acetoacetic acid has been researched along with Hypoglycemia in 13 studies
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since hypoglycemic neonates do not exhibit compensative ketosis, we investigated the possible involvement of carnitine deficiency or omega-oxidation in neonatal hypoglycemia." | 7.67 | Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia. ( Cartier, B; Divry, P; Maire, I; Sann, L; Vianey-Laud, C, 1987) |
| "The brain mitochondrial NAD+/NADH ratio, as a reflection of the oxidation-reduction (redox) state of cellular compartment, was determined under conditions of hypoxia, anoxia, hypoxia-ischemia, complete ischemia and hypoglycemia in immature rats." | 3.69 | Cerebral mitochondrial redox states during metabolic stress in the immature rat. ( Brucklacher, RM; Vannucci, RC, 1994) |
| "Since hypoglycemic neonates do not exhibit compensative ketosis, we investigated the possible involvement of carnitine deficiency or omega-oxidation in neonatal hypoglycemia." | 3.67 | Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia. ( Cartier, B; Divry, P; Maire, I; Sann, L; Vianey-Laud, C, 1987) |
| "Normally, the presence of ketosis implies 2 things: that lipid energy metabolism has been activated and that the entire pathway of lipid degradation is intact." | 2.39 | Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995) |
| "Ketosis is normal during fasting, after prolonged exercise, and when a high-fat diet is consumed." | 2.39 | Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995) |
| "To achieve this aim, one would need ketosis, severe hypoglycemia, and low lactatemia." | 1.29 | Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. ( Agarwal, KC; Ciraolo, ST; David, F; Fernandez, CA; Koshy, J; Lucas, D; Previs, SF; Stevens, MP; Tammaro, A; Tserng, KY, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Polidori, D | 1 |
| Iijima, H | 1 |
| Goda, M | 1 |
| Maruyama, N | 1 |
| Inagaki, N | 1 |
| Crawford, PA | 1 |
| Akram, M | 1 |
| Julio-Amilpas, A | 1 |
| Montiel, T | 1 |
| Soto-Tinoco, E | 1 |
| Gerónimo-Olvera, C | 1 |
| Massieu, L | 1 |
| BERGMAN, EN | 1 |
| KON, K | 1 |
| FAJANS, SS | 1 |
| FLOYD, JC | 1 |
| KNOPF, RF | 1 |
| CONN, JW | 1 |
| Mitchell, GA | 1 |
| Kassovska-Bratinova, S | 1 |
| Boukaftane, Y | 1 |
| Robert, MF | 1 |
| Wang, SP | 1 |
| Ashmarina, L | 1 |
| Lambert, M | 1 |
| Lapierre, P | 1 |
| Potier, E | 1 |
| Ciraolo, ST | 1 |
| Previs, SF | 1 |
| Fernandez, CA | 1 |
| Agarwal, KC | 1 |
| David, F | 1 |
| Koshy, J | 1 |
| Lucas, D | 1 |
| Tammaro, A | 1 |
| Stevens, MP | 1 |
| Tserng, KY | 1 |
| Davis, SN | 1 |
| Colburn, C | 1 |
| Dobbins, R | 1 |
| Nadeau, S | 1 |
| Neal, D | 1 |
| Williams, P | 1 |
| Cherrington, AD | 1 |
| Vannucci, RC | 1 |
| Brucklacher, RM | 1 |
| Newrick, PG | 1 |
| Braatvedt, G | 1 |
| Stansbie, D | 1 |
| Corrall, RJ | 1 |
| Fletcher, JM | 1 |
| Pitt, JJ | 1 |
| Avogaro, A | 1 |
| Nosadini, R | 1 |
| Doria, A | 1 |
| Tremolada, C | 1 |
| Baccaglini, U | 1 |
| Ambrosio, F | 1 |
| Merkel, C | 1 |
| Nosadini, A | 1 |
| Trevisan, R | 1 |
| Fioretto, P | 1 |
| Sann, L | 1 |
| Divry, P | 1 |
| Cartier, B | 1 |
| Vianey-Laud, C | 1 |
| Maire, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467] | 58 participants (Actual) | Observational [Patient Registry] | 2022-03-15 | Completed | |||
| Fasting Tolerance in Patients With Medium-chain Acyl-CoA Dehydrogenase Deficiency (MCADD) in the First Six Months of Life: an Investigator-initiated Human Pilot-study[NCT03761693] | 20 participants (Anticipated) | Interventional | 2019-05-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetoacetic acid and Hypoglycemia
| Article | Year |
|---|---|
A focused review of the role of ketone bodies in health and disease.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alzheimer Disease; Blood Glucose; Diabetic Ketoacidos | 2013 |
Medical aspects of ketone body metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biological Evolution; Brain; Humans; Hydroxybutyrates | 1995 |
3 trials available for acetoacetic acid and Hypoglycemia
| Article | Year |
|---|---|
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biological Variation, Population; Blood Glucose; Canagliflozin | 2018 |
Suppression of lipolysis in normal man does not inhibit recovery from insulin-induced hypoglycaemia.
Topics: Acetoacetates; Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Fatty Acids, Noneste | 1993 |
Fasting medium chain acyl-coenzyme A dehydrogenase--deficient children can make ketones.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acyl-CoA Dehydrogenase; Age of Onset; Carbon Isotopes; Child; | 2001 |
8 other studies available for acetoacetic acid and Hypoglycemia
| Article | Year |
|---|---|
Protection of hypoglycemia-induced neuronal death by β-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenosine Triphosphate; Animals; Brain Injuries; Brain Ischemi | 2015 |
ACETOACETATE TURNOVER AND OXIDATION RATES IN OVINE PREGNANCY KETOSIS.
Topics: Acetoacetates; Acidosis; Animals; Blood Chemical Analysis; Carbon Isotopes; Fasting; Female; Glucose | 1964 |
A COMPARISON OF LEUCINE- AND ACETOACETATE-INDUCED HYPOGLYCEMIA IN MAN.
Topics: Acetoacetates; Biomedical Research; Chlorpropamide; Drug Synergism; Hypoglycemia; Insulin; Leucine; | 1964 |
Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Butylene Glycols; Dichloroacetic Acid; | 1995 |
Evidence that the brain of the conscious dog is insulin sensitive.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Brain; Cerebrovascular Circulation; Consciou | 1995 |
Cerebral mitochondrial redox states during metabolic stress in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Diseases; Brain Ischem | 1994 |
Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental | 1990 |
Ketogenesis in hypoglycemic neonates. Carnitine and dicarboxylic acids in neonatal hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Carnitine; Creatinine; Dicarboxylic Acids; Fatt | 1987 |