acetoacetic acid has been researched along with Diabetes Mellitus, Type 1 in 34 studies
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "People with type 1 diabetes frequently encounter elevated levels of the ketone bodies acetoacetate (AA), beta-hydroxybutyrate (BHB), and acetone (ACE)." | 2.69 | Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. ( Jain, SK; McVie, R, 1999) |
| "In diabetes, mainly type-1, ketoacidosis is the pathological response to glucose malabsorption." | 2.66 | Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. ( Balcerczyk, A; Dąbek, A; Pirola, L; Wojtala, M, 2020) |
| "Hyperketonemia is a condition with elevated blood levels of acetoacetate, 3-β-hydroxybutyrate, and acetone." | 2.53 | Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes. ( Jain, SK; Kanikarla-Marie, P, 2016) |
| "Diabetic ketoacidosis is a life-threatening complication of Type 1 diabetes." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "Outcomes examined were prevention of diabetic ketoacidosis, time to recovery from diabetic ketoacidosis, healthcare costs and patient or caregiver satisfaction." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "No study assessed prevention of diabetic ketoacidosis." | 2.49 | Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. ( Craig, ME; Klocker, AA; Phelan, H; Twigg, SM, 2013) |
| "Type 1 diabetes is associated with elevated levels of blood PAI-1 and cardiovascular disease (CVD) incidence." | 1.37 | Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells. ( Jain, SK; Velusamy, T, 2011) |
| "Net uptake of ketones was seen in IDDM subjects before but not after insulin." | 1.28 | Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects. ( Björkman, O; Blomqvist, G; Grill, V; Gutniak, M; Lindqvist, M; Reichard, P; Seitz, RJ; Stone-Elander, S; Widén, L, 1990) |
| "In the IDDM subjects, the mean reductions in glucose concentration were 99 mg% and 84 mg% during continuous and intermittent exercise, respectively." | 1.27 | Responses to continuous and intermittent exercise in healthy and insulin-dependent diabetic children. ( Cerny, FJ; Sills, IN, 1983) |
| "Another six IDDM patients and six normal subjects were given saline, lactic acid, and saline infusions at the same rates of infusion after an overnight fast during euglycemic insulin-glucose clamp." | 1.27 | Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids. ( Avogaro, A; Doria, A; Duner, E; Fioretto, P; Iori, E; Merkel, C; Nosadini, R; Trevisan, R; Valerio, A; Velussi, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (29.41) | 18.7374 |
| 1990's | 13 (38.24) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Dąbek, A | 1 |
| Wojtala, M | 1 |
| Pirola, L | 1 |
| Balcerczyk, A | 1 |
| Kanikarla-Marie, P | 1 |
| Jain, SK | 8 |
| Velusamy, T | 1 |
| Kurepa, D | 1 |
| Pramanik, AK | 1 |
| Kakkilaya, V | 1 |
| Caldito, G | 1 |
| Groome, LJ | 1 |
| Bocchini, JA | 3 |
| Klocker, AA | 1 |
| Phelan, H | 1 |
| Twigg, SM | 1 |
| Craig, ME | 1 |
| Yamanouchi, K | 1 |
| Abe, R | 1 |
| Takeda, A | 1 |
| Atsumi, Y | 1 |
| Shichiri, M | 1 |
| Sato, Y | 1 |
| Harano, Y | 2 |
| Kannan, K | 2 |
| Lim, G | 3 |
| Matthews-Greer, J | 1 |
| McVie, R | 5 |
| Corey, HE | 1 |
| Prisco, F | 1 |
| Picardi, A | 1 |
| Iafusco, D | 1 |
| Lorini, R | 1 |
| Minicucci, L | 1 |
| Martinucci, ME | 1 |
| Toni, S | 1 |
| Cerutti, F | 1 |
| Rabbone, I | 1 |
| Buzzetti, R | 1 |
| Crino, A | 1 |
| Pozzilli, P | 1 |
| Sills, IN | 1 |
| Cerny, FJ | 1 |
| Kosugi, K | 1 |
| Hyosu, T | 1 |
| Suzuki, M | 1 |
| Hidaka, H | 1 |
| Kashiwagi, A | 1 |
| Uno, S | 1 |
| Shigeta, Y | 1 |
| Hall, SE | 1 |
| Wastney, ME | 1 |
| Bolton, TM | 1 |
| Braaten, JT | 1 |
| Berman, M | 1 |
| Nicholson, JK | 1 |
| O'Flynn, MP | 1 |
| Sadler, PJ | 1 |
| Macleod, AF | 1 |
| Juul, SM | 1 |
| Sönksen, PH | 1 |
| Edge, JA | 1 |
| Harris, DA | 2 |
| Phillips, PE | 1 |
| Pal, BR | 1 |
| Matthews, DR | 1 |
| Dunger, DB | 2 |
| Avogaro, A | 7 |
| Crepaldi, C | 1 |
| Piarulli, F | 1 |
| Milan, D | 1 |
| Valerio, A | 4 |
| Pavan, P | 1 |
| Sacerdoti, D | 1 |
| Calabrò, A | 1 |
| Macdonald, I | 1 |
| Crepaldi, G | 2 |
| Scognamiglio, R | 1 |
| Tiengo, A | 3 |
| Jaramillo, JJ | 1 |
| Chen, Y | 1 |
| Pounder, DJ | 1 |
| Stevenson, RJ | 1 |
| Taylor, KK | 1 |
| Acerini, CL | 1 |
| Matyka, KA | 1 |
| Watts, AP | 1 |
| Umpleby, AM | 1 |
| Russell-Jones, DL | 1 |
| Jackson, R | 1 |
| Levine, SN | 1 |
| McGarry, JD | 1 |
| Gnudi, L | 1 |
| Maran, A | 1 |
| Miola, M | 1 |
| Duner, E | 4 |
| Marescotti, C | 2 |
| Iori, E | 3 |
| Nosadini, R | 7 |
| Watanabe, T | 1 |
| Sugiyama, H | 1 |
| Uchimura, I | 1 |
| Maezawa, H | 1 |
| Grill, V | 1 |
| Gutniak, M | 1 |
| Björkman, O | 1 |
| Lindqvist, M | 1 |
| Stone-Elander, S | 1 |
| Seitz, RJ | 1 |
| Blomqvist, G | 1 |
| Reichard, P | 1 |
| Widén, L | 1 |
| Møller, N | 1 |
| Jørgensen, JO | 1 |
| Møller, J | 1 |
| Orskov, L | 1 |
| Pørksen, N | 1 |
| Alberti, KG | 1 |
| Schmitz, O | 1 |
| Doria, A | 4 |
| Tremolada, C | 1 |
| Baccaglini, U | 1 |
| Ambrosio, F | 1 |
| Merkel, C | 2 |
| Nosadini, A | 1 |
| Trevisan, R | 6 |
| Fioretto, P | 4 |
| Semplicini, A | 1 |
| Angeli, P | 1 |
| Rigon, E | 1 |
| Sama, B | 1 |
| Jori, E | 1 |
| Velussi, M | 1 |
| Féry, F | 1 |
| Balasse, EO | 1 |
| Cobelli, C | 2 |
| Toffolo, G | 2 |
| Saccà, L | 1 |
| Vigorito, C | 1 |
| de Kreutzenberg, S | 1 |
| Tessari, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modulating Physiologic Effects Of Phospholipid Metabolism In Obesity And Diabetes; AIM 4: Composition and Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome[NCT02122666] | 100 participants (Anticipated) | Observational | 2014-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for acetoacetic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Type 1; Diet, Ketogenic; Epigenesi | 2020 |
Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
Topics: Acetoacetates; Diabetes Mellitus, Type 1; Energy Metabolism; Glucose; Humans; Ketone Bodies; Ketones | 2016 |
Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Critical Care; Crown-Rump Length; Diabetes Mellitus, Type 1; D | 2013 |
[Blood level of ketone bodies and its clinical significance].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2002 |
3 trials available for acetoacetic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The hemodynamic abnormalities in short-term insulin deficiency: the role of prostaglandin inhibition.
Topics: 3-Hydroxybutyric Acid; 6-Ketoprostaglandin F1 alpha; Acetoacetates; Adult; Blood Glucose; Diabetes M | 1996 |
Effects of low-dose recombinant human insulin-like growth factor-I on insulin sensitivity, growth hormone and glucagon levels in young adults with insulin-dependent diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; D | 1998 |
Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Child; Diabetes Mellitus, Type 1; Erythrocytes; Gluta | 1999 |
27 other studies available for acetoacetic acid and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Ketoacido | 2011 |
Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers.
Topics: Acetoacetates; Adult; Case-Control Studies; Chemokine CCL2; Diabetes Mellitus, Type 1; Diabetes, Ges | 2012 |
The effect of walking before and after breakfast on blood glucose levels in patients with type 1 diabetes treated with intensive insulin therapy.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type | 2002 |
Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes.
Topics: Acetoacetates; Adolescent; Age of Onset; Cells, Cultured; Child; Diabetes Mellitus, Type 1; Diabetic | 2003 |
The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA).
Topics: Acetoacetates; Acid-Base Equilibrium; Adolescent; Adult; Anions; Child; Child, Preschool; Diabetes M | 2006 |
Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study).
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Blood Glucose; Child; Child, Preschool; Diabetes M | 2006 |
Responses to continuous and intermittent exercise in healthy and insulin-dependent diabetic children.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Blood Glucose; Butyrates; Child; Diabetes Mellitus | 1983 |
Ketone bodies as markers for type 1 (insulin-dependent) diabetes and their value in the monitoring of diabetic control.
Topics: Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Child; Circadian Rhythm; Diabetes Mellitus, T | 1984 |
Ketone body kinetics in humans: the effects of insulin-dependent diabetes, obesity, and starvation.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetic Ketoaci | 1984 |
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Amino Acids; Diabetes Mellitus, Type 1; Diabet | 1984 |
Evidence for a role for insulin and growth hormone in overnight regulation of 3-hydroxybutyrate in normal and diabetic adolescents.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Adult; Age Factors; C-Peptide; Child; Circadian Rh | 1993 |
Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in Type-I diabetic patients.
Topics: Acetoacetates; Adolescent; Case-Control Studies; Child; Diabetes Mellitus, Type 1; Female; Humans; K | 1998 |
Alcoholic ketoacidosis at autopsy.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis | 1998 |
Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Di | 1999 |
Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetylcysteine; Antioxidants; Cyclic AMP; Diabetes Mellitus, T | 2002 |
What if Minkowski had been ageusic? An alternative angle on diabetes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Blood Glucose; Diabetes Mellitus, Type 1; Diab | 1992 |
The effects of different plasma insulin concentrations on lipolytic and ketogenic responses to epinephrine in normal and type 1 (insulin-dependent) diabetic humans.
Topics: Acetoacetates; Adult; Blood Glucose; Blood Pressure; C-Peptide; Diabetes Mellitus, Type 1; Epinephri | 1992 |
Serum ketone response to glucagon as a marker of insulin dependency in diabetics.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Biomarkers; Blood Glucose; C-Peptide; Diabetes Mellitus | 1991 |
Cerebral blood flow and substrate utilization in insulin-treated diabetic subjects.
Topics: Acetoacetates; Adult; Blood Glucose; Brain; Carbon Dioxide; Cerebrovascular Circulation; Diabetes Me | 1990 |
Lack of effects of hyperglycemia on the disposal of 3-hydroxybutyrate in insulin-dependent diabetic patients.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, | 1990 |
Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental | 1990 |
Tubular Na+ handling in type I insulin-dependent diabetics during saline and ketone body infusion.
Topics: Acetoacetates; Adult; Blood Pressure; Diabetes Mellitus, Type 1; Glomerular Filtration Rate; Glucose | 1989 |
Ketone bodies increase glomerular filtration rate in normal man and in patients with type 1 (insulin-dependent) diabetes mellitus.
Topics: Acetoacetates; Bicarbonates; Diabetes Mellitus, Type 1; Female; Glomerular Filtration Rate; Hemodyna | 1987 |
Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids.
Topics: Acetates; Acetic Acid; Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Child; Diabetes Mellit | 1987 |
Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabet | 1985 |
Acetoacetate and 3-hydroxybutyrate kinetics in obese and insulin-dependent diabetic humans.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic | 1985 |
Ketone body metabolism in normal and diabetic human skeletal muscle.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Carbon Radioisotopes; Diabetes Mellitus; Diabetes Melli | 1985 |