acetogenins has been researched along with Malaria--Falciparum* in 1 studies
1 other study(ies) available for acetogenins and Malaria--Falciparum
| Article | Year |
|---|---|
Antiplasmodial activity of acetogenins and inhibitory effect on Plasmodium falciparum adenylate translocase.
Three Annonaceous acetogenins exhibited in vitro antimalarial activities on a chloroquine-resistant Plasmodium falciparum strain, with IC50s ranging from 5 to 10 microM. Structure-activity relationships showed that maximal antimalarial activity occurred in the presence of at least one tetrahydrofuran moiety and a synergistic action with chloroquine was observed. These acetogenins partially inhibited the P. falciparum adenylate translocase. Topics: Acetogenins; Aminoquinolines; Animals; Antimalarials; Drug Resistance, Microbial; Electron Transport Complex I; Fatty Alcohols; Humans; Lactones; Malaria, Falciparum; Microbial Sensitivity Tests; Mitochondrial ADP, ATP Translocases; Plant Extracts; Plasmodium falciparum; Sensitivity and Specificity; Structure-Activity Relationship | 2004 |