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acetoacetic acid and Diabetes Mellitus, Adult-Onset

acetoacetic acid has been researched along with Diabetes Mellitus, Adult-Onset in 21 studies

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Research Excerpts

ExcerptRelevanceReference
" In order to study the effect of HMG-CoA reductase inhibitor (pravastatin) on ketone formation, changes in the plasma levels of ketone bodies by treatment with pravastatin were studied in 18 non-insulin dependent diabetics with hypercholesterolemia."7.70Effect of pravastatin on plasma ketone bodies in diabetics with hypercholesterolemia. ( Chiba, T; Fukuda, M; Nagakubo, H; Ogawa, S; Oouchi, M; Sato, C; Sato, T; Sugimura, K, 1998)
"Three clinical studies were conducted: a bariatric surgery cohort study of participants with morbid obesity who underwent either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) studied over four and twelve weeks, and two randomized placebo-controlled, crossover double blind studies of liraglutide vs."5.69Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. ( Alexandrou, A; Angelidi, AM; Connelly, MA; Kokkinos, A; Mantzoros, CS; Mingrone, G; Sanoudou, D, 2023)
"Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment."5.48Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018)
" As alterations in hepatic gluconeogenesis and glycogen metabolism are hallmarks that characterize insulin resistance and type 2 diabetes, we tested whether imposed changes in the extracellular redox state could modulate these processes."3.81The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes. ( Corkey, BE; Jones Iv, AR; Kleckner, AS; Liesa, M; Nocito, L; Yoo, EJ, 2015)
" In order to study the effect of HMG-CoA reductase inhibitor (pravastatin) on ketone formation, changes in the plasma levels of ketone bodies by treatment with pravastatin were studied in 18 non-insulin dependent diabetics with hypercholesterolemia."3.70Effect of pravastatin on plasma ketone bodies in diabetics with hypercholesterolemia. ( Chiba, T; Fukuda, M; Nagakubo, H; Ogawa, S; Oouchi, M; Sato, C; Sato, T; Sugimura, K, 1998)
"A complication of diabetes is diabetic ketoacidosis (DKA), which if left untreated is a life threatening condition."2.53Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review. ( Brooke, J; Ojo, O; Stiell, M, 2016)
"Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"The eruptive xanthoma lesions gradually diminished in size and number and eventually disappeared by 12 months."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment."1.48Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018)
"Breath acetone of the type 2 diabetes mellitus patients showed positive correlations with plasma glucose when the level of plasma glucose tended to decrease during hospitalization."1.40Analysis of ketone bodies in exhaled breath and blood of ten healthy Japanese at OGTT using a portable gas chromatograph. ( Hinokio, Y; Koseki, T; Takahashi, N; Tanda, N; Washio, J, 2014)
"Our results suggest that genetic susceptibility plays an important role in inducing underdevelopment and NTD in cultured CDs embryos in sub-teratogenic medium and in protecting the CDr embryos under the same conditions."1.32Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions. ( Ornoy, A; Weksler-Zangen, S; Yaffe, P, 2003)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's7 (33.33)18.2507
2000's2 (9.52)29.6817
2010's9 (42.86)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Angelidi, AM1
Kokkinos, A1
Sanoudou, D1
Connelly, MA1
Alexandrou, A1
Mingrone, G1
Mantzoros, CS1
Min, SH1
Oh, TJ1
Baek, SI1
Lee, DH1
Kim, KM1
Moon, JH1
Choi, SH1
Park, KS1
Jang, HC1
Lim, S1
Polidori, D1
Iijima, H1
Goda, M1
Maruyama, N1
Inagaki, N1
Crawford, PA1
Tsuchiya, S1
Sawada, S1
Takeda, K1
Takahashi, K1
Nakajima, T1
Kohata, M1
Kurosawa, S1
Satake, C1
Imai, J1
Kikuchi, K1
Aiba, S1
Katagiri, H1
Mahendran, Y1
Vangipurapu, J1
Cederberg, H1
Stancáková, A1
Pihlajamäki, J1
Soininen, P1
Kangas, AJ1
Paananen, J1
Civelek, M1
Saleem, NK1
Pajukanta, P1
Lusis, AJ1
Bonnycastle, LL1
Morken, MA1
Collins, FS1
Mohlke, KL1
Boehnke, M1
Ala-Korpela, M1
Kuusisto, J1
Laakso, M1
Tanda, N1
Hinokio, Y1
Washio, J1
Takahashi, N1
Koseki, T1
Nocito, L1
Kleckner, AS1
Yoo, EJ1
Jones Iv, AR1
Liesa, M1
Corkey, BE1
Brooke, J1
Stiell, M1
Ojo, O1
Vigili de Kreutzenberg, S1
Avogaro, A1
Oh, SJ1
Choi, JM1
Yun, KU1
Oh, JM1
Kwak, HC1
Oh, JG1
Lee, KS1
Kim, BH1
Heo, TH1
Kim, SK1
Harano, Y2
Weksler-Zangen, S1
Yaffe, P1
Ornoy, A1
Kosugi, K1
Hyosu, T1
Suzuki, M2
Hidaka, H1
Kashiwagi, A1
Uno, S1
Shigeta, Y1
Nicholson, JK1
O'Flynn, MP1
Sadler, PJ1
Macleod, AF1
Juul, SM1
Sönksen, PH1
Akanji, AO1
Osifo, E1
Kirk, M1
Hockaday, TD1
Pounder, DJ1
Stevenson, RJ1
Taylor, KK1
Sato, T1
Oouchi, M1
Nagakubo, H1
Chiba, T1
Ogawa, S1
Sato, C1
Sugimura, K1
Fukuda, M1
McGarry, JD1
Watanabe, T1
Sugiyama, H1
Uchimura, I1
Maezawa, H1
Kosegawa, I1
Miura, S1
Negishi, K1
Itabashi, A1
Katayama, S1
Ishii, J1
Kamata, S1
Fujita, C1
Henry, RR1
Brechtel, G1
Lim, KH1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk[NCT03851874]28 participants (Actual)Interventional2011-10-31Completed
Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI[NCT01562678]Phase 428 participants (Actual)Interventional2012-03-31Completed
Saxenda: Underlying Mechanisms and Clinical Outcomes[NCT02944500]Phase 428 participants (Actual)Interventional2016-11-30Active, not recruiting
Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467]58 participants (Actual)Observational [Patient Registry]2022-03-15Completed
Modulating Physiologic Effects Of Phospholipid Metabolism In Obesity And Diabetes; AIM 4: Composition and Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome[NCT02122666]100 participants (Anticipated)Observational2014-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change Between Highly Desirable vs. Less Desirable Food Cues in the Effect Size of Cortical Activation During Food Visualization

Effect size (region of interest z-scores, derived from z-maps of the brain) shown below is the difference in parietal cortex activation to highly desirable (high fat or high calorie, e.g. cakes, pies, fries) versus less desirable (low fat or low calorie, e.g. vegetables, fruits) food cues for each treatment condition (liraglutide or placebo) at the end of the treatment period. (NCT01562678)
Timeframe: 18 days of Liraglutide or placebo treatment

Interventionz-scores of activation in cortex (Mean)
Liraglutide-0.42
Placebo0.53

Reviews

2 reviews available for acetoacetic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review.
    International journal of environmental research and public health, 2016, 08-23, Volume: 13, Issue:9

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dia

2016
[Blood level of ketone bodies and its clinical significance].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type

2002

Trials

3 trials available for acetoacetic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.
    Diabetes, obesity & metabolism, 2018, Volume: 20, Issue:5

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Biological Variation, Population; Blood Glucose; Canagliflozin

2018
The effects of changes in plasma nonesterified fatty acid levels on oxidative metabolism during moderate exercise in patients with non-insulin-dependent diabetes mellitus.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Glucose; Calorimetry, Indirect; Diabetes Mellitus, Type

1993

Other Studies

16 other studies available for acetoacetic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes.
    Diabetes & metabolism, 2018, Volume: 44, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Benzhydryl Compounds; Case-Control Studies; Diabe

2018
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
    Endocrine journal, 2019, Jan-28, Volume: 66, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B

2019
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.
    Diabetes, 2013, Volume: 62, Issue:10

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Area Under Curve; Biomarkers; Blood Glucose; Diabetes Mellitus

2013
Analysis of ketone bodies in exhaled breath and blood of ten healthy Japanese at OGTT using a portable gas chromatograph.
    Journal of breath research, 2014, Nov-24, Volume: 8, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Asian People; Blood Glucose; Breath Tests; Chr

2014
The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cysteine; Cystine; Diabetes Mellitus, Type 2; Glucone

2015
The role of point-of-care 3-hydroxybutyrate testing in patients with type 2 diabetes undergoing coronary angiography.
    Journal of endocrinological investigation, 2017, Volume: 40, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Blood Glucose; Coronary Angiography; Coronary Disease; D

2017
Hepatic expression of cytochrome P450 in type 2 diabetic Goto-Kakizaki rats.
    Chemico-biological interactions, 2012, Feb-05, Volume: 195, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Cytochrome P-450 CYP1A1; Cytochrome P-

2012
Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Catalase; Diabetes Mellitus, Type 2; Disease Models,

2003
Ketone bodies as markers for type 1 (insulin-dependent) diabetes and their value in the monitoring of diabetic control.
    Diabetologia, 1984, Volume: 26, Issue:5

    Topics: Acetoacetates; Adolescent; Adult; Aged; Blood Glucose; Child; Circadian Rhythm; Diabetes Mellitus, T

1984
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.
    The Biochemical journal, 1984, Jan-15, Volume: 217, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Amino Acids; Diabetes Mellitus, Type 1; Diabet

1984
Alcoholic ketoacidosis at autopsy.
    Journal of forensic sciences, 1998, Volume: 43, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis

1998
Effect of pravastatin on plasma ketone bodies in diabetics with hypercholesterolemia.
    The Tohoku journal of experimental medicine, 1998, Volume: 185, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Aged, 80 and over; Body Mass Index; Cholesterol; Diabete

1998
What if Minkowski had been ageusic? An alternative angle on diabetes.
    Science (New York, N.Y.), 1992, Oct-30, Volume: 258, Issue:5083

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adipose Tissue; Blood Glucose; Diabetes Mellitus, Type 1; Diab

1992
Serum ketone response to glucagon as a marker of insulin dependency in diabetics.
    Diabetes research and clinical practice, 1991, Volume: 14, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Biomarkers; Blood Glucose; C-Peptide; Diabetes Mellitus

1991
Blood ketone bodies in NIDDM: relationship with diabetic control and endogenous insulin secretion.
    Diabetes research (Edinburgh, Scotland), 1991, Volume: 18, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Die

1991
Effects of ketone bodies on carbohydrate metabolism in non-insulin-dependent (type II) diabetes mellitus.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:8

    Topics: Acetoacetates; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Gluc

1990