Page last updated: 2024-10-15

acetoacetic acid and Hyperglycemia

acetoacetic acid has been researched along with Hyperglycemia in 15 studies

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"Erythrocytes were washed, suspended in buffers containing 5 mM glucose (simulates euglycemia) or 25 mM glucose (simulates hyperglycemia), and incubated with acetone (5 and 10 mM, acetoacetate (5 and 10 mM), or beta-hydroxybutyrate (5 and 25 mM) for 24 hours at 37 C."3.69In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."1.39Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Type 1 diabetes is associated with elevated levels of blood PAI-1 and cardiovascular disease (CVD) incidence."1.37Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells. ( Jain, SK; Velusamy, T, 2011)
"To investigate in vitro effects of ketosis and hyperglycemia on feline erythrocyte Heinz body formation, reduced glutathione (GSH) concentration, and D- and L-lactate production, and to identify potential metabolic mechanisms of oxidative stress in diabetic cats."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"Neither high glucose concentration nor ketosis had direct effects on Heinz body formation or GSH values."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"High glucose concentration and ketosis do not account directly for oxidative damage and glyoxalase induction in feline erythrocytes in vitro, although high concentrations of beta-hydroxybutyrate may stimulate D-lactate formation."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's3 (20.00)18.2507
2000's5 (33.33)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Polidori, D1
Iijima, H1
Goda, M1
Maruyama, N1
Inagaki, N1
Crawford, PA1
Mahendran, Y1
Vangipurapu, J1
Cederberg, H1
Stancáková, A1
Pihlajamäki, J1
Soininen, P1
Kangas, AJ1
Paananen, J1
Civelek, M1
Saleem, NK1
Pajukanta, P1
Lusis, AJ1
Bonnycastle, LL1
Morken, MA1
Collins, FS1
Mohlke, KL1
Boehnke, M1
Ala-Korpela, M1
Kuusisto, J1
Laakso, M1
Keltanen, T1
Sajantila, A1
Palo, JU1
Partanen, T1
Valonen, T1
Lindroos, K1
Velusamy, T1
Jain, SK1
Harano, Y1
NATH, MC1
CHAKRABARTI, CH1
NAYUDU, SG1
Khan, AS1
Talbot, JA1
Tieszen, KL1
Gardener, EA1
Gibson, JM1
New, JP1
Ramakrishnan, R1
Sheeladevi, R1
Suthanthirarajan, N1
Namasivayam, A1
Everett-Grueter, C1
Edgerton, DS1
Donahue, EP1
Vaughan, S1
Chu, CA1
Sindelar, DK1
Cherrington, AD1
Taboulet, P1
Deconinck, N1
Thurel, A1
Haas, L1
Manamani, J1
Porcher, R1
Schmit, C1
Fontaine, JP1
Gautier, JF1
Fallin, CW1
Christopher, MM1
Rodríguez, T1
Busquets, S1
Alvarez, B1
Agell, N1
Lpez-Soriano, FJ1
Argilś, JM1
Møller, N1
Jørgensen, JO1
Møller, J1
Orskov, L1
Pørksen, N1
Alberti, KG1
Schmitz, O1
Baron, AD1
Brechtel, G1
Edelman, SV1
Zusman, I1
Ornoy, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467]58 participants (Actual)Observational [Patient Registry]2022-03-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for acetoacetic acid and Hyperglycemia

ArticleYear
[Blood level of ketone bodies and its clinical significance].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type

2002

Trials

1 trial available for acetoacetic acid and Hyperglycemia

ArticleYear
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biological Variation, Population; Blood Glucose; Canagliflozin

2018

Other Studies

13 other studies available for acetoacetic acid and Hyperglycemia

ArticleYear
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.
    Diabetes, 2013, Volume: 62, Issue:10

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Area Under Curve; Biomarkers; Blood Glucose; Diabetes Mellitus

2013
Assessment of Traub formula and ketone bodies in cause of death investigations.
    International journal of legal medicine, 2013, Volume: 127, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl

2013
Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2011, Volume: 17, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Ketoacido

2011
Effect of methionine and casein on acetoacetate induced hyperglycemia.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1955, Volume: 88, Issue:3

    Topics: Acetoacetates; Animals; Caseins; Hyperglycemia; Methionine; Rats

1955
Evaluation of a bedside blood ketone sensor: the effects of acidosis, hyperglycaemia and acetoacetate on sensor performance.
    Diabetic medicine : a journal of the British Diabetic Association, 2004, Volume: 21, Issue:7

    Topics: Acetoacetates; Acidosis; Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; Diabet

2004
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
    Brain research bulletin, 2005, Sep-30, Volume: 67, Issue:1-2

    Topics: Acetoacetates; Ammonium Chloride; Animals; Brain; Brain Chemistry; Diabetes Complications; Diabetic

2005
The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Blood Glucose; Cyclic AMP; Dogs; Fat Emu

2006
Correlation between urine ketones (acetoacetate) and capillary blood ketones (3-beta-hydroxybutyrate) in hyperglycaemic patients.
    Diabetes & metabolism, 2007, Volume: 33, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Hy

2007
In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production.
    American journal of veterinary research, 1996, Volume: 57, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Cat Diseases; Cats; Erythrocytes; Female; Gl

1996
Protein turnover in skeletal muscle of the diabetic rat: activation of ubiquitin-dependent proteolysis.
    International journal of molecular medicine, 1998, Volume: 1, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Animals; Body Weight; Diabetes Mellitus, Exper

1998
Lack of effects of hyperglycemia on the disposal of 3-hydroxybutyrate in insulin-dependent diabetic patients.
    Acta endocrinologica, 1990, Volume: 123, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids,

1990
Effects of free fatty acids and ketone bodies on in vivo non-insulin-mediated glucose utilization and production in humans.
    Metabolism: clinical and experimental, 1989, Volume: 38, Issue:11

    Topics: Acetoacetates; Adult; Fatty Acids, Nonesterified; Glucose; Humans; Hyperglycemia; Insulin; Ketone Bo

1989
Effects of hyperglycemia and ketone bodies on the in vitro development of early somite rate embryos.
    Pediatric pathology, 1987, Volume: 7, Issue:5-6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Congenital Abnormalities; Cu

1987