation of acute acetonitrile toxicity in rats.
Topics: Acetone; Acetonitriles; Animals; Cyanides; Dose-Response Relationship, Drug; Drug Synergism; Female; Kinetics; Lethal Dose 50; Rats; Rats, Inbred Strains; Seizures; Thiosulfates; Tremor | 1985 |
Hypopituitarism and ketotic hypoglycemia.
Topics: Acetone; Acidosis; Arginine; Body Height; Body Weight; Child; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Growth; Growth Hormone; Humans; Hypoglycemia; Hypopituitarism; Insulin; Iodine Isotopes; Metyrapone; Pituitary-Adrenal Function Tests; Prednisone; Seizures; Thyroid Function Tests; Thyroid Hormones | 1971 |
Carbohydrate metabolism in brain during convulsions and its modification by phenobarbitone.
Topics: Acetone; Animals; Brain; Carbohydrate Metabolism; Citrates; Electric Stimulation; Fumarates; Ketoglutaric Acids; Malates; Male; Mice; Mice, Inbred ICR; Oxaloacetates; Phenobarbital; Pyruvates; Seizures; Succinates | 1973 |
Focal seizures as a manifestation of hyperglycemia without ketoacidosis. A case report.
Topics: Acetone; Blood Glucose; Humans; Hyperglycemia; Insulin; Male; Middle Aged; Seizures | 1971 |
[Effect of acetone upon pentamethylenetetrazole convulsions].
Topics: Acetone; Animals; Central Nervous System; Female; Male; Mice; Pentylenetetrazole; Reserpine; Seizures | 1970 |
[Cerebral convulsion as symptom in spontaneous hypoglycemia in childhood].
Topics: Acetone; Adrenal Cortex Hormones; Blood Glucose; Child, Preschool; Diagnosis, Differential; Diet Therapy; Dietary Fats; Electroencephalography; Epinephrine; Female; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Infant; Insulin; Leucine; Male; Prognosis; Seizures; Tolbutamide | 1971 |
[Critical studies on hyperglycemic syndrome with hyperosmolarity and without acidoketosis. Apropos of 5 cases].
Topics: Acetone; Aged; Blood Urea Nitrogen; Dehydration; Diabetic Coma; Diuresis; Female; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Hypernatremia; Hypokalemia; Hypotonic Solutions; Insulin; Male; Osmolar Concentration; Reflex, Abnormal; Seizures; Water-Electrolyte Balance | 1968 |
Studies on Withania ashwagandha Kaul. VI. The effect of the alkaloidal fractions (acetone, alcohol and water soluble) on the central nervous system.
Topics: Acetone; Alkaloids; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Drug Synergism; Electroshock; Ethanol; Female; Heart Rate; Lysergic Acid Diethylamide; Male; Pentobarbital; Phenoxybenzamine; Plant Extracts; Plants, Medicinal; Rats; Reserpine; Respiration; Seizures; Sleep; Solubility; Urethane; Water | 1968 |