acetoacetic acid has been researched along with Seizures in 4 studies
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Consistent with these observations, acetoacetate reduced quantal size at hippocampal synapses and suppresses glutamate release and seizures evoked with 4-aminopyridine in the brain." | 3.76 | Metabolic control of vesicular glutamate transport and release. ( Edwards, RH; Gray, JA; Hara, C; Inoue, T; Juge, N; Miyaji, T; Moriyama, Y; Nicoll, RA; Omote, H; Uneyama, H, 2010) |
| "Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)." | 1.33 | A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats. ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| "As an indicator of ketosis in epilepsy patients consuming a ketogenic diet, breath acetone may be useful for understanding the mechanism of the diet, elucidating the importance of ketosis in seizure protection, and ultimately, enhancing the efficacy of the diet by improving patient monitoring." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pifferi, F | 1 |
| Tremblay, S | 1 |
| Plourde, M | 1 |
| Tremblay-Mercier, J | 1 |
| Bentourkia, M | 1 |
| Cunnane, SC | 2 |
| Juge, N | 1 |
| Gray, JA | 1 |
| Omote, H | 1 |
| Miyaji, T | 1 |
| Inoue, T | 1 |
| Hara, C | 1 |
| Uneyama, H | 1 |
| Edwards, RH | 1 |
| Nicoll, RA | 1 |
| Moriyama, Y | 1 |
| Nylen, K | 1 |
| Likhodii, SS | 2 |
| Hum, KM | 1 |
| Burnham, WM | 1 |
| Musa-Veloso, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetoacetic acid and Seizures
| Article | Year |
|---|---|
Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate.
Topics: Acetoacetates; Animals; Brain; Carbon Radioisotopes; Child; Diet, Ketogenic; Fatty Acids, Unsaturate | 2008 |
3 other studies available for acetoacetic acid and Seizures
| Article | Year |
|---|---|
Metabolic control of vesicular glutamate transport and release.
Topics: 4-Aminopyridine; Acetoacetates; Animals; Astrocytes; Behavior, Animal; Cells, Cultured; Chlorides; C | 2010 |
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Antic | 2006 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |