Page last updated: 2024-10-15

acetoacetic acid and Weight Reduction

acetoacetic acid has been researched along with Weight Reduction in 4 studies

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Research Excerpts

ExcerptRelevanceReference
"Three clinical studies were conducted: a bariatric surgery cohort study of participants with morbid obesity who underwent either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) studied over four and twelve weeks, and two randomized placebo-controlled, crossover double blind studies of liraglutide vs."5.69Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. ( Alexandrou, A; Angelidi, AM; Connelly, MA; Kokkinos, A; Mantzoros, CS; Mingrone, G; Sanoudou, D, 2023)
"Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out."2.71Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. ( Boyar, K; Di Rocco, A; Heymsfield, SB; Hyams, K; Nonas, C; Vanitallie, TB, 2005)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Spigoni, V1
Cinquegrani, G1
Iannozzi, NT1
Frigeri, G1
Maggiolo, G1
Maggi, M1
Parello, V1
Dei Cas, A1
Angelidi, AM1
Kokkinos, A1
Sanoudou, D1
Connelly, MA1
Alexandrou, A1
Mingrone, G1
Mantzoros, CS1
Aksungar, FB1
Sarıkaya, M1
Coskun, A1
Serteser, M1
Unsal, I1
Vanitallie, TB1
Nonas, C1
Di Rocco, A1
Boyar, K1
Hyams, K1
Heymsfield, SB1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk[NCT03851874]28 participants (Actual)Interventional2011-10-31Completed
Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI[NCT01562678]Phase 428 participants (Actual)Interventional2012-03-31Completed
Saxenda: Underlying Mechanisms and Clinical Outcomes[NCT02944500]Phase 428 participants (Actual)Interventional2016-11-30Active, not recruiting
Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome[NCT05469997]50 participants (Anticipated)Interventional2023-01-31Not yet recruiting
Effect of a Lipidic and Proteic Controlled Diet on Resting Energy Expenditure, Body Composition and Symptoms in Patients With Parkinson's Disease[NCT02687698]36 participants (Anticipated)Interventional2016-02-29Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change Between Highly Desirable vs. Less Desirable Food Cues in the Effect Size of Cortical Activation During Food Visualization

Effect size (region of interest z-scores, derived from z-maps of the brain) shown below is the difference in parietal cortex activation to highly desirable (high fat or high calorie, e.g. cakes, pies, fries) versus less desirable (low fat or low calorie, e.g. vegetables, fruits) food cues for each treatment condition (liraglutide or placebo) at the end of the treatment period. (NCT01562678)
Timeframe: 18 days of Liraglutide or placebo treatment

Interventionz-scores of activation in cortex (Mean)
Liraglutide-0.42
Placebo0.53

Reviews

1 review available for acetoacetic acid and Weight Reduction

ArticleYear
Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Carbohydrates; Diet, Ketogenic; Humans; Ketone Bodies; Ketones

2022

Trials

2 trials available for acetoacetic acid and Weight Reduction

ArticleYear
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005

Other Studies

1 other study available for acetoacetic acid and Weight Reduction

ArticleYear
Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up.
    The journal of nutrition, health & aging, 2017, Volume: 21, Issue:6

    Topics: Acetoacetates; Adult; Blood Glucose; Body Mass Index; Caloric Restriction; Diet; Fasting; Female; Fo

2017