acetoacetic acid has been researched along with Disease Models, Animal in 14 studies
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Consistent with these observations, acetoacetate reduced quantal size at hippocampal synapses and suppresses glutamate release and seizures evoked with 4-aminopyridine in the brain." | 3.76 | Metabolic control of vesicular glutamate transport and release. ( Edwards, RH; Gray, JA; Hara, C; Inoue, T; Juge, N; Miyaji, T; Moriyama, Y; Nicoll, RA; Omote, H; Uneyama, H, 2010) |
| " In this study, we tested the changes in blood glucose and ketone (βHB) levels in response to acute, sub-chronic, and chronic administration of various ketogenic compounds in either a post-exercise or rested state." | 1.51 | Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models. ( Ari, C; Bharwani, S; D'Agostino, DP; Diamond, DM; Goldhagen, CR; Kindy, MS; Koutnik, AP; Kovács, Z; Murdun, C; Park, C; Rogers, C, 2019) |
| "Sporadic Alzheimer's disease (AD) is responsible for 60%-80% of dementia cases, and the most opportune time for preventive intervention is in the earliest stage of its preclinical phase." | 1.43 | Ketones block amyloid entry and improve cognition in an Alzheimer's model. ( Dharshaun, T; Eisenberg, D; Gao, M; Han, P; Maalouf, M; Reiman, EM; Ryan, C; Schweizer, FE; Shi, J; Whitelegge, J; Wu, J; Yin, JX; Zhao, M, 2016) |
| "Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)." | 1.33 | A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats. ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006) |
| "Our results suggest that genetic susceptibility plays an important role in inducing underdevelopment and NTD in cultured CDs embryos in sub-teratogenic medium and in protecting the CDr embryos under the same conditions." | 1.32 | Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions. ( Ornoy, A; Weksler-Zangen, S; Yaffe, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ari, C | 1 |
| Murdun, C | 1 |
| Koutnik, AP | 1 |
| Goldhagen, CR | 1 |
| Rogers, C | 1 |
| Park, C | 1 |
| Bharwani, S | 1 |
| Diamond, DM | 1 |
| Kindy, MS | 1 |
| D'Agostino, DP | 1 |
| Kovács, Z | 1 |
| Bazzigaluppi, P | 1 |
| Lake, EM | 1 |
| Beckett, TL | 1 |
| Koletar, MM | 1 |
| Weisspapir, I | 1 |
| Heinen, S | 1 |
| Mester, J | 1 |
| Lai, A | 1 |
| Janik, R | 1 |
| Dorr, A | 1 |
| McLaurin, J | 1 |
| Stanisz, GJ | 1 |
| Carlen, PL | 1 |
| Stefanovic, B | 1 |
| Zou, X | 1 |
| Meng, J | 1 |
| Li, L | 1 |
| Han, W | 1 |
| Li, C | 1 |
| Zhong, R | 1 |
| Miao, X | 1 |
| Cai, J | 1 |
| Zhang, Y | 1 |
| Zhu, D | 1 |
| Yin, JX | 1 |
| Maalouf, M | 1 |
| Han, P | 1 |
| Zhao, M | 1 |
| Gao, M | 1 |
| Dharshaun, T | 1 |
| Ryan, C | 1 |
| Whitelegge, J | 1 |
| Wu, J | 1 |
| Eisenberg, D | 1 |
| Reiman, EM | 1 |
| Schweizer, FE | 1 |
| Shi, J | 1 |
| Kadowaki, A | 1 |
| Sada, N | 1 |
| Juge, N | 2 |
| Wakasa, A | 1 |
| Moriyama, Y | 2 |
| Inoue, T | 2 |
| Ramakrishnan, R | 2 |
| Sheeladevi, R | 2 |
| Namasivayam, A | 2 |
| Kim, SH | 1 |
| Yang, SO | 1 |
| Kim, HS | 1 |
| Kim, Y | 1 |
| Park, T | 1 |
| Choi, HK | 1 |
| Gray, JA | 1 |
| Omote, H | 1 |
| Miyaji, T | 1 |
| Hara, C | 1 |
| Uneyama, H | 1 |
| Edwards, RH | 1 |
| Nicoll, RA | 1 |
| Liu, YY | 1 |
| Wang, SJ | 1 |
| Han, BB | 1 |
| Weksler-Zangen, S | 1 |
| Yaffe, P | 1 |
| Ornoy, A | 1 |
| Skiba, M | 1 |
| Maciejewska-Paszek, I | 1 |
| Pawłowska-Góral, K | 1 |
| Aleksiewicz, R | 1 |
| Wardas, M | 1 |
| Suthanthirarajan, N | 1 |
| Nylen, K | 1 |
| Likhodii, SS | 1 |
| Hum, KM | 1 |
| Burnham, WM | 1 |
| de Jaeger, A | 1 |
| Proulx, F | 1 |
| Yandza, T | 1 |
| Dugas, MA | 1 |
| Boeuf, B | 1 |
| Manika, A | 1 |
| Lacroix, J | 1 |
| Lambert, M | 1 |
14 other studies available for acetoacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biomarkers; Blood Glucose; Butylene Glycols; Carbohyd | 2019 |
Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Astrocytes; Blood Glucose; Brain; Brain Ischemia; Cel | 2018 |
Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice.
Topics: Acetoacetates; Animals; Cell Proliferation; Cyclin D1; Disease Models, Animal; Gene Expression Regul | 2016 |
Ketones block amyloid entry and improve cognition in an Alzheimer's model.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; | 2016 |
Neuronal inhibition and seizure suppression by acetoacetate and its analog, 2-phenylbutyrate.
Topics: Acetoacetates; Animals; Calcium Channels; Diet, Ketogenic; Disease Models, Animal; Electroencephalog | 2017 |
Regulation of protein kinases and coregulatory interplay of S-100beta and serotonin transporter on serotonin levels in diabetic rat brain.
Topics: Acetoacetates; Alloxan; Analysis of Variance; Animals; Blood Glucose; Brain; Carbonates; Diabetes Me | 2009 |
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine | 2009 |
Metabolic control of vesicular glutamate transport and release.
Topics: 4-Aminopyridine; Acetoacetates; Animals; Astrocytes; Behavior, Animal; Cells, Cultured; Chlorides; C | 2010 |
[Effects of acetoacetate extract of Radix Aconite on hepatic contents of LA, LDH, PA, Gn and ATPase activities in deficient cold model rats].
Topics: Acetoacetates; Adenosine Triphosphatases; Animals; Disease Models, Animal; Diterpenes; Drugs, Chines | 2011 |
Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Catalase; Diabetes Mellitus, Type 2; Disease Models, | 2003 |
Hepatoprotective action of PGE1 analogue estimated by measuring the concentrations of acetoacetate and beta-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Disease; Administration, Oral; Alanine Transaminase; Ani | 2003 |
An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-alpha expression in rat brain.
Topics: Acetoacetates; Ammonium Chloride; Animals; Brain; Brain Chemistry; Diabetes Complications; Diabetic | 2005 |
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Antic | 2006 |
Markers of cellular dysoxia during orthotopic liver transplantation in pigs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biomarkers; Carnitine; Cell Hypoxia; Cytosol; Disease | 1998 |