acetoacetic acid and Cancer of Liver studies

acetoacetic acid and Cancer of Liver

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Research Excerpts

Treatment

Excerpt	Reference
"Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases."	( Chen, TL; Chien, CY; Chiu, WC; Liao, YJ; Suk, FM; Wu, CY, 2022)
"Morris hepatoma 7777 cells freshly isolated from highly malignant tumors grown in the hindlimb of buffalo rats actively convert ketone bodies to cholesterol and fatty acids."	( Elson, C; Hildebrandt, LA; Shrago, E; Spennetta, T, 1995)

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (30.00)	18.7374
1990's	4 (40.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	1 (10.00)	24.3611
2020's	1 (10.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

3 (30.00)

18.7374

1990's

4 (40.00)

18.2507

2000's

1 (10.00)

29.6817

2010's

1 (10.00)

24.3611

2020's

1 (10.00)

2.80

Authors

Authors	Studies
Suk, FM	3
Wu, CY	3
Chiu, WC	3
Chien, CY	3
Chen, TL	3
Liao, YJ	3
Wang, MR	1
Zhang, X	1
Liu, YQ	1
Uehara, Y	1
Engel, T	1
Li, Z	1
Goepfert, C	1
Rust, S	1
Zhou, X	1
Langer, C	1
Schachtrup, C	1
Wiekowski, J	1
Lorkowski, S	1
Assmann, G	1
von Eckardstein, A	1
BROWN, GW	1
CHAIKOFF, IL	1
CHAPMAN, DD	1
Tani, T	2
Taki, Y	2
Aoyama, H	1
Jikkoh, A	1
Arii, S	1
Ozawa, K	4
Tobe, T	2
Hildebrandt, LA	1
Spennetta, T	1
Elson, C	1
Shrago, E	1
Kajimura, K	1
Moriyasu, F	1
Someda, H	1
Okuma, M	1
Mori, K	2
Higashi, S	1
Tabata, N	1
Kondo, KH	1
Kai, M	1
Miyamoto, K	1
Maeda, Y	1
Setoguchi, T	1
Iwata, S	1
Shimahara, Y	1
Kobayashi, N	1
Kumada, K	1
Yamaoka, Y	1
Jikko, A	1
Minematsu, S	1
Yamamoto, M	1
Kamiyama, Y	1

Studies

Suk, FM

Wu, CY

Chiu, WC

Chien, CY

Chen, TL

Liao, YJ

Wang, MR

Zhang, X

Liu, YQ

Uehara, Y

Engel, T

Li, Z

Goepfert, C

Rust, S

Zhou, X

Langer, C

Schachtrup, C

Wiekowski, J

Lorkowski, S

Assmann, G

von Eckardstein, A

BROWN, GW

CHAIKOFF, IL

CHAPMAN, DD

Tani, T

Taki, Y

Aoyama, H

Jikkoh, A

Arii, S

Ozawa, K

Tobe, T

Hildebrandt, LA

Spennetta, T

Elson, C

Shrago, E

Kajimura, K

Moriyasu, F

Someda, H

Okuma, M

Mori, K

Higashi, S

Tabata, N

Kondo, KH

Kai, M

Miyamoto, K

Maeda, Y

Setoguchi, T

Iwata, S

Shimahara, Y

Kobayashi, N

Kumada, K

Yamaoka, Y

Jikko, A

Minematsu, S

Yamamoto, M

Kamiyama, Y

Other Studies

10 other study(ies) available for acetoacetic acid and Cancer of Liver

Article	Year
HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells. Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Synthase; Ketone Bodies; Ketones; Liver Neoplasms; Male; Sorafenib; Treatment Outcome	2022
HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells. Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Synthase; Ketone Bodies; Ketones; Liver Neoplasms; Male; Sorafenib; Treatment Outcome	2022
HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells. Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Synthase; Ketone Bodies; Ketones; Liver Neoplasms; Male; Sorafenib; Treatment Outcome	2022
[Acetoacetate extract from Celastrus orbiculatus Thunb inhibits growth of RFP-xenografted human liver carcinoma]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2012, Volume: 20, Issue:5 Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Celastrus; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Plant Extracts; Xenograft Model Antitumor Assays	2012
Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1. Diabetes, 2002, Volume: 51, Issue:10 Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Cholesterol, HDL; Diabetes Mellitus, Experimental; Down-Regulation; Fatty Acids, Unsaturated; Gene Expression; Hepatocytes; Humans; Liver Neoplasms; Macrophages, Peritoneal; Mice; Tumor Cells, Cultured	2002
Demonstration of beta-oxidation and acetoacetate formation in a mouse hepatoma. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 84, Issue:3 Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Neoplasms, Experimental; Oxidation-Reduction	1953
Changes in acetoacetate/beta-hydroxybutyrate ratio in arterial blood following hepatic artery embolization in man. Life sciences, 1984, Sep-10, Volume: 35, Issue:11 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Hepatic Artery; Hepatic Veins; Humans; Hydroxybutyrates; Liver Neoplasms; Male; Middle Aged; NAD; Time Factors	1984
Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells. The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carcinoma, Hepatocellular; Cell Separation; Citrates; Fatty Acids; Hydroxybutyrates; Ketone Bodies; Lipids; Liver Neoplasms; Male; Rats; Rats, Inbred BUF; Subcellular Fractions; Tissue Distribution	1995
Transcatheter hepatic arterial drug infusion therapy for hepatocellular carcinoma. Effect on the arterial ketone body ratio. Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antineoplastic Agents; Butyrates; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Hepatic Artery; Humans; Hydroxybutyrates; Infusions, Intra-Arterial; Ketone Bodies; Liver Neoplasms; Male; Middle Aged; Time Factors	1993
A predominant increase of arterial beta-hydroxybutyrate concentration during partial hepatectomies in patients with impaired indocyanine green clearance test. The Journal of surgical research, 1999, Volume: 81, Issue:2 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Coloring Agents; Female; Hepatectomy; Hepatic Veins; Humans; Indocyanine Green; Ketone Bodies; Liver Diseases; Liver Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Radial Artery; Regression Analysis	1999
Diurnal fluctuations of arterial ketone body ratio in normal subjects and patients with liver dysfunction. Gastroenterology, 1991, Volume: 100, Issue:5 Pt 1 Topics: Acetoacetates; Adult; Aged; Blood Glucose; Carcinoma, Hepatocellular; Chronic Disease; Circadian Rhythm; Fatty Acids; Female; Hepatic Encephalopathy; Hepatitis; Humans; Hydroxybutyrates; Insulin; Ketone Bodies; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction	1991
Short-term changes in blood ketone body ratios in the phase immediately after hepatic artery embolization: their clinical significance. The American journal of the medical sciences, 1986, Volume: 291, Issue:2 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Hepatic Artery; Humans; Hydroxybutyrates; Ketone Bodies; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction; Time Factors	1986

Article

Year

HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells.

Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22

Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Synthase; Ketone Bodies; Ketones; Liver Neoplasms; Male; Sorafenib; Treatment Outcome

2022

HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells.

Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22

2022

HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells.

Molecules (Basel, Switzerland), 2022, Nov-18, Volume: 27, Issue:22

2022

[Acetoacetate extract from Celastrus orbiculatus Thunb inhibits growth of RFP-xenografted human liver carcinoma].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2012, Volume: 20, Issue:5

Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Celastrus; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Plant Extracts; Xenograft Model Antitumor Assays

2012

Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.

Diabetes, 2002, Volume: 51, Issue:10

Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Cholesterol, HDL; Diabetes Mellitus, Experimental; Down-Regulation; Fatty Acids, Unsaturated; Gene Expression; Hepatocytes; Humans; Liver Neoplasms; Macrophages, Peritoneal; Mice; Tumor Cells, Cultured

2002

Demonstration of beta-oxidation and acetoacetate formation in a mouse hepatoma.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 84, Issue:3

Topics: Acetoacetates; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Neoplasms, Experimental; Oxidation-Reduction

1953

Changes in acetoacetate/beta-hydroxybutyrate ratio in arterial blood following hepatic artery embolization in man.

Life sciences, 1984, Sep-10, Volume: 35, Issue:11

Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Hepatic Artery; Hepatic Veins; Humans; Hydroxybutyrates; Liver Neoplasms; Male; Middle Aged; NAD; Time Factors

1984

Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells.

The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1

Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Carcinoma, Hepatocellular; Cell Separation; Citrates; Fatty Acids; Hydroxybutyrates; Ketone Bodies; Lipids; Liver Neoplasms; Male; Rats; Rats, Inbred BUF; Subcellular Fractions; Tissue Distribution

1995

Transcatheter hepatic arterial drug infusion therapy for hepatocellular carcinoma. Effect on the arterial ketone body ratio.

Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:6

Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antineoplastic Agents; Butyrates; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Hepatic Artery; Humans; Hydroxybutyrates; Infusions, Intra-Arterial; Ketone Bodies; Liver Neoplasms; Male; Middle Aged; Time Factors

1993

A predominant increase of arterial beta-hydroxybutyrate concentration during partial hepatectomies in patients with impaired indocyanine green clearance test.

The Journal of surgical research, 1999, Volume: 81, Issue:2

Topics: 3-Hydroxybutyric Acid; Acetoacetates; Coloring Agents; Female; Hepatectomy; Hepatic Veins; Humans; Indocyanine Green; Ketone Bodies; Liver Diseases; Liver Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Radial Artery; Regression Analysis

1999

Diurnal fluctuations of arterial ketone body ratio in normal subjects and patients with liver dysfunction.

Gastroenterology, 1991, Volume: 100, Issue:5 Pt 1

Topics: Acetoacetates; Adult; Aged; Blood Glucose; Carcinoma, Hepatocellular; Chronic Disease; Circadian Rhythm; Fatty Acids; Female; Hepatic Encephalopathy; Hepatitis; Humans; Hydroxybutyrates; Insulin; Ketone Bodies; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction

1991

Short-term changes in blood ketone body ratios in the phase immediately after hepatic artery embolization: their clinical significance.

The American journal of the medical sciences, 1986, Volume: 291, Issue:2

Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Hepatic Artery; Humans; Hydroxybutyrates; Ketone Bodies; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction; Time Factors

1986